{"id":"https://openalex.org/W2076774201","doi":"https://doi.org/10.1212/wnl.54.3.558","title":"Cortical cerebral metabolism correlates with MRI lesion load and cognitive dysfunction in MS","display_name":"Cortical cerebral metabolism correlates with MRI lesion load and cognitive dysfunction in MS","publication_year":2000,"publication_date":"2000-02-08","ids":{"openalex":"https://openalex.org/W2076774201","doi":"https://doi.org/10.1212/wnl.54.3.558","mag":"2076774201","pmid":"https://pubmed.ncbi.nlm.nih.gov/10680783"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.54.3.558","doi":"https://doi.org/10.1212/wnl.54.3.558","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.54.3.558","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041173492","display_name":"Morten Blinkenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"M. Blinkenberg","raw_affiliation_strings":["From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Rune","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"K. Rune","raw_affiliation_strings":["From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103449697","display_name":"C.V. Jensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"C.V. Jensen","raw_affiliation_strings":["From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032454346","display_name":"Mads Henrik Ravnborg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"M. Ravnborg","raw_affiliation_strings":["From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053390455","display_name":"S\u00f8ren Kyllingsb\u00e6k","orcid":"https://orcid.org/0000-0002-4100-437X","observed_orcids":["https://orcid.org/0000-0002-4100-437X"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S. Kyllingsb\u00e6k","raw_affiliation_strings":["From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043207267","display_name":"S\u00f8ren Holm","orcid":"https://orcid.org/0000-0001-9524-0717","observed_orcids":["https://orcid.org/0000-0001-9524-0717"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S. Holm","raw_affiliation_strings":["From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049536373","display_name":"Olaf Bjarne Paulson","orcid":"https://orcid.org/0000-0001-7712-8596","observed_orcids":["https://orcid.org/0000-0001-7712-8596"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"O.B. Paulson","raw_affiliation_strings":["From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066796645","display_name":"Per Soelberg S\u00f8rensen","orcid":"https://orcid.org/0000-0002-2818-3780","observed_orcids":["https://orcid.org/0000-0002-2818-3780"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"P.S. S\u00f8rensen","raw_affiliation_strings":["From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the MS Research Unit (Drs. BlinkenbergRune, Ravnborg, and S\u00f8rensen) and Neurobiology Research Unit (Drs. Blinkenberg and Paulson, and S. Kyllingsb\u00e6k), Departments of Neurology, Neurophysiology (Dr. Ravnborg), Nuclear Medicine (Dr. Holm), Copenhagen University Hospital; the Danish Research Center of Magnetic Resonance (Drs. Jensen and Paulson), Copenhagen University Hospital; the Department of Neurology (Dr. Rune), N\u00e6stved County Hospital; and the Department of Psychology (S. Kyllingsb\u00e6k),","institution_ids":["https://openalex.org/I2802567020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802567020"],"apc_list":null,"apc_paid":null,"fwci":5.7765,"has_fulltext":false,"cited_by_count":150,"citation_normalized_percentile":{"value":0.96577718,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"54","issue":"3","first_page":"558","last_page":"558"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":1.0},{"id":"https://openalex.org/keywords/cerebral-glucose-metabolism","display_name":"brain glucose metabolism","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cortical-metabolism","display_name":"cortical metabolism","score":0.5189999938011169},{"id":"https://openalex.org/keywords/mri-lesion-load","display_name":"MRI lesion burden","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9559999704360962},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.8199999928474426},{"id":"https://openalex.org/keywords/white-matter-lesions","display_name":"white matter lesions","score":0.8019999861717224},{"id":"https://openalex.org/keywords/neurodisability","display_name":"neurodisability","score":0.8199999928474426},{"id":"https://openalex.org/keywords/motor-evoked-potentials","display_name":"motor evoked potentials","score":0.7990000247955322},{"id":"https://openalex.org/keywords/dorsolateral-prefrontal-cortex","display_name":"dorsolateral prefrontal cortex","score":0.871999979019165},{"id":"https://openalex.org/keywords/caudate-and-putamen","display_name":"caudate and putamen","score":0.6759999990463257},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.6320202350616455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5738962292671204},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.49052995443344116},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4844910800457001},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4831101894378662},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.43591558933258057},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3264620304107666},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2917236089706421},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.25815391540527344}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1212/wnl.54.3.558","doi":"https://doi.org/10.1212/wnl.54.3.558","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.54.3.558","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:10680783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10680783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/e8a3d7e1-919f-4fda-8b83-18fbe92e81b5","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/e8a3d7e1-919f-4fda-8b83-18fbe92e81b5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blinkenberg, M, Rune, K, Jensen, C V, Ravnborg, M, Kyllingsbaek, S, Holm, S, Paulson, O B & S\u00f8rensen, P S 2000, 'Cortical cerebral metabolism correlates with MRI lesion load and cognitive dysfunction in MS', Neurology, vol. 54, no. 3, pp. 558-564. https://doi.org/10.1212/wnl.54.3.558","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W106847405","https://openalex.org/W1951442280","https://openalex.org/W1963636378","https://openalex.org/W1965232975","https://openalex.org/W1968126783","https://openalex.org/W1968381353","https://openalex.org/W1968800620","https://openalex.org/W1971936787","https://openalex.org/W1973352717","https://openalex.org/W1973744141","https://openalex.org/W1974963806","https://openalex.org/W1976112598","https://openalex.org/W1976712777","https://openalex.org/W1977774988","https://openalex.org/W1980808469","https://openalex.org/W1982425966","https://openalex.org/W1986557161","https://openalex.org/W1988600099","https://openalex.org/W1990005524","https://openalex.org/W1996180460","https://openalex.org/W1998277621","https://openalex.org/W1998842270","https://openalex.org/W2000808619","https://openalex.org/W2001552417","https://openalex.org/W2013144682","https://openalex.org/W2017381757","https://openalex.org/W2018775366","https://openalex.org/W2019406234","https://openalex.org/W2020017307","https://openalex.org/W2023180387","https://openalex.org/W2030792741","https://openalex.org/W2031115386","https://openalex.org/W2037653184","https://openalex.org/W2038794847","https://openalex.org/W2038969610","https://openalex.org/W2039055134","https://openalex.org/W2042020448","https://openalex.org/W2043814913","https://openalex.org/W2044474088","https://openalex.org/W2048656464","https://openalex.org/W2053468690","https://openalex.org/W2057512340","https://openalex.org/W2061938237","https://openalex.org/W2062453566","https://openalex.org/W2063245542","https://openalex.org/W2065008157","https://openalex.org/W2068599327","https://openalex.org/W2070217033","https://openalex.org/W2071816031","https://openalex.org/W2075464053","https://openalex.org/W2075566501","https://openalex.org/W2075770542","https://openalex.org/W2077069417","https://openalex.org/W2081566651","https://openalex.org/W2086421286","https://openalex.org/W2090306035","https://openalex.org/W2091893882","https://openalex.org/W2096045372","https://openalex.org/W2097867833","https://openalex.org/W2099652807","https://openalex.org/W2099757921","https://openalex.org/W2104404889","https://openalex.org/W2105572318","https://openalex.org/W2108716064","https://openalex.org/W2111215903","https://openalex.org/W2112165124","https://openalex.org/W2113160492","https://openalex.org/W2117514707","https://openalex.org/W2120357670","https://openalex.org/W2129794982","https://openalex.org/W2130355701","https://openalex.org/W2135143862","https://openalex.org/W2137352602","https://openalex.org/W2140362680","https://openalex.org/W2142004577","https://openalex.org/W2144171253","https://openalex.org/W2152080733","https://openalex.org/W2154637671","https://openalex.org/W2157271972","https://openalex.org/W2159504924","https://openalex.org/W2165547142","https://openalex.org/W2312952586","https://openalex.org/W2314441349","https://openalex.org/W4317564269"],"related_works":["https://openalex.org/W2416096123","https://openalex.org/W1973744141","https://openalex.org/W2005276576","https://openalex.org/W1984707599","https://openalex.org/W1921505795","https://openalex.org/W2524367416","https://openalex.org/W4230530167","https://openalex.org/W2550241167","https://openalex.org/W2007090065","https://openalex.org/W1980808469"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"study":[2],"the":[3,6,35,39,47,98,112,180,223],"association":[4,176],"between":[5,177,194],"cortical":[7,51,99,124,156,209,248],"cerebral":[8,148,249],"metabolic":[9],"rate":[10],"of":[11,38,62,179],"glucose":[12],"(CMRglc),":[13],"MRI":[14,28,238],"T2-weighted":[15],"total":[16],"lesion":[17,29,144,241],"area":[18],"(TLA),":[19],"cognitive":[20,70,159,184,233],"dysfunction,":[21,234],"and":[22,69,71,79,81,101,121,139,158,169,183,196,207],"neurologic":[23,72,197],"disability":[24,160,198],"in":[25,34,50,90,97,111,146,214],"MS.":[26],"BACKGROUND:":[27],"load":[30,145],"is":[31,44,211],"widely":[32],"used":[33],"clinical":[36],"evaluation":[37],"MS":[40,59,215],"patient":[41],"but":[42],"little":[43],"known":[45],"about":[46],"associated":[48],"changes":[49],"activation.":[52],"METHODS:":[53],"Twenty-three":[54],"patients":[55,216],"with":[56,83,127,142,218,227,232],"clinically":[57],"definite":[58],"underwent":[60],"measurements":[61],"CMRglc,":[63],"TLA,":[64],"motor":[65],"evoked":[66],"potentials":[67],"(MEPs),":[68],"disability.":[73],"CMRglc":[74,91,107,125,157,195,210,224],"was":[75,109,191],"calculated":[76],"using":[77],"PET":[78],"18-F-deoxyglucose":[80],"compared":[82,217],"nine":[84],"normal":[85,219],"control":[86,220],"subjects.":[87,221],"RESULTS:":[88],"Reductions":[89],"(p":[92,150],"<":[93,151],"0.01)":[94],"were":[95],"found":[96],"global":[100],"regional":[102,106,143,208],"lobar":[103],"measurements.":[104],"Furthermore,":[105,222],"(rCMRglc)":[108],"reduced":[110,212],"dorsolateral":[113],"prefrontal":[114],"cortex,":[115,117],"orbitofrontal":[116],"caudate,":[118],"putamen,":[119],"thalamus,":[120],"hippocampus.":[122],"Global":[123,155,206],"correlated":[126,141,162],"TLA":[128,228],"(Spearman":[129],"rank":[130],"correlation":[131,193],"coefficient":[132],"[SRCC]":[133],"=":[134,137,153,164,167],"-0.66,":[135],"p":[136,166],"0.001),":[138],"rCMRglc":[140,178],"all":[147],"lobes":[149],"or":[152,203],"0.05).":[154],"also":[161],"(SRCC":[163],"0.58,":[165],"0.015),":[168],"stepwise":[170],"regression":[171],"analysis":[172],"showed":[173],"a":[174,244],"significant":[175],"right":[181],"thalamus":[182],"performance":[185],"as":[186,188,229,231],"well":[187,230],"TLA.":[189],"There":[190],"no":[192],"(Expanded":[199],"Disability":[200],"Status":[201],"Scale)":[202],"MEP.":[204],"CONCLUSION:":[205],"significantly":[213],"reductions":[225],"correlate":[226],"which":[235],"indicates":[236],"that":[237],"white":[239],"matter":[240],"burden":[242],"has":[243],"deteriorating":[245],"effect":[246],"on":[247],"neural":[250],"function.":[251]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}