{"id":"https://openalex.org/W2077067540","doi":"https://doi.org/10.1016/j.it.2013.06.003","title":"Toll-like receptor regulation of effector T lymphocyte function","display_name":"Toll-like receptor regulation of effector T lymphocyte function","publication_year":2013,"publication_date":"2013-07-22","ids":{"openalex":"https://openalex.org/W2077067540","doi":"https://doi.org/10.1016/j.it.2013.06.003","mag":"2077067540","pmid":"https://pubmed.ncbi.nlm.nih.gov/23886621"},"language":"en","primary_location":{"id":"doi:10.1016/j.it.2013.06.003","doi":"https://doi.org/10.1016/j.it.2013.06.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.it.2013.06.003","pdf_url":null,"source":{"id":"https://openalex.org/S84926904","display_name":"Trends in Immunology","issn_l":"1471-4906","issn":["1471-4906","1471-4981"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066853381","display_name":"Joseph Michael Reynolds","orcid":"https://orcid.org/0000-0003-3490-0544","observed_orcids":["https://orcid.org/0000-0003-3490-0544"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I189273616","display_name":"Rosalind Franklin University of Medicine and Science","ror":"https://ror.org/04fegvg32","country_code":"US","type":"education","lineage":["https://openalex.org/I189273616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M. Reynolds","raw_affiliation_strings":["Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, 7455 Fannin, Unit 906, Houston, TX 77030, USA; Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay, North Chicago, IL 60064, USA","Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, 7455 Fannin, Unit 906, Houston, TX 77030, USA","Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay, North Chicago, IL 60064, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, 7455 Fannin, Unit 906, Houston, TX 77030, USA; Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay, North Chicago, IL 60064, USA","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I189273616"]},{"raw_affiliation_string":"Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, 7455 Fannin, Unit 906, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay, North Chicago, IL 60064, USA","institution_ids":["https://openalex.org/I189273616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100767305","display_name":"Chen Dong","orcid":"https://orcid.org/0000-0002-0084-9130","observed_orcids":["https://orcid.org/0000-0002-0084-9130"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chen Dong","raw_affiliation_strings":["Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, 7455 Fannin, Unit 906, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, 7455 Fannin, Unit 906, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100767305"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":1.4834,"has_fulltext":false,"cited_by_count":132,"citation_normalized_percentile":{"value":0.84611231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"34","issue":"10","first_page":"511","last_page":"519"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/t-cell-effector-function","display_name":"T cell effector function","score":0.8500000238418579},{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.7850000262260437},{"id":"https://openalex.org/keywords/toll-like-receptor-signaling","display_name":"Toll-like receptor signaling","score":0.5979999899864197},{"id":"https://openalex.org/keywords/innate-immune-signaling","display_name":"innate immune signaling","score":0.6069999933242798},{"id":"https://openalex.org/keywords/adaptive-immune-response","display_name":"adaptive immune response","score":0.7319999933242798},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/pattern-recognition-receptors","display_name":"pattern recognition receptors","score":0.8159999847412109},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6897637248039246},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6517066955566406},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6212135553359985},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.590129554271698},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.5828138589859009},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5788973569869995},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.575289785861969},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.5103420615196228},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.47716039419174194},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.46460622549057007},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.44219139218330383},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4234573245048523},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37162113189697266},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06795984506607056}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.it.2013.06.003","doi":"https://doi.org/10.1016/j.it.2013.06.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.it.2013.06.003","pdf_url":null,"source":{"id":"https://openalex.org/S84926904","display_name":"Trends in Immunology","issn_l":"1471-4906","issn":["1471-4906","1471-4981"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Immunology","raw_type":"journal-article"},{"id":"pmid:23886621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23886621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":109,"referenced_works":["https://openalex.org/W1483162601","https://openalex.org/W1483242994","https://openalex.org/W1495069464","https://openalex.org/W1514540900","https://openalex.org/W1519633296","https://openalex.org/W1520479678","https://openalex.org/W1524786677","https://openalex.org/W1554022361","https://openalex.org/W1573032931","https://openalex.org/W1770811198","https://openalex.org/W1832248617","https://openalex.org/W1894405407","https://openalex.org/W1915217100","https://openalex.org/W1950448919","https://openalex.org/W1961234435","https://openalex.org/W1965742783","https://openalex.org/W1969072247","https://openalex.org/W1971799655","https://openalex.org/W1972776583","https://openalex.org/W1982662898","https://openalex.org/W1987219992","https://openalex.org/W1987536937","https://openalex.org/W1987628377","https://openalex.org/W1994624777","https://openalex.org/W1995930566","https://openalex.org/W1998585620","https://openalex.org/W2001988677","https://openalex.org/W2003807404","https://openalex.org/W2004465286","https://openalex.org/W2004647500","https://openalex.org/W2008152503","https://openalex.org/W2010623178","https://openalex.org/W2012291120","https://openalex.org/W2014133727","https://openalex.org/W2014750930","https://openalex.org/W2014913358","https://openalex.org/W2017929603","https://openalex.org/W2019052607","https://openalex.org/W2019720275","https://openalex.org/W2028252121","https://openalex.org/W2030689421","https://openalex.org/W2035809809","https://openalex.org/W2047376205","https://openalex.org/W2048763742","https://openalex.org/W2050925766","https://openalex.org/W2051476172","https://openalex.org/W2052012708","https://openalex.org/W2052554412","https://openalex.org/W2053434264","https://openalex.org/W2054974176","https://openalex.org/W2057121293","https://openalex.org/W2058801589","https://openalex.org/W2060351820","https://openalex.org/W2063120378","https://openalex.org/W2070542788","https://openalex.org/W2071275789","https://openalex.org/W2074067501","https://openalex.org/W2074075011","https://openalex.org/W2074234815","https://openalex.org/W2074576387","https://openalex.org/W2076361525","https://openalex.org/W2077783001","https://openalex.org/W2078332608","https://openalex.org/W2079036853","https://openalex.org/W2086264253","https://openalex.org/W2093897672","https://openalex.org/W2094040702","https://openalex.org/W2096782178","https://openalex.org/W2098336582","https://openalex.org/W2101303899","https://openalex.org/W2101649073","https://openalex.org/W2102143593","https://openalex.org/W2102958639","https://openalex.org/W2104848162","https://openalex.org/W2105864815","https://openalex.org/W2107235439","https://openalex.org/W2107556895","https://openalex.org/W2107715779","https://openalex.org/W2108578752","https://openalex.org/W2109491705","https://openalex.org/W2110753254","https://openalex.org/W2114360891","https://openalex.org/W2114637517","https://openalex.org/W2115533257","https://openalex.org/W2119865930","https://openalex.org/W2121477549","https://openalex.org/W2124163410","https://openalex.org/W2125221059","https://openalex.org/W2129319296","https://openalex.org/W2130421043","https://openalex.org/W2131748081","https://openalex.org/W2131982022","https://openalex.org/W2136268380","https://openalex.org/W2136835089","https://openalex.org/W2138986864","https://openalex.org/W2145460651","https://openalex.org/W2151218267","https://openalex.org/W2151777859","https://openalex.org/W2152842365","https://openalex.org/W2155664411","https://openalex.org/W2158468056","https://openalex.org/W2158932972","https://openalex.org/W2159513688","https://openalex.org/W2161290719","https://openalex.org/W2161903097","https://openalex.org/W2165040190","https://openalex.org/W2167159137","https://openalex.org/W2167996547","https://openalex.org/W2413415525"],"related_works":["https://openalex.org/W1542238822","https://openalex.org/W7096211527","https://openalex.org/W8387223","https://openalex.org/W2412285629","https://openalex.org/W4214925106","https://openalex.org/W130896527","https://openalex.org/W2220092687","https://openalex.org/W2047054188","https://openalex.org/W118937234","https://openalex.org/W2090640877"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}