{"id":"https://openalex.org/W2076513735","doi":"https://doi.org/10.1098/rstb.2003.1346","title":"Modelling cartilage mechanobiology","display_name":"Modelling cartilage mechanobiology","publication_year":2003,"publication_date":"2003-08-12","ids":{"openalex":"https://openalex.org/W2076513735","doi":"https://doi.org/10.1098/rstb.2003.1346","mag":"2076513735","pmid":"https://pubmed.ncbi.nlm.nih.gov/14561337","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1693248"},"language":"en","primary_location":{"id":"doi:10.1098/rstb.2003.1346","doi":"https://doi.org/10.1098/rstb.2003.1346","is_oa":false,"landing_page_url":"https://doi.org/10.1098/rstb.2003.1346","pdf_url":null,"source":{"id":"https://openalex.org/S91660768","display_name":"Philosophical Transactions of the Royal Society B Biological Sciences","issn_l":"0962-8436","issn":["0962-8436","1471-2970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1693248","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110014819","display_name":"Dennis R. Professor Carter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dennis R. Carter","raw_affiliation_strings":["Biomechanical Engineering Division, Mechanical Engineering Department, 215 Durand Building, Stanford University, Stanford, CA 94305, USA","The Rehabilitation R&amp;D Centre, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomechanical Engineering Division, Mechanical Engineering Department, 215 Durand Building, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"The Rehabilitation R&amp;D Centre, VA Palo Alto Health Care System, Palo Alto, CA 94304, USA","institution_ids":["https://openalex.org/I204866599"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016954935","display_name":"Marcy Zenobi\u2010Wong","orcid":"https://orcid.org/0000-0002-8522-9909","observed_orcids":["https://orcid.org/0000-0002-8522-9909"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4210090941","display_name":"Institute for Biomedical Engineering","ror":"https://ror.org/00baskk38","country_code":"CH","type":"facility","lineage":["https://openalex.org/I202697423","https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4210090941"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marcy Wong","raw_affiliation_strings":["Institute for Biomedical Engineering, ETH, Gloriastrasse 35, 8092 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Engineering, ETH, Gloriastrasse 35, 8092 Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4210090941"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5110014819"],"corresponding_institution_ids":["https://openalex.org/I204866599","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":2.6167,"has_fulltext":false,"cited_by_count":182,"citation_normalized_percentile":{"value":0.8911338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"358","issue":"1437","first_page":"1461","last_page":"1471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.2741999924182892,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.035999998450279236,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cartilage-mechanobiology","display_name":"cartilage mechanobiology","score":0.9700000286102295},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.8349999785423279},{"id":"https://openalex.org/keywords/endochondral-ossification","display_name":"endochondral ossification","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cartilage-growth","display_name":"cartilage growth","score":0.6200000047683716},{"id":"https://openalex.org/keywords/poroelasticity","display_name":"poroelasticity","score":0.6240000128746033},{"id":"https://openalex.org/keywords/fluid-exudation","display_name":"fluid exudation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cyclic-tensile-strain","display_name":"cyclic tensile strain","score":0.7279999852180481},{"id":"https://openalex.org/keywords/hydrostatic-pressure","display_name":"hydrostatic pressure","score":0.8080000281333923},{"id":"https://openalex.org/keywords/chondrocyte-phenotype","display_name":"chondrocyte phenotype","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cartilage-thickness","display_name":"cartilage thickness","score":0.6200000047683716},{"id":"https://openalex.org/keywords/joint-mechanics","display_name":"joint mechanics","score":0.8240000009536743},{"id":"https://openalex.org/keywords/finite-element-analysis","display_name":"finite element analysis","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C181965411","wikidata":"https://www.wikidata.org/wiki/Q2314330","display_name":"Poromechanics","level":4,"score":0.8432074785232544},{"id":"https://openalex.org/C2780171871","wikidata":"https://www.wikidata.org/wiki/Q6804676","display_name":"Mechanobiology","level":2,"score":0.8272726535797119},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.8110179901123047},{"id":"https://openalex.org/C17938293","wikidata":"https://www.wikidata.org/wiki/Q3312710","display_name":"Endochondral ossification","level":3,"score":0.7002854347229004},{"id":"https://openalex.org/C2910081258","wikidata":"https://www.wikidata.org/wiki/Q177807","display_name":"Hydrostatic pressure","level":2,"score":0.5506108999252319},{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.47421765327453613},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.46038153767585754},{"id":"https://openalex.org/C2778842504","wikidata":"https://www.wikidata.org/wiki/Q1121544","display_name":"Ossification","level":2,"score":0.42555534839630127},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.37792712450027466},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3716166615486145},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.29677724838256836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23205256462097168},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20273837447166443},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.1788051724433899},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.13786989450454712},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11917215585708618},{"id":"https://openalex.org/C105569014","wikidata":"https://www.wikidata.org/wiki/Q3271208","display_name":"Porous medium","level":3,"score":0.10135039687156677},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07245498895645142},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1098/rstb.2003.1346","doi":"https://doi.org/10.1098/rstb.2003.1346","is_oa":false,"landing_page_url":"https://doi.org/10.1098/rstb.2003.1346","pdf_url":null,"source":{"id":"https://openalex.org/S91660768","display_name":"Philosophical Transactions of the Royal Society B Biological Sciences","issn_l":"0962-8436","issn":["0962-8436","1471-2970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:443587","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1693248","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1693248","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1693248","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Philos Trans R Soc Lond B Biol Sci","raw_type":"Text"},{"id":"pmid:14561337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14561337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Philosophical transactions of the Royal Society of London. Series B, Biological sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:443587","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1693248","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W32916265","https://openalex.org/W153073735","https://openalex.org/W177822318","https://openalex.org/W199669449","https://openalex.org/W1954475373","https://openalex.org/W1966081937","https://openalex.org/W1968649940","https://openalex.org/W1969693271","https://openalex.org/W1973343738","https://openalex.org/W1975098157","https://openalex.org/W1982031316","https://openalex.org/W1985603154","https://openalex.org/W1989307073","https://openalex.org/W1991987132","https://openalex.org/W1995039844","https://openalex.org/W1995304439","https://openalex.org/W1995577167","https://openalex.org/W1995578874","https://openalex.org/W1998129825","https://openalex.org/W2011736517","https://openalex.org/W2013572062","https://openalex.org/W2016944916","https://openalex.org/W2019042780","https://openalex.org/W2022805915","https://openalex.org/W2026143674","https://openalex.org/W2033524895","https://openalex.org/W2037596655","https://openalex.org/W2049411403","https://openalex.org/W2050310812","https://openalex.org/W2055072688","https://openalex.org/W2069674129","https://openalex.org/W2076788207","https://openalex.org/W2086382719","https://openalex.org/W2087418982","https://openalex.org/W2089955270","https://openalex.org/W2090073689","https://openalex.org/W2103008958","https://openalex.org/W2106418042","https://openalex.org/W2111312751","https://openalex.org/W2125525443","https://openalex.org/W2135124706","https://openalex.org/W2154576425","https://openalex.org/W2160040618","https://openalex.org/W2161067266","https://openalex.org/W2169731710","https://openalex.org/W2170112876","https://openalex.org/W2460749004","https://openalex.org/W3023870838","https://openalex.org/W3132178687","https://openalex.org/W4249441050"],"related_works":["https://openalex.org/W32916265","https://openalex.org/W7095167908","https://openalex.org/W201703602","https://openalex.org/W1499019497","https://openalex.org/W2327420532","https://openalex.org/W2385463182","https://openalex.org/W2088752908","https://openalex.org/W2016145855","https://openalex.org/W2081644306","https://openalex.org/W2418163344"],"abstract_inverted_index":{"The":[0],"growth,":[1],"maintenance":[2],"and":[3,12,48,81,109,160,194,196],"ossification":[4,44],"of":[5,38,58,112,183,190],"cartilage":[6,50,70,79,114,123,184],"are":[7,13,22,99,142,186],"fundamental":[8],"to":[9,34,102,144,150,164],"skeletal":[10,46],"development":[11],"regulated":[14],"throughout":[15],"life":[16],"by":[17,24,127],"the":[18,36,60,107,122,133,140,151,170],"mechanical":[19],"cues":[20],"that":[21,64],"imposed":[23],"physical":[25],"activities.":[26],"Finite":[27],"element":[28],"computer":[29,180],"analyses":[30,117],"have":[31,62],"been":[32],"used":[33],"study":[35,103],"role":[37],"local":[39,65],"tissue":[40,195],"mechanics":[41],"on":[42],"endochondral":[43],"patterns,":[45],"morphology":[47],"articular":[49,92,113,138],"thickness":[51],"distributions.":[52],"Using":[53],"single-phase":[54,84,134],"continuum":[55],"material":[56,85],"representations":[57],"cartilage,":[59,93],"results":[61,189],"indicated":[63],"intermittent":[66],"hydrostatic":[67],"pressure":[68,130],"promotes":[69],"maintenance.":[71],"Cyclic":[72],"tensile":[73,146],"strains":[74],"(or":[75,95],"shear),":[76],"however,":[77],"promote":[78],"growth":[80],"ossification.":[82],"Because":[83],"models":[86,98],"cannot":[87],"capture":[88],"fluid":[89,120,129,153,158],"exudation":[90,159],"in":[91,148,191],"poroelastic":[94,116],"biphasic)":[96],"solid/fluid":[97],"often":[100],"implemented":[101],"joint":[104],"mechanics.":[105],"In":[106,136],"middle":[108],"deep":[110],"layers":[111,139],"where":[115],"predict":[118],"little":[119],"exudation,":[121],"phenotype":[124],"is":[125,157],"maintained":[126],"cyclic":[128],"(consistent":[131],"with":[132,188],"theory).":[135],"superficial":[137,171],"chondrocytes":[141],"exposed":[143],"tangential":[145],"strain":[147],"addition":[149],"high":[152],"pressure.":[154],"Furthermore,":[155],"there":[156],"matrix":[161],"consolidation,":[162],"leading":[163],"cell":[165,193],"'flattening'.":[166],"As":[167],"a":[168],"result,":[169],"layer":[172],"assumes":[173],"an":[174],"altered,":[175],"more":[176],"fibrous":[177],"phenotype.":[178],"These":[179],"model":[181],"predictions":[182],"mechanobiology":[185],"consistent":[187],"vitro":[192],"molecular":[197],"biology":[198],"experiments.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
