{"id":"https://openalex.org/W2076973727","doi":"https://doi.org/10.1002/path.1701","title":"Cell and tissue responses to genotoxic stress","display_name":"Cell and tissue responses to genotoxic stress","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2076973727","doi":"https://doi.org/10.1002/path.1701","mag":"2076973727","pmid":"https://pubmed.ncbi.nlm.nih.gov/15643669"},"language":"en","primary_location":{"id":"doi:10.1002/path.1701","doi":"https://doi.org/10.1002/path.1701","is_oa":false,"landing_page_url":"https://doi.org/10.1002/path.1701","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012430901","display_name":"Philip John Coates","orcid":"https://orcid.org/0000-0003-1518-6306","observed_orcids":["https://orcid.org/0000-0003-1518-6306"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip J Coates","raw_affiliation_strings":["Cancer Biology and Clinical Pathology Unit, Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK. p.j.coates@dundee.ac.uk","Cancer Biology and Clinical Pathology Unit, Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Clinical Pathology Unit, Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK. p.j.coates@dundee.ac.uk","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]},{"raw_affiliation_string":"Cancer Biology and Clinical Pathology Unit, Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113627739","display_name":"Sally A. Lorimore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sally A Lorimore","raw_affiliation_strings":["Cancer Biology and Clinical Pathology Unit, Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Clinical Pathology Unit, Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023838985","display_name":"Eric G. Wright","orcid":"https://orcid.org/0009-0008-1526-3053","observed_orcids":["https://orcid.org/0009-0008-1526-3053"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eric G Wright","raw_affiliation_strings":["Cancer Biology and Clinical Pathology Unit, Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Clinical Pathology Unit, Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":0.8959,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.6474994,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"205","issue":"2","first_page":"221","last_page":"235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.11739999800920486,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genotoxic-stress","display_name":"genotoxic stress","score":0.9739999771118164},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8669999837875366},{"id":"https://openalex.org/keywords/dna-repair-pathways","display_name":"DNA repair pathways","score":0.9900000095367432},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8769999742507935},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8119999766349792},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9470000267028809},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4099999964237213},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.890999972820282},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7338716983795166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6288104057312012},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5958276391029358},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5746572613716125},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5423156023025513},{"id":"https://openalex.org/C2780096491","wikidata":"https://www.wikidata.org/wiki/Q60574533","display_name":"Cellular stress response","level":4,"score":0.5270001292228699},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.512939453125},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.48667246103286743},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.47583627700805664},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4117621183395386},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2870732843875885},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21220716834068298},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.20726549625396729},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16533368825912476},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.1580568253993988}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/path.1701","doi":"https://doi.org/10.1002/path.1701","is_oa":false,"landing_page_url":"https://doi.org/10.1002/path.1701","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"},{"id":"pmid:15643669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15643669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire_cris_publications/7b5ca38b-c5f8-4a7a-a833-fe123e9d3719","doi":null,"is_oa":false,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/7b5ca38b-c5f8-4a7a-a833-fe123e9d3719","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Coates, P J, Lorimore, S A & Wright, E G 2005, 'Cell and tissue responses to genotoxic stress', Journal of Pathology, vol. 205, no. 2, pp. 221-35. https://doi.org/10.1002/path.1701","raw_type":"info:eu-repo/semantics/review"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320329013","display_name":"Blood Cancer UK","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":228,"referenced_works":["https://openalex.org/W90002144","https://openalex.org/W132441100","https://openalex.org/W194612039","https://openalex.org/W951089740","https://openalex.org/W1499871629","https://openalex.org/W1507319558","https://openalex.org/W1509538618","https://openalex.org/W1541806623","https://openalex.org/W1542926523","https://openalex.org/W1544851750","https://openalex.org/W1568134298","https://openalex.org/W1574172480","https://openalex.org/W1616121322","https://openalex.org/W1622118769","https://openalex.org/W1624574179","https://openalex.org/W1650797637","https://openalex.org/W1792024194","https://openalex.org/W1835534931","https://openalex.org/W1852111329","https://openalex.org/W1859632767","https://openalex.org/W1915306531","https://openalex.org/W1959049775","https://openalex.org/W1965037168","https://openalex.org/W1965581435","https://openalex.org/W1966969821","https://openalex.org/W1967989711","https://openalex.org/W1968551667","https://openalex.org/W1969359572","https://openalex.org/W1970412570","https://openalex.org/W1970858946","https://openalex.org/W1974666401","https://openalex.org/W1975644211","https://openalex.org/W1978554125","https://openalex.org/W1982305402","https://openalex.org/W1984813288","https://openalex.org/W1985679430","https://openalex.org/W1985775217","https://openalex.org/W1987721350","https://openalex.org/W1989947080","https://openalex.org/W1992783176","https://openalex.org/W1994711799","https://openalex.org/W1994888353","https://openalex.org/W1996390094","https://openalex.org/W1997388033","https://openalex.org/W1997439972","https://openalex.org/W1997778522","https://openalex.org/W1998621234","https://openalex.org/W2001585133","https://openalex.org/W2004579265","https://openalex.org/W2005389118","https://openalex.org/W2007731150","https://openalex.org/W2010378709","https://openalex.org/W2012071848","https://openalex.org/W2012126331","https://openalex.org/W2014323289","https://openalex.org/W2014928083","https://openalex.org/W2018042307","https://openalex.org/W2018070800","https://openalex.org/W2018211174","https://openalex.org/W2019179222","https://openalex.org/W2019219567","https://openalex.org/W2019405732","https://openalex.org/W2019983585","https://openalex.org/W2021194794","https://openalex.org/W2022811243","https://openalex.org/W2024781204","https://openalex.org/W2025448979","https://openalex.org/W2025595360","https://openalex.org/W2026047561","https://openalex.org/W2028044172","https://openalex.org/W2029224024","https://openalex.org/W2029998767","https://openalex.org/W2030922363","https://openalex.org/W2031209757","https://openalex.org/W2032015300","https://openalex.org/W2032154992","https://openalex.org/W2032361307","https://openalex.org/W2032676869","https://openalex.org/W2033255734","https://openalex.org/W2033510659","https://openalex.org/W2033853356","https://openalex.org/W2034269086","https://openalex.org/W2034270010","https://openalex.org/W2034918846","https://openalex.org/W2036048948","https://openalex.org/W2036103078","https://openalex.org/W2038798987","https://openalex.org/W2039422087","https://openalex.org/W2040068538","https://openalex.org/W2040533326","https://openalex.org/W2042616537","https://openalex.org/W2043360124","https://openalex.org/W2045435101","https://openalex.org/W2046056065","https://openalex.org/W2049910278","https://openalex.org/W2052660678","https://openalex.org/W2053851309","https://openalex.org/W2054311839","https://openalex.org/W2054889035","https://openalex.org/W2055187302","https://openalex.org/W2055349083","https://openalex.org/W2055907878","https://openalex.org/W2056872792","https://openalex.org/W2057072455","https://openalex.org/W2060418052","https://openalex.org/W2060695937","https://openalex.org/W2062238292","https://openalex.org/W2063589273","https://openalex.org/W2063822655","https://openalex.org/W2064225392","https://openalex.org/W2065022250","https://openalex.org/W2067819328","https://openalex.org/W2067919956","https://openalex.org/W2068739126","https://openalex.org/W2068755461","https://openalex.org/W2070019711","https://openalex.org/W2071507111","https://openalex.org/W2073864860","https://openalex.org/W2074478484","https://openalex.org/W2075248335","https://openalex.org/W2076684955","https://openalex.org/W2077565908","https://openalex.org/W2078581194","https://openalex.org/W2078830718","https://openalex.org/W2078883185","https://openalex.org/W2080029904","https://openalex.org/W2080415915","https://openalex.org/W2080772875","https://openalex.org/W2081608638","https://openalex.org/W2082399676","https://openalex.org/W2082541302","https://openalex.org/W2083330028","https://openalex.org/W2083696181","https://openalex.org/W2084308117","https://openalex.org/W2084969545","https://openalex.org/W2087732778","https://openalex.org/W2089574530","https://openalex.org/W2091493364","https://openalex.org/W2093294267","https://openalex.org/W2093386392","https://openalex.org/W2094558289","https://openalex.org/W2094808692","https://openalex.org/W2095092396","https://openalex.org/W2095307442","https://openalex.org/W2095537212","https://openalex.org/W2100894466","https://openalex.org/W2100964039","https://openalex.org/W2101430535","https://openalex.org/W2102441837","https://openalex.org/W2102660785","https://openalex.org/W2103519814","https://openalex.org/W2103635892","https://openalex.org/W2106845421","https://openalex.org/W2107318442","https://openalex.org/W2108966286","https://openalex.org/W2110003207","https://openalex.org/W2110223248","https://openalex.org/W2110929110","https://openalex.org/W2111447146","https://openalex.org/W2111599074","https://openalex.org/W2112453969","https://openalex.org/W2112881364","https://openalex.org/W2114069643","https://openalex.org/W2115020985","https://openalex.org/W2115124693","https://openalex.org/W2116554142","https://openalex.org/W2117903145","https://openalex.org/W2118508998","https://openalex.org/W2118733942","https://openalex.org/W2119885778","https://openalex.org/W2120729450","https://openalex.org/W2120921507","https://openalex.org/W2122254308","https://openalex.org/W2124037827","https://openalex.org/W2124076790","https://openalex.org/W2125236946","https://openalex.org/W2128485340","https://openalex.org/W2129311237","https://openalex.org/W2129905922","https://openalex.org/W2129919885","https://openalex.org/W2130883309","https://openalex.org/W2131646714","https://openalex.org/W2132787016","https://openalex.org/W2134757872","https://openalex.org/W2134906851","https://openalex.org/W2134935590","https://openalex.org/W2141375360","https://openalex.org/W2143629217","https://openalex.org/W2144850556","https://openalex.org/W2146598467","https://openalex.org/W2149022825","https://openalex.org/W2150611871","https://openalex.org/W2153314251","https://openalex.org/W2153863159","https://openalex.org/W2155640249","https://openalex.org/W2158005145","https://openalex.org/W2158006041","https://openalex.org/W2158689768","https://openalex.org/W2161452450","https://openalex.org/W2163183874","https://openalex.org/W2165150104","https://openalex.org/W2165928290","https://openalex.org/W2167184679","https://openalex.org/W2167284102","https://openalex.org/W2167894711","https://openalex.org/W2168989880","https://openalex.org/W2172114218","https://openalex.org/W2184000058","https://openalex.org/W2220538814","https://openalex.org/W2312862539","https://openalex.org/W2313048860","https://openalex.org/W2314477394","https://openalex.org/W2316548913","https://openalex.org/W2326787949","https://openalex.org/W2327174419","https://openalex.org/W2328913237","https://openalex.org/W2330668639","https://openalex.org/W2330684871","https://openalex.org/W2400514435","https://openalex.org/W2409740128","https://openalex.org/W2416507115","https://openalex.org/W2420967061","https://openalex.org/W2474946733","https://openalex.org/W4210989642","https://openalex.org/W4235457469","https://openalex.org/W4285719527","https://openalex.org/W4313343390","https://openalex.org/W6680026159"],"related_works":["https://openalex.org/W2062343447","https://openalex.org/W2991324771","https://openalex.org/W60466767","https://openalex.org/W2255115200","https://openalex.org/W2152542861","https://openalex.org/W3131102773","https://openalex.org/W1579558998","https://openalex.org/W1128618774","https://openalex.org/W3208209688","https://openalex.org/W71911686"],"abstract_inverted_index":{"Cancers":[0],"arise":[1],"as":[2,171],"a":[3,13,192,206],"consequence":[4],"of":[5,8,19,32,43,52,76,92,96,110,119,153,161,176,211,222,234,248],"the":[6,30,41,57,93,142,169,217,229],"accumulation":[7],"multiple":[9],"genetic":[10,129,232],"mutations":[11,39],"in":[12,17,131,140,182],"susceptible":[14],"cell,":[15],"resulting":[16],"perturbation":[18],"regulatory":[20],"networks":[21],"that":[22,35,136,158],"control":[23],"proliferation,":[24],"survival,":[25],"and":[26,40,56,61,73,80,90,104,123,156,186,188,214,224,231,242],"cellular":[27,33],"function.":[28],"Here,":[29],"sources":[31],"stress":[34,178,204],"can":[36,179],"cause":[37],"oncogenic":[38],"responses":[42,99,106,210,236],"cells":[44,213],"to":[45,84,107,115,144,168,216,228,239],"DNA":[46,111],"damage":[47,112],"are":[48,68,100,113,159],"reviewed.":[49],"The":[50,134],"role":[51,135],"different":[53,98],"repair":[54,66],"pathways":[55],"potential":[58,94],"for":[59,71,128,194,245],"cell-":[60,72,103,223],"tissue-specific":[62,74,105,120,225],"reliance":[63],"on":[64,148],"individual":[65,86],"mechanisms":[67],"discussed.":[69],"Evidence":[70],"activation":[75],"p53-mediated":[77],"growth":[78],"arrest":[79],"apoptosis":[81],"after":[82,199],"exposure":[83],"an":[85],"genotoxin":[87],"is":[88,125,164],"assessed":[89],"some":[91],"mediators":[95],"these":[97,132,235],"provided.":[101],"These":[102],"particular":[108],"forms":[109,247],"likely":[114],"be":[116,180,191],"key":[117],"determinants":[118],"tumour":[121,184,197],"susceptibility,":[122],"there":[124],"good":[126],"evidence":[127],"variations":[130],"responses.":[133],"genotoxic":[137,177,203],"agents":[138],"play":[139],"altering":[141],"microenvironment":[143,170],"produce":[145],"indirect":[146,174],"effects":[147,175],"tumourigenesis":[149],"through":[150],"altered":[151],"production":[152],"free":[154],"radicals":[155],"cytokines":[157],"characteristic":[160],"inflammatory-type":[162],"processes":[163],"also":[165],"evaluated.":[166],"Changes":[167],"direct":[172],"or":[173,201],"involved":[181],"both":[183],"initiation":[185],"progression":[187],"may":[189],"even":[190],"prerequisite":[193],"tumourigenesis.":[195],"Therefore,":[196],"susceptibility":[198],"endogenous":[200],"exogenous":[202],"represents":[205],"balance":[207],"between":[208],"cell-intrinsic":[209],"target":[212],"changes":[215],"microenvironment.":[218],"A":[219],"fuller":[220],"understanding":[221],"responses,":[226],"alterations":[227],"microenvironment,":[230],"modifiers":[233],"could":[237],"lead":[238],"novel":[240],"prevention":[241],"therapeutic":[243],"strategies":[244],"common":[246],"human":[249],"malignancy.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
