{"id":"https://openalex.org/W2076555669","doi":"https://doi.org/10.1111/febs.12545","title":"Extracting signal from noise: kinetic mechanisms from a Michaelis\u2013Menten\u2010like expression for enzymatic fluctuations","display_name":"Extracting signal from noise: kinetic mechanisms from a Michaelis\u2013Menten\u2010like expression for enzymatic fluctuations","publication_year":2013,"publication_date":"2013-10-11","ids":{"openalex":"https://openalex.org/W2076555669","doi":"https://doi.org/10.1111/febs.12545","mag":"2076555669","pmid":"https://pubmed.ncbi.nlm.nih.gov/24428386"},"language":"en","primary_location":{"id":"doi:10.1111/febs.12545","doi":"https://doi.org/10.1111/febs.12545","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.12545","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087838801","display_name":"Jeffrey R. Moffitt","orcid":"https://orcid.org/0000-0002-3836-3101","observed_orcids":["https://orcid.org/0000-0002-3836-3101"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey R. Moffitt","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University Cambridge MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University Cambridge MA USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010743284","display_name":"Carlos Bustamante","orcid":"https://orcid.org/0000-0002-2970-0073","observed_orcids":["https://orcid.org/0000-0002-2970-0073"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carlos Bustamante","raw_affiliation_strings":["Department of Chemistry Department of Physics Department of Molecular and Cellular Biology Howard Hughes Medical Institute University of California Berkeley CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Department of Physics Department of Molecular and Cellular Biology Howard Hughes Medical Institute University of California Berkeley CA USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010743284","https://openalex.org/A5087838801"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I95457486"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.5324,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.45169922,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"281","issue":"2","first_page":"498","last_page":"517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.3921000063419342,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.3921000063419342,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.33809998631477356,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11520","display_name":"Advanced Thermodynamics and Statistical Mechanics","score":0.06159999966621399,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.7070000171661377},{"id":"https://openalex.org/keywords/randomness","display_name":"randomness","score":0.38499999046325684},{"id":"https://openalex.org/keywords/michaelis-menten-kinetics","display_name":"Michaelis-Menten kinetics","score":0.8320000171661377},{"id":"https://openalex.org/keywords/single-molecule-measurement","display_name":"single-molecule measurement","score":0.5249999761581421},{"id":"https://openalex.org/keywords/coefficient-of-variation","display_name":"coefficient of variation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/substrate-dependence","display_name":"substrate dependence","score":0.7710000276565552},{"id":"https://openalex.org/keywords/reaction-mechanism","display_name":"reaction mechanism","score":0.4950000047683716},{"id":"https://openalex.org/keywords/kinetic-parameters","display_name":"kinetic parameters","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C125112378","wikidata":"https://www.wikidata.org/wiki/Q176640","display_name":"Randomness","level":2,"score":0.838844358921051},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.6325567960739136},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.5977293848991394},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.5423158407211304},{"id":"https://openalex.org/C64915919","wikidata":"https://www.wikidata.org/wiki/Q613955","display_name":"Michaelis\u2013Menten kinetics","level":4,"score":0.5124698281288147},{"id":"https://openalex.org/C64258800","wikidata":"https://www.wikidata.org/wiki/Q7604395","display_name":"Statistical fluctuations","level":2,"score":0.5051105618476868},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4578373432159424},{"id":"https://openalex.org/C2780009758","wikidata":"https://www.wikidata.org/wiki/Q6804172","display_name":"Measure (data warehouse)","level":2,"score":0.45157378911972046},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3452449440956116},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3404971957206726},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3091942071914673},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2616766393184662},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.24817830324172974},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2394525110721588},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1793254017829895},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.1297157108783722},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.10222658514976501},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09585055708885193},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08010169863700867},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/febs.12545","doi":"https://doi.org/10.1111/febs.12545","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.12545","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmid:24428386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24428386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320308318","display_name":"Helen Hay Whitney Foundation","ror":"https://ror.org/037ebw447"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W7522513","https://openalex.org/W165336997","https://openalex.org/W206135789","https://openalex.org/W1487659884","https://openalex.org/W1525055187","https://openalex.org/W1618955965","https://openalex.org/W1965091117","https://openalex.org/W1975928024","https://openalex.org/W1981231268","https://openalex.org/W1986068257","https://openalex.org/W1989856847","https://openalex.org/W1993834778","https://openalex.org/W1994532328","https://openalex.org/W1995171139","https://openalex.org/W1997291694","https://openalex.org/W1998791241","https://openalex.org/W2007050345","https://openalex.org/W2014965368","https://openalex.org/W2019298011","https://openalex.org/W2026163190","https://openalex.org/W2028383422","https://openalex.org/W2032896731","https://openalex.org/W2035648603","https://openalex.org/W2040391135","https://openalex.org/W2040536746","https://openalex.org/W2046413608","https://openalex.org/W2050814486","https://openalex.org/W2054281275","https://openalex.org/W2056776034","https://openalex.org/W2056872780","https://openalex.org/W2062875344","https://openalex.org/W2068614068","https://openalex.org/W2076034830","https://openalex.org/W2079275870","https://openalex.org/W2079531003","https://openalex.org/W2083630006","https://openalex.org/W2087974611","https://openalex.org/W2104097315","https://openalex.org/W2113343496","https://openalex.org/W2113946722","https://openalex.org/W2114229182","https://openalex.org/W2116479507","https://openalex.org/W2117321459","https://openalex.org/W2121214210","https://openalex.org/W2125053230","https://openalex.org/W2126023294","https://openalex.org/W2129185533","https://openalex.org/W2130964922","https://openalex.org/W2133737876","https://openalex.org/W2135570071","https://openalex.org/W2141634848","https://openalex.org/W2144746026","https://openalex.org/W2146156928","https://openalex.org/W2147157132","https://openalex.org/W2147827238","https://openalex.org/W2149116338","https://openalex.org/W2151912765","https://openalex.org/W2154602821","https://openalex.org/W2155748850","https://openalex.org/W2162016003","https://openalex.org/W2163279392","https://openalex.org/W2166454051","https://openalex.org/W2243690352","https://openalex.org/W2258630975","https://openalex.org/W2586256972","https://openalex.org/W4240315944","https://openalex.org/W7009171728"],"related_works":["https://openalex.org/W165336997","https://openalex.org/W2925925156","https://openalex.org/W2113946722","https://openalex.org/W2066107370","https://openalex.org/W2606725132","https://openalex.org/W2611773415","https://openalex.org/W2104097315","https://openalex.org/W2165542427","https://openalex.org/W3019083666","https://openalex.org/W2042906865"],"abstract_inverted_index":{"Enzyme-catalyzed":[0],"reactions":[1],"are":[2],"naturally":[3],"stochastic,":[4],"and":[5,59,146],"precision":[6],"measurements":[7],"of":[8,33,42,49,80,82,96,111,129,156],"these":[9,27],"fluctuations,":[10],"made":[11],"possible":[12,24,97],"by":[13,137,143],"single-molecule":[14],"methods,":[15],"promise":[16],"to":[17],"provide":[18],"fundamentally":[19],"new":[20,37,139],"constraints":[21],"on":[22,56,92],"the":[23,40,65,77,83,93,108,112,121,126,134,138,153],"mechanisms":[25],"underlying":[26],"reactions.":[28,53],"We":[29,54,132],"review":[30],"some":[31],"aspects":[32],"statistical":[34,47,61],"kinetics:":[35],"a":[36,57,101],"field":[38],"with":[39],"goal":[41],"extracting":[43],"mechanistic":[44],"information":[45,135],"from":[46],"measures":[48],"fluctuations":[50,119],"in":[51,73],"chemical":[52],"focus":[55],"widespread":[58],"important":[60],"measure":[62],"known":[63],"as":[64],"randomness":[66,113],"parameter.":[67],"This":[68],"parameter":[69,114],"is":[70,76,116,124],"remarkably":[71],"simple":[72],"that":[74,115,148],"it":[75,88],"squared":[78],"coefficient":[79],"variation":[81],"cycle":[84],"completion":[85],"times,":[86],"although":[87],"places":[89],"significant":[90],"limits":[91],"minimal":[94],"complexity":[95],"enzymatic":[98],"mechanisms.":[99],"Recently,":[100],"general":[102],"expression":[103,123,145,150],"has":[104],"been":[105],"introduced":[106,142],"for":[107,117,125],"substrate":[109],"dependence":[110],"rate":[118,128],"what":[120],"Michaelis-Menten":[122],"mean":[127],"product":[130],"generation.":[131],"discuss":[133],"provided":[136],"kinetic":[140],"parameters":[141],"this":[144,149],"demonstrate":[147],"can":[151],"simplify":[152],"vast":[154],"majority":[155],"published":[157],"models.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}