{"id":"https://openalex.org/W2076562032","doi":"https://doi.org/10.4020/jhrs.27.op27_4","title":"Mechanisms of Complex Fractionated Electrogram-Targeted Ablation in a Model for Chronic Atrial Fibrillation","display_name":"Mechanisms of Complex Fractionated Electrogram-Targeted Ablation in a Model for Chronic Atrial Fibrillation","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2076562032","doi":"https://doi.org/10.4020/jhrs.27.op27_4","mag":"2076562032"},"language":"en","primary_location":{"id":"doi:10.4020/jhrs.27.op27_4","doi":"https://doi.org/10.4020/jhrs.27.op27_4","is_oa":true,"landing_page_url":"https://doi.org/10.4020/jhrs.27.op27_4","pdf_url":null,"source":{"id":"https://openalex.org/S207372207","display_name":"Journal of Arrhythmia","issn_l":"1880-4276","issn":["1880-4276","1883-2148"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Arrhythmia","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.4020/jhrs.27.op27_4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110104540","display_name":"Takashi Ashihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Ashihara","raw_affiliation_strings":["Department of Cardiovascular Medicine, Shiga University of Medical Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Shiga University of Medical Science","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012809660","display_name":"Ryo Haraguchi","orcid":"https://orcid.org/0000-0002-2433-2793","observed_orcids":["https://orcid.org/0000-0002-2433-2793"]},"institutions":[{"id":"https://openalex.org/I4405286384","display_name":"National Cerebral and Cardiovascular Center Research Institute","ror":"https://ror.org/01zywn143","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210111404","https://openalex.org/I4405286384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Haraguchi","raw_affiliation_strings":["National Cerebral and Cardiovascular Center Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cerebral and Cardiovascular Center Research Institute","institution_ids":["https://openalex.org/I4405286384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112646504","display_name":"Shin Inada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286384","display_name":"National Cerebral and Cardiovascular Center Research Institute","ror":"https://ror.org/01zywn143","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210111404","https://openalex.org/I4405286384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin Inada","raw_affiliation_strings":["National Cerebral and Cardiovascular Center Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cerebral and Cardiovascular Center Research Institute","institution_ids":["https://openalex.org/I4405286384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100998539","display_name":"Kazuo Nakazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286384","display_name":"National Cerebral and Cardiovascular Center Research Institute","ror":"https://ror.org/01zywn143","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210111404","https://openalex.org/I4405286384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo Nakazawa","raw_affiliation_strings":["National Cerebral and Cardiovascular Center Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cerebral and Cardiovascular Center Research Institute","institution_ids":["https://openalex.org/I4405286384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066929032","display_name":"Tomoya Ozawa","orcid":"https://orcid.org/0000-0002-3105-8278","observed_orcids":["https://orcid.org/0000-0002-3105-8278"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoya Ozawa","raw_affiliation_strings":["Department of Cardiovascular Medicine, Shiga University of Medical Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Shiga University of Medical Science","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109402906","display_name":"Yuko Nakazawa","orcid":"https://orcid.org/0009-0000-3725-300X","observed_orcids":["https://orcid.org/0009-0000-3725-300X"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Nakazawa","raw_affiliation_strings":["Department of Cardiovascular Medicine, Shiga University of Medical Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Shiga University of Medical Science","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101941391","display_name":"Makoto Ito","orcid":"https://orcid.org/0000-0001-7733-1594","observed_orcids":["https://orcid.org/0000-0001-7733-1594"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Ito","raw_affiliation_strings":["Department of Cardiovascular Medicine, Shiga University of Medical Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Shiga University of Medical Science","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026028224","display_name":"Minoru Horie","orcid":"https://orcid.org/0000-0002-9029-2339","observed_orcids":["https://orcid.org/0000-0002-9029-2339"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Horie","raw_affiliation_strings":["Department of Cardiovascular Medicine, Shiga University of Medical Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Shiga University of Medical Science","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070924694","display_name":"Natalia A. Trayanova","orcid":"https://orcid.org/0000-0002-8661-063X","observed_orcids":["https://orcid.org/0000-0002-8661-063X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia Trayanova","raw_affiliation_strings":["Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1540,"currency":"USD","value_usd":1540},"apc_paid":{"value":1540,"currency":"USD","value_usd":1540},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"Supplement","first_page":"OP27_4","last_page":"OP27_4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.4399000108242035,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.4399000108242035,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.31049999594688416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.2354000061750412,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complex-fractionated-atrial-electrograms","display_name":"complex fractionated atrial electrograms","score":0.9750000238418579},{"id":"https://openalex.org/keywords/chronic-atrial-fibrillation","display_name":"chronic atrial fibrillation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/spiral-wave-reentry","display_name":"spiral wave reentry","score":0.9480000138282776},{"id":"https://openalex.org/keywords/atrial-fibroblasts","display_name":"atrial fibroblasts","score":0.8330000042915344},{"id":"https://openalex.org/keywords/electrical-coupling","display_name":"electrical coupling","score":0.8339999914169312},{"id":"https://openalex.org/keywords/atrial-myocytes","display_name":"atrial myocytes","score":0.6380000114440918},{"id":"https://openalex.org/keywords/excitation-propagation","display_name":"excitation propagation","score":0.703000009059906},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.8820000290870667},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.6930000185966492},{"id":"https://openalex.org/keywords/atrial-fibrillation-termination","display_name":"atrial fibrillation termination","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9587447643280029},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.7634367346763611},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7065494060516357},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6220383644104004},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.5830827951431274}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4020/jhrs.27.op27_4","doi":"https://doi.org/10.4020/jhrs.27.op27_4","is_oa":true,"landing_page_url":"https://doi.org/10.4020/jhrs.27.op27_4","pdf_url":null,"source":{"id":"https://openalex.org/S207372207","display_name":"Journal of Arrhythmia","issn_l":"1880-4276","issn":["1880-4276","1883-2148"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Arrhythmia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4020/jhrs.27.op27_4","doi":"https://doi.org/10.4020/jhrs.27.op27_4","is_oa":true,"landing_page_url":"https://doi.org/10.4020/jhrs.27.op27_4","pdf_url":null,"source":{"id":"https://openalex.org/S207372207","display_name":"Journal of Arrhythmia","issn_l":"1880-4276","issn":["1880-4276","1883-2148"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Arrhythmia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2165334534","https://openalex.org/W2014963731","https://openalex.org/W2914168741","https://openalex.org/W1765620587","https://openalex.org/W2599773697","https://openalex.org/W2140418580","https://openalex.org/W1876215826","https://openalex.org/W2028840718","https://openalex.org/W2161267130","https://openalex.org/W200500626"],"abstract_inverted_index":{"Background:":[0],"We":[1],"have":[2],"recently":[3],"demonstrated":[4],"in":[5,18,60,156],"computer":[6],"simulations":[7,56],"that":[8,40],"electrotonic":[9],"interactions":[10],"between":[11,137,174],"atrial":[12,24,29],"myocytes":[13],"and":[14,70,140,169],"heterogeneously-distributed":[15],"fibroblasts":[16],"result":[17],"the":[19,61,75,79,84,107,119,127,130,145,152,188],"genesis":[20],"of":[21,57,63,74,86,98,109,129,151,187,190],"complex":[22],"fractionated":[23],"electrograms":[25],"(CFAEs)":[26],"during":[27],"chronic":[28,65,99],"fibrillation":[30],"(AF).":[31],"However,":[32],"previous":[33],"research":[34],"has":[35],"not":[36],"provided":[37],"sufficient":[38],"evidence":[39],"ablation":[41,59,110,115,138,175],"targeting":[42],"such":[43],"fibroblast-derived":[44],"CFAEs":[45],"can":[46],"terminate":[47,104],"AF.":[48],"Methods:":[49],"To":[50],"clarify":[51],"this":[52],"issue,":[53],"we":[54,71],"repeated":[55],"CFAE-targeted":[58,87,114,163,191],"model":[62,97],"human":[64],"AF":[66,80,157,192],"under":[67],"heart":[68],"failure,":[69],"analyzed":[72],"details":[73],"excitation":[76],"propagation":[77],"until":[78],"was":[81,101,148],"terminated":[82],"by":[83,125],"application":[85],"ablation.":[88,193],"Results:":[89],"(1)":[90],"Sustained":[91],"spiral":[92,120,134,146],"wave":[93,123,135,147],"reentry,":[94],"as":[95,106],"a":[96,142],"AF,":[100],"found":[102],"to":[103,184],"earlier":[105],"number":[108],"sites":[111,176],"increased.":[112],"(2)":[113],"site":[116],"transiently":[117],"pinned":[118],"wave,":[121],"preventing":[122],"breakup":[124],"blocking":[126],"shortcut":[128],"reentry.":[131],"(3)":[132],"The":[133],"drifted":[136],"sites,":[139],"after":[141],"short":[143],"time":[144],"pushed":[149],"out":[150],"CFAE":[153],"area,":[154],"resulting":[155],"termination.":[158],"(4)":[159],"For":[160],"more":[161],"effective":[162],"ablation,":[164],"avoiding":[165],"collagen":[166],"accumulation":[167],"area":[168],"keeping":[170],"an":[171],"appropriate":[172],"distance":[173],"were":[177],"required.":[178],"Conclusion:":[179],"Our":[180],"findings":[181],"might":[182],"contribute":[183],"better":[185],"understanding":[186],"mechanisms":[189]},"counts_by_year":[],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2016-06-24T00:00:00"}
