{"id":"https://openalex.org/W2076561009","doi":"https://doi.org/10.1016/j.jcv.2011.05.020","title":"Quantification of complex precore mutations of hepatitis B virus by SimpleProbe real time PCR and dual melting analysis","display_name":"Quantification of complex precore mutations of hepatitis B virus by SimpleProbe real time PCR and dual melting analysis","publication_year":2011,"publication_date":"2011-06-26","ids":{"openalex":"https://openalex.org/W2076561009","doi":"https://doi.org/10.1016/j.jcv.2011.05.020","mag":"2076561009","pmid":"https://pubmed.ncbi.nlm.nih.gov/21665530","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3133867"},"language":"en","primary_location":{"id":"doi:10.1016/j.jcv.2011.05.020","doi":"https://doi.org/10.1016/j.jcv.2011.05.020","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcv.2011.05.020","pdf_url":null,"source":{"id":"https://openalex.org/S6589812","display_name":"Journal of Clinical Virology","issn_l":"1386-6532","issn":["1386-6532","1873-5967"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3133867","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101877755","display_name":"Hui Nie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Nie","raw_affiliation_strings":["Department of Mcrobiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mcrobiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902, United States","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039423651","display_name":"Alison A. Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154179","display_name":"Hepatitis B Foundation","ror":"https://ror.org/052emna24","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210154179"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison A. Evans","raw_affiliation_strings":["Hepatitis B Foundation, Doylestown, PA 18902, United States","School of Public Health, Drexel University, Philadelphia, PA 19102, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatitis B Foundation, Doylestown, PA 18902, United States","institution_ids":["https://openalex.org/I4210154179"]},{"raw_affiliation_string":"School of Public Health, Drexel University, Philadelphia, PA 19102, United States","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011917178","display_name":"W. Thomas London","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Thomas London","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, PA 19111, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, PA 19111, United States","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041693287","display_name":"Timothy M. Block","orcid":"https://orcid.org/0000-0002-0343-7668","observed_orcids":["https://orcid.org/0000-0002-0343-7668"]},"institutions":[{"id":"https://openalex.org/I4210154179","display_name":"Hepatitis B Foundation","ror":"https://ror.org/052emna24","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210154179"]},{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy M. Block","raw_affiliation_strings":["Department of Mcrobiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902, United States","Hepatitis B Foundation, Doylestown, PA 18902, United States","Institute for Hepatitis and Virus Research, Doylestown, PA 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mcrobiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902, United States","institution_ids":["https://openalex.org/I72816309"]},{"raw_affiliation_string":"Hepatitis B Foundation, Doylestown, PA 18902, United States","institution_ids":["https://openalex.org/I4210154179"]},{"raw_affiliation_string":"Institute for Hepatitis and Virus Research, Doylestown, PA 18902, United States","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113575699","display_name":"Xiangdong David Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiangdong David Ren","raw_affiliation_strings":["Department of Mcrobiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902, United States","Institute for Hepatitis and Virus Research, Doylestown, PA 18902, United States","Reniguard Life Sciences Inc, Doylestown, PA 18902, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mcrobiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902, United States","institution_ids":["https://openalex.org/I72816309"]},{"raw_affiliation_string":"Institute for Hepatitis and Virus Research, Doylestown, PA 18902, United States","institution_ids":["https://openalex.org/I4210157427"]},{"raw_affiliation_string":"Reniguard Life Sciences Inc, Doylestown, PA 18902, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5113575699"],"corresponding_institution_ids":["https://openalex.org/I4210157427","https://openalex.org/I72816309"],"apc_list":{"value":4210,"currency":"USD","value_usd":4210},"apc_paid":null,"fwci":0.2174,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.59453099,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"51","issue":"4","first_page":"234","last_page":"240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/precore-mutations","display_name":"precore mutations","score":0.9049999713897705},{"id":"https://openalex.org/keywords/g1896a-mutation","display_name":"G1896A mutation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hbeag-seroconversion","display_name":"HBeAg seroconversion","score":0.9409999847412109},{"id":"https://openalex.org/keywords/ultrasensitive-detection","display_name":"ultrasensitive detection","score":0.6000000238418579},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma-risk","display_name":"hepatocellular carcinoma risk","score":0.7590000033378601},{"id":"https://openalex.org/keywords/clinical-biomarkers","display_name":"clinical biomarkers","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.8094415068626404},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7267840504646301},{"id":"https://openalex.org/C2775940106","wikidata":"https://www.wikidata.org/wiki/Q10478733","display_name":"HBeAg","level":5,"score":0.6299197673797607},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6047388315200806},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.581737756729126},{"id":"https://openalex.org/C84133368","wikidata":"https://www.wikidata.org/wiki/Q6813768","display_name":"Melting curve analysis","level":4,"score":0.5688143968582153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5226414203643799},{"id":"https://openalex.org/C2780617729","wikidata":"https://www.wikidata.org/wiki/Q1356878","display_name":"Hepadnaviridae","level":4,"score":0.4679891765117645},{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.4413910508155823},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4245443344116211},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3872564435005188},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37304794788360596},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28281670808792114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16069158911705017},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14475393295288086},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.14270293712615967},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006513","descriptor_name":"Hepatitis B e Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014773","descriptor_name":"Virology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019411","descriptor_name":"Clinical Laboratory Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044366","descriptor_name":"Transition Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jcv.2011.05.020","doi":"https://doi.org/10.1016/j.jcv.2011.05.020","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jcv.2011.05.020","pdf_url":null,"source":{"id":"https://openalex.org/S6589812","display_name":"Journal of Clinical Virology","issn_l":"1386-6532","issn":["1386-6532","1873-5967"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Virology","raw_type":"journal-article"},{"id":"pmid:21665530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21665530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology","raw_type":"Evaluation Study"},{"id":"pmh:oai:europepmc.org:2411543","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3133867","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3133867","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3133867","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Clin Virol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2411543","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3133867","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3788508942","display_name":"Early Detection of Liver Cancer","funder_award_id":"U01CA084951","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1503369770","https://openalex.org/W1583533449","https://openalex.org/W1587647239","https://openalex.org/W1963623444","https://openalex.org/W1984762719","https://openalex.org/W2002076753","https://openalex.org/W2009029675","https://openalex.org/W2018479084","https://openalex.org/W2029108694","https://openalex.org/W2044202668","https://openalex.org/W2052849822","https://openalex.org/W2064081948","https://openalex.org/W2076640757","https://openalex.org/W2096370921","https://openalex.org/W2102543330","https://openalex.org/W2108185026","https://openalex.org/W2108917871","https://openalex.org/W2132254613","https://openalex.org/W2141044770","https://openalex.org/W2156015715","https://openalex.org/W2158381708","https://openalex.org/W2160740567","https://openalex.org/W2167744756","https://openalex.org/W2299505145","https://openalex.org/W2341832533","https://openalex.org/W2463930553","https://openalex.org/W3149727786","https://openalex.org/W4211067702"],"related_works":["https://openalex.org/W2356267570","https://openalex.org/W2392508128","https://openalex.org/W2361651975","https://openalex.org/W1975595321","https://openalex.org/W7025226501","https://openalex.org/W618559379","https://openalex.org/W2139408813","https://openalex.org/W2345624256","https://openalex.org/W7046380297","https://openalex.org/W2067322873"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
