{"id":"https://openalex.org/W2076913285","doi":"https://doi.org/10.1111/j.1537-2995.2009.02333.x","title":"IMMUNOHEMATOLOGY: Understanding loss of donor white blood cell immunogenicity after pathogen reduction: mechanisms of action in ultraviolet illumination and riboflavin treatment","display_name":"IMMUNOHEMATOLOGY: Understanding loss of donor white blood cell immunogenicity after pathogen reduction: mechanisms of action in ultraviolet illumination and riboflavin treatment","publication_year":2009,"publication_date":"2009-08-04","ids":{"openalex":"https://openalex.org/W2076913285","doi":"https://doi.org/10.1111/j.1537-2995.2009.02333.x","mag":"2076913285","pmid":"https://pubmed.ncbi.nlm.nih.gov/19682337","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2865145"},"language":"en","primary_location":{"id":"doi:10.1111/j.1537-2995.2009.02333.x","doi":"https://doi.org/10.1111/j.1537-2995.2009.02333.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1537-2995.2009.02333.x","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2865145","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037801155","display_name":"Rachael P. Jackman","orcid":"https://orcid.org/0000-0001-8591-7819","observed_orcids":["https://orcid.org/0000-0001-8591-7819"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210093991","display_name":"Blood Systems Research Institute","ror":"https://ror.org/01ekg2j77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210093991"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rachael P. Jackman","raw_affiliation_strings":["Department of Laboratory Medicine and Medicine, Blood Systems Research Institute, University of California, San Francisco, California, USA. rjackman@bloodsystems.org","CaridianBCT Biotechnologies, Lakewood, Colorado","From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Medicine, Blood Systems Research Institute, University of California, San Francisco, California, USA. rjackman@bloodsystems.org","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210093991"]},{"raw_affiliation_string":"CaridianBCT Biotechnologies, Lakewood, Colorado","institution_ids":[]},{"raw_affiliation_string":"From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210093991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110149897","display_name":"John W. Heitman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210093991","display_name":"Blood Systems Research Institute","ror":"https://ror.org/01ekg2j77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210093991"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Heitman","raw_affiliation_strings":["From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California; and CaridianBCT Biotechnologies, Lakewood, Colorado","CaridianBCT Biotechnologies, Lakewood, Colorado","From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California; and CaridianBCT Biotechnologies, Lakewood, Colorado","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210093991"]},{"raw_affiliation_string":"CaridianBCT Biotechnologies, Lakewood, Colorado","institution_ids":[]},{"raw_affiliation_string":"From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210093991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056177877","display_name":"Susanne Marschner","orcid":"https://orcid.org/0000-0002-7862-6201","observed_orcids":["https://orcid.org/0000-0002-7862-6201"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210093991","display_name":"Blood Systems Research Institute","ror":"https://ror.org/01ekg2j77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210093991"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susanne Marschner","raw_affiliation_strings":["From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California; and CaridianBCT Biotechnologies, Lakewood, Colorado","CaridianBCT Biotechnologies, Lakewood, Colorado","From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California; and CaridianBCT Biotechnologies, Lakewood, Colorado","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210093991"]},{"raw_affiliation_string":"CaridianBCT Biotechnologies, Lakewood, Colorado","institution_ids":[]},{"raw_affiliation_string":"From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210093991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056842803","display_name":"Raymond P. Goodrich","orcid":"https://orcid.org/0000-0002-5945-4571","observed_orcids":["https://orcid.org/0000-0002-5945-4571"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210093991","display_name":"Blood Systems Research Institute","ror":"https://ror.org/01ekg2j77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210093991"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond P. Goodrich","raw_affiliation_strings":["From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California; and CaridianBCT Biotechnologies, Lakewood, Colorado","CaridianBCT Biotechnologies, Lakewood, Colorado","From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California; and CaridianBCT Biotechnologies, Lakewood, Colorado","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210093991"]},{"raw_affiliation_string":"CaridianBCT Biotechnologies, Lakewood, Colorado","institution_ids":[]},{"raw_affiliation_string":"From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210093991"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051080788","display_name":"Philip J. Norris","orcid":"https://orcid.org/0000-0003-0526-2088","observed_orcids":["https://orcid.org/0000-0003-0526-2088"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210093991","display_name":"Blood Systems Research Institute","ror":"https://ror.org/01ekg2j77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210093991"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip J. Norris","raw_affiliation_strings":["From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California; and CaridianBCT Biotechnologies, Lakewood, Colorado","CaridianBCT Biotechnologies, Lakewood, Colorado","From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California; and CaridianBCT Biotechnologies, Lakewood, Colorado","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210093991"]},{"raw_affiliation_string":"CaridianBCT Biotechnologies, Lakewood, Colorado","institution_ids":[]},{"raw_affiliation_string":"From the Blood Systems Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210093991"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037801155"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210093991"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":1.0177,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.74590413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"49","issue":"12","first_page":"2686","last_page":"2699"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pathogen-inactivation","display_name":"pathogen inactivation","score":0.765999972820282},{"id":"https://openalex.org/keywords/uv-irradiation","display_name":"UV irradiation","score":0.847000002861023},{"id":"https://openalex.org/keywords/riboflavin","display_name":"riboflavin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/anti-hla-antibodies","display_name":"HLA antibodies","score":0.7089999914169312},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9739999771118164},{"id":"https://openalex.org/keywords/allosensitization","display_name":"allosensitization","score":0.9760000109672546},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.8080000281333923},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.8899999856948853},{"id":"https://openalex.org/keywords/hla-class-ii","display_name":"HLA class II","score":0.906000018119812},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8289999961853027},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.5189999938011169},{"id":"https://openalex.org/keywords/stat5","display_name":"STAT5","score":0.9580000042915344},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.857616662979126},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6381779909133911},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6356114745140076},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5607537627220154},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5199462175369263},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4897203743457794},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4689564108848572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35090672969818115},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2584407925605774},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07709893584251404}],"mesh":[{"descriptor_ui":"D001793","descriptor_name":"Blood Preservation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007519","descriptor_name":"Isoantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012256","descriptor_name":"Riboflavin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017848","descriptor_name":"Blood-Borne Pathogens","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1537-2995.2009.02333.x","doi":"https://doi.org/10.1111/j.1537-2995.2009.02333.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1537-2995.2009.02333.x","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},{"id":"pmid:19682337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19682337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2865145","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2865145","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Transfusion","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2865145","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2865145","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Transfusion","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G251715326","display_name":null,"funder_award_id":"HL083388","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7817843703","display_name":"Mechanisms and clinical effects of microchimerism in transfused trauma patients","funder_award_id":"R01HL083388","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W19838161","https://openalex.org/W38936029","https://openalex.org/W207432979","https://openalex.org/W306603769","https://openalex.org/W1833690096","https://openalex.org/W1856990953","https://openalex.org/W1965034547","https://openalex.org/W1967732565","https://openalex.org/W1968799461","https://openalex.org/W1973376649","https://openalex.org/W1974422506","https://openalex.org/W1989717734","https://openalex.org/W1996665075","https://openalex.org/W2000517438","https://openalex.org/W2003962192","https://openalex.org/W2004537448","https://openalex.org/W2007164263","https://openalex.org/W2015742956","https://openalex.org/W2020928599","https://openalex.org/W2024425333","https://openalex.org/W2025051597","https://openalex.org/W2027658945","https://openalex.org/W2028801369","https://openalex.org/W2036320527","https://openalex.org/W2037658560","https://openalex.org/W2037915962","https://openalex.org/W2037950222","https://openalex.org/W2038347882","https://openalex.org/W2044406822","https://openalex.org/W2044478209","https://openalex.org/W2044749722","https://openalex.org/W2045913670","https://openalex.org/W2051696890","https://openalex.org/W2062144558","https://openalex.org/W2068585118","https://openalex.org/W2089902214","https://openalex.org/W2091719108","https://openalex.org/W2092966502","https://openalex.org/W2096234619","https://openalex.org/W2107584112","https://openalex.org/W2114610485","https://openalex.org/W2124086914","https://openalex.org/W2126333644","https://openalex.org/W2135708985","https://openalex.org/W2147854238","https://openalex.org/W2176910277","https://openalex.org/W2317099662","https://openalex.org/W2337578667","https://openalex.org/W2410921299","https://openalex.org/W2434525932","https://openalex.org/W2461975612","https://openalex.org/W4250903776"],"related_works":["https://openalex.org/W2108555975","https://openalex.org/W2259951926","https://openalex.org/W2980057939","https://openalex.org/W1949978944","https://openalex.org/W60319666","https://openalex.org/W1522975662","https://openalex.org/W2588338310","https://openalex.org/W2556597641","https://openalex.org/W2007164263","https://openalex.org/W2057395613"],"abstract_inverted_index":{"BACKGROUND:":[0],"Donor":[1],"white":[2],"blood":[3,32,89],"cells":[4,91,112,148,177,195,224],"(WBCs)":[5],"present":[6],"in":[7,24,42,47,65,93,124,137,166,182,209],"transfusion":[8,26],"products":[9,33],"can":[10],"lead":[11],"to":[12,36,72,83,102,133],"immune":[13,135],"sequelae":[14],"such":[15],"as":[16],"production":[17,200],"of":[18,31,38,57,68,86,109,118,121,154,169,172,188],"HLA":[19,155],"antibodies":[20],"or":[21,206],"graft-versus-host":[22],"disease":[23],"susceptible":[25],"recipients.":[27],"Eliminating":[28],"the":[29,66,104],"immunogenicity":[30,189],"may":[34],"prove":[35],"be":[37],"clinical":[39],"benefit,":[40],"particularly":[41],"patients":[43],"requiring":[44],"multiple":[45],"transfusions":[46],"whom":[48],"allosensitization":[49],"is":[50],"common.":[51],"This":[52,99],"study":[53,100],"examines":[54],"a":[55,119,170,179],"method":[56],"pathogen":[58],"reduction":[59],"based":[60],"on":[61],"ultraviolet":[62,145],"light":[63],"illumination":[64],"presence":[67],"riboflavin.":[69],"In":[70],"addition":[71],"pathogens,":[73],"WBCs":[74],"treated":[75,176],"with":[76,142,193],"this":[77,107],"system":[78],"are":[79],"affected":[80],"and":[81,126,131,158,161,201],"fail":[82],"stimulate":[84,134],"proliferation":[85],"allogeneic":[87,138],"peripheral":[88],"mononuclear":[90],"(PBMNCs)":[92],"vitro.":[94],"STUDY":[95],"DESIGN":[96],"AND":[97],"METHODS:":[98],"sought":[101],"determine":[103],"mechanisms":[105],"regulating":[106],"loss":[108,187],"immunogenicity.":[110],"Treated":[111],"were":[113],"examined":[114],"for":[115],"surface":[116,152,167],"expression":[117,153,168],"number":[120,171],"molecules":[122,160],"involved":[123],"activation":[125],"adhesion,":[127],"viability,":[128],"cell-cell":[129,183,220],"conjugation,":[130],"ability":[132],"responses":[136],"PBMNCs.":[139],"RESULTS:":[140],"Compared":[141],"untreated":[143],"controls,":[144],"(UV)-irradiated":[146],"antigen-presenting":[147],"showed":[149],"slightly":[150],"reduced":[151],"Class":[156],"II":[157],"costimulatory":[159],"had":[162,178],"more":[163],"significant":[164],"reductions":[165],"adhesion":[173,221],"molecules.":[174],"Furthermore,":[175],"severe":[180],"defect":[181],"conjugation.":[184],"The":[185],"observed":[186],"was":[190],"nearly":[191],"complete,":[192],"UV-irradiated":[194,223],"stimulating":[196],"barely":[197],"measurable":[198],"interferon-gamma":[199],"no":[202],"detectable":[203],"STAT-3,":[204],"STAT-5,":[205],"CD3-epsilon":[207],"phosphorylation":[208],"allospecific":[210],"primed":[211],"T":[212],"cells.":[213],"CONCLUSION:":[214],"These":[215],"results":[216],"suggest":[217],"that":[218],"defective":[219],"prevents":[222],"from":[225],"inducing":[226],"T-cell":[227],"activation.":[228]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
