{"id":"https://openalex.org/W2076775111","doi":"https://doi.org/10.1161/01.cir.52.2.297","title":"The pathophysiology of idiopathic mitral valve prolapse.","display_name":"The pathophysiology of idiopathic mitral valve prolapse.","publication_year":1975,"publication_date":"1975-08-01","ids":{"openalex":"https://openalex.org/W2076775111","doi":"https://doi.org/10.1161/01.cir.52.2.297","mag":"2076775111","pmid":"https://pubmed.ncbi.nlm.nih.gov/1149211"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.52.2.297","doi":"https://doi.org/10.1161/01.cir.52.2.297","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.52.2.297","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.52.2.297","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.52.2.297","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045464851","display_name":"Donald O. Nutter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D O Nutter","raw_affiliation_strings":["D O Nutter"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D O Nutter","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111819526","display_name":"Carolyn Wickliffe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Wickliffe","raw_affiliation_strings":["C Wickliffe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C Wickliffe","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056130488","display_name":"Charles A. Gilbert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C A Gilbert","raw_affiliation_strings":["C A Gilbert"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C A Gilbert","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113298208","display_name":"C Moody","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Moody","raw_affiliation_strings":["C Moody"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C Moody","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010753140","display_name":"Spencer B. King","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S B King","raw_affiliation_strings":["Division of Cardiology , Department of Medicine , Emory University School of Medicine , Atlanta , Georgia","S B King3rd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology , Department of Medicine , Emory University School of Medicine , Atlanta , Georgia","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"S B King3rd","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.4886,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.96450137,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"52","issue":"2","first_page":"297","last_page":"305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-mitral-valve-prolapse","display_name":"idiopathic mitral valve prolapse","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitral-regurgitation","display_name":"mitral regurgitation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.8429999947547913},{"id":"https://openalex.org/keywords/left-ventricular-function","display_name":"left ventricular function","score":0.7300000190734863},{"id":"https://openalex.org/keywords/coronary-circulation","display_name":"coronary circulation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.8600000143051147},{"id":"https://openalex.org/keywords/myocardial-lactate-extraction","display_name":"myocardial lactate extraction","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.7450000047683716},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.875}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.962562620639801},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.8320020437240601},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8252142667770386},{"id":"https://openalex.org/C2781030672","wikidata":"https://www.wikidata.org/wiki/Q735652","display_name":"Mitral valve prolapse","level":3,"score":0.7593562602996826},{"id":"https://openalex.org/C2781231445","wikidata":"https://www.wikidata.org/wiki/Q5319569","display_name":"Asynergy","level":5,"score":0.6877534985542297},{"id":"https://openalex.org/C2993373945","wikidata":"https://www.wikidata.org/wiki/Q268292","display_name":"Mitral regurgitation","level":2,"score":0.6493076086044312},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.5785797834396362},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.43752095103263855},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.4332053065299988},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4130849838256836},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.411247581243515},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2768484354019165},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2278585433959961},{"id":"https://openalex.org/C2778535784","wikidata":"https://www.wikidata.org/wiki/Q7281300","display_name":"Radionuclide ventriculography","level":4,"score":0.11268773674964905}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002306","descriptor_name":"Cardiac Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002932","descriptor_name":"Cineangiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006328","descriptor_name":"Cardiac Catheterization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006337","descriptor_name":"Heart Murmurs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008944","descriptor_name":"Mitral Valve Insufficiency","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008944","descriptor_name":"Mitral Valve Insufficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010138","descriptor_name":"Pacemaker, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017023","descriptor_name":"Coronary Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.cir.52.2.297","doi":"https://doi.org/10.1161/01.cir.52.2.297","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.52.2.297","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.52.2.297","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:1149211","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1149211","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1161/01.cir.52.2.297","doi":"https://doi.org/10.1161/01.cir.52.2.297","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.52.2.297","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.52.2.297","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8500000238418579}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2076775111.pdf","grobid_xml":"https://content.openalex.org/works/W2076775111.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W55456158","https://openalex.org/W1977773385","https://openalex.org/W1979304134","https://openalex.org/W1994940637","https://openalex.org/W2017666214","https://openalex.org/W2034444889","https://openalex.org/W2035242739","https://openalex.org/W2045868958","https://openalex.org/W2063984736","https://openalex.org/W2087144444","https://openalex.org/W2088535138","https://openalex.org/W2100229476","https://openalex.org/W2115320866","https://openalex.org/W2115977820","https://openalex.org/W2127133385","https://openalex.org/W2336120846","https://openalex.org/W4240611730","https://openalex.org/W4256255376"],"related_works":["https://openalex.org/W2070367976","https://openalex.org/W1518603627","https://openalex.org/W2417870057","https://openalex.org/W1988761442","https://openalex.org/W1998704996","https://openalex.org/W1999756640","https://openalex.org/W1982866950","https://openalex.org/W2020247329","https://openalex.org/W1927842449","https://openalex.org/W1999154727"],"abstract_inverted_index":{"Left":[0],"ventricular":[1,90,130,157],"structure,":[2],"function,":[3,158],"and":[4,60,65,84,149,200,266],"the":[5,36,102,114,240,245,264],"coronary":[6,175,246],"circulation":[7,247],"were":[8,55,132,252],"studied":[9],"in":[10,58,79,82,86,97,108,121,136,147,152,169,180,201,219,269],"a":[11,49,231],"subset":[12],"of":[13,22,32,76,99,110,124,129,171,194,203,239,244,249],"patients":[14,24,183],"with":[15,29],"mitral":[16,41,63],"valve":[17,42],"leaflet":[18],"prolapse.":[19],"This":[20],"group":[21],"26":[23],"(21":[25],"females,":[26],"five":[27],"males,":[28],"mean":[30],"age":[31],"46":[33],"years),":[34],"had":[35],"syndrome":[37],"identified":[38],"as":[39,160],"idiopathic":[40],"prolapse":[43],"(IMVP),":[44],"which":[45],"was":[46,75,95,106,119,167,177,189],"characterized":[47],"by":[48,255],"systolic":[50],"click-murmur,":[51],"clinical":[52,265],"symptoms":[53],"that":[54,224],"highly":[56],"variable":[57],"duration":[59],"intensity,":[61],"angiographically-documented":[62],"prolapse,":[64],"no":[66],"obvious":[67],"associated":[68,237],"systemic":[69],"or":[70,234,248],"cardiovascular":[71],"disease.":[72],"Mitral":[73],"regurgitation":[74],"moderate":[77],"degree":[78],"four,":[80],"mild":[81],"14,":[83],"absent":[85],"eight.":[87],"The":[88],"left":[89,156],"(LV)":[91],"end-diastolic":[92],"volume":[93],"index":[94,105],"elevated":[96,107],"ten":[98,204],"25":[100,172,182],"(40%),":[101],"LV":[103,115],"mass":[104],"six":[109,220],"17":[111,170],"(35%),":[112],"but":[113],"anterior":[116,145],"wall":[117],"thickness":[118],"increase":[120],"only":[122,192],"one":[123,193],"17.":[125],"Three":[126],"major":[127],"patterns":[128],"contraction":[131],"identified:":[133],"1)":[134],"normal":[135,179],"seven;":[137],"2)":[138],"abnormal,":[139],"usually":[140],"an":[141,161,235],"inferior":[142],"deformity":[143],"and/or":[144],"asynergy,":[146],"eight;":[148],"3)":[150],"hyperkinetic":[151],"11.":[153],"Normal":[154],"resting":[155],"assessed":[159],"ejection":[162],"fraction":[163],"greater":[164],"than":[165],"55%,":[166],"present":[168],"(68%).":[173],"Selective":[174],"arteriography":[176],"essentially":[178],"all":[181],"studied.":[184],"An":[185],"ischemic":[186],"ECG":[187],"response":[188],"detected":[190],"during":[191,217],"12":[195],"maximal":[196],"treadmill":[197],"exercise":[198],"tests":[199,208],"none":[202],"atrial":[205],"pacing":[206],"stress":[207],"(AP).":[209],"Myocardial":[210],"lactate":[211],"extraction":[212],"did":[213],"not":[214,227,253],"change":[215],"significantly":[216],"AP":[218],"patients.":[221],"We":[222],"conclude":[223],"cardiomyopathy":[225],"does":[226],"appear":[228],"to":[229,262],"be":[230],"primary":[232],"cause":[233],"important":[236],"component":[238],"IMVP":[241,270],"syndrome.":[242],"Abnormalities":[243],"myocardial":[250],"metabolism":[251],"demonstrated":[254],"available":[256],"methods.":[257],"A":[258],"proposed":[259],"pathophysiological":[260],"mechanism":[261],"explain":[263],"angiographic":[267],"findings":[268],"is":[271],"discussed.":[272]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}