{"id":"https://openalex.org/W2077516224","doi":"https://doi.org/10.1111/j.1749-6632.2002.tb02922.x","title":"Cellular Protection with Proanthocyanidins Derived from Grape Seeds","display_name":"Cellular Protection with Proanthocyanidins Derived from Grape Seeds","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2077516224","doi":"https://doi.org/10.1111/j.1749-6632.2002.tb02922.x","mag":"2077516224","pmid":"https://pubmed.ncbi.nlm.nih.gov/12074978"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.2002.tb02922.x","doi":"https://doi.org/10.1111/j.1749-6632.2002.tb02922.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.2002.tb02922.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019498762","display_name":"Debasis Bagchi","orcid":"https://orcid.org/0000-0001-9478-6427","observed_orcids":["https://orcid.org/0000-0001-9478-6427"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]},{"id":"https://openalex.org/I138873065","display_name":"Long Island University","ror":"https://ror.org/0324fzh77","country_code":"US","type":"education","lineage":["https://openalex.org/I138873065"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"DEBASIS BAGCHI","raw_affiliation_strings":["Department of Pharmacy Services, Creighton University School of Pharmacy & Allied Health Professions, Omaha, Nebraska 68178, USA. debsis@creighton.edu","Creighton University School of Pharmacy & Allied Health Professions, Omaha, Nebraska 68178, USA","Department of Pharmacology, Toxicology and Medicinal Chemistry, AMS College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York 11201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Services, Creighton University School of Pharmacy & Allied Health Professions, Omaha, Nebraska 68178, USA. debsis@creighton.edu","institution_ids":["https://openalex.org/I114493937"]},{"raw_affiliation_string":"Creighton University School of Pharmacy & Allied Health Professions, Omaha, Nebraska 68178, USA","institution_ids":["https://openalex.org/I114493937"]},{"raw_affiliation_string":"Department of Pharmacology, Toxicology and Medicinal Chemistry, AMS College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York 11201, USA","institution_ids":["https://openalex.org/I138873065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025047849","display_name":"Manashi Bagchi","orcid":"https://orcid.org/0000-0002-1527-6419","observed_orcids":["https://orcid.org/0000-0002-1527-6419"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MANASHI BAGCHI","raw_affiliation_strings":["Creighton University School of Pharmacy & Allied Health Professions, Omaha, Nebraska 68178, USA","Creighton University School of Pharmacy and Allied Health Professions, Omaha, Nebraska 68178 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Creighton University School of Pharmacy & Allied Health Professions, Omaha, Nebraska 68178, USA","institution_ids":["https://openalex.org/I114493937"]},{"raw_affiliation_string":"Creighton University School of Pharmacy and Allied Health Professions, Omaha, Nebraska 68178 USA","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062695970","display_name":"SIDNEY J. STOHS","orcid":"https://orcid.org/0000-0001-5575-5759","observed_orcids":["https://orcid.org/0000-0001-5575-5759"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SIDNEY J. STOHS","raw_affiliation_strings":["Creighton University School of Pharmacy & Allied Health Professions, Omaha, Nebraska 68178, USA","Creighton University School of Pharmacy and Allied Health Professions, Omaha, Nebraska 68178 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Creighton University School of Pharmacy & Allied Health Professions, Omaha, Nebraska 68178, USA","institution_ids":["https://openalex.org/I114493937"]},{"raw_affiliation_string":"Creighton University School of Pharmacy and Allied Health Professions, Omaha, Nebraska 68178 USA","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110883647","display_name":"Sidhartha D. Ray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138873065","display_name":"Long Island University","ror":"https://ror.org/0324fzh77","country_code":"US","type":"education","lineage":["https://openalex.org/I138873065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SIDHARTHA D. RAY","raw_affiliation_strings":["Department of Pharmacology, Toxicology and Medicinal Chemistry, AMS College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York 11201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology and Medicinal Chemistry, AMS College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York 11201, USA","institution_ids":["https://openalex.org/I138873065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056267400","display_name":"Chandan K. Sen","orcid":"https://orcid.org/0000-0003-3151-5202","observed_orcids":["https://orcid.org/0000-0003-3151-5202","https://orcid.org/0000-0002-2936-417X"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CHANDAN K. SEN","raw_affiliation_strings":["Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047768346","display_name":"Harry G. Preuss","orcid":"https://orcid.org/0000-0002-9170-4913","observed_orcids":["https://orcid.org/0000-0002-9170-4913"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HARRY G. PREUSS","raw_affiliation_strings":["Department of Physiology and Biophysics, Georgetown University, Medical Center, Washington, DC 20007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Georgetown University, Medical Center, Washington, DC 20007, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5019498762"],"corresponding_institution_ids":["https://openalex.org/I114493937","https://openalex.org/I138873065"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":5.6679,"has_fulltext":false,"cited_by_count":269,"citation_normalized_percentile":{"value":0.96902412,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"957","issue":"1","first_page":"260","last_page":"270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.04149999842047691,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grape-seed-proanthocyanidins","display_name":"grape seed proanthocyanidins","score":0.9779999852180481},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.796999990940094},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9100000262260437},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.6700000166893005},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.7689999938011169},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.925000011920929},{"id":"https://openalex.org/keywords/immunotoxicity","display_name":"immunotoxicity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.6830000281333923},{"id":"https://openalex.org/keywords/cyp2e1","display_name":"CYP2E1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6740000247955322},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.6069999933242798},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9980000257492065},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6480000019073486},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/t-cell-adhesion","display_name":"T cell adhesion","score":0.8100000023841858},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.5860000252723694},{"id":"https://openalex.org/keywords/tumor-cell-killing","display_name":"tumor cell killing","score":0.5929999947547913},{"id":"https://openalex.org/keywords/oral-keratinocytes","display_name":"oral keratinocytes","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6874502897262573},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.5959941744804382},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5851185321807861},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5811563730239868},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5412824153900146},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5275270938873291},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5007398128509521},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.49968910217285156},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.45989516377449036},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.42734912037849426},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3773784339427948},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3257180452346802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2661415636539459},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2001468539237976},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.06811496615409851},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000872","descriptor_name":"Anthocyanins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000872","descriptor_name":"Anthocyanins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012639","descriptor_name":"Seeds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D027843","descriptor_name":"Vitis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044945","descriptor_name":"Proanthocyanidins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.2002.tb02922.x","doi":"https://doi.org/10.1111/j.1749-6632.2002.tb02922.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.2002.tb02922.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:12074978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12074978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W80851243","https://openalex.org/W96114049","https://openalex.org/W99833540","https://openalex.org/W107764151","https://openalex.org/W375688760","https://openalex.org/W1487531210","https://openalex.org/W1554374902","https://openalex.org/W1593911429","https://openalex.org/W1907068960","https://openalex.org/W1977026888","https://openalex.org/W1991388123","https://openalex.org/W2020785892","https://openalex.org/W2037711564","https://openalex.org/W2062965061","https://openalex.org/W2072641576","https://openalex.org/W2089692757","https://openalex.org/W2121628915","https://openalex.org/W2409236211","https://openalex.org/W3006675229","https://openalex.org/W3023678583"],"related_works":["https://openalex.org/W1593911429","https://openalex.org/W2143656347","https://openalex.org/W1487531210","https://openalex.org/W99833540","https://openalex.org/W2052190542","https://openalex.org/W2765652612","https://openalex.org/W2149583984","https://openalex.org/W2007876572","https://openalex.org/W1586135191","https://openalex.org/W1989420792"],"abstract_inverted_index":{"Grape":[0],"seed":[1],"proanthocyanidins":[2],"have":[3,20],"been":[4],"reported":[5],"to":[6,219],"possess":[7],"a":[8,200,237],"broad":[9],"spectrum":[10],"of":[11,73,117,144,159,217],"pharmacological":[12],"and":[13,37,53,55,63,71,87,109,114,126,135,147,163,171,196,233,250],"medicinal":[14],"properties":[15],"against":[16,30,78,90],"oxidative":[17],"stress.":[18],"We":[19],"demonstrated":[21,56,184],"that":[22,228],"IH636":[23],"proanthocyanidin":[24],"extract":[25],"(GSPE)":[26],"provides":[27],"excellent":[28],"protection":[29,89,156],"free":[31,45],"radicals":[32],"in":[33,35,38,83,95,138,157,175,241],"both":[34],"vitro":[36],"vivo":[39],"models.":[40],"GSPE":[41,76,120,151,183,211,229],"had":[42],"significantly":[43,213],"better":[44],"radical":[46],"scavenging":[47],"ability":[48],"than":[49],"vitamins":[50],"C,":[51],"E":[52],"beta-carotene":[54],"significant":[57],"cytotoxicity":[58,94],"towards":[59],"human":[60,84,96],"breast,":[61],"lung":[62],"gastric":[64],"adenocarcinoma":[65],"cells,":[66],"while":[67],"enhancing":[68],"the":[69,112,189,204],"growth":[70],"viability":[72],"normal":[74],"cells.":[75],"protected":[77],"tobacco-induced":[79],"apoptotic":[80,170],"cell":[81,101,173],"death":[82,174],"oral":[85],"keratinocytes":[86],"provided":[88,153],"cancer":[91],"chemotherapeutic":[92],"drug-induced":[93],"liver":[97],"cells":[98],"by":[99,119,208,221],"modulating":[100],"cycle/apoptosis":[102],"regulatory":[103],"genes":[104],"such":[105],"as":[106,166,168,236],"bcl2,":[107],"p53":[108],"c-myc.":[110],"Recently,":[111],"bioavailability":[113],"mechanistic":[115],"pathways":[116],"cytoprotection":[118],"were":[121,149],"examined":[122],"on":[123,188],"acetaminophen-induced":[124],"hepatotoxicity":[125],"nephrotoxicity,":[127],"amiodarone-induced":[128],"pulmonary":[129],"toxicity,":[130],"doxorubicin-induced":[131],"cardiotoxicity,":[132],"DMN-induced":[133],"immunotoxicity":[134],"MOCAP-induced":[136],"neurotoxicity":[137],"mice.":[139],"Serum":[140],"chemistry":[141,161],"changes,":[142],"integrity":[143],"genomic":[145],"DNA":[146,164],"histopathology":[148],"assessed.":[150],"pre-exposure":[152],"near":[154],"complete":[155],"terms":[158],"serum":[160],"changes":[162],"damage,":[165],"well":[167],"abolished":[169],"necrotic":[172],"all":[176],"tissues.":[177],"Histopathological":[178],"examination":[179],"reconfirmed":[180],"these":[181],"findings.":[182],"concentration-/dose-dependent":[185],"inhibitory":[186],"effects":[187],"drug":[190],"metabolizing":[191],"enzyme":[192],"cytochrome":[193],"P450":[194],"2E1,":[195],"this":[197],"may":[198,234],"be":[199],"major":[201],"pathway":[202],"for":[203],"anti-toxic":[205],"potential":[206,238],"exerted":[207],"GSPE.":[209],"Furthermore,":[210],"treatment":[212],"decreased":[214],"TNFalpha-induced":[215],"adherence":[216],"T-cells":[218],"HUVEC":[220],"inhibiting":[222],"VCAM-1":[223],"expression.":[224],"These":[225],"results":[226],"demonstrate":[227],"is":[230],"highly":[231],"bioavailable":[232],"serve":[235],"therapeutic":[239],"tool":[240],"protecting":[242],"multiple":[243],"target":[244],"organs":[245],"from":[246],"structurally":[247],"diverse":[248],"drug-":[249],"chemical-induced":[251],"toxicity.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
