{"id":"https://openalex.org/W2076735554","doi":"https://doi.org/10.1136/bmj.g4972","title":"Genome project aims to transform treatment of cancer and rare diseases","display_name":"Genome project aims to transform treatment of cancer and rare diseases","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2076735554","doi":"https://doi.org/10.1136/bmj.g4972","mag":"2076735554","pmid":"https://pubmed.ncbi.nlm.nih.gov/25085691"},"language":"en","primary_location":{"id":"doi:10.1136/bmj.g4972","doi":"https://doi.org/10.1136/bmj.g4972","is_oa":false,"landing_page_url":"https://doi.org/10.1136/bmj.g4972","pdf_url":null,"source":{"id":"https://openalex.org/S4393917726","display_name":"BMJ","issn_l":"1756-1833","issn":["1756-1833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ","raw_type":"journal-article"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113634947","display_name":"Rickman J. Godlee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"R. Godlee","raw_affiliation_strings":["London","1London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London","institution_ids":[]},{"raw_affiliation_string":"1London","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5113634947"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"349","issue":"aug01 7","first_page":"g4972","last_page":"g4972"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13656","display_name":"Science, Research, and Medicine","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/100-000-genomes-project","display_name":"100,000 Genomes Project","score":0.9980000257492065},{"id":"https://openalex.org/keywords/human-genome-sequencing","display_name":"human genome sequencing","score":0.699999988079071},{"id":"https://openalex.org/keywords/cancer-genomics","display_name":"cancer genomics","score":0.7400000095367432},{"id":"https://openalex.org/keywords/rare-diseases","display_name":"rare diseases","score":0.9919999837875366},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6899999976158142},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.6600000262260437},{"id":"https://openalex.org/keywords/genomics-england","display_name":"Genomics England","score":0.6850000023841858},{"id":"https://openalex.org/keywords/public-research-funding","display_name":"government research funding","score":0.5979999899864197},{"id":"https://openalex.org/keywords/wellcome-trust","display_name":"Wellcome Trust","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2778137410","wikidata":"https://www.wikidata.org/wiki/Q2732820","display_name":"Government (linguistics)","level":2,"score":0.6459563374519348},{"id":"https://openalex.org/C2993486354","wikidata":"https://www.wikidata.org/wiki/Q14212","display_name":"Prime minister","level":3,"score":0.598209023475647},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48097455501556396},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4797954857349396},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.4718325734138489},{"id":"https://openalex.org/C106977388","wikidata":"https://www.wikidata.org/wiki/Q2752427","display_name":"Medical research","level":2,"score":0.4112706482410431},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.3885079324245453},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.3882145881652832},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.37831419706344604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3667370080947876},{"id":"https://openalex.org/C3116431","wikidata":"https://www.wikidata.org/wiki/Q31728","display_name":"Public administration","level":1,"score":0.3240066468715668},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.20415496826171875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18656310439109802},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.1563008427619934},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14459756016731262},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.13309425115585327},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11331772804260254},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10703939199447632},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10322993993759155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09690737724304199},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015698","descriptor_name":"Genomic Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016045","descriptor_name":"Human Genome Project","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035583","descriptor_name":"Rare Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035583","descriptor_name":"Rare Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D036281","descriptor_name":"Genetic Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1136/bmj.g4972","doi":"https://doi.org/10.1136/bmj.g4972","is_oa":false,"landing_page_url":"https://doi.org/10.1136/bmj.g4972","pdf_url":null,"source":{"id":"https://openalex.org/S4393917726","display_name":"BMJ","issn_l":"1756-1833","issn":["1756-1833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ","raw_type":"journal-article"},{"id":"pmid:25085691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25085691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ (Clinical research ed.)","raw_type":"News"},{"id":"pmh:oai:open-archive.highwire.org:bmj:349/aug01_7/g4972","doi":null,"is_oa":false,"landing_page_url":"http://www.bmj.com/cgi/content/short/349/aug01_7/g4972","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2038926937"],"related_works":["https://openalex.org/W1969020670","https://openalex.org/W1992101241","https://openalex.org/W1970035431","https://openalex.org/W2146858470","https://openalex.org/W1965115482","https://openalex.org/W1993499484","https://openalex.org/W2270147641","https://openalex.org/W4226322299","https://openalex.org/W2560340240","https://openalex.org/W4312805979"],"abstract_inverted_index":{"Patients":[0],"with":[1,64],"cancer":[2],"and":[3,38,51],"rare":[4,121],"diseases":[5,50,122],"will":[6],"make":[7],"up":[8,47,128],"the":[9,14,23,82,93,112,116],"first":[10],"40\u2009000":[11],"people":[12],"in":[13,27,81],"United":[15],"Kingdom":[16],"to":[17,32,45,53,91,110,129],"have":[18],"their":[19],"genome":[20],"sequenced":[21],"over":[22],"next":[24],"four":[25],"years":[26],"an":[28],"ambitious":[29],"government":[30],"plan":[31],"facilitate":[33],"extensive":[34],"new":[35,86],"scientific":[36],"research":[37,42,87,117],"medical":[39],"development.":[40],"The":[41,131],"is":[43,109],"likely":[44],"speed":[46],"diagnosis":[48,125],"of":[49,96,102],"lead":[52],"targeted":[54],"therapy":[55],"that":[56,74,115],"will,":[57],"for":[58,105],"example,":[59],"reduce":[60],"side":[61],"effects":[62],"associated":[63],"chemotherapy.\n\nThe":[65],"prime":[66],"minister,":[67],"David":[68],"Cameron,":[69],"announced":[70],"on":[71,120],"1":[72],"August":[73],"\u00a3300m":[75],"(\u20ac380m;":[76],"$500m)":[77],"was":[78],"being":[79],"invested":[80],"100\u2009000":[83,97],"Genomes":[84],"Project,":[85],"launched":[88],"last":[89],"November":[90],"decode":[92],"human":[94],"genomes":[95],"people.1":[98],"\n\nTom":[99],"Fowler,":[100],"director":[101],"public":[103],"health":[104],"Genomics":[106],"England,":[107],"which":[108],"deliver":[111],"project,":[113],"said":[114],"carried":[118],"out":[119],"could":[123],"increase":[124],"rates":[126],"by":[127],"60%.":[130],"Wellcome":[132],"Trust":[133],"\u2026":[134]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}