{"id":"https://openalex.org/W2076922804","doi":"https://doi.org/10.4088/jcp.v69n0716","title":"Neuroleptic Malignant Syndrome Associated With Atypical Antipsychotics in Pediatric Patients","display_name":"Neuroleptic Malignant Syndrome Associated With Atypical Antipsychotics in Pediatric Patients","publication_year":2008,"publication_date":"2008-07-15","ids":{"openalex":"https://openalex.org/W2076922804","doi":"https://doi.org/10.4088/jcp.v69n0716","mag":"2076922804","pmid":"https://pubmed.ncbi.nlm.nih.gov/18572981"},"language":"en","primary_location":{"id":"doi:10.4088/jcp.v69n0716","doi":"https://doi.org/10.4088/jcp.v69n0716","is_oa":false,"landing_page_url":"https://doi.org/10.4088/jcp.v69n0716","pdf_url":null,"source":{"id":"https://openalex.org/S17992710","display_name":"The Journal of Clinical Psychiatry","issn_l":"0160-6689","issn":["0160-6689","1534-8628","1555-2101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4322614534","host_organization_name":"Physicians Postgraduate Press, Inc.","host_organization_lineage":["https://openalex.org/P4322614534"],"host_organization_lineage_names":["Physicians Postgraduate Press, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058499524","display_name":"Paul E. Croarkin","orcid":"https://orcid.org/0000-0001-6843-6503","observed_orcids":["https://orcid.org/0000-0001-6843-6503"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul E. Croarkin","raw_affiliation_strings":["Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA. Paul.Croarkin@childrens.com","Department of Psychiatry, University of Texas Southwestern Medical Center Dallas TX USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA. Paul.Croarkin@childrens.com","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Psychiatry, University of Texas Southwestern Medical Center Dallas TX USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028128941","display_name":"Graham J. Emslie","orcid":"https://orcid.org/0000-0003-1851-4328","observed_orcids":["https://orcid.org/0000-0003-1851-4328"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Graham J. Emslie","raw_affiliation_strings":["Psychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010530746","display_name":"Taryn L. Mayes","orcid":"https://orcid.org/0000-0002-5992-6081","observed_orcids":["https://orcid.org/0000-0002-5992-6081"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taryn L. Mayes","raw_affiliation_strings":["University of Texas at Austin#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Austin#TAB#","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6782,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.9223944,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"69","issue":"7","first_page":"1157","last_page":"1165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11921","display_name":"Electroconvulsive Therapy Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11921","display_name":"Electroconvulsive Therapy Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12666","display_name":"Historical Psychiatry and Medical Practices","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroleptic-malignant-syndrome","display_name":"neuroleptic malignant syndrome","score":1.0},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.9769999980926514},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.7350000143051147},{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":0.9860000014305115},{"id":"https://openalex.org/keywords/risperidone","display_name":"risperidone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/olanzapine","display_name":"olanzapine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/quetiapine","display_name":"quetiapine","score":1.0},{"id":"https://openalex.org/keywords/ziprasidone","display_name":"ziprasidone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aripiprazole","display_name":"aripiprazole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2777270317","wikidata":"https://www.wikidata.org/wiki/Q205517","display_name":"Ziprasidone","level":4,"score":0.8906441330909729},{"id":"https://openalex.org/C2780634440","wikidata":"https://www.wikidata.org/wiki/Q408535","display_name":"Quetiapine","level":3,"score":0.8581403493881226},{"id":"https://openalex.org/C2776619155","wikidata":"https://www.wikidata.org/wiki/Q201872","display_name":"Olanzapine","level":3,"score":0.8230162262916565},{"id":"https://openalex.org/C2780057945","wikidata":"https://www.wikidata.org/wiki/Q412443","display_name":"Risperidone","level":3,"score":0.784244954586029},{"id":"https://openalex.org/C2777964233","wikidata":"https://www.wikidata.org/wiki/Q1424956","display_name":"Neuroleptic malignant syndrome","level":2,"score":0.7765814065933228},{"id":"https://openalex.org/C2780211496","wikidata":"https://www.wikidata.org/wiki/Q411188","display_name":"Aripiprazole","level":3,"score":0.7030172944068909},{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.686226487159729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6802991628646851},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.6060734391212463},{"id":"https://openalex.org/C2776921671","wikidata":"https://www.wikidata.org/wiki/Q758295","display_name":"Atypical antipsychotic","level":4,"score":0.5953402519226074},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5903528332710266},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.46145710349082947},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.29893428087234497}],"mesh":[{"descriptor_ui":"D000068180","descriptor_name":"Aripiprazole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077152","descriptor_name":"Olanzapine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003024","descriptor_name":"Clozapine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003987","descriptor_name":"Dibenzothiazepines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009459","descriptor_name":"Neuroleptic Malignant Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009459","descriptor_name":"Neuroleptic Malignant Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015363","descriptor_name":"Quinolones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018967","descriptor_name":"Risperidone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4088/jcp.v69n0716","doi":"https://doi.org/10.4088/jcp.v69n0716","is_oa":false,"landing_page_url":"https://doi.org/10.4088/jcp.v69n0716","pdf_url":null,"source":{"id":"https://openalex.org/S17992710","display_name":"The Journal of Clinical Psychiatry","issn_l":"0160-6689","issn":["0160-6689","1534-8628","1555-2101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4322614534","host_organization_name":"Physicians Postgraduate Press, Inc.","host_organization_lineage":["https://openalex.org/P4322614534"],"host_organization_lineage_names":["Physicians Postgraduate Press, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Psychiatry","raw_type":"journal-article"},{"id":"pmid:18572981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18572981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2059188621","https://openalex.org/W2058543168","https://openalex.org/W1967422684","https://openalex.org/W2099471595","https://openalex.org/W2119909389","https://openalex.org/W2034850720","https://openalex.org/W2593383108","https://openalex.org/W2158961912","https://openalex.org/W3212582160","https://openalex.org/W3001768113"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"retrospectively":[2],"examine":[3],"published":[4,90],"cases":[5,156,173],"of":[6,102,165,172,192,215],"neuroleptic":[7,47],"malignant":[8,48],"syndrome":[9,49],"(NMS)":[10],"in":[11,39,65,86,104,200,206,219],"patients":[12,105,178,182],"aged":[13,106],"18":[14,107],"and":[15,29,42,52,64,71,89,95,122,130,132,137,149,222],"below":[16],"who":[17,110],"had":[18,111],"been":[19,112],"treated":[20,113],"with":[21,54,114,124,151,161,188,197,224],"atypical":[22,56,73,115,189],"antipsychotics":[23,74],"(clozapine,":[24],"risperidone,":[25],"olanzapine,":[26],"quetiapine,":[27],"ziprasidone,":[28],"aripiprazole).":[30],"DATA":[31,117,142],"SOURCES:":[32],"Information":[33],"was":[34,50],"collected":[35],"via":[36],"MEDLINE":[37],"searches":[38],"February":[40],"2006":[41],"May":[43],"2007.":[44],"The":[45,58,170],"term":[46],"used":[51],"cross-referenced":[53],"individual":[55],"antipsychotics.":[57,116,190],"authors":[59],"also":[60,140],"contacted":[61],"(by":[62],"telephone":[63],"writing)":[66],"pharmaceutical":[67],"companies":[68],"that":[69],"produce":[70],"market":[72],"for":[75,134,159],"any":[76,225],"data":[77],"on":[78],"NMS.":[79,135],"STUDY":[80],"SELECTION:":[81],"Twenty":[82,144],"case":[83,145],"reports":[84,146],"(written":[85],"English":[87],"only":[88],"from":[91],"1991-2007)":[92],"were":[93,120,139,147],"identified":[94,148],"reviewed.":[96,141],"These":[97],"publications":[98],"all":[99],"described":[100,199],"symptoms":[101],"NMS":[103,185,203],"or":[108],"younger":[109],"EXTRACTION:":[118],"Data":[119],"reviewed":[121],"compared":[123],"3":[125],"diagnostic":[126,167],"criteria":[127,158],"(DSM-IV-TR,":[128],"Levenson's,":[129],"Caroff":[131],"Mann's)":[133],"Interventions":[136],"outcomes":[138],"SYNTHESIS:":[143],"presented":[150],"a":[152,212],"descriptive":[153],"approach.":[154],"Sixteen":[155],"met":[157],"NMS,":[160],"at":[162],"least":[163],"1":[164],"the":[166],"sets":[168],"utilized.":[169],"majority":[171],"involved":[174],"male":[175],"subjects.":[176],"All":[177],"recovered.":[179],"CONCLUSIONS:":[180],"Young":[181],"can":[183],"develop":[184],"during":[186],"treatment":[187],"Symptoms":[191],"this":[193,207],"disorder":[194],"are":[195],"consistent":[196],"those":[198],"adults.":[201],"Although":[202],"is":[204,227],"rare":[205],"population,":[208],"clinicians":[209],"should":[210],"maintain":[211],"high":[213],"index":[214],"suspicion.":[216],"Appropriate":[217],"caution":[218],"treating":[220],"children":[221],"adolescents":[223],"antipsychotic":[226],"warranted.":[228]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
