{"id":"https://openalex.org/W2076776969","doi":"https://doi.org/10.1158/1538-7445.am2011-9","title":"Abstract 9: 2-deoxyglucose caused toxicity is regulated by the Bcl-2 family and is enhanced by Bcl-2 antagonist in lymphoma cell lines","display_name":"Abstract 9: 2-deoxyglucose caused toxicity is regulated by the Bcl-2 family and is enhanced by Bcl-2 antagonist in lymphoma cell lines","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2076776969","doi":"https://doi.org/10.1158/1538-7445.am2011-9","mag":"2076776969"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-9","doi":"https://doi.org/10.1158/1538-7445.am2011-9","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-9","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059446923","display_name":"Oksana Zagorodna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oksana Zagorodna","raw_affiliation_strings":["1Univ. of Iowa College of Medicine, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Iowa College of Medicine, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101141461","display_name":"Sean M. Martin","orcid":"https://orcid.org/0009-0003-6720-178X","observed_orcids":["https://orcid.org/0009-0003-6720-178X"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Martin","raw_affiliation_strings":["1Univ. of Iowa College of Medicine, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Iowa College of Medicine, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027873387","display_name":"Tomomi Kuwana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomomi Kuwana","raw_affiliation_strings":["1Univ. of Iowa College of Medicine, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Iowa College of Medicine, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044316011","display_name":"Douglas R. Spitz","orcid":"https://orcid.org/0000-0002-1254-8765","observed_orcids":["https://orcid.org/0000-0002-1254-8765"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Spitz","raw_affiliation_strings":["1Univ. of Iowa College of Medicine, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Iowa College of Medicine, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062506908","display_name":"Charles Michael Knudson","orcid":"https://orcid.org/0000-0003-3964-5466","observed_orcids":["https://orcid.org/0000-0003-3964-5466"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Michael Knudson","raw_affiliation_strings":["1Univ. of Iowa College of Medicine, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Iowa College of Medicine, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"9","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-deoxy-d-glucose","display_name":"2-deoxyglucose","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.7860000133514404},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.902999997138977},{"id":"https://openalex.org/keywords/building-information-modeling","display_name":"building information modeling","score":0.6650000214576721},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.6039999723434448},{"id":"https://openalex.org/keywords/abt-737","display_name":"ABT-737","score":0.9520000219345093},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8059999942779541},{"id":"https://openalex.org/keywords/chop","display_name":"CHOP","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mannose","display_name":"mannose","score":0.6489999890327454},{"id":"https://openalex.org/keywords/glycolysis-inhibition","display_name":"glycolysis inhibition","score":0.734000027179718},{"id":"https://openalex.org/keywords/t-cell-lymphoma","display_name":"T-cell lymphoma","score":0.7879999876022339},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6100000143051147},{"id":"https://openalex.org/keywords/bmf","display_name":"BMF","score":0.5299999713897705},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5450000166893005},{"id":"https://openalex.org/keywords/clonogenic-survival","display_name":"clonogenic survival","score":0.6759999990463257},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/bh3-only-proteins","display_name":"BH3-only proteins","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7387040257453918},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6124517917633057},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5010502338409424},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.4984781742095947},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4833543002605438},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4625828266143799},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4516817331314087},{"id":"https://openalex.org/C2776789625","wikidata":"https://www.wikidata.org/wiki/Q4875408","display_name":"Bcl-xL","level":4,"score":0.4274426996707916},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3243290185928345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26193687319755554},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09545725584030151},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-9","doi":"https://doi.org/10.1158/1538-7445.am2011-9","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-9","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2038722548","https://openalex.org/W2051305571","https://openalex.org/W31527528","https://openalex.org/W7098483199","https://openalex.org/W2898654662","https://openalex.org/W2144089463","https://openalex.org/W2032769297","https://openalex.org/W2907958400","https://openalex.org/W2906328052","https://openalex.org/W2054485562"],"abstract_inverted_index":{"Abstract":[0],"Introduction.":[1],"2-deoxyglucose":[2],"(2DG)":[3],"is":[4,46,215,303,312,326],"a":[5,216,231,244,294,327],"glucose":[6],"analog":[7],"and":[8,50,60,91,106,123,143,170,195,278,286,302,318,324],"inhibitor":[9],"of":[10,27,41,53,79,97,100,115,133,164,173,188,204,219,300,321,343,348],"glycolysis":[11],"that":[12,192,213,225,274,296,309],"has":[13,31],"been":[14,33],"shown":[15,234],"to":[16,21,24,35,83,110,129,183,228,235,247],"have":[17],"anti-cancer":[18],"activity,":[19],"proposed":[20],"be":[22],"due":[23],"altered":[25],"metabolism":[26],"cancer":[28],"cells.":[29,176],"2DG":[30,45,84,134,147,174,200,210,220,226,275,310,325],"also":[32,223,254],"reported":[34],"induce":[36],"ER":[37,241,249,283],"stress":[38,250,284],"through":[39],"inhibition":[40,323],"N-linked":[42],"glycosylation.":[43],"Whether":[44],"effective":[47,330],"in":[48,118],"lymphoma":[49,119],"the":[51,102,112,298,315,319,344,349],"mechanisms":[52],"cell":[54,64,74,81,120,137,185,258,280],"death":[55,117,138,281],"are":[56,126],"not":[57,271],"known.":[58],"Materials":[59],"Methods.":[61],"Five":[62],"tumor":[63],"lines":[65,82],"were":[66,108,197],"independently":[67],"derived":[68],"from":[69,159,209,257],"Lck-Bax":[70],"driven":[71],"murine":[72],"T":[73],"lymphomas":[75],"(TCLs).":[76],"The":[77,136],"sensitivity":[78],"these":[80],"was":[85,268],"determined":[86],"by":[87,252,282,305,314],"plasma":[88],"membrane":[89],"integrity":[90],"clonogenic":[92,171],"survival.":[93],"Caspase":[94,144],"inhibitors,":[95],"overexpression":[96],"Bcl-2,":[98],"downregulation":[99,203],"Bim,":[101],"Bcl-2":[103,165,178,316,322],"antagonist":[104],"ABT-737,":[105,180],"mannose":[107,261],"utilized":[109],"determine":[111],"molecular":[113],"mechanism":[114],"2DG-caused":[116],"lines.":[121],"Results":[122],"Conclusions.":[124],"TCLs":[125,182],"uniformly":[127],"sensitive":[128],"physiologically":[130],"relevant":[131],"concentrations":[132],"treatment.":[135,148,201],"pathway":[139],"involves":[140,297],"Bax":[141,301],"\u201cactivation\u201d":[142],"cleavage":[145],"following":[146,199,240],"However,":[149,289],"qVD-OPh":[150],"effectively":[151,262],"inhibited":[152],"caspase":[153],"activity":[154],"while":[155],"providing":[156],"minimal":[157],"protection":[158],"death.":[160,186,259],"In":[161],"contrast,":[162],"expression":[163],"enhanced":[166],"both":[167,193,290],"short":[168],"term":[169],"survival":[172],"treated":[175],"A":[177],"antagonist,":[179],"sensitized":[181],"2DG-induced":[184],"Examination":[187],"BH3-only":[189],"members":[190],"demonstrated":[191],"Bim":[194,205,214,238,266],"Bmf":[196],"upregulated":[198,276],"Importantly,":[202],"with":[206],"shRNAs":[207],"protected":[208,256],"treatment,":[211],"demonstrating":[212],"critical":[217],"mediator":[218],"toxicity.":[221],"We":[222,307],"observed":[224],"led":[227],"CHOP":[229,264],"induction,":[230],"transcription":[232],"factor":[233],"directly":[236],"mediate":[237],"upregulation":[239,267],"stress.":[242],"Mannose,":[243],"reagent":[245],"known":[246],"alleviate":[248],"induced":[251,279],"2DG,":[253],"transiently":[255],"While":[260],"blocked":[263,272,304],"upregulation,":[265],"delayed":[269],"but":[270],"indicating":[273],"BIM":[277],"dependent":[285],"independent":[287],"mechanism.":[288],"pathways":[291],"converge":[292],"at":[293],"step":[295],"activation":[299],"Bcl-2.":[306],"conclude":[308],"toxicity":[311],"regulated":[313],"family,":[317],"combination":[320],"candidate":[328],"for":[329,333,352],"therapeutic":[331],"strategy":[332],"lymphoma.":[334],"Citation":[335],"Format:":[336],"{Authors}.":[337],"{Abstract":[338],"title}":[339],"[abstract].":[340],"In:":[341],"Proceedings":[342],"102nd":[345],"Annual":[346],"Meeting":[347],"American":[350],"Association":[351],"Cancer":[353,363],"Research;":[354],"2011":[355],"Apr":[356],"2-6;":[357],"Orlando,":[358],"FL.":[359],"Philadelphia":[360],"(PA):":[361],"AACR;":[362],"Res":[364],"2011;71(8":[365],"Suppl):Abstract":[366],"nr":[367],"9.":[368],"doi:10.1158/1538-7445.AM2011-9":[369]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
