{"id":"https://openalex.org/W2076580178","doi":"https://doi.org/10.1385/nmm:8:3:389","title":"Mitochondrial UCP4 Mediates an Adaptive Shift in Energy Metabolism and Increases the Resistance of Neurons to Metabolic and Oxidative Stress","display_name":"Mitochondrial UCP4 Mediates an Adaptive Shift in Energy Metabolism and Increases the Resistance of Neurons to Metabolic and Oxidative Stress","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2076580178","doi":"https://doi.org/10.1385/nmm:8:3:389","mag":"2076580178","pmid":"https://pubmed.ncbi.nlm.nih.gov/16775390"},"language":"en","primary_location":{"id":"doi:10.1385/nmm:8:3:389","doi":"https://doi.org/10.1385/nmm:8:3:389","is_oa":false,"landing_page_url":"https://doi.org/10.1385/nmm:8:3:389","pdf_url":null,"source":{"id":"https://openalex.org/S45104802","display_name":"NeuroMolecular Medicine","issn_l":"1535-1084","issn":["1535-1084","1559-1174"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroMolecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100407515","display_name":"Dong Liu","orcid":"https://orcid.org/0000-0003-2043-5346","observed_orcids":["https://orcid.org/0000-0003-2043-5346"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Liu","raw_affiliation_strings":["Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA","Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore,","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068840254","display_name":"Sic L. Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sic. L. Chan","raw_affiliation_strings":["Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore,","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051173396","display_name":"Nadja Cristhina de Souza-Pinto","orcid":"https://orcid.org/0000-0003-4206-964X","observed_orcids":["https://orcid.org/0000-0003-4206-964X"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadja C. de Souza-Pinto","raw_affiliation_strings":["Laboratory of Molecular Gerontology, National Institute of Aging Intramural Research Program, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Gerontology, National Institute of Aging Intramural Research Program, Baltimore","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024793076","display_name":"John R. Slevin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Slevin","raw_affiliation_strings":["Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109865877","display_name":"Robert P. Wersto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert P. Wersto","raw_affiliation_strings":["Research Resources Branch, National Institute of Aging Intramural Research Program, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Resources Branch, National Institute of Aging Intramural Research Program, Baltimore","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028221595","display_name":"Ming Zhan","orcid":"https://orcid.org/0000-0002-4668-727X","observed_orcids":["https://orcid.org/0000-0002-4668-727X","https://orcid.org/0000-0003-0122-4834"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Zhan","raw_affiliation_strings":["Research Resources Branch, National Institute of Aging Intramural Research Program, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Resources Branch, National Institute of Aging Intramural Research Program, Baltimore","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004388241","display_name":"Khadija Mustafa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khadija Mustafa","raw_affiliation_strings":["Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038923785","display_name":"Rafael de Cabo","orcid":"https://orcid.org/0000-0003-2830-5693","observed_orcids":["https://orcid.org/0000-0003-2830-5693","https://orcid.org/0000-0002-3354-2442"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rafael de Cabo","raw_affiliation_strings":["Laboratory of Experimental Gerontology, National Institute on Aging Intramural Research Program, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Gerontology, National Institute on Aging Intramural Research Program, Baltimore","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083040475","display_name":"Mark P. Mattson","orcid":"https://orcid.org/0000-0002-9816-4155","observed_orcids":["https://orcid.org/0000-0002-9816-4155","https://orcid.org/0009-0000-5542-5565"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark P. Mattson","raw_affiliation_strings":["Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore","Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore","institution_ids":["https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":5.0377,"has_fulltext":false,"cited_by_count":178,"citation_normalized_percentile":{"value":0.96697268,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"8","issue":"3","first_page":"389","last_page":"414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ucp4","display_name":"UCP4","score":0.984000027179718},{"id":"https://openalex.org/keywords/uncoupling-proteins","display_name":"uncoupling proteins","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mitochondrial-uncoupling","display_name":"mitochondrial uncoupling","score":0.7509999871253967},{"id":"https://openalex.org/keywords/neuronal-energy-metabolism","display_name":"neuronal energy metabolism","score":0.9750000238418579},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.878000020980835},{"id":"https://openalex.org/keywords/mitochondrial-calcium-overload","display_name":"mitochondrial calcium overload","score":0.7639999985694885},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9750000238418579},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.6380000114440918},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.7739999890327454},{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.9300000071525574},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.875},{"id":"https://openalex.org/keywords/cold-exposure","display_name":"cold exposure","score":0.6330000162124634},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.8999999761581421},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6416893005371094},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5633673667907715},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5413655042648315},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5208064317703247},{"id":"https://openalex.org/C2779134199","wikidata":"https://www.wikidata.org/wiki/Q1076381","display_name":"Oligomycin","level":4,"score":0.5020170211791992},{"id":"https://openalex.org/C66517615","wikidata":"https://www.wikidata.org/wiki/Q912751","display_name":"Cellular respiration","level":3,"score":0.48804059624671936},{"id":"https://openalex.org/C2779406938","wikidata":"https://www.wikidata.org/wiki/Q24720289","display_name":"Uncoupling protein","level":4,"score":0.46973904967308044},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4666571319103241},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3016358017921448},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2255018949508667},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.08263421058654785},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071245","descriptor_name":"Mitochondrial Uncoupling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031204","descriptor_name":"Caloric Restriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1385/nmm:8:3:389","doi":"https://doi.org/10.1385/nmm:8:3:389","is_oa":false,"landing_page_url":"https://doi.org/10.1385/nmm:8:3:389","pdf_url":null,"source":{"id":"https://openalex.org/S45104802","display_name":"NeuroMolecular Medicine","issn_l":"1535-1084","issn":["1535-1084","1559-1174"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroMolecular Medicine","raw_type":"journal-article"},{"id":"pmid:16775390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16775390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuromolecular medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W76885403","https://openalex.org/W143137125","https://openalex.org/W222406721","https://openalex.org/W344636036","https://openalex.org/W1482216160","https://openalex.org/W1505503094","https://openalex.org/W1507112934","https://openalex.org/W1507242444","https://openalex.org/W1514719303","https://openalex.org/W1533021419","https://openalex.org/W1556263878","https://openalex.org/W1572605366","https://openalex.org/W1585781020","https://openalex.org/W1592701645","https://openalex.org/W1594539479","https://openalex.org/W1830456158","https://openalex.org/W1849928642","https://openalex.org/W1900866157","https://openalex.org/W1920015810","https://openalex.org/W1965650841","https://openalex.org/W1966723868","https://openalex.org/W1970080134","https://openalex.org/W1970126151","https://openalex.org/W1976748679","https://openalex.org/W1977358187","https://openalex.org/W1977719197","https://openalex.org/W1978190113","https://openalex.org/W1978776261","https://openalex.org/W1980905658","https://openalex.org/W1983502552","https://openalex.org/W1984098639","https://openalex.org/W1984142219","https://openalex.org/W1985977889","https://openalex.org/W1996024251","https://openalex.org/W1996168790","https://openalex.org/W1999946108","https://openalex.org/W2000139634","https://openalex.org/W2001808016","https://openalex.org/W2004993911","https://openalex.org/W2006827323","https://openalex.org/W2009339203","https://openalex.org/W2011745910","https://openalex.org/W2012182881","https://openalex.org/W2013451725","https://openalex.org/W2016139827","https://openalex.org/W2019144539","https://openalex.org/W2022257866","https://openalex.org/W2027900036","https://openalex.org/W2027950911","https://openalex.org/W2028132430","https://openalex.org/W2028638764","https://openalex.org/W2030245467","https://openalex.org/W2030286287","https://openalex.org/W2036128027","https://openalex.org/W2036573181","https://openalex.org/W2037246989","https://openalex.org/W2039908421","https://openalex.org/W2042180296","https://openalex.org/W2049003733","https://openalex.org/W2049262630","https://openalex.org/W2051859853","https://openalex.org/W2054383249","https://openalex.org/W2055191740","https://openalex.org/W2055364952","https://openalex.org/W2058137794","https://openalex.org/W2060772604","https://openalex.org/W2062344501","https://openalex.org/W2064196264","https://openalex.org/W2064310817","https://openalex.org/W2067460515","https://openalex.org/W2070819834","https://openalex.org/W2071491738","https://openalex.org/W2072678001","https://openalex.org/W2076944010","https://openalex.org/W2077113902","https://openalex.org/W2077445707","https://openalex.org/W2078141675","https://openalex.org/W2082782176","https://openalex.org/W2085034683","https://openalex.org/W2086198406","https://openalex.org/W2087282685","https://openalex.org/W2087330945","https://openalex.org/W2088257156","https://openalex.org/W2088718796","https://openalex.org/W2091237743","https://openalex.org/W2092087384","https://openalex.org/W2095290615","https://openalex.org/W2095816719","https://openalex.org/W2096426937","https://openalex.org/W2099479611","https://openalex.org/W2101846365","https://openalex.org/W2101870887","https://openalex.org/W2103405659","https://openalex.org/W2105135681","https://openalex.org/W2110123210","https://openalex.org/W2117104323","https://openalex.org/W2118614496","https://openalex.org/W2119939221","https://openalex.org/W2121491699","https://openalex.org/W2127232885","https://openalex.org/W2136689463","https://openalex.org/W2141950542","https://openalex.org/W2143579765","https://openalex.org/W2146083668","https://openalex.org/W2154127217","https://openalex.org/W2154385453","https://openalex.org/W2154628078","https://openalex.org/W2154682611","https://openalex.org/W2156172044","https://openalex.org/W2156744437","https://openalex.org/W2156974283","https://openalex.org/W2158009878","https://openalex.org/W2159054550","https://openalex.org/W2164016655","https://openalex.org/W2164982575","https://openalex.org/W2165343587","https://openalex.org/W2166788705","https://openalex.org/W2300148646","https://openalex.org/W2340324006","https://openalex.org/W4232713202"],"related_works":["https://openalex.org/W2753879294","https://openalex.org/W2017812288","https://openalex.org/W2002655273","https://openalex.org/W2064579667","https://openalex.org/W2522632888","https://openalex.org/W1511403368","https://openalex.org/W3176461289","https://openalex.org/W1964046674","https://openalex.org/W4402764010","https://openalex.org/W1967512189"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}