{"id":"https://openalex.org/W2076894975","doi":"https://doi.org/10.1006/jsre.2001.6323","title":"Vascular Effects of Poly-N-Acetylglucosamine in Isolated Rat Aortic Rings","display_name":"Vascular Effects of Poly-N-Acetylglucosamine in Isolated Rat Aortic Rings","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W2076894975","doi":"https://doi.org/10.1006/jsre.2001.6323","mag":"2076894975","pmid":"https://pubmed.ncbi.nlm.nih.gov/11796021"},"language":"en","primary_location":{"id":"doi:10.1006/jsre.2001.6323","doi":"https://doi.org/10.1006/jsre.2001.6323","is_oa":false,"landing_page_url":"https://doi.org/10.1006/jsre.2001.6323","pdf_url":null,"source":{"id":"https://openalex.org/S45161156","display_name":"Journal of Surgical Research","issn_l":"0022-4804","issn":["0022-4804","1095-8673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105422718","display_name":"Yasuhiko Ikeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasuhiko Ikeda","raw_affiliation_strings":["Department of Physiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088089771","display_name":"Lindon Howard Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindon H. Young","raw_affiliation_strings":["Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108800192","display_name":"John N. Vournakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121427","display_name":"Marine Polymer Technologies (United States)","ror":"https://ror.org/02fx6bp88","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John N. Vournakis","raw_affiliation_strings":["Marine Polymer Technologies, Inc. Danvers, Massachusetts, 01923"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marine Polymer Technologies, Inc. Danvers, Massachusetts, 01923","institution_ids":["https://openalex.org/I4210121427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110287816","display_name":"Allan M. Lefer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan M. Lefer","raw_affiliation_strings":["Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107","institution_ids":["https://openalex.org/I149251103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":3.0472,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.90741947,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"102","issue":"2","first_page":"215","last_page":"220"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/poly-n-acetylglucosamine","display_name":"poly-N-acetylglucosamine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.8330000042915344},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.6650000214576721},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/endothelin-a-receptor","display_name":"ETA receptor","score":0.6129999756813049},{"id":"https://openalex.org/keywords/endothelium-dependent-contraction","display_name":"endothelium-dependent contraction","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.890999972820282},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.6919999718666077},{"id":"https://openalex.org/keywords/chitin","display_name":"chitin","score":0.6200000047683716},{"id":"https://openalex.org/keywords/deendothelialization","display_name":"deendothelialization","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.8677244186401367},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6082098484039307},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5496958494186401},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.5167735815048218},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.494158536195755},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.49330487847328186},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.475844144821167},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4518052637577057},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44102615118026733},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4299767017364502},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3619503974914551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35124629735946655},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.25896531343460083},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22364985942840576}],"mesh":[{"descriptor_ui":"D000117","descriptor_name":"Acetylglucosamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017466","descriptor_name":"Receptors, Endothelin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019796","descriptor_name":"15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1006/jsre.2001.6323","doi":"https://doi.org/10.1006/jsre.2001.6323","is_oa":false,"landing_page_url":"https://doi.org/10.1006/jsre.2001.6323","pdf_url":null,"source":{"id":"https://openalex.org/S45161156","display_name":"Journal of Surgical Research","issn_l":"0022-4804","issn":["0022-4804","1095-8673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Research","raw_type":"journal-article"},{"id":"pmid:11796021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11796021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of surgical research","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.pcom.edu:scholarly_papers-1582","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.pcom.edu/scholarly_papers/459","pdf_url":null,"source":{"id":"https://openalex.org/S4377196547","display_name":"Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I106460735","host_organization_name":"Philadelphia College of Osteopathic Medicine","host_organization_lineage":["https://openalex.org/I106460735"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PCOM Scholarly Works","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2314865018","display_name":null,"funder_award_id":"HL-07599","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W50040476","https://openalex.org/W1857469095","https://openalex.org/W1980762198","https://openalex.org/W1986868134","https://openalex.org/W2007737411","https://openalex.org/W2012185701","https://openalex.org/W2018215013","https://openalex.org/W2021783313","https://openalex.org/W2027721232","https://openalex.org/W2050986294","https://openalex.org/W2068986973","https://openalex.org/W2072625531","https://openalex.org/W2073497750","https://openalex.org/W2092145002","https://openalex.org/W2126624423","https://openalex.org/W2162804111","https://openalex.org/W2263824859"],"related_works":["https://openalex.org/W2049957217","https://openalex.org/W2286247777","https://openalex.org/W2139611942","https://openalex.org/W2067114562","https://openalex.org/W2004619700","https://openalex.org/W3171764519","https://openalex.org/W2149323448","https://openalex.org/W2760171591","https://openalex.org/W1959173986","https://openalex.org/W3148148266"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}