{"id":"https://openalex.org/W2076566491","doi":"https://doi.org/10.1016/s0531-5565(03)00134-7","title":"Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)","display_name":"Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)","publication_year":2003,"publication_date":"2003-06-09","ids":{"openalex":"https://openalex.org/W2076566491","doi":"https://doi.org/10.1016/s0531-5565(03)00134-7","mag":"2076566491","pmid":"https://pubmed.ncbi.nlm.nih.gov/12915213"},"language":"en","primary_location":{"id":"doi:10.1016/s0531-5565(03)00134-7","doi":"https://doi.org/10.1016/s0531-5565(03)00134-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0531-5565(03)00134-7","pdf_url":null,"source":{"id":"https://openalex.org/S122591147","display_name":"Experimental Gerontology","issn_l":"0531-5565","issn":["0531-5565","1873-6815"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Gerontology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115594299","display_name":"Qin Ouyang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Qin Ouyang","raw_affiliation_strings":["Section for Transplantation Immunology and Immunohematology, University of T\u00fcbingen, Germany. qouyang@bccancer.bc.ca","Section for Transplantation Immunology and Immunohematology, University of T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section for Transplantation Immunology and Immunohematology, University of T\u00fcbingen, Germany. qouyang@bccancer.bc.ca","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Section for Transplantation Immunology and Immunohematology, University of T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wolfgang M Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang M Wagner","raw_affiliation_strings":["Section for Transplantation Immunology and Immunohematology, University of T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section for Transplantation Immunology and Immunohematology, University of T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052806458","display_name":"David Voehringer","orcid":"https://orcid.org/0000-0001-6650-0639","observed_orcids":["https://orcid.org/0000-0001-6650-0639"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"David Voehringer","raw_affiliation_strings":["Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042997680","display_name":"Anders Wikby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94616838","display_name":"J\u00f6nk\u00f6ping University","ror":"https://ror.org/03t54am93","country_code":"SE","type":"education","lineage":["https://openalex.org/I94616838"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anders Wikby","raw_affiliation_strings":["Department of Natural Science and Biomedicine, School of Health Sciences, University of J\u00f6nk\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Natural Science and Biomedicine, School of Health Sciences, University of J\u00f6nk\u00f6ping, Sweden","institution_ids":["https://openalex.org/I94616838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090353466","display_name":"Tatjana Klatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tatjana Klatt","raw_affiliation_strings":["Section for Transplantation Immunology and Immunohematology, University of T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section for Transplantation Immunology and Immunohematology, University of T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007396551","display_name":"Steffen Walter","orcid":"https://orcid.org/0000-0002-0249-2622","observed_orcids":["https://orcid.org/0000-0002-0249-2622"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Walter","raw_affiliation_strings":["Department of Immunology, University of T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103419349","display_name":"Claudia A. Mu\u0308ller","orcid":"https://orcid.org/0000-0002-0689-3431","observed_orcids":["https://orcid.org/0000-0002-0689-3431"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia A M\u00fcller","raw_affiliation_strings":["Section for Transplantation Immunology and Immunohematology, University of T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section for Transplantation Immunology and Immunohematology, University of T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103101493","display_name":"Hanspeter Pircher","orcid":"https://orcid.org/0000-0002-9487-1311","observed_orcids":["https://orcid.org/0000-0002-9487-1311"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hanspeter Pircher","raw_affiliation_strings":["Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027331206","display_name":"Graham Pawelec","orcid":"https://orcid.org/0000-0002-3600-0163","observed_orcids":["https://orcid.org/0000-0002-3600-0163"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Graham Pawelec","raw_affiliation_strings":["Section for Transplantation Immunology and Immunohematology, University of T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section for Transplantation Immunology and Immunohematology, University of T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5115594299"],"corresponding_institution_ids":["https://openalex.org/I8087733"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":3.8406,"has_fulltext":false,"cited_by_count":244,"citation_normalized_percentile":{"value":0.94435621,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"38","issue":"8","first_page":"911","last_page":"920"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.11569999903440475,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.06790000200271606,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"cytomegalovirus","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/klrg1","display_name":"KLRG1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/clonal-expansion","display_name":"clonal expansion","score":0.5659999847412109},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.7639999985694885},{"id":"https://openalex.org/keywords/t-cell-dysfunction","display_name":"T cell dysfunction","score":0.6740000247955322},{"id":"https://openalex.org/keywords/replicative-senescence","display_name":"replicative senescence","score":0.7900000214576721},{"id":"https://openalex.org/keywords/interferon-gamma-secretion","display_name":"interferon-gamma secretion","score":0.6700000166893005},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.37700000405311584},{"id":"https://openalex.org/keywords/tetramer-staining","display_name":"tetramer staining","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7550825476646423},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7110801339149475},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5930429697036743},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.5439919233322144},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5030185580253601},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4706413447856903},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4690048396587372},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.46652325987815857},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44695979356765747},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.42231640219688416},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33120739459991455},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11084127426147461},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015789","descriptor_name":"HLA-A2 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0531-5565(03)00134-7","doi":"https://doi.org/10.1016/s0531-5565(03)00134-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0531-5565(03)00134-7","pdf_url":null,"source":{"id":"https://openalex.org/S122591147","display_name":"Experimental Gerontology","issn_l":"0531-5565","issn":["0531-5565","1873-6815"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Gerontology","raw_type":"journal-article"},{"id":"pmid:12915213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12915213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental gerontology","raw_type":"Comparative Study"},{"id":"pmh:oai:freidok.uni-freiburg.de:46949","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/46949","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Experimental Gerontology. - 38, 8 (2003) , 911-920, ISSN: 0531-5565","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1521600055","https://openalex.org/W1612595544","https://openalex.org/W1906284818","https://openalex.org/W1976789091","https://openalex.org/W1981560461","https://openalex.org/W1983991488","https://openalex.org/W1984453600","https://openalex.org/W1985005581","https://openalex.org/W1992779885","https://openalex.org/W1994340919","https://openalex.org/W2013933972","https://openalex.org/W2031041877","https://openalex.org/W2050466666","https://openalex.org/W2052361881","https://openalex.org/W2061789305","https://openalex.org/W2067069532","https://openalex.org/W2071843907","https://openalex.org/W2075052419","https://openalex.org/W2076879571","https://openalex.org/W2086973683","https://openalex.org/W2089500922","https://openalex.org/W2091252356","https://openalex.org/W2095349033","https://openalex.org/W2097789339","https://openalex.org/W2100433064","https://openalex.org/W2110062670","https://openalex.org/W2115364134","https://openalex.org/W2131157462","https://openalex.org/W2133908456","https://openalex.org/W2135358991","https://openalex.org/W2142294933","https://openalex.org/W2143682490","https://openalex.org/W2159305020","https://openalex.org/W2161911625","https://openalex.org/W2370317860"],"related_works":["https://openalex.org/W2081208716","https://openalex.org/W1610483123","https://openalex.org/W2115364134","https://openalex.org/W2150728666","https://openalex.org/W1533059496","https://openalex.org/W7061759627","https://openalex.org/W1601717047","https://openalex.org/W2115516753","https://openalex.org/W4233395593","https://openalex.org/W2134723433"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}