{"id":"https://openalex.org/W2076662006","doi":"https://doi.org/10.1161/01.res.0000042702.04920.bf","title":"Involvement of Src Family Protein Tyrosine Kinases in Ca 2+ Sensitization of Coronary Artery Contraction Mediated by a Sphingosylphosphorylcholine-Rho-Kinase Pathway","display_name":"Involvement of Src Family Protein Tyrosine Kinases in Ca 2+ Sensitization of Coronary Artery Contraction Mediated by a Sphingosylphosphorylcholine-Rho-Kinase Pathway","publication_year":2002,"publication_date":"2002-11-14","ids":{"openalex":"https://openalex.org/W2076662006","doi":"https://doi.org/10.1161/01.res.0000042702.04920.bf","mag":"2076662006","pmid":"https://pubmed.ncbi.nlm.nih.gov/12433841"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.0000042702.04920.bf","doi":"https://doi.org/10.1161/01.res.0000042702.04920.bf","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.0000042702.04920.bf","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084661301","display_name":"Fumiaki Nakao","orcid":"https://orcid.org/0000-0003-3819-3154","observed_orcids":["https://orcid.org/0000-0003-3819-3154"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]},{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumiaki Nakao","raw_affiliation_strings":["From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I173915773","https://openalex.org/I178574317"]},{"raw_affiliation_string":"the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110354095","display_name":"Sei Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]},{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sei Kobayashi","raw_affiliation_strings":["From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I173915773","https://openalex.org/I178574317"]},{"raw_affiliation_string":"the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069255706","display_name":"Kimiko Mogami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]},{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kimiko Mogami","raw_affiliation_strings":["From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I173915773","https://openalex.org/I178574317"]},{"raw_affiliation_string":"the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066378738","display_name":"Yoichi Mizukami","orcid":"https://orcid.org/0000-0002-3290-0754","observed_orcids":["https://orcid.org/0000-0002-3290-0754"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]},{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichi Mizukami","raw_affiliation_strings":["From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I173915773","https://openalex.org/I178574317"]},{"raw_affiliation_string":"the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068682760","display_name":"Satoshi Shirao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]},{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Shirao","raw_affiliation_strings":["From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I173915773","https://openalex.org/I178574317"]},{"raw_affiliation_string":"the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Saori Miwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]},{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Saori Miwa","raw_affiliation_strings":["From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I173915773","https://openalex.org/I178574317"]},{"raw_affiliation_string":"the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004191574","display_name":"Natsuko Todoroki-Ikeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]},{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Natsuko Todoroki-Ikeda","raw_affiliation_strings":["From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I173915773","https://openalex.org/I178574317"]},{"raw_affiliation_string":"the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101952689","display_name":"Masaaki Ito","orcid":"https://orcid.org/0000-0002-1661-9647","observed_orcids":["https://orcid.org/0000-0002-1661-9647"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]},{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Ito","raw_affiliation_strings":["From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I173915773","https://openalex.org/I178574317"]},{"raw_affiliation_string":"the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105788500","display_name":"Masunori Matsuzaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]},{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masunori Matsuzaki","raw_affiliation_strings":["From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Cardiovascular Medicine (F.N., M.M.) and Molecular Physiology (F.N., S.K., K.M., Y.M., S.S., S.M., N.T.-I.), Yamaguchi University School of Medicine, Yamaguchi, Japan; and the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I173915773","https://openalex.org/I178574317"]},{"raw_affiliation_string":"the First Department of Internal Medicine (M.I.), Mie University School of Medicine, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3385,"has_fulltext":true,"cited_by_count":102,"citation_normalized_percentile":{"value":0.78386351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"91","issue":"10","first_page":"953","last_page":"960"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8490999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8490999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.13819999992847443,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.9649999737739563},{"id":"https://openalex.org/keywords/fyn","display_name":"Fyn","score":0.8100000023841858},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.972000002861023},{"id":"https://openalex.org/keywords/sphingosylphosphorylcholine","display_name":"sphingosylphosphorylcholine","score":0.9440000057220459},{"id":"https://openalex.org/keywords/rho-kinase","display_name":"Rho kinase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/calcium-sensitization","display_name":"calcium sensitization","score":0.921999990940094},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-contraction","display_name":"vascular smooth muscle contraction","score":0.9120000004768372},{"id":"https://openalex.org/keywords/coronary-arteries","display_name":"coronary arteries","score":0.8289999961853027},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":0.9850000143051147},{"id":"https://openalex.org/keywords/myosin-phosphatase","display_name":"myosin phosphatase","score":0.7590000033378601},{"id":"https://openalex.org/keywords/pp1-inhibitor","display_name":"PP1 inhibitor","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C201800478","wikidata":"https://www.wikidata.org/wiki/Q24721770","display_name":"Rho-associated protein kinase","level":3,"score":0.6035284399986267},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5804449319839478},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5029410719871521},{"id":"https://openalex.org/C2779976819","wikidata":"https://www.wikidata.org/wiki/Q7582406","display_name":"Src family kinase","level":4,"score":0.4786742329597473},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4691642224788666},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.44434529542922974},{"id":"https://openalex.org/C199217515","wikidata":"https://www.wikidata.org/wiki/Q24720987","display_name":"cGMP-dependent protein kinase","level":5,"score":0.4150097668170929},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41350236535072327},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.387011855840683},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3854745030403137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3840876817703247},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32723313570022583},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.2685988247394562},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22993195056915283}],"mesh":[{"descriptor_ui":"D000215","descriptor_name":"Acylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007537","descriptor_name":"Isometric Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007537","descriptor_name":"Isometric Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010168","descriptor_name":"Palmitates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010767","descriptor_name":"Phosphorylcholine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010767","descriptor_name":"Phosphorylcholine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010767","descriptor_name":"Phosphorylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015290","descriptor_name":"Second Messenger Systems","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054460","descriptor_name":"rho-Associated Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.res.0000042702.04920.bf","doi":"https://doi.org/10.1161/01.res.0000042702.04920.bf","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.0000042702.04920.bf","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:12433841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12433841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"},{"id":"mag:2887287640","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/01.RES.0000042702.04920.BF?related-urls=yes&legid=circresaha%3B01.RES.0000042702.04920.BFv1","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1494227533","https://openalex.org/W1514066364","https://openalex.org/W1963728493","https://openalex.org/W1965907479","https://openalex.org/W1978675594","https://openalex.org/W1980358798","https://openalex.org/W1984107562","https://openalex.org/W1985285041","https://openalex.org/W1986619046","https://openalex.org/W1987162518","https://openalex.org/W1993379452","https://openalex.org/W2000293531","https://openalex.org/W2003904482","https://openalex.org/W2007009112","https://openalex.org/W2010720361","https://openalex.org/W2021174692","https://openalex.org/W2026102591","https://openalex.org/W2030042069","https://openalex.org/W2030202169","https://openalex.org/W2032295238","https://openalex.org/W2035589742","https://openalex.org/W2043834087","https://openalex.org/W2061229454","https://openalex.org/W2062058957","https://openalex.org/W2073535369","https://openalex.org/W2085060915","https://openalex.org/W2090895449","https://openalex.org/W2092263034","https://openalex.org/W2092484320","https://openalex.org/W2104886379","https://openalex.org/W2104901736","https://openalex.org/W2114844324","https://openalex.org/W2115427263","https://openalex.org/W2128915459","https://openalex.org/W2134980730","https://openalex.org/W2137985055","https://openalex.org/W2142475134","https://openalex.org/W2142746098","https://openalex.org/W2160864876","https://openalex.org/W2169976308"],"related_works":["https://openalex.org/W1973378429","https://openalex.org/W2092263034","https://openalex.org/W607161628","https://openalex.org/W2104886379","https://openalex.org/W7145146840","https://openalex.org/W3148225637","https://openalex.org/W2008238500","https://openalex.org/W2146060996","https://openalex.org/W2062705455","https://openalex.org/W2130125689"],"abstract_inverted_index":{"We":[0,47,62],"recently":[1],"reported":[2],"that":[3,106],"sphingosylphosphorylcholine":[4],"(SPC)":[5],"is":[6,34],"a":[7,37,199],"novel":[8],"messenger":[9],"for":[10,32],"Rho-kinase-mediated":[11],"Ca(2+)":[12,56,192],"sensitization":[13,57,193],"of":[14,25,52,60,110,114,129,150,167,183,194],"vascular":[15],"smooth":[16],"muscle":[17],"(VSM)":[18],"contraction.":[19],"Subcellular":[20],"localization":[21],"and":[22,58,67,80,90,145,156,178,181],"kinase":[23],"activity":[24],"Src":[26],"family":[27],"protein":[28],"kinases":[29],"(SrcPTKs),":[30],"except":[31],"c-Src,":[33,115],"controlled":[35],"by":[36,43,95,126,138,143,154,160,171,175,198],"reversible":[38],"S-palmitoylation,":[39],"an":[40,123,162,188],"event":[41,124],"inhibited":[42,82,142,174],"eicosapentaenoic":[44],"acid":[45],"(EPA).":[46],"examined":[48],"the":[49,91,117,120,132,135],"possible":[50],"involvement":[51],"SrcPTKs":[53,77,151],"in":[54,73,103,191],"SPC-induced":[55,83,148],"effects":[59],"EPA.":[61,127],"used":[63],"porcine":[64],"coronary":[65],"VSM":[66,70,195],"rat":[68],"aortic":[69],"cells":[71],"(VSMCs)":[72],"primary":[74],"culture.":[75],"An":[76],"inhibitor,":[78],"PP1,":[79,157,177],"EPA":[81,144,155],"contraction,":[84],"concentration-dependently,":[85],"without":[86],"affecting":[87],"[Ca(2+)](i)":[88],"levels":[89],"Ca(2+)-dependent":[92],"contraction":[93],"induced":[94,108,170],"high":[96],"K(+)":[97],"depolarization.":[98],"A":[99],"digitized":[100],"immunocytochemical":[101],"analysis":[102],"VSMCs":[104],"revealed":[105],"SPC":[107,139,172],"translocation":[109],"Fyn,":[111,186],"but":[112,158],"not":[113,159],"from":[116,131],"cytosol":[118,133],"to":[119,134],"cell":[121,136],"membrane,":[122],"abolished":[125],"Translocation":[128,180],"Rho-kinase":[130,163],"membrane":[137],"was":[140,152,173],"also":[141],"PP1.":[146],"The":[147],"activation":[149,182],"blocked":[153],"Y27632,":[161],"inhibitor.":[164],"Rho-kinase-dependent":[165],"phosphorylation":[166],"myosin":[168],"phosphatase":[169],"EPA,":[176],"Y27632.":[179],"SrcPTKs,":[184],"including":[185],"play":[187],"important":[189],"role":[190],"contractions":[196],"mediated":[197],"SPC-Rho-kinase":[200],"pathway.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
