{"id":"https://openalex.org/W2076820945","doi":"https://doi.org/10.1111/j.1349-7006.1994.tb02904.x","title":"Association of Vascular Endothelial Growth Factor Expression with Tumor Angiogenesis and with Early Relapse in Primary Breast Cancer","display_name":"Association of Vascular Endothelial Growth Factor Expression with Tumor Angiogenesis and with Early Relapse in Primary Breast Cancer","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W2076820945","doi":"https://doi.org/10.1111/j.1349-7006.1994.tb02904.x","mag":"2076820945","pmid":"https://pubmed.ncbi.nlm.nih.gov/7525523","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5919354"},"language":"en","primary_location":{"id":"doi:10.1111/j.1349-7006.1994.tb02904.x","doi":"https://doi.org/10.1111/j.1349-7006.1994.tb02904.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.1994.tb02904.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.1994.tb02904.x","source":{"id":"https://openalex.org/S4210193983","display_name":"Japanese Journal of Cancer Research","issn_l":"0910-5050","issn":["0910-5050","1344-6428","1876-4673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.1994.tb02904.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091245889","display_name":"Masakazu Toi","orcid":"https://orcid.org/0000-0003-1488-9958","observed_orcids":["https://orcid.org/0000-0003-1488-9958"]},"institutions":[{"id":"https://openalex.org/I3020605285","display_name":"Tokyo Metropolitan Komagome Hospital","ror":"https://ror.org/04eqd2f30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3020605285"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masakazu Toi","raw_affiliation_strings":["Department of Surgery, Tokyo Metropolitan Komagome Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tokyo Metropolitan Komagome Hospital","institution_ids":["https://openalex.org/I3020605285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072201896","display_name":"Seigo Hoshina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020605285","display_name":"Tokyo Metropolitan Komagome Hospital","ror":"https://ror.org/04eqd2f30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3020605285"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seigo Hoshina","raw_affiliation_strings":["Department of Surgery, Tokyo Metropolitan Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113","Tokyo Metropolitan Komagome Hospital;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tokyo Metropolitan Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113","institution_ids":["https://openalex.org/I3020605285"]},{"raw_affiliation_string":"Tokyo Metropolitan Komagome Hospital;","institution_ids":["https://openalex.org/I3020605285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053554193","display_name":"Toshiaki Takayanagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020605285","display_name":"Tokyo Metropolitan Komagome Hospital","ror":"https://ror.org/04eqd2f30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3020605285"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Takayanagi","raw_affiliation_strings":["Department of Surgery, Tokyo Metropolitan Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113","Tokyo Metropolitan Komagome Hospital;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tokyo Metropolitan Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113","institution_ids":["https://openalex.org/I3020605285"]},{"raw_affiliation_string":"Tokyo Metropolitan Komagome Hospital;","institution_ids":["https://openalex.org/I3020605285"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109937933","display_name":"Takeshi Tominaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020605285","display_name":"Tokyo Metropolitan Komagome Hospital","ror":"https://ror.org/04eqd2f30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3020605285"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Tominaga","raw_affiliation_strings":["Department of Surgery, Tokyo Metropolitan Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113","Tokyo Metropolitan Komagome Hospital;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tokyo Metropolitan Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113","institution_ids":["https://openalex.org/I3020605285"]},{"raw_affiliation_string":"Tokyo Metropolitan Komagome Hospital;","institution_ids":["https://openalex.org/I3020605285"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091245889"],"corresponding_institution_ids":["https://openalex.org/I3020605285"],"apc_list":null,"apc_paid":null,"fwci":5.4145,"has_fulltext":false,"cited_by_count":387,"citation_normalized_percentile":{"value":0.97027675,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"85","issue":"10","first_page":"1045","last_page":"1049"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7889999747276306},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.968999981880188},{"id":"https://openalex.org/keywords/early-recurrence","display_name":"early recurrence","score":0.8999999761581421},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8410000205039978},{"id":"https://openalex.org/keywords/factor-viii","display_name":"factor VIII","score":0.7400000095367432},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.8259999752044678},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8152201175689697},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.7865763902664185},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.7610718011856079},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5875861048698425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5714489817619324},{"id":"https://openalex.org/C2776436680","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microvessel","level":3,"score":0.5706353187561035},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5047084093093872},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4711952209472656},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.4551827609539032},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4455415606498718},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.4236263632774353},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3990258276462555},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3786141276359558},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3202131986618042},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.2595584988594055}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1349-7006.1994.tb02904.x","doi":"https://doi.org/10.1111/j.1349-7006.1994.tb02904.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.1994.tb02904.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.1994.tb02904.x","source":{"id":"https://openalex.org/S4210193983","display_name":"Japanese Journal of Cancer Research","issn_l":"0910-5050","issn":["0910-5050","1344-6428","1876-4673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4863481","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5919354","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5919354","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5919354","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jpn J Cancer Res","raw_type":"Text"},{"id":"pmid:7525523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7525523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of cancer research : Gann","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1349-7006.1994.tb02904.x","doi":"https://doi.org/10.1111/j.1349-7006.1994.tb02904.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.1994.tb02904.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.1994.tb02904.x","source":{"id":"https://openalex.org/S4210193983","display_name":"Japanese Journal of Cancer Research","issn_l":"0910-5050","issn":["0910-5050","1344-6428","1876-4673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2076820945.pdf","grobid_xml":"https://content.openalex.org/works/W2076820945.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W144095189","https://openalex.org/W1044883788","https://openalex.org/W1482104159","https://openalex.org/W1528036810","https://openalex.org/W1580788756","https://openalex.org/W1969328947","https://openalex.org/W1976402556","https://openalex.org/W1983763042","https://openalex.org/W1985528986","https://openalex.org/W1991958278","https://openalex.org/W2003412145","https://openalex.org/W2003598961","https://openalex.org/W2010618512","https://openalex.org/W2016904444","https://openalex.org/W2037761545","https://openalex.org/W2038540837","https://openalex.org/W2062627489","https://openalex.org/W2071525349","https://openalex.org/W2074070420","https://openalex.org/W2084506573","https://openalex.org/W2133138712","https://openalex.org/W2135335125","https://openalex.org/W2159738525","https://openalex.org/W2187668060","https://openalex.org/W3147894994"],"related_works":["https://openalex.org/W2099011923","https://openalex.org/W7100113547","https://openalex.org/W1984758613","https://openalex.org/W2364688559","https://openalex.org/W2472011331","https://openalex.org/W2091733153","https://openalex.org/W2010685545","https://openalex.org/W2135335125","https://openalex.org/W1983246916","https://openalex.org/W4404025202"],"abstract_inverted_index":{"Angiogenesis":[0],"is":[1,119],"an":[2],"independent":[3],"prognostic":[4],"indicator":[5],"in":[6,34,63,71,131],"breast":[7,37,133],"cancer.":[8,134],"In":[9],"this":[10],"report,":[11],"the":[12,29,86,96,115,123],"relationship":[13],"between":[14,82],"expression":[15,40,84,116],"of":[16,41,88,100,108,117,125],"vascular":[17],"endothelial":[18,26],"growth":[19],"factor":[20,60],"(VEGF;":[21],"a":[22,79],"selective":[23],"mitogen":[24],"for":[25,59],"cells)":[27],"and":[28,85,127],"microvessel":[30,52,89],"density":[31],"was":[32,43,55,66,78,103,112],"examined":[33],"103":[35],"primary":[36,132],"cancers.":[38],"The":[39,51],"VEGF":[42,83,118],"evaluated":[44],"by":[45,57],"immunocytochemical":[46],"staining":[47],"using":[48],"anti-VEGF":[49],"antibody.":[50],"density,":[53],"which":[54],"determined":[56],"immunostaining":[58],"VIII":[61],"antigen,":[62],"VEGF-rich":[64,101],"tumors":[65,73,102],"clearly":[67],"higher":[68],"than":[69,106],"that":[70,95,107,114],"VEGF-poor":[72,109],"(P":[74],"<":[75],"0.01).":[76],"There":[77],"good":[80],"correlation":[81],"increment":[87],"density.":[90],"Furthermore,":[91],"postoperative":[92],"survey":[93],"demonstrated":[94],"relapse-free":[97],"survival":[98],"rate":[99],"significantly":[104],"worse":[105],"tumors.":[110],"It":[111],"suggested":[113],"closely":[120],"associated":[121],"with":[122,128],"promotion":[124],"angiogenesis":[126],"early":[129],"relapse":[130]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
