{"id":"https://openalex.org/W2076525119","doi":"https://doi.org/10.1016/j.ccr.2011.01.032","title":"How environment affects drug activity: Localization, compartmentalization and reactions of a vanadium insulin-enhancing compound, dipicolinatooxovanadium(V)","display_name":"How environment affects drug activity: Localization, compartmentalization and reactions of a vanadium insulin-enhancing compound, dipicolinatooxovanadium(V)","publication_year":2011,"publication_date":"2011-01-28","ids":{"openalex":"https://openalex.org/W2076525119","doi":"https://doi.org/10.1016/j.ccr.2011.01.032","mag":"2076525119"},"language":"en","primary_location":{"id":"doi:10.1016/j.ccr.2011.01.032","doi":"https://doi.org/10.1016/j.ccr.2011.01.032","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ccr.2011.01.032","pdf_url":null,"source":{"id":"https://openalex.org/S117186765","display_name":"Coordination Chemistry Reviews","issn_l":"0010-8545","issn":["0010-8545","1873-3840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Coordination Chemistry Reviews","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052889522","display_name":"Debbie C. Crans","orcid":"https://orcid.org/0000-0001-7792-3450","observed_orcids":["https://orcid.org/0000-0001-7792-3450"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Debbie C. Crans","raw_affiliation_strings":["Dept. of Cell and Molecular Biology, Colorado State University, Fort Collins, CO 80523, United States","Dept. of Chemistry, Colorado State University, Fort Collins, CO 80523, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Cell and Molecular Biology, Colorado State University, Fort Collins, CO 80523, United States","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Dept. of Chemistry, Colorado State University, Fort Collins, CO 80523, United States","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082618414","display_name":"Alejandro M. Trujillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandro M. Trujillo","raw_affiliation_strings":["Dept. of Cell and Molecular Biology, Colorado State University, Fort Collins, CO 80523, United States","Dept. of Chemistry, Colorado State University, Fort Collins, CO 80523, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Cell and Molecular Biology, Colorado State University, Fort Collins, CO 80523, United States","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Dept. of Chemistry, Colorado State University, Fort Collins, CO 80523, United States","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082497671","display_name":"Philip S. Pharazyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip S. Pharazyn","raw_affiliation_strings":["Dept. of Chemistry, Colorado State University, Fort Collins, CO 80523, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Chemistry, Colorado State University, Fort Collins, CO 80523, United States","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113585092","display_name":"Mitchell D. Cohen","orcid":"https://orcid.org/0009-0005-4746-4069","observed_orcids":["https://orcid.org/0009-0005-4746-4069"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell D. Cohen","raw_affiliation_strings":["Dept. of Environmental Medicine, NYU School of Medicine, Tuxedo, NY 10987, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Environmental Medicine, NYU School of Medicine, Tuxedo, NY 10987, United States","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052889522"],"corresponding_institution_ids":["https://openalex.org/I92446798"],"apc_list":{"value":5740,"currency":"USD","value_usd":5740},"apc_paid":null,"fwci":5.9582,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.96616317,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"255","issue":"19-20","first_page":"2178","last_page":"2192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12136","display_name":"Vanadium and Halogenation Chemistry","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12136","display_name":"Vanadium and Halogenation Chemistry","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11746","display_name":"Inorganic and Organometallic Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vanadium-complexes","display_name":"vanadium complexes","score":0.8740000128746033},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7739999890327454},{"id":"https://openalex.org/keywords/compartmentalization","display_name":"compartmentalization","score":0.6679999828338623},{"id":"https://openalex.org/keywords/hydrolysis","display_name":"hydrolysis","score":0.6890000104904175},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.7170000076293945},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9545541405677795},{"id":"https://openalex.org/C110455231","wikidata":"https://www.wikidata.org/wiki/Q897788","display_name":"Compartmentalization (fire protection)","level":3,"score":0.8215316534042358},{"id":"https://openalex.org/C504678139","wikidata":"https://www.wikidata.org/wiki/Q722","display_name":"Vanadium","level":2,"score":0.8160477876663208},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.6209419965744019},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.53718101978302},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4105093479156494},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.34185945987701416},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2451247274875641},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18666312098503113},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12577441334724426}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ccr.2011.01.032","doi":"https://doi.org/10.1016/j.ccr.2011.01.032","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ccr.2011.01.032","pdf_url":null,"source":{"id":"https://openalex.org/S117186765","display_name":"Coordination Chemistry Reviews","issn_l":"0010-8545","issn":["0010-8545","1873-3840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Coordination Chemistry Reviews","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":148,"referenced_works":["https://openalex.org/W117932624","https://openalex.org/W171879838","https://openalex.org/W340877871","https://openalex.org/W605982883","https://openalex.org/W943187587","https://openalex.org/W1508156998","https://openalex.org/W1521172536","https://openalex.org/W1559780175","https://openalex.org/W1568886595","https://openalex.org/W1586550818","https://openalex.org/W1876341852","https://openalex.org/W1963919105","https://openalex.org/W1967161220","https://openalex.org/W1968821990","https://openalex.org/W1969190638","https://openalex.org/W1969346158","https://openalex.org/W1970401962","https://openalex.org/W1973230057","https://openalex.org/W1973667360","https://openalex.org/W1973994610","https://openalex.org/W1975786697","https://openalex.org/W1976145421","https://openalex.org/W1978821730","https://openalex.org/W1980008385","https://openalex.org/W1980518643","https://openalex.org/W1981714298","https://openalex.org/W1982798990","https://openalex.org/W1983057459","https://openalex.org/W1984922623","https://openalex.org/W1985288948","https://openalex.org/W1986323140","https://openalex.org/W1987553535","https://openalex.org/W1989833983","https://openalex.org/W1989956576","https://openalex.org/W1992337223","https://openalex.org/W1997839321","https://openalex.org/W1999015737","https://openalex.org/W2000529728","https://openalex.org/W2001839740","https://openalex.org/W2002046159","https://openalex.org/W2005777918","https://openalex.org/W2006826463","https://openalex.org/W2010583888","https://openalex.org/W2010649610","https://openalex.org/W2011787700","https://openalex.org/W2012037669","https://openalex.org/W2013299564","https://openalex.org/W2015517106","https://openalex.org/W2016297156","https://openalex.org/W2016773795","https://openalex.org/W2018692971","https://openalex.org/W2018698890","https://openalex.org/W2021703663","https://openalex.org/W2021786204","https://openalex.org/W2023735749","https://openalex.org/W2024796877","https://openalex.org/W2027250675","https://openalex.org/W2029254183","https://openalex.org/W2030158981","https://openalex.org/W2031019334","https://openalex.org/W2031917755","https://openalex.org/W2034703335","https://openalex.org/W2034797387","https://openalex.org/W2035684763","https://openalex.org/W2035997527","https://openalex.org/W2036156503","https://openalex.org/W2036617397","https://openalex.org/W2037004647","https://openalex.org/W2040262816","https://openalex.org/W2040328392","https://openalex.org/W2040708743","https://openalex.org/W2040749749","https://openalex.org/W2041097548","https://openalex.org/W2041117325","https://openalex.org/W2041901256","https://openalex.org/W2043501167","https://openalex.org/W2044310404","https://openalex.org/W2045329548","https://openalex.org/W2046019078","https://openalex.org/W2046708076","https://openalex.org/W2046770888","https://openalex.org/W2046905278","https://openalex.org/W2049641412","https://openalex.org/W2053270277","https://openalex.org/W2056424732","https://openalex.org/W2058680766","https://openalex.org/W2060063310","https://openalex.org/W2060712167","https://openalex.org/W2061807210","https://openalex.org/W2062609826","https://openalex.org/W2064759630","https://openalex.org/W2065083690","https://openalex.org/W2065202460","https://openalex.org/W2067470335","https://openalex.org/W2067511622","https://openalex.org/W2068353681","https://openalex.org/W2070247876","https://openalex.org/W2071300647","https://openalex.org/W2071893453","https://openalex.org/W2075044765","https://openalex.org/W2077764031","https://openalex.org/W2078386170","https://openalex.org/W2078624622","https://openalex.org/W2079256203","https://openalex.org/W2079489161","https://openalex.org/W2080200553","https://openalex.org/W2081729013","https://openalex.org/W2086876539","https://openalex.org/W2086997985","https://openalex.org/W2088129183","https://openalex.org/W2089456721","https://openalex.org/W2089883628","https://openalex.org/W2090236181","https://openalex.org/W2091204011","https://openalex.org/W2093547786","https://openalex.org/W2094108755","https://openalex.org/W2094474874","https://openalex.org/W2094726566","https://openalex.org/W2096381504","https://openalex.org/W2099156392","https://openalex.org/W2102547716","https://openalex.org/W2108162138","https://openalex.org/W2111111891","https://openalex.org/W2115529762","https://openalex.org/W2122102685","https://openalex.org/W2123612637","https://openalex.org/W2124813748","https://openalex.org/W2134063758","https://openalex.org/W2137832971","https://openalex.org/W2139026937","https://openalex.org/W2143732485","https://openalex.org/W2143785190","https://openalex.org/W2153707112","https://openalex.org/W2156148874","https://openalex.org/W2157038473","https://openalex.org/W2312285875","https://openalex.org/W2317835617","https://openalex.org/W2329396091","https://openalex.org/W2417602986","https://openalex.org/W2464464717","https://openalex.org/W2615054036","https://openalex.org/W3110337031","https://openalex.org/W4232294306","https://openalex.org/W4239070823","https://openalex.org/W4239152447","https://openalex.org/W4246656865","https://openalex.org/W4248107770","https://openalex.org/W4253924799"],"related_works":["https://openalex.org/W1968821990","https://openalex.org/W2018698890","https://openalex.org/W2977765488","https://openalex.org/W2068353681","https://openalex.org/W1989956576","https://openalex.org/W2035201731","https://openalex.org/W2089883628","https://openalex.org/W1967906720","https://openalex.org/W2062449031","https://openalex.org/W2067605543"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
