{"id":"https://openalex.org/W2076919082","doi":"https://doi.org/10.1081/dct-100106266","title":"INHIBITION OF GENOTOXICITY BY SAFFRON (CROCUS SATIVUSL.) IN MICE","display_name":"INHIBITION OF GENOTOXICITY BY SAFFRON (CROCUS SATIVUSL.) IN MICE","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2076919082","doi":"https://doi.org/10.1081/dct-100106266","mag":"2076919082","pmid":"https://pubmed.ncbi.nlm.nih.gov/11665650"},"language":"en","primary_location":{"id":"doi:10.1081/dct-100106266","doi":"https://doi.org/10.1081/dct-100106266","is_oa":false,"landing_page_url":"https://doi.org/10.1081/dct-100106266","pdf_url":null,"source":{"id":"https://openalex.org/S17820993","display_name":"Drug and Chemical Toxicology","issn_l":"0148-0545","issn":["0148-0545","1525-6014"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug and Chemical Toxicology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2076919082"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067599934","display_name":"Kumpati Premkumar","orcid":"https://orcid.org/0000-0001-9314-0974","observed_orcids":["https://orcid.org/0000-0001-9314-0974"]},"institutions":[{"id":"https://openalex.org/I215927","display_name":"University of Madras","ror":"https://ror.org/04jmt9361","country_code":"IN","type":"education","lineage":["https://openalex.org/I215927"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K. Premkumar","raw_affiliation_strings":["Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600113, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600113, India","institution_ids":["https://openalex.org/I215927"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103497060","display_name":"Suresh K. Abraham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152429107","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28","country_code":"IN","type":"education","lineage":["https://openalex.org/I152429107"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Suresh K. Abraham","raw_affiliation_strings":["School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110 067, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110 067, India","institution_ids":["https://openalex.org/I152429107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110787580","display_name":"S. Santhiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I215927","display_name":"University of Madras","ror":"https://ror.org/04jmt9361","country_code":"IN","type":"education","lineage":["https://openalex.org/I215927"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S. T. Santhiya","raw_affiliation_strings":["Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences University of Madras, Taramani, Chennai, 600 113, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences University of Madras, Taramani, Chennai, 600 113, India","institution_ids":["https://openalex.org/I215927"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081611580","display_name":"P. M. Gopinath","orcid":"https://orcid.org/0009-0005-3421-9734","observed_orcids":["https://orcid.org/0009-0005-3421-9734"]},"institutions":[{"id":"https://openalex.org/I215927","display_name":"University of Madras","ror":"https://ror.org/04jmt9361","country_code":"IN","type":"education","lineage":["https://openalex.org/I215927"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P. M. Gopinath","raw_affiliation_strings":["Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences University of Madras, Taramani, Chennai, 600 113, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences University of Madras, Taramani, Chennai, 600 113, India","institution_ids":["https://openalex.org/I215927"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072135547","display_name":"Anjaneyulu Sai Ramesh","orcid":"https://orcid.org/0000-0002-5592-875X","observed_orcids":["https://orcid.org/0000-0002-5592-875X"]},"institutions":[{"id":"https://openalex.org/I215927","display_name":"University of Madras","ror":"https://ror.org/04jmt9361","country_code":"IN","type":"education","lineage":["https://openalex.org/I215927"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A. Ramesh","raw_affiliation_strings":["Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences University of Madras, Taramani, Chennai, 600 113, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences University of Madras, Taramani, Chennai, 600 113, India","institution_ids":["https://openalex.org/I215927"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2874,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.75928918,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"24","issue":"4","first_page":"421","last_page":"428"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saffron","display_name":"saffron","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.7839999794960022},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":1.0},{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"mitomycin C","score":1.0},{"id":"https://openalex.org/keywords/urethane","display_name":"urethane","score":0.9789999723434448},{"id":"https://openalex.org/keywords/bone-marrow-micronucleus-test","display_name":"bone marrow micronucleus test","score":0.8640000224113464},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C2779571273","wikidata":"https://www.wikidata.org/wiki/Q15041677","display_name":"Crocus sativus","level":2,"score":0.963392972946167},{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.8777766227722168},{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.7859492301940918},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6267091035842896},{"id":"https://openalex.org/C36681516","wikidata":"https://www.wikidata.org/wiki/Q1700733","display_name":"Micronucleus","level":4,"score":0.6065055131912231},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5864490866661072},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.555708110332489},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5556302070617676},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.49091511964797974},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.46520334482192993},{"id":"https://openalex.org/C2777637054","wikidata":"https://www.wikidata.org/wiki/Q424767","display_name":"Crocin","level":2,"score":0.4377385377883911},{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.41445812582969666},{"id":"https://openalex.org/C2781422964","wikidata":"https://www.wikidata.org/wiki/Q12529398","display_name":"Antimutagen","level":4,"score":0.4120691418647766},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.34177494049072266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3181847035884857},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30030637979507446},{"id":"https://openalex.org/C2776639595","wikidata":"https://www.wikidata.org/wiki/Q221696","display_name":"Mutagen","level":3,"score":0.27790263295173645},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.24154284596443176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1742200255393982},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.16404297947883606},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0864051878452301},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07978397607803345},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015162","descriptor_name":"Micronucleus Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016587","descriptor_name":"Antimutagenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D027622","descriptor_name":"Crocus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1081/dct-100106266","doi":"https://doi.org/10.1081/dct-100106266","is_oa":false,"landing_page_url":"https://doi.org/10.1081/dct-100106266","pdf_url":null,"source":{"id":"https://openalex.org/S17820993","display_name":"Drug and Chemical Toxicology","issn_l":"0148-0545","issn":["0148-0545","1525-6014"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug and Chemical Toxicology","raw_type":"journal-article"},{"id":"pmid:11665650","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11665650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug and chemical toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W71395891","https://openalex.org/W77902439","https://openalex.org/W129370812","https://openalex.org/W568177745","https://openalex.org/W1499700118","https://openalex.org/W1502234489","https://openalex.org/W1514403557","https://openalex.org/W1581414347","https://openalex.org/W1775749144","https://openalex.org/W1911702895","https://openalex.org/W1967935927","https://openalex.org/W1975325378","https://openalex.org/W1977912999","https://openalex.org/W1982276474","https://openalex.org/W1988316941","https://openalex.org/W2026979678","https://openalex.org/W2029031988","https://openalex.org/W2035002706","https://openalex.org/W2046447930","https://openalex.org/W2046650238","https://openalex.org/W2054212654","https://openalex.org/W2076429988","https://openalex.org/W2084760140","https://openalex.org/W2086079198","https://openalex.org/W2090343590","https://openalex.org/W2091510450","https://openalex.org/W2094228967","https://openalex.org/W2095556565","https://openalex.org/W2407312637","https://openalex.org/W2614442853"],"related_works":["https://openalex.org/W2154032197","https://openalex.org/W2099845327","https://openalex.org/W2581823761","https://openalex.org/W2070871457","https://openalex.org/W2188414012","https://openalex.org/W4255754997","https://openalex.org/W2057128933","https://openalex.org/W2072951436","https://openalex.org/W3200912616","https://openalex.org/W2810821495"],"abstract_inverted_index":{"Experiments":[0],"were":[1,51,75],"carried":[2],"out":[3],"to":[4],"ascertain":[5],"whether":[6],"or":[7],"not":[8,107],"saffron":[9,91,137],"(dried":[10],"stigmas":[11],"of":[12,34,67,71,97,154],"Crocus":[13],"sativus":[14],"L.),":[15],"a":[16],"commonly":[17],"used":[18],"agent":[19],"for":[20,53],"flavoring":[21],"and":[22,42,62,101,123],"coloring":[23],"food":[24],"can":[25,92],"exert":[26],"modulatory":[27],"effects":[28,74,153],"on":[29,157],"the":[30,68,78,95,112,121,141,151,155],"in":[31,77,120,129],"vivo":[32],"genotoxicity":[33,96],"cisplatin":[35],"(CIS),":[36],"cyclophosphamide":[37],"(CPH),":[38],"mitomycin":[39],"C":[40],"(MMC)":[41],"urethane":[43],"(URE).":[44],"For":[45],"this":[46],"purpose,":[47],"Swiss":[48],"albino":[49],"mice":[50],"pretreated":[52],"five":[54],"consecutive":[55],"days":[56],"with":[57,90,136,140],"three":[58],"doses":[59],"(20,":[60],"40":[61],"80":[63],"mg/kg":[64],"body":[65],"weight)":[66],"aqueous":[69],"extract":[70],"saffron.":[72],"Genotoxic":[73],"assessed":[76,119],"mouse":[79],"bone":[80],"marrow":[81],"micronucleus":[82],"test.":[83],"The":[84],"results":[85],"obtained":[86],"suggest":[87],"that":[88],"pretreatment":[89,135,149],"significantly":[93,144],"inhibit":[94],"CIS,":[98],"CPH,":[99],"MMC":[100],"URE.":[102],"This":[103],"inhibitory":[104,152],"effect":[105],"was":[106,118,132],"always":[108],"dose-dependent.":[109],"In":[110],"addition,":[111],"hepatic":[113],"glutathione":[114],"S-transferase":[115],"(GST)":[116],"activity":[117,131],"control":[122],"treated":[124],"animals.":[125],"No":[126],"significant":[127],"change":[128],"GST":[130,146,158],"observed":[133],"after":[134],"alone.":[138],"Treatment":[139],"genotoxins":[142,156],"alone":[143],"inhibited":[145],"activity.":[147,159],"Saffron":[148],"attenuated":[150]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
