{"id":"https://openalex.org/W2077043080","doi":"https://doi.org/10.1038/ncomms5729","title":"Highly modular bow-tie gene circuits with programmable dynamic behaviour","display_name":"Highly modular bow-tie gene circuits with programmable dynamic behaviour","publication_year":2014,"publication_date":"2014-10-14","ids":{"openalex":"https://openalex.org/W2077043080","doi":"https://doi.org/10.1038/ncomms5729","mag":"2077043080","pmid":"https://pubmed.ncbi.nlm.nih.gov/25311543","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4197411"},"language":"en","primary_location":{"id":"doi:10.1038/ncomms5729","doi":"https://doi.org/10.1038/ncomms5729","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms5729","pdf_url":"https://www.nature.com/articles/ncomms5729.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/ncomms5729.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014416721","display_name":"Laura Prochazka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Laura Prochazka","raw_affiliation_strings":["Department of Biosystems Science and Engineering (D-BSSE), Swiss Federal Institute of Technology (ETH) Z\u00fcrich, Mattenstrasse 26, Basel 4058, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering (D-BSSE), Swiss Federal Institute of Technology (ETH) Z\u00fcrich, Mattenstrasse 26, Basel 4058, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079344906","display_name":"Bartolomeo Angelici","orcid":"https://orcid.org/0000-0002-9311-2276","observed_orcids":["https://orcid.org/0000-0002-9311-2276"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Bartolomeo Angelici","raw_affiliation_strings":["Department of Biosystems Science and Engineering (D-BSSE), Swiss Federal Institute of Technology (ETH) Z\u00fcrich, Mattenstrasse 26, Basel 4058, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering (D-BSSE), Swiss Federal Institute of Technology (ETH) Z\u00fcrich, Mattenstrasse 26, Basel 4058, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007086634","display_name":"Benjamin Haefliger","orcid":"https://orcid.org/0000-0002-7802-0883","observed_orcids":["https://orcid.org/0000-0002-7802-0883"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Benjamin Haefliger","raw_affiliation_strings":["Department of Biosystems Science and Engineering (D-BSSE), Swiss Federal Institute of Technology (ETH) Z\u00fcrich, Mattenstrasse 26, Basel 4058, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering (D-BSSE), Swiss Federal Institute of Technology (ETH) Z\u00fcrich, Mattenstrasse 26, Basel 4058, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072659013","display_name":"Yaakov Benenson","orcid":"https://orcid.org/0000-0003-1880-6507","observed_orcids":["https://orcid.org/0000-0003-1880-6507"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Yaakov Benenson","raw_affiliation_strings":["Department of Biosystems Science and Engineering (D-BSSE), Swiss Federal Institute of Technology (ETH) Z\u00fcrich, Mattenstrasse 26, Basel 4058, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering (D-BSSE), Swiss Federal Institute of Technology (ETH) Z\u00fcrich, Mattenstrasse 26, Basel 4058, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072659013"],"corresponding_institution_ids":["https://openalex.org/I35440088"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":null,"fwci":2.1858,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.88084879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"4729","last_page":"4729"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-gene-circuits","display_name":"synthetic gene circuits","score":0.9810000061988831},{"id":"https://openalex.org/keywords/transcriptional-activator","display_name":"transcriptional activator","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hek293-cells","display_name":"HEK293 cells","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mammalian-cells","display_name":"mammalian cells","score":0.4959999918937683},{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"protein dynamics","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.8051003217697144},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.6533697247505188},{"id":"https://openalex.org/C2779478453","wikidata":"https://www.wikidata.org/wiki/Q6889748","display_name":"Modularity (biology)","level":2,"score":0.5933980345726013},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5817950963973999},{"id":"https://openalex.org/C134146338","wikidata":"https://www.wikidata.org/wiki/Q1815901","display_name":"Electronic circuit","level":2,"score":0.5462770462036133},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.4489426612854004},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4321352243423462},{"id":"https://openalex.org/C102414288","wikidata":"https://www.wikidata.org/wiki/Q1172461","display_name":"Recombinase","level":4,"score":0.4221498370170593},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.4194886386394501},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35681015253067017},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2750287652015686},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2628215253353119},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19510090351104736},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18448784947395325},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.16990387439727783},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.09919688105583191},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/ncomms5729","doi":"https://doi.org/10.1038/ncomms5729","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms5729","pdf_url":"https://www.nature.com/articles/ncomms5729.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:25311543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25311543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3358820","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4197411","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4197411","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4197411","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5729","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/ncomms5729","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/ncomms5729","doi":"https://doi.org/10.1038/ncomms5729","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms5729","pdf_url":"https://www.nature.com/articles/ncomms5729.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G637553077","display_name":"MicroRNA Expression Profiling Circuits for Detection and Destruction of Cancer","funder_award_id":"R01CA155320","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320321652","display_name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","ror":"https://ror.org/05a28rw58"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2077043080.pdf","grobid_xml":"https://content.openalex.org/works/W2077043080.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1528557493","https://openalex.org/W1606635237","https://openalex.org/W1608357724","https://openalex.org/W1645305843","https://openalex.org/W1645799104","https://openalex.org/W1647075334","https://openalex.org/W1967729506","https://openalex.org/W1976414476","https://openalex.org/W1985827391","https://openalex.org/W2002326013","https://openalex.org/W2007491699","https://openalex.org/W2011083779","https://openalex.org/W2011206688","https://openalex.org/W2012175205","https://openalex.org/W2014456467","https://openalex.org/W2014624348","https://openalex.org/W2016959279","https://openalex.org/W2017400430","https://openalex.org/W2024826635","https://openalex.org/W2030513301","https://openalex.org/W2030513350","https://openalex.org/W2036719828","https://openalex.org/W2037174767","https://openalex.org/W2039015219","https://openalex.org/W2040516865","https://openalex.org/W2046013132","https://openalex.org/W2049758852","https://openalex.org/W2051073702","https://openalex.org/W2055060972","https://openalex.org/W2059247879","https://openalex.org/W2060339242","https://openalex.org/W2074106315","https://openalex.org/W2074163433","https://openalex.org/W2075031385","https://openalex.org/W2078334027","https://openalex.org/W2082398508","https://openalex.org/W2084615691","https://openalex.org/W2084736928","https://openalex.org/W2086527676","https://openalex.org/W2086976827","https://openalex.org/W2095463884","https://openalex.org/W2096881442","https://openalex.org/W2105336002","https://openalex.org/W2115181199","https://openalex.org/W2120661262","https://openalex.org/W2125987139","https://openalex.org/W2130979840","https://openalex.org/W2134759932","https://openalex.org/W2149146453","https://openalex.org/W2155234942","https://openalex.org/W2158075875","https://openalex.org/W2161405552","https://openalex.org/W2162590238","https://openalex.org/W2168458927","https://openalex.org/W2186876778","https://openalex.org/W2316378629"],"related_works":["https://openalex.org/W4254649798","https://openalex.org/W282108424","https://openalex.org/W1973339647","https://openalex.org/W4386318985","https://openalex.org/W3153508581","https://openalex.org/W1982919520","https://openalex.org/W59185488","https://openalex.org/W4213324126","https://openalex.org/W2076742616","https://openalex.org/W2782151283"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}