{"id":"https://openalex.org/W2076912367","doi":"https://doi.org/10.1172/jci107088","title":"Critical Role of the Carbohydrate Side Chains of Collagen in Platelet Aggregation","display_name":"Critical Role of the Carbohydrate Side Chains of Collagen in Platelet Aggregation","publication_year":1972,"publication_date":"1972-10-01","ids":{"openalex":"https://openalex.org/W2076912367","doi":"https://doi.org/10.1172/jci107088","mag":"2076912367","pmid":"https://pubmed.ncbi.nlm.nih.gov/4341438","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/332969"},"language":"en","primary_location":{"id":"doi:10.1172/jci107088","doi":"https://doi.org/10.1172/jci107088","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci107088","pdf_url":"http://www.jci.org/articles/view/107088/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/107088/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111825425","display_name":"Carolyn McI Chesney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn McI. Chesney","raw_affiliation_strings":["From the Hematology and Developmental Biology Units of the Department of Medicine , Massachusetts General Hospital and the Department of Medicine ,","Harvard Medical School , Boston , Massachusetts 02114","From the Hematology and Developmental Biology Units of the Department of Medicine, Massachusetts General Hospital and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hematology and Developmental Biology Units of the Department of Medicine , Massachusetts General Hospital and the Department of Medicine ,","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School , Boston , Massachusetts 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"From the Hematology and Developmental Biology Units of the Department of Medicine, Massachusetts General Hospital and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108389932","display_name":"Elvin Harper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elvin Harper","raw_affiliation_strings":["From the Hematology and Developmental Biology Units of the Department of Medicine , Massachusetts General Hospital and the Department of Medicine ,","Harvard Medical School , Boston , Massachusetts 02114","From the Hematology and Developmental Biology Units of the Department of Medicine, Massachusetts General Hospital and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hematology and Developmental Biology Units of the Department of Medicine , Massachusetts General Hospital and the Department of Medicine ,","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School , Boston , Massachusetts 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"From the Hematology and Developmental Biology Units of the Department of Medicine, Massachusetts General Hospital and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Colman","raw_affiliation_strings":["From the Hematology and Developmental Biology Units of the Department of Medicine , Massachusetts General Hospital and the Department of Medicine ,","Harvard Medical School , Boston , Massachusetts 02114","From the Hematology and Developmental Biology Units of the Department of Medicine, Massachusetts General Hospital and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Hematology and Developmental Biology Units of the Department of Medicine , Massachusetts General Hospital and the Department of Medicine ,","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School , Boston , Massachusetts 02114","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"From the Hematology and Developmental Biology Units of the Department of Medicine, Massachusetts General Hospital and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":15.6048,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.99425759,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"51","issue":"10","first_page":"2693","last_page":"2701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.7649999856948853},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hydroxylysine","display_name":"hydroxylysine","score":0.8320000171661377},{"id":"https://openalex.org/keywords/galactose-oxidase","display_name":"galactose oxidase","score":0.9449999928474426},{"id":"https://openalex.org/keywords/aldehyde-formation","display_name":"aldehyde formation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/sodium-borohydride-reduction","display_name":"sodium borohydride reduction","score":0.843999981880188},{"id":"https://openalex.org/keywords/bacterial-collagenase","display_name":"bacterial collagenase","score":0.8180000185966492},{"id":"https://openalex.org/keywords/collagen-telopeptides","display_name":"collagen telopeptides","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cross-links","display_name":"cross-links","score":0.7580000162124634},{"id":"https://openalex.org/keywords/platelet-membrane","display_name":"platelet membrane","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C2777438722","wikidata":"https://www.wikidata.org/wiki/Q2782385","display_name":"Galactose oxidase","level":3,"score":0.8573698997497559},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8124535083770752},{"id":"https://openalex.org/C2776661909","wikidata":"https://www.wikidata.org/wiki/Q419226","display_name":"Hydroxylysine","level":4,"score":0.764558732509613},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6618731617927551},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6303220987319946},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.627833366394043},{"id":"https://openalex.org/C2778173381","wikidata":"https://www.wikidata.org/wiki/Q66589593","display_name":"Galactose","level":2,"score":0.5540722608566284},{"id":"https://openalex.org/C193143273","wikidata":"https://www.wikidata.org/wiki/Q419389","display_name":"Lysyl oxidase","level":3,"score":0.48546817898750305},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.4608442783355713},{"id":"https://openalex.org/C2780009322","wikidata":"https://www.wikidata.org/wiki/Q7202246","display_name":"Platelet adhesiveness","level":4,"score":0.44990405440330505},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24162638187408447},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.18865904211997986},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.08872058987617493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07557263970375061},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001894","descriptor_name":"Borohydrides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003012","descriptor_name":"Microbial Collagenase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004589","descriptor_name":"Electrophoresis, Disc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007842","descriptor_name":"Lathyrism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010973","descriptor_name":"Platelet Adhesiveness","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci107088","doi":"https://doi.org/10.1172/jci107088","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci107088","pdf_url":"http://www.jci.org/articles/view/107088/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:332969","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/332969","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:4341438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4341438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci107088","doi":"https://doi.org/10.1172/jci107088","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci107088","pdf_url":"http://www.jci.org/articles/view/107088/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2076912367.pdf","grobid_xml":"https://content.openalex.org/works/W2076912367.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W11326810","https://openalex.org/W1483815930","https://openalex.org/W1572078619","https://openalex.org/W1583217938","https://openalex.org/W1598549227","https://openalex.org/W1965938737","https://openalex.org/W1974758744","https://openalex.org/W1978145883","https://openalex.org/W1998800504","https://openalex.org/W2009827512","https://openalex.org/W2012214760","https://openalex.org/W2013561395","https://openalex.org/W2042890491","https://openalex.org/W2046320938","https://openalex.org/W2048363459","https://openalex.org/W2051904120","https://openalex.org/W2058470564","https://openalex.org/W2065858903","https://openalex.org/W2078328099","https://openalex.org/W2084168776","https://openalex.org/W2086460205","https://openalex.org/W2108974499","https://openalex.org/W2182850016","https://openalex.org/W2310863261","https://openalex.org/W2315909069","https://openalex.org/W2324922197","https://openalex.org/W2417412038","https://openalex.org/W2436883511","https://openalex.org/W2896912282","https://openalex.org/W4240909227"],"related_works":["https://openalex.org/W2094611378","https://openalex.org/W2000027687","https://openalex.org/W2993878857","https://openalex.org/W117531483","https://openalex.org/W2092963630","https://openalex.org/W2092794968","https://openalex.org/W2020874770","https://openalex.org/W1982660564","https://openalex.org/W2944835975","https://openalex.org/W1587937608"],"abstract_inverted_index":{"The":[0,128],"reaction":[1],"between":[2],"human":[3],"platelet":[4,49,72,100,110,154,183],"membrane":[5,178],"glucosyl":[6],"transferase":[7],"and":[8,23,161],"collagen":[9,55,84,94,106,113,137],"has":[10],"recently":[11],"been":[12],"proposed":[13],"as":[14],"the":[15,29,35,39,63,81,90,135,142,164,172],"mechanism":[16],"for":[17,109,141,171],"pletelet-collagen":[18],"adhesion.":[19],"Collagen":[20],"contains":[21,121],"glucosyl-galactose":[22],"galactose":[24,30,45,165],"side":[25],"chains":[26],"linked":[27],"through":[28],"to":[31,42,85],"hydroxylysine.":[32],"Oxidation":[33],"of":[34,38,54,62,71,83,89,104,126,131,163,174],"6-hydroxymethyl":[36],"position":[37],"galactosyl":[40],"residue":[41],"aldehydes":[43,64],"with":[44,68,77,95,149],"oxidase":[46],"completely":[47],"abolishes":[48,80],"aggregation.":[50,101,111,155,184],"This":[51],"enzymatic":[52],"modification":[53],"can":[56],"be":[57,169],"fully":[58],"reversed":[59],"by":[60,66],"reduction":[61,148],"formed":[65],"NaBH(4)":[67,150],"complete":[69],"restoration":[70],"aggregating":[73,145],"ability.":[74],"Limited":[75],"digestion":[76],"bacterial":[78],"collagenase":[79],"ability":[82],"aggregate":[86],"platelets.":[87],"Removal":[88],"N-terminal":[91],"telopeptides":[92],"from":[93],"trypsin":[96],"does":[97,151],"not":[98,139,152],"affect":[99],"Tertiary":[102],"structure":[103],"soluble":[105],"is":[107,114],"essential":[108],"Normal":[112],"less":[115],"effective":[116],"than":[117],"lathyritic":[118,136],"collagen,":[119],"which":[120,180],"only":[122],"a":[123,175],"small":[124],"number":[125,130],"cross-links.":[127],"decreased":[129],"aldehyde":[132],"groups":[133],"in":[134,144],"are":[138],"responsible":[140],"increase":[143],"ability,":[146],"since":[147],"alter":[153],"These":[156],"results":[157],"suggest":[158],"that":[159],"integrity":[160],"accessibility":[162],"receptor":[166],"site":[167],"may":[168],"crucial":[170],"formation":[173],"ternary":[176],"collagenenzyme-platelet":[177],"complex":[179],"must":[181],"precede":[182]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
