{"id":"https://openalex.org/W2077518331","doi":"https://doi.org/10.3109/00365599.2012.727859","title":"Combination of real-time elastography and urine prostate cancer gene 3 (PCA3) detects more than 97% of significant prostate cancers","display_name":"Combination of real-time elastography and urine prostate cancer gene 3 (PCA3) detects more than 97% of significant prostate cancers","publication_year":2012,"publication_date":"2012-10-04","ids":{"openalex":"https://openalex.org/W2077518331","doi":"https://doi.org/10.3109/00365599.2012.727859","mag":"2077518331","pmid":"https://pubmed.ncbi.nlm.nih.gov/23035756"},"language":"en","primary_location":{"id":"doi:10.3109/00365599.2012.727859","doi":"https://doi.org/10.3109/00365599.2012.727859","is_oa":true,"landing_page_url":"https://doi.org/10.3109/00365599.2012.727859","pdf_url":null,"source":{"id":"https://openalex.org/S4210197097","display_name":"Scandinavian Journal of Urology","issn_l":"2168-1805","issn":["2168-1805","2168-1813"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.3109/00365599.2012.727859","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033782988","display_name":"Yngve Nyg\u00e5rd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Yngve Nyg\u00e5rd","raw_affiliation_strings":["Department of Urology, Haukeland University Hospital, Norway","Department of Urology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Haukeland University Hospital, Norway","institution_ids":["https://openalex.org/I2800740805"]},{"raw_affiliation_string":"Department of Urology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088685391","display_name":"Svein Andreas Haukaas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Svein A. Haukaas","raw_affiliation_strings":["Department of Urology; Department of Surgical Sciences","Department of Surgical Sciences","Department of Urology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology; Department of Surgical Sciences","institution_ids":[]},{"raw_affiliation_string":"Department of Surgical Sciences","institution_ids":[]},{"raw_affiliation_string":"Department of Urology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006956038","display_name":"Jo Erling Riise Waage","orcid":"https://orcid.org/0009-0001-9458-8743","observed_orcids":["https://orcid.org/0009-0001-9458-8743"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jo E. R. Waage","raw_affiliation_strings":["Gastrointestinal Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065497368","display_name":"OLE JOHAN HALVORSEN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ole J. Halvorsen","raw_affiliation_strings":["Pathology, Haukeland University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Haukeland University Hospital","institution_ids":["https://openalex.org/I2800740805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056039603","display_name":"Karsten Gravdal","orcid":"https://orcid.org/0009-0004-5914-0515","observed_orcids":["https://orcid.org/0009-0004-5914-0515"]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Karsten Gravdal","raw_affiliation_strings":["Pathology, Haukeland University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Haukeland University Hospital","institution_ids":["https://openalex.org/I2800740805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056182884","display_name":"Jannicke Frug\u00e5rd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jannicke Frug\u00e5rd","raw_affiliation_strings":["Department of Urology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068445062","display_name":"Lars A. Akslen","orcid":"https://orcid.org/0000-0003-2710-9543","observed_orcids":["https://orcid.org/0000-0003-2710-9543"]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Lars A. Akslen","raw_affiliation_strings":["Pathology, Haukeland University Hospital; The Gade Institute, University of Bergen, Norway","Pathology, Haukeland University Hospital","The Gade Institute, University of Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Haukeland University Hospital; The Gade Institute, University of Bergen, Norway","institution_ids":["https://openalex.org/I2800740805","https://openalex.org/I4432739"]},{"raw_affiliation_string":"Pathology, Haukeland University Hospital","institution_ids":["https://openalex.org/I2800740805"]},{"raw_affiliation_string":"The Gade Institute, University of Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030558226","display_name":"Christian Beisland","orcid":"https://orcid.org/0000-0002-3216-4937","observed_orcids":["https://orcid.org/0000-0002-3216-4937"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christian Beisland","raw_affiliation_strings":["Department of Urology; Department of Surgical Sciences","Department of Surgical Sciences","Department of Urology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology; Department of Surgical Sciences","institution_ids":[]},{"raw_affiliation_string":"Department of Surgical Sciences","institution_ids":[]},{"raw_affiliation_string":"Department of Urology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030558226"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.401,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.80925548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"47","issue":"3","first_page":"211","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.7914999723434448,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.7914999723434448,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.1859000027179718,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9390000104904175},{"id":"https://openalex.org/keywords/real-time-elastography","display_name":"real-time elastography","score":0.9539999961853027},{"id":"https://openalex.org/keywords/prostate-cancer-biomarkers","display_name":"prostate cancer biomarkers","score":0.6169999837875366},{"id":"https://openalex.org/keywords/combined-diagnostic-tests","display_name":"combined diagnostic testing","score":0.515999972820282},{"id":"https://openalex.org/keywords/cancer-detection","display_name":"cancer detection","score":0.6340000033378601},{"id":"https://openalex.org/keywords/radical-prostatectomy","display_name":"radical prostatectomy","score":0.7620000243186951},{"id":"https://openalex.org/keywords/transrectal-ultrasound","display_name":"transrectal ultrasound","score":0.7250000238418579},{"id":"https://openalex.org/keywords/false-negative-detection","display_name":"false negative detection","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.787054717540741},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.7632611989974976},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6550162434577942},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6216826438903809},{"id":"https://openalex.org/C2777690781","wikidata":"https://www.wikidata.org/wiki/Q1324974","display_name":"Elastography","level":3,"score":0.5802967548370361},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5165209174156189},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.46734505891799927},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39296796917915344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3544059991836548},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35049325227737427},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.21486464142799377},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.088524729013443}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009664","descriptor_name":"Norway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D054459","descriptor_name":"Elasticity Imaging Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/00365599.2012.727859","doi":"https://doi.org/10.3109/00365599.2012.727859","is_oa":true,"landing_page_url":"https://doi.org/10.3109/00365599.2012.727859","pdf_url":null,"source":{"id":"https://openalex.org/S4210197097","display_name":"Scandinavian Journal of Urology","issn_l":"2168-1805","issn":["2168-1805","2168-1813"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Urology","raw_type":"journal-article"},{"id":"pmid:23035756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23035756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of urology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.3109/00365599.2012.727859","doi":"https://doi.org/10.3109/00365599.2012.727859","is_oa":true,"landing_page_url":"https://doi.org/10.3109/00365599.2012.727859","pdf_url":null,"source":{"id":"https://openalex.org/S4210197097","display_name":"Scandinavian Journal of Urology","issn_l":"2168-1805","issn":["2168-1805","2168-1813"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Urology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1535063162","https://openalex.org/W1550022481","https://openalex.org/W1989378496","https://openalex.org/W2015561332","https://openalex.org/W2035809577","https://openalex.org/W2055631758","https://openalex.org/W2059103408","https://openalex.org/W2067378511","https://openalex.org/W2084078957","https://openalex.org/W2098905361","https://openalex.org/W2100762183","https://openalex.org/W2119063172","https://openalex.org/W2132803044","https://openalex.org/W2149700494","https://openalex.org/W2154121139","https://openalex.org/W2169385858","https://openalex.org/W2187487994","https://openalex.org/W4248836268"],"related_works":["https://openalex.org/W2124501483","https://openalex.org/W2474281237","https://openalex.org/W2523829534","https://openalex.org/W7097744246","https://openalex.org/W2086529805","https://openalex.org/W154329003","https://openalex.org/W2149700494","https://openalex.org/W2807074121","https://openalex.org/W2101447838","https://openalex.org/W2354064455"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,25,84,121,175,183,213,226],"prostate":[2,15,42,78,112,208,224,245],"cancer":[3,38,113,158,209],"gene":[4],"3":[5],"(PCA3)":[6],"score":[7,86,123,185,217],"in":[8,40,48,99,126,136,148,161,171,180,188,237],"urine":[9,68],"is":[10,20],"a":[11,21,66,90],"promising":[12],"biomarker":[13],"for":[14,62,110],"cancer.":[16,246],"Real-time":[17],"elastography":[18],"(RTE)":[19],"well-documented":[22],"ultrasound":[23],"modality.":[24],"objective":[26],"of":[27,94,139,151,173,191,202,215,222,229,241],"this":[28],"study":[29],"was":[30,82,87,97,124,159,177,186],"to":[31,35,56],"evaluate":[32],"the":[33,41,108,118,145],"ability":[34],"detect":[36],"significant":[37,207,223],"foci":[39],"with":[43,77,89,101,206,243],"these":[44],"methods":[45],"alone":[46],"and":[47,70,114,164,218,231],"combination.":[49],"MATERIAL":[50],"AND":[51],"METHODS:":[52],"From":[53],"September":[54,57],"2009":[55],"2010,":[58],"40":[59],"patients":[60,106,128,141,153,163,204],"planned":[61],"radical":[63],"prostatectomy":[64],"underwent":[65],"PCA3":[67,85,122,184,216,232],"test":[69],"RTE":[71,96,130,143,165,176,194,219,230],"before":[72],"operation.":[73],"A":[74],"Hitachi":[75],"EUB-8500":[76],"end-fire":[79],"transrectal":[80],"probe":[81],"used.":[83],"evaluated":[88,98],"standard":[91],"cut-off":[92],"value":[93],"35.":[95],"correlation":[100],"whole-mount":[102],"section":[103],"pathology.":[104],"Three":[105],"fulfilled":[107],"criteria":[109],"insignificant":[111],"were":[115,210],"excluded":[116],"from":[117],"study.":[119],"RESULTS:":[120],"increased":[125,187],"26":[127],"(70%).":[129],"identified":[131,166],"at":[132],"least":[133],"one":[134,157,169],"tumour":[135,147,170],"33":[137],"out":[138,150,190,201],"37":[140,152,203],"(89%).":[142],"detected":[144,220],"largest":[146],"27":[149],"(73%).":[154],"More":[155],"than":[156,168],"present":[160],"29":[162],"more":[167],"13":[172],"these.":[174],"false":[178],"positive":[179],"four":[181,192],"patients.":[182,195],"three":[189],"false-negative":[193],"By":[196],"combining":[197],"both":[198],"methods,":[199],"36":[200],"(97%)":[205],"detected.":[211],"CONCLUSIONS:":[212],"combination":[214],"97%":[221],"cancers.":[225],"combinative":[227],"use":[228],"will":[233],"be":[234],"further":[235],"investigated":[236],"an":[238],"unselected":[239],"series":[240],"men":[242],"suspected":[244]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
