{"id":"https://openalex.org/W2076513077","doi":"https://doi.org/10.1371/journal.pone.0076810","title":"Impact of Interleukin-6 \u2013174 G>C Gene Promoter Polymorphism on Neuroblastoma","display_name":"Impact of Interleukin-6 \u2013174 G>C Gene Promoter Polymorphism on Neuroblastoma","publication_year":2013,"publication_date":"2013-10-21","ids":{"openalex":"https://openalex.org/W2076513077","doi":"https://doi.org/10.1371/journal.pone.0076810","mag":"2076513077","pmid":"https://pubmed.ncbi.nlm.nih.gov/24204677","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3804531"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0076810","doi":"https://doi.org/10.1371/journal.pone.0076810","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0076810","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076810&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076810&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024151797","display_name":"Francesca Totaro","orcid":"https://orcid.org/0009-0007-9448-5094","observed_orcids":["https://orcid.org/0009-0007-9448-5094"]},"institutions":[{"id":"https://openalex.org/I4210128854","display_name":"CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Totaro","raw_affiliation_strings":["Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy ; CEINGE - Biotecnologie Avanzate, Naples, Italy","CEINGE \u2013 Biotecnologie Avanzate, Naples, Italy","Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy ; CEINGE - Biotecnologie Avanzate, Naples, Italy","institution_ids":["https://openalex.org/I4210128854","https://openalex.org/I71267560"]},{"raw_affiliation_string":"CEINGE \u2013 Biotecnologie Avanzate, Naples, Italy","institution_ids":["https://openalex.org/I4210128854"]},{"raw_affiliation_string":"Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036229619","display_name":"Flora Cimmino","orcid":"https://orcid.org/0000-0003-1538-9285","observed_orcids":["https://orcid.org/0000-0003-1538-9285"]},"institutions":[{"id":"https://openalex.org/I4210128854","display_name":"CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Flora Cimmino","raw_affiliation_strings":["CEINGE \u2013 Biotecnologie Avanzate, Naples, Italy","Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEINGE \u2013 Biotecnologie Avanzate, Naples, Italy","institution_ids":["https://openalex.org/I4210128854"]},{"raw_affiliation_string":"Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062445008","display_name":"Piero Pignataro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128854","display_name":"CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piero Pignataro","raw_affiliation_strings":["CEINGE \u2013 Biotecnologie Avanzate, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEINGE \u2013 Biotecnologie Avanzate, Naples, Italy","institution_ids":["https://openalex.org/I4210128854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019028923","display_name":"Giovanni Acierno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128854","display_name":"CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Acierno","raw_affiliation_strings":["CEINGE \u2013 Biotecnologie Avanzate, Naples, Italy","Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEINGE \u2013 Biotecnologie Avanzate, Naples, Italy","institution_ids":["https://openalex.org/I4210128854"]},{"raw_affiliation_string":"Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002585694","display_name":"Marilena De Mariano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marilena De Mariano","raw_affiliation_strings":["IRCCS AOU San Martino-IST, National Cancer Research Institute, Genoa, Italy","Terapia Immunologica, IRCCS AOU San Martino-IST-Istituto Nazionale per la ricerca sul cancro, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS AOU San Martino-IST, National Cancer Research Institute, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472"]},{"raw_affiliation_string":"Terapia Immunologica, IRCCS AOU San Martino-IST-Istituto Nazionale per la ricerca sul cancro, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032601645","display_name":"Luca Longo","orcid":"https://orcid.org/0000-0002-5153-4243","observed_orcids":["https://orcid.org/0000-0002-5153-4243"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Longo","raw_affiliation_strings":["IRCCS AOU San Martino-IST, National Cancer Research Institute, Genoa, Italy","Terapia Immunologica, IRCCS AOU San Martino-IST-Istituto Nazionale per la ricerca sul cancro, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS AOU San Martino-IST, National Cancer Research Institute, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472"]},{"raw_affiliation_string":"Terapia Immunologica, IRCCS AOU San Martino-IST-Istituto Nazionale per la ricerca sul cancro, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047048269","display_name":"Gian Paolo Tonini","orcid":"https://orcid.org/0000-0001-5366-7878","observed_orcids":["https://orcid.org/0000-0001-5366-7878"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gian Paolo Tonini","raw_affiliation_strings":["Laboratory of Neuroblastoma, Onco/Hematology Department SDB University of Padua, Pediatric Research Institute, Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroblastoma, Onco/Hematology Department SDB University of Padua, Pediatric Research Institute, Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022755764","display_name":"Achille Iolascon","orcid":"https://orcid.org/0000-0002-9558-0356","observed_orcids":["https://orcid.org/0000-0002-9558-0356"]},"institutions":[{"id":"https://openalex.org/I4210128854","display_name":"CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Achille Iolascon","raw_affiliation_strings":["CEINGE \u2013 Biotecnologie Avanzate, Naples, Italy","Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEINGE \u2013 Biotecnologie Avanzate, Naples, Italy","institution_ids":["https://openalex.org/I4210128854"]},{"raw_affiliation_string":"Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068562700","display_name":"Mario Capasso","orcid":"https://orcid.org/0000-0003-3306-1259","observed_orcids":["https://orcid.org/0000-0003-3306-1259"]},"institutions":[{"id":"https://openalex.org/I4210128854","display_name":"CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Mario Capasso","raw_affiliation_strings":["CEINGE \u2013 Biotecnologie Avanzate, Naples, Italy","Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEINGE \u2013 Biotecnologie Avanzate, Naples, Italy","institution_ids":["https://openalex.org/I4210128854"]},{"raw_affiliation_string":"Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5068562700"],"corresponding_institution_ids":["https://openalex.org/I4210128854","https://openalex.org/I71267560"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.3218,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.78806155,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"10","first_page":"e76810","last_page":"e76810"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9900000095367432},{"id":"https://openalex.org/keywords/il-6-174-g-c-polymorphism","display_name":"IL-6 -174 G/C polymorphism","score":0.8820000290870667},{"id":"https://openalex.org/keywords/rs1800795","display_name":"rs1800795","score":0.9950000047683716},{"id":"https://openalex.org/keywords/promoter-polymorphism","display_name":"promoter polymorphism","score":0.7599999904632568},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7419999837875366},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7419999837875366},{"id":"https://openalex.org/keywords/high-risk-neuroblastoma","display_name":"high-risk neuroblastoma","score":0.8149999976158142},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5659999847412109},{"id":"https://openalex.org/keywords/transcriptional-activity","display_name":"transcriptional activity","score":0.9599999785423279},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8009999990463257},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5077003240585327},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47384387254714966},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.46967679262161255},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44053342938423157},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43846723437309265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.429916650056839},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2745910584926605},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.08173391222953796}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0076810","doi":"https://doi.org/10.1371/journal.pone.0076810","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0076810","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076810&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2808976","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3804531","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:24204677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24204677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3804531","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3804531/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.774.9478","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.774.9478","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/02/09/pone.0076810.PMC3804531.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:d23dff8fd16945f9afeb345922a8de97","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d23dff8fd16945f9afeb345922a8de97","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 10, p e76810 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/829168","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/_Impact_of_Interleukin_6_8211_174_G_gt_C_Gene_Promoter_Polymorphism_on_Neuroblastoma_/829168","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0076810","doi":"https://doi.org/10.1371/journal.pone.0076810","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0076810","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0076810&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3965397300","display_name":null,"funder_award_id":"GR-2010","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G5894394399","display_name":null,"funder_award_id":"10537","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G6145283138","display_name":null,"funder_award_id":"2010-2311890","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"}],"funders":[{"id":"https://openalex.org/F4320310983","display_name":"Fondazione Italiana per la Lotta al Neuroblastoma","ror":"https://ror.org/02zn32y15"},{"id":"https://openalex.org/F4320317420","display_name":"Associazione Oncologia Pediatrica e Neuroblastoma ONLUS","ror":"https://ror.org/00q82b288"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2076513077.pdf","grobid_xml":"https://content.openalex.org/works/W2076513077.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W73626961","https://openalex.org/W1507469709","https://openalex.org/W1967874493","https://openalex.org/W1968530152","https://openalex.org/W1971636277","https://openalex.org/W1972698844","https://openalex.org/W1978298539","https://openalex.org/W2003165120","https://openalex.org/W2012404242","https://openalex.org/W2014143877","https://openalex.org/W2047569750","https://openalex.org/W2055737465","https://openalex.org/W2064088530","https://openalex.org/W2074468582","https://openalex.org/W2079957854","https://openalex.org/W2089022749","https://openalex.org/W2089788088","https://openalex.org/W2092507665","https://openalex.org/W2102128323","https://openalex.org/W2111275015","https://openalex.org/W2112331344","https://openalex.org/W2114002267","https://openalex.org/W2115475246","https://openalex.org/W2132841383","https://openalex.org/W2136138472","https://openalex.org/W2142802339","https://openalex.org/W2145270322","https://openalex.org/W2145836134","https://openalex.org/W2164756216","https://openalex.org/W2166213580","https://openalex.org/W2167668076","https://openalex.org/W2168064716"],"related_works":["https://openalex.org/W7098102824","https://openalex.org/W2114002267","https://openalex.org/W2800613533","https://openalex.org/W3127305708","https://openalex.org/W1536294568","https://openalex.org/W2082534397","https://openalex.org/W2045183612","https://openalex.org/W2613184452","https://openalex.org/W6887891894","https://openalex.org/W2102128323"],"abstract_inverted_index":{"BACKGROUND:":[0],"Common":[1],"variants":[2],"in":[3,25,64,82,89,117,147,214,218,233],"DNA":[4],"may":[5,256],"predispose":[6],"to":[7,72,98,119,235],"onset":[8],"and":[9,50,58,66,88,106,143,154],"progression":[10,239],"of":[11,17,35,43,76,130,173,207,229,237],"neuroblastoma":[12],"(NB).":[13],"The":[14,146,226,248],"genotype":[15,131,167],"GG":[16],"single":[18],"nucleotide":[19],"polymorphism":[20],"(SNP)":[21],"rs1800795":[22,46],"(-174":[23],"G>C)":[24],"interleukin":[26],"(IL)-6":[27],"promoter":[28],"has":[29],"been":[30],"associated":[31,135,210],"with":[32,136,170,194,211,216,242],"lower":[33],"survival":[34,246],"high-risk":[36,144],"NB.":[37],"RESULT:":[38],"To":[39],"evaluate":[40,73],"the":[41,74,77,100,165,183,243],"impact":[42],"IL-6":[44,103,112,174,208],"SNP":[45,78,113,230,253],"on":[47,79],"disease":[48],"risk":[49],"phenotype,":[51],"we":[52,62,180],"analyzed":[53],"326":[54],"Italian":[55],"NB":[56,91,120,217,262],"patients":[57],"511":[59],"controls.":[60],"Moreover,":[61,200],"performed":[63],"silico":[65,148],"quantitative":[67],"Real":[68],"Time":[69],"(qRT)-PCR":[70],"analyses":[71,159],"influence":[75],"gene":[80,104,178,221],"expression":[81,105,222],"198":[83],"lymphoblastoid":[84],"cell":[85],"lines":[86],"(LCLs)":[87],"31":[90],"tumors,":[92],"respectively.":[93],"Kaplan-Meier":[94,201],"analysis":[95,202],"was":[96],"used":[97],"verify":[99],"association":[101],"between":[102],"patient":[107],"survival.":[108],"We":[109],"found":[110],"that":[111,126,164,182,204,252],"is":[114,133,168,240],"not":[115],"involved":[116],"susceptibility":[118],"development.":[121],"However,":[122],"our":[123],"results":[124],"show":[125],"a":[127,137,188,258],"low":[128,138],"frequency":[129],"CC":[132,166],"significantly":[134,189],"overall":[139],"survival,":[140],"advanced":[141],"stage,":[142],"phenotype.":[145],"(p":[149,156,197],"=":[150,157,198],"2.61":[151],"\u00d7":[152],"10(-5))":[153],"qRT-PCR":[155],"0.03)":[158],"showed":[160,181],"similar":[161],"trend":[162],"indicating":[163],"correlated":[169],"increased":[171,190],"level":[172],"expression.":[175],"In":[176],"report":[177],"assay,":[179],"-174":[184],"C":[185],"variant":[186],"had":[187],"transcriptional":[191],"activity":[192],"compared":[193],"G":[195],"allele":[196],"0.0006).":[199],"demonstrated":[203],"high":[205],"levels":[206],"are":[209],"poor":[212],"outcome":[213],"children":[215],"two":[219],"independent":[220],"array":[223],"datasets.":[224],"CONCLUSIONS:":[225],"biological":[227],"effect":[228],"IL-6-174":[231,254],"G>C":[232,255],"relation":[234],"promotion":[236],"cancer":[238],"consistent":[241],"observed":[244],"decreased":[245],"time.":[247],"present":[249],"study":[250],"suggests":[251],"be":[257],"useful":[259],"marker":[260],"for":[261],"prognosis.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
