{"id":"https://openalex.org/W207708690","doi":null,"title":"Renoprotective effects of combined endothelin-converting enzyme/neutral endopeptidase inhibitor SLV338 in acute and chronic experimental renal damage.","display_name":"Renoprotective effects of combined endothelin-converting enzyme/neutral endopeptidase inhibitor SLV338 in acute and chronic experimental renal damage.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W207708690","mag":"207708690","pmid":"https://pubmed.ncbi.nlm.nih.gov/21888014"},"language":"en","primary_location":{"id":"pmid:21888014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21888014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical laboratory","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090379669","display_name":"Yuliya Sharkovska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yuliya Sharkovska","raw_affiliation_strings":["Institute for Nutritional Science, University of Potsdam, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Nutritional Science, University of Potsdam, Germany","institution_ids":["https://openalex.org/I176453806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007484586","display_name":"Philipp Kalk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philipp Kalk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017332628","display_name":"Karoline von Websky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karoline von Websky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082183114","display_name":"Katharina Relle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katharina Relle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059070828","display_name":"Thiemo Pfab","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thiemo Pfab","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026754112","display_name":"Markus Alter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Markus Alter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051629956","display_name":"Yvan Fischer","orcid":"https://orcid.org/0009-0006-8632-3469","observed_orcids":["https://orcid.org/0009-0006-8632-3469"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yvan Fischer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022687335","display_name":"Berthold Hocher","orcid":"https://orcid.org/0000-0001-8143-0579","observed_orcids":["https://orcid.org/0000-0001-8143-0579"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Berthold Hocher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4336,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.87551434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"57","issue":"7-8","first_page":"507","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutral-endopeptidase-inhibition","display_name":"neutral endopeptidase inhibition","score":0.7820000052452087},{"id":"https://openalex.org/keywords/endothelin-converting-enzyme-inhibition","display_name":"endothelin-converting enzyme inhibition","score":0.953000009059906},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.8339999914169312},{"id":"https://openalex.org/keywords/renal-ischemia-reperfusion","display_name":"renal ischemia-reperfusion","score":0.8539999723434448},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.7639999985694885},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.7820000052452087},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/glomerulosclerosis","display_name":"glomerulosclerosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.8519999980926514},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.8830000162124634},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.7039999961853027},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.5109999775886536},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.823893129825592},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.6587743163108826},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.6249080300331116},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6145101189613342},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5919913649559021},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.5819507837295532},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5677385926246643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5671023726463318},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.476202130317688},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4706646203994751},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.42986243963241577},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05115419626235962}],"mesh":[{"descriptor_ui":"D000072396","descriptor_name":"Endothelin-Converting Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003250","descriptor_name":"Constriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005923","descriptor_name":"Glomerulosclerosis, Focal Segmental","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D009392","descriptor_name":"Nephrectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015260","descriptor_name":"Neprilysin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:21888014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21888014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical laboratory","raw_type":"Journal Article"},{"id":"pmh:oai:kobv.de-opus4-uni-potsdam:37159","doi":null,"is_oa":false,"landing_page_url":"https://publishup.uni-potsdam.de/frontdoor/index/index/docId/37159","pdf_url":null,"source":{"id":"https://openalex.org/S4306400594","display_name":"publish.UP (University of Potsdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176453806","host_organization_name":"University of Potsdam","host_organization_lineage":["https://openalex.org/I176453806"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"mag:207708690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21888014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1489561788","https://openalex.org/W1489794536","https://openalex.org/W1533862150","https://openalex.org/W1978556591","https://openalex.org/W1987464405","https://openalex.org/W1988064984","https://openalex.org/W1991742244","https://openalex.org/W1992584057","https://openalex.org/W1992666213","https://openalex.org/W1998137947","https://openalex.org/W2019288442","https://openalex.org/W2031012006","https://openalex.org/W2034044544","https://openalex.org/W2038044228","https://openalex.org/W2045516356","https://openalex.org/W2055920452","https://openalex.org/W2063013576","https://openalex.org/W2076584321","https://openalex.org/W2094988613","https://openalex.org/W2112116635","https://openalex.org/W2127968729","https://openalex.org/W2130196477","https://openalex.org/W2132602077","https://openalex.org/W2143954917","https://openalex.org/W2144582052","https://openalex.org/W2156753852"],"related_works":["https://openalex.org/W2169011613","https://openalex.org/W1987464405","https://openalex.org/W2047125482","https://openalex.org/W2313813711","https://openalex.org/W2112068096","https://openalex.org/W2025099449","https://openalex.org/W2255826847","https://openalex.org/W2055920452","https://openalex.org/W2403154797","https://openalex.org/W2289440307"],"abstract_inverted_index":{"BACKGROUND:":[0],"Acute":[1,71,195],"kidney":[2,30,41,62,87,298],"injury":[3],"(AKI)":[4],"as":[5,7,64,66,114],"well":[6,65],"chronic":[8,40,67],"renal":[9,68,72,128,131,196,255,259,273,279,307,315],"failure":[10,31,63,73,223],"are":[11],"associated":[12],"with":[13,166,173,217,263],"a":[14,34,50,199,227,319],"huge":[15],"mortality/morbidity.":[16],"However,":[17],"so":[18],"far":[19],"no":[20],"drugs":[21],"have":[22],"been":[23],"approved":[24],"for":[25,36,88,101,154],"the":[26,37,46,85,162],"treatment":[27,38,238],"of":[28,39,48,60,84],"acute":[29,61,305],"and":[32,82,122,125,185,190,258,300],"only":[33,234],"few":[35],"disease":[42],"(CKD).":[43],"We":[44],"analysed":[45],"effect":[47],"SLV338,":[49],"neutral":[51],"endopeptidase":[52],"(NEP)/endothelin":[53],"converting":[54],"enzyme":[55],"(ECE)-inhibitor":[56],"in":[57,76,135,214,230,288,303,318,324],"animal":[58],"models":[59],"failure.":[69,308],"METHODS:":[70],"was":[74,98,118,133,159,178,207,224],"induced":[75,134],"male":[77,136],"Wistar":[78],"rats":[79,139],"by":[80,140,210,226],"uninephrectomy":[81],"clamping":[83],"remaining":[86],"55":[89],"minutes.":[90],"SLV338":[91,167,218,237,264,296],"(total":[92],"dose:":[93],"4.9":[94],"mg/kg)":[95],"or":[96],"vehicle":[97],"continuously":[99],"infused":[100],"2":[102,124],"hours":[103],"(starting":[104],"20":[105],"minutes":[106],"prior":[107],"to":[108,151,243],"clamping).":[109],"Sham":[110],"operated":[111],"animals":[112,215],"served":[113],"controls.":[115],"Plasma":[116],"creatinine":[117,202],"measured":[119],"at":[120],"baseline":[121],"day":[123],"8":[126],"after":[127,236],"ischemia-reperfusion.":[129],"Hypertensive":[130],"damage":[132,275,317],"Sprague":[137],"Dawley":[138],"nitric":[141],"oxide":[142],"deficiency":[143],"using":[144],"L-NAME":[145,247,286],"(50":[146],"mg/kg":[147,169],"per":[148,170],"day,":[149,171],"added":[150],"drinking":[152],"water":[153],"4":[155],"weeks).":[156],"One":[157],"group":[158,287],"treated":[160,216],"over":[161],"same":[163],"time":[164],"period":[165],"(30":[168],"mixed":[172],"food).":[174],"Systolic":[175],"blood":[176,186,269,320],"pressure":[177,321],"monitored":[179],"weekly.":[180],"At":[181],"study":[182],"end,":[183],"urine":[184],"samples":[187],"were":[188,192],"collected":[189],"kidneys":[191],"harvested.":[193],"RESULTS:":[194],"ischemia-reperfusion":[197],"caused":[198,249],"5-fold":[200],"plasma":[201],"elevation":[203],"(day":[204],"2),":[205],"which":[206],"significantly":[208,267],"attenuated":[209],"more":[211],"than":[212],"50%":[213],"(p":[219,239,282],"<":[220,283],"0.05).":[221],"Renal":[222],"accompanied":[225],"67%":[228],"mortality":[229,302],"vehicle-treated":[231],"rats,":[232],"but":[233,271],"20%":[235],"=":[240],"0.03":[241],"compared":[242],"sham":[244],"controls).":[245],"Chronic":[246],"administration":[248],"hypertension,":[250],"urinary":[251],"albumin":[252],"excretion,":[253],"glomerulosclerosis,":[254,278],"arterial":[256,280],"remodelling,":[257],"interstitial":[260],"fibrosis.":[261],"Treatment":[262],"did":[265],"not":[266],"affect":[268],"pressure,":[270],"abolished":[272],"tissue":[274,316],"(interstitial":[276],"fibrosis,":[277],"remodelling":[281],"0.05":[284],"versus":[285],"each":[289],"case).":[290],"CONCLUSIONS:":[291],"The":[292],"dual":[293],"ECE/NEP":[294,311],"inhibitor":[295],"preserves":[297],"function":[299],"reduces":[301],"severe":[304],"ischemic":[306],"Moreover,":[309],"combined":[310],"inhibition":[312],"prevents":[313],"hypertensive":[314],"independent":[322],"manner":[323],"L-NAME-treated":[325],"rats.":[326]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}