{"id":"https://openalex.org/W2076804102","doi":"https://doi.org/10.1172/jci108133","title":"Thyrotropin-induced hyperthyroidism caused by selective pituitary resistance to thyroid hormone. A new syndrome of \"inappropriate secretion of TSH\".","display_name":"Thyrotropin-induced hyperthyroidism caused by selective pituitary resistance to thyroid hormone. A new syndrome of \"inappropriate secretion of TSH\".","publication_year":1975,"publication_date":"1975-09-01","ids":{"openalex":"https://openalex.org/W2076804102","doi":"https://doi.org/10.1172/jci108133","mag":"2076804102","pmid":"https://pubmed.ncbi.nlm.nih.gov/1159077","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/301911"},"language":"en","primary_location":{"id":"doi:10.1172/jci108133","doi":"https://doi.org/10.1172/jci108133","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci108133","pdf_url":"http://www.jci.org/articles/view/108133/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/108133/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113469620","display_name":"M C Gershengorn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M C Gershengorn","raw_affiliation_strings":["From the Clinical Endocrinology Branch, National Institute of Arthritis,","Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Endocrinology Branch, National Institute of Arthritis,","institution_ids":[]},{"raw_affiliation_string":"Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108610151","display_name":"B D Weintraub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B D Weintraub","raw_affiliation_strings":["From the Clinical Endocrinology Branch , National Institute of Arthritis,","Metabolism, and Digestive Diseases , National Institutes of Health , Bethesda , Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Endocrinology Branch , National Institute of Arthritis,","institution_ids":[]},{"raw_affiliation_string":"Metabolism, and Digestive Diseases , National Institutes of Health , Bethesda , Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":5.4192,"has_fulltext":true,"cited_by_count":217,"citation_normalized_percentile":{"value":0.95918894,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"56","issue":"3","first_page":"633","last_page":"642"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inappropriate-tsh-secretion","display_name":"inappropriate TSH secretion","score":0.9020000100135803},{"id":"https://openalex.org/keywords/pituitary-resistance-to-thyroid-hormone","display_name":"pituitary resistance to thyroid hormone","score":0.9049999713897705},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.718999981880188},{"id":"https://openalex.org/keywords/thyrotropin-releasing-hormone-stimulation","display_name":"thyrotropin-releasing hormone stimulation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.7580000162124634},{"id":"https://openalex.org/keywords/propylthiouracil","display_name":"propylthiouracil","score":0.9929999709129333},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8864883184432983},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8758060932159424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7157062292098999},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.7053275108337402},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6757493019104004},{"id":"https://openalex.org/C2775960720","wikidata":"https://www.wikidata.org/wiki/Q377342","display_name":"Propylthiouracil","level":3,"score":0.6686964631080627},{"id":"https://openalex.org/C2778288131","wikidata":"https://www.wikidata.org/wiki/Q327362","display_name":"Triiodothyronine","level":3,"score":0.6671675443649292},{"id":"https://openalex.org/C2776216936","wikidata":"https://www.wikidata.org/wiki/Q24726011","display_name":"Thyrotropin-releasing hormone","level":3,"score":0.6540931463241577},{"id":"https://openalex.org/C4134927","wikidata":"https://www.wikidata.org/wiki/Q7671336","display_name":"TRH stimulation test","level":4,"score":0.6495703458786011},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.447219580411911},{"id":"https://openalex.org/C2777886399","wikidata":"https://www.wikidata.org/wiki/Q211544","display_name":"Thyroid-stimulating hormone","level":3,"score":0.42094382643699646}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008713","descriptor_name":"Methimazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013960","descriptor_name":"Thyroid Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci108133","doi":"https://doi.org/10.1172/jci108133","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci108133","pdf_url":"http://www.jci.org/articles/view/108133/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:1159077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1159077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:301911","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC301911/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"mag:2186510017","doi":null,"is_oa":false,"landing_page_url":"https://dm5migu4zj3pb.cloudfront.net/manuscripts/108000/108133/JCI75108133.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1172/jci108133","doi":"https://doi.org/10.1172/jci108133","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci108133","pdf_url":"http://www.jci.org/articles/view/108133/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306493","display_name":"Abbott Laboratories","ror":"https://ror.org/0052svj16"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2076804102.pdf","grobid_xml":"https://content.openalex.org/works/W2076804102.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W29855230","https://openalex.org/W102059784","https://openalex.org/W130306605","https://openalex.org/W1541507678","https://openalex.org/W1964683728","https://openalex.org/W1971459605","https://openalex.org/W1972111689","https://openalex.org/W1972489058","https://openalex.org/W1978594820","https://openalex.org/W1981045579","https://openalex.org/W1984505489","https://openalex.org/W2008086985","https://openalex.org/W2012015520","https://openalex.org/W2016437206","https://openalex.org/W2019236289","https://openalex.org/W2030962379","https://openalex.org/W2057466848","https://openalex.org/W2058767944","https://openalex.org/W2060195558","https://openalex.org/W2063426399","https://openalex.org/W2066958968","https://openalex.org/W2075805067","https://openalex.org/W2108002609","https://openalex.org/W2123037889","https://openalex.org/W2123331118","https://openalex.org/W2132713197","https://openalex.org/W2134067239","https://openalex.org/W2134874648","https://openalex.org/W2140522098","https://openalex.org/W2161620876","https://openalex.org/W2170296755","https://openalex.org/W2323176824","https://openalex.org/W2337051283","https://openalex.org/W2413385694","https://openalex.org/W2437820287"],"related_works":["https://openalex.org/W2186510017","https://openalex.org/W2093980353","https://openalex.org/W4230324955","https://openalex.org/W7118079069","https://openalex.org/W2031631620","https://openalex.org/W2141414300","https://openalex.org/W2097988030","https://openalex.org/W1997433974","https://openalex.org/W2071275119","https://openalex.org/W2083416047"],"abstract_inverted_index":{"An":[0],"18-yr-old":[1],"woman":[2],"with":[3,181,189],"clinical":[4],"and":[5,44,64,78,116,118,142,152,202],"laboratory":[6],"features":[7],"of":[8,15,22,29,56,67,110,127,137,146,167,173,187,193,199,208,214],"hyperthyroidism":[9],"had":[10,25],"persistently":[11],"elevated":[12,96,190,200],"serum":[13,62,74,97,102,114,191],"levels":[14,192],"immunoreative":[16],"thyrotropin":[17],"(TSH).":[18],"During":[19],"11":[20],"yr":[21],"follow-up":[23],"there":[24,37],"been":[26],"no":[27],"evidence":[28],"a":[30,39,124,163],"pituitary":[31,140,169],"tumor.":[32],"After":[33,82],"thyrotropin-releasing":[34],"hormone":[35,70,154],"(TRH),":[36],"was":[38,88,91],"marked":[40],"increase":[41],"in":[42,46,134,143,184,196],"TSH":[43,86,103,148,195],"secondarily":[45],"triiodothyronine":[47],"(T3),":[48],"the":[49,53,57,84,95,135,144,147,168,171,185,197],"latter":[50],"observation":[51],"confirming":[52],"biologic":[54],"activity":[55],"TSH.":[58,111,120],"Exogenous":[59],"T3":[60,63,98,117],"raised":[61,119],"several":[65],"measurements":[66],"peripheral":[68],"thyroid":[69,153,174,204],"effect,":[71],"while":[72],"decreasing":[73],"TSH,":[75],"thyroxine":[76],"(T4),":[77],"thyroidal":[79],"radioiodine":[80],"uptake.":[81],"T3,":[83],"TRH-stimulated":[85],"response":[87],"decreased":[89],"but":[90,104],"still":[92],"inappropriate":[93],"for":[94],"levels.":[99],"Dexamethasone":[100],"reduced":[101,113],"did":[105],"not":[106],"inhibit":[107],"TRH":[108,150],"stimulation":[109,151],"Propylthiouracil":[112],"T4":[115],"This":[121,156,176],"patient":[122],"represents":[123],"new":[125],"syndrome":[126,157],"TSH-induced":[128],"hyperthyroidism,":[129],"differing":[130],"from":[131],"previous":[132,182],"reports":[133,183],"absence":[136],"an":[138],"obvious":[139],"tumor":[141],"responsiveness":[145],"to":[149,159,170],"suppression.":[155],"appears":[158],"be":[160],"caused":[161],"by":[162],"selective,":[164],"partial":[165],"resistance":[166],"action":[172],"hormone.":[175],"case":[177],"is":[178,216],"also":[179],"compared":[180],"literature":[186],"patients":[188],"immunoreactive":[194],"presence":[198],"total":[201],"free":[203],"hormones.":[205],"A":[206],"classification":[207],"these":[209],"cases,":[210],"termed":[211],"\"inappropriate":[212],"secretion":[213],"TSH,\"":[215],"proposed.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}