{"id":"https://openalex.org/W2076908474","doi":"https://doi.org/10.1517/13543784.5.5.581","title":"Monthly Update: Central & Peripheral Nervous Systems: Pharmacology of antimigraine 5-HT 1D receptor agonists","display_name":"Monthly Update: Central & Peripheral Nervous Systems: Pharmacology of antimigraine 5-HT 1D receptor agonists","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2076908474","doi":"https://doi.org/10.1517/13543784.5.5.581","mag":"2076908474"},"language":"en","primary_location":{"id":"doi:10.1517/13543784.5.5.581","doi":"https://doi.org/10.1517/13543784.5.5.581","is_oa":false,"landing_page_url":"https://doi.org/10.1517/13543784.5.5.581","pdf_url":null,"source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113669368","display_name":"Pramod R. Saxena","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pramod R Saxena","raw_affiliation_strings":["Dutch Migraine Research Group, Cardiovascular Research Institute \u2018COEUR\u2019"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dutch Migraine Research Group, Cardiovascular Research Institute \u2018COEUR\u2019","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039941295","display_name":"Michel Dominique Ferrari","orcid":"https://orcid.org/0000-0001-9691-9449","observed_orcids":["https://orcid.org/0000-0001-9691-9449"]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michel D Ferrari","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, PO Box 1738, 3000, DR, Rotterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, PO Box 1738, 3000, DR, Rotterdam","institution_ids":["https://openalex.org/I913958620"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5827,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.88966511,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"5","issue":"5","first_page":"581","last_page":"593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-ht1d-receptor-agonist","display_name":"5-HT1D receptor agonist","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sumatriptan","display_name":"sumatriptan","score":0.968999981880188},{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.6380000114440918},{"id":"https://openalex.org/keywords/cluster-headache","display_name":"cluster headache","score":0.9549999833106995},{"id":"https://openalex.org/keywords/zolmitriptan","display_name":"zolmitriptan","score":0.9089999794960022},{"id":"https://openalex.org/keywords/naratriptan","display_name":"naratriptan","score":0.9319999814033508},{"id":"https://openalex.org/keywords/receptor-selectivity","display_name":"receptor selectivity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/adenylyl-cyclase-inhibition","display_name":"adenylate cyclase inhibition","score":0.8859999775886536},{"id":"https://openalex.org/keywords/carotid-blood-flow","display_name":"carotid blood flow","score":0.781000018119812},{"id":"https://openalex.org/keywords/arteriovenous-anastomosis","display_name":"arteriovenous anastomoses","score":0.8859999775886536},{"id":"https://openalex.org/keywords/trigeminal-ganglion","display_name":"trigeminal ganglion","score":0.7020000219345093},{"id":"https://openalex.org/keywords/headache-recurrence","display_name":"headache recurrence","score":0.6320000290870667},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2778871607","wikidata":"https://www.wikidata.org/wiki/Q416978","display_name":"Sumatriptan","level":4,"score":0.9386825561523438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6853615641593933},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6185149550437927},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5099693536758423},{"id":"https://openalex.org/C2779085531","wikidata":"https://www.wikidata.org/wiki/Q218820","display_name":"Zolmitriptan","level":5,"score":0.48635798692703247},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3801037073135376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.368463397026062},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3249385356903076}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1517/13543784.5.5.581","doi":"https://doi.org/10.1517/13543784.5.5.581","is_oa":false,"landing_page_url":"https://doi.org/10.1517/13543784.5.5.581","pdf_url":null,"source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1963978820","https://openalex.org/W1966579748","https://openalex.org/W1976782762","https://openalex.org/W1982599679","https://openalex.org/W1983664314","https://openalex.org/W1983962867","https://openalex.org/W1984868484","https://openalex.org/W1987195942","https://openalex.org/W1988490723","https://openalex.org/W1990459441","https://openalex.org/W2003684536","https://openalex.org/W2004700633","https://openalex.org/W2006151920","https://openalex.org/W2006888340","https://openalex.org/W2009626941","https://openalex.org/W2010425214","https://openalex.org/W2017566753","https://openalex.org/W2021812411","https://openalex.org/W2023636762","https://openalex.org/W2027535097","https://openalex.org/W2027733704","https://openalex.org/W2032361350","https://openalex.org/W2033316355","https://openalex.org/W2037344126","https://openalex.org/W2046020771","https://openalex.org/W2047829253","https://openalex.org/W2050432578","https://openalex.org/W2054150134","https://openalex.org/W2056873086","https://openalex.org/W2061772288","https://openalex.org/W2062761297","https://openalex.org/W2067253081","https://openalex.org/W2070703662","https://openalex.org/W2072463279","https://openalex.org/W2073893257","https://openalex.org/W2074050181","https://openalex.org/W2075487573","https://openalex.org/W2078596134","https://openalex.org/W2079814114","https://openalex.org/W2080257082","https://openalex.org/W2081620981","https://openalex.org/W2084711776","https://openalex.org/W2089726262","https://openalex.org/W2093816404","https://openalex.org/W2094907245","https://openalex.org/W2096757024","https://openalex.org/W2099441174","https://openalex.org/W2113588456","https://openalex.org/W2113897056","https://openalex.org/W2114314315","https://openalex.org/W2122525900","https://openalex.org/W2130178038","https://openalex.org/W2143289456","https://openalex.org/W2152334475","https://openalex.org/W2154121435","https://openalex.org/W2264473966","https://openalex.org/W2412507161","https://openalex.org/W2416154070","https://openalex.org/W2735058582","https://openalex.org/W2735965069","https://openalex.org/W2951810393"],"related_works":["https://openalex.org/W4245764066","https://openalex.org/W1989571045","https://openalex.org/W2471210234","https://openalex.org/W2413129050","https://openalex.org/W2045156319","https://openalex.org/W2075397373","https://openalex.org/W2125285971","https://openalex.org/W4232225789","https://openalex.org/W2417308169","https://openalex.org/W2589940750"],"abstract_inverted_index":{"The":[0,64,206],"5-HT":[1],"1D":[2],"receptor":[3,62,100,118,209],"agonist":[4],"sumatriptan":[5,20,217],"is":[6,70,103],"undoubtedly":[7],"a":[8,173],"significant":[9],"advance":[10],"in":[11,39,80,128,166,188],"the":[12,55,90,97,105,113,116,167],"management":[13],"of":[14,59,67,96,223],"migraine":[15],"and":[16,37,57,120,179,185],"cluster":[17],"attacks.":[18],"Notwithstanding,":[19],"has":[21],"some":[22,155,214],"important":[23],"shortcomings,":[24,46],"which":[25],"include":[26],"low":[27],"oral":[28],"bioavailability,":[29,221],"headache":[30,226],"recurrence":[31],"(possibly":[32],"due":[33],"to":[34,77,123,212,220],"short":[35],"t1/2)":[36],"contraindication":[38],"patients":[40],"with":[41,107,218],"coronary":[42],"artery":[43,163],"disease.":[44],"These":[45],"as":[47,49,102,150],"well":[48,151],"lofty":[50],"sales":[51],"potentials,":[52],"have":[53],"stimulated":[54],"search":[56],"design":[58],"second-generation":[60],"5-HT1D":[61,99,208],"agonists.":[63],"large":[65],"list":[66],"such":[68],"compounds":[69,134],"growing,":[71],"but":[72],"those":[73],"that":[74],"are":[75,201],"likely":[76],"be":[78,124],"marketed":[79],"this":[81],"millennium":[82],"include:":[83],"zolmitriptan,":[84],"MK-462,":[85],"naratriptan,":[86],"BMS-180048":[87],"and,":[88],"perhaps,":[89],"non-indole":[91],"derivative":[92],"alniditan.":[93],"However,":[94],"none":[95],"newer":[98,207],"agonists,":[101],"also":[104,202],"case":[106],"sumatriptan,":[108],"shows":[109],"selectivity":[110],"towards":[111],"either":[112],"5-HT1D\u03b1":[114],"or":[115,145,170,225],"5-HT1D\u03b2":[117],"subtype":[119],"there":[121],"seems":[122],"little":[125],"qualitative":[126],"difference":[127],"their":[129],"pharmacological":[130],"profiles.":[131],"Thus,":[132],"these":[133],"suppress":[135],"adenylyl":[136],"cyclase":[137],"activity,":[138],"contract":[139],"isolated":[140],"cerebral":[141,148],"(e.g.,":[142,158],"human,":[143],"bovine":[144],"canine":[146],"middle":[147],"artery)":[149],"as,":[152],"though":[153],"weakly,":[154],"peripheral":[156],"arteries":[157],"human":[159],"coronaries),":[160],"reduce":[161],"carotid":[162],"blood":[164],"flow":[165],"cat,":[168],"dog":[169],"pig":[171],"by":[172,204],"selective":[174],"action":[175,224],"on":[176],"arteriovenous":[177,199],"anastomoses,":[178],"inhibit":[180],"dural":[181],"plasma":[182],"extravasation":[183],"(rat)":[184],"evoked":[186],"potentials":[187],"dorsal":[189],"horn":[190],"neurones":[191],"(cat)":[192],"following":[193],"trigeminal":[194],"ganglion":[195],"stimulation.":[196],"Human":[197],"brachial":[198],"anastomoses":[200],"constricted":[203],"sumatriptan.":[205],"agonists":[210],"appear":[211],"offer":[213],"advantage":[215],"over":[216],"respect":[219],"onset":[222],"recurrence.":[227]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}
