{"id":"https://openalex.org/W2076487515","doi":"https://doi.org/10.1006/jaut.1997.0126","title":"Rat Pancreatic Islet and Skin Xenograft Survival in CD4 and CD8 Knockout Mice","display_name":"Rat Pancreatic Islet and Skin Xenograft Survival in CD4 and CD8 Knockout Mice","publication_year":1997,"publication_date":"1997-06-01","ids":{"openalex":"https://openalex.org/W2076487515","doi":"https://doi.org/10.1006/jaut.1997.0126","mag":"2076487515","pmid":"https://pubmed.ncbi.nlm.nih.gov/9218759"},"language":"en","primary_location":{"id":"doi:10.1006/jaut.1997.0126","doi":"https://doi.org/10.1006/jaut.1997.0126","is_oa":true,"landing_page_url":"https://doi.org/10.1006/jaut.1997.0126","pdf_url":null,"source":{"id":"https://openalex.org/S187826688","display_name":"Journal of Autoimmunity","issn_l":"0896-8411","issn":["0896-8411","1095-9157"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Autoimmunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1006/jaut.1997.0126","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Nancy R. Krieger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy R. Krieger","raw_affiliation_strings":["Department of Surgery, Stanford University School of Medicine, CA, USA","Departments of Surgery and Medicine, Stanford University School of Medicine, Stanford, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Stanford University School of Medicine, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Departments of Surgery and Medicine, Stanford University School of Medicine, Stanford, CA, U.S.A","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014964663","display_name":"Hiroaki Ito","orcid":"https://orcid.org/0000-0003-3769-7115","observed_orcids":["https://orcid.org/0000-0003-3769-7115","https://orcid.org/0009-0008-6907-1524"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroaki Ito","raw_affiliation_strings":["Departments of Surgery and Medicine, Stanford University School of Medicine, Stanford, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery and Medicine, Stanford University School of Medicine, Stanford, CA, U.S.A","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063861097","display_name":"C. Garrison Fathman","orcid":"https://orcid.org/0000-0002-7534-1497","observed_orcids":["https://orcid.org/0000-0002-7534-1497"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Garrison Fathman","raw_affiliation_strings":["Departments of Surgery and Medicine, Stanford University School of Medicine, Stanford, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery and Medicine, Stanford University School of Medicine, Stanford, CA, U.S.A","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5420,"currency":"USD","value_usd":5420},"apc_paid":{"value":5420,"currency":"USD","value_usd":5420},"fwci":3.8319,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.93343521,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"10","issue":"3","first_page":"309","last_page":"315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xenograft-rejection","display_name":"xenograft rejection","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/skin-xenografts","display_name":"skin xenografts","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cd4-knockout-mice","display_name":"CD4 knockout mice","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cd8-knockout-mice","display_name":"CD8 knockout mice","score":1.0},{"id":"https://openalex.org/keywords/wistar-furth-rats","display_name":"Wistar-Furth rats","score":0.6110000014305115},{"id":"https://openalex.org/keywords/t-cell-mediated-rejection","display_name":"T cell-mediated rejection","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.8357573747634888},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.7184884548187256},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.607504665851593},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.4520639181137085},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3478364944458008},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3347296118736267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32440051436424255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29697951674461365},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29020529985427856},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29014164209365845},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.25511980056762695},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.15770936012268066},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05663910508155823}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000945","descriptor_name":"Antigens, Differentiation, T-Lymphocyte","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011920","descriptor_name":"Rats, Inbred WF","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016038","descriptor_name":"Skin Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016827","descriptor_name":"CD8 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/jaut.1997.0126","doi":"https://doi.org/10.1006/jaut.1997.0126","is_oa":true,"landing_page_url":"https://doi.org/10.1006/jaut.1997.0126","pdf_url":null,"source":{"id":"https://openalex.org/S187826688","display_name":"Journal of Autoimmunity","issn_l":"0896-8411","issn":["0896-8411","1095-9157"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Autoimmunity","raw_type":"journal-article"},{"id":"pmid:9218759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9218759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of autoimmunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1006/jaut.1997.0126","doi":"https://doi.org/10.1006/jaut.1997.0126","is_oa":true,"landing_page_url":"https://doi.org/10.1006/jaut.1997.0126","pdf_url":null,"source":{"id":"https://openalex.org/S187826688","display_name":"Journal of Autoimmunity","issn_l":"0896-8411","issn":["0896-8411","1095-9157"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Autoimmunity","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G184197431","display_name":"ANTI-CD4 INDUCED TRANSPLANTATION TOLERANCE","funder_award_id":"5r01dk043711-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2341635210","display_name":null,"funder_award_id":"DK44837","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6849277616","display_name":null,"funder_award_id":"DK-43711","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8461679918","display_name":"PATHOPHYSIOLOGY AND IMMUNOTHERAPY OF NOD DISEASE","funder_award_id":"5p01dk044837-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1494218680","https://openalex.org/W1966818078","https://openalex.org/W1986152239","https://openalex.org/W1989642841","https://openalex.org/W1990604944","https://openalex.org/W1992419153","https://openalex.org/W2007621457","https://openalex.org/W2008299115","https://openalex.org/W2010488047","https://openalex.org/W2014012740","https://openalex.org/W2026751311","https://openalex.org/W2026832758","https://openalex.org/W2027388097","https://openalex.org/W2030867534","https://openalex.org/W2031330165","https://openalex.org/W2035454865","https://openalex.org/W2038341581","https://openalex.org/W2044747237","https://openalex.org/W2045134465","https://openalex.org/W2048863509","https://openalex.org/W2050959380","https://openalex.org/W2055738534","https://openalex.org/W2060199817","https://openalex.org/W2068707979","https://openalex.org/W2079717284","https://openalex.org/W2081302659","https://openalex.org/W2093077251","https://openalex.org/W2112604002","https://openalex.org/W2134434827","https://openalex.org/W2141116067","https://openalex.org/W2250712710","https://openalex.org/W2399793005","https://openalex.org/W2410841304","https://openalex.org/W2412433265","https://openalex.org/W2414669277","https://openalex.org/W2422287352","https://openalex.org/W6713205133","https://openalex.org/W6714344533","https://openalex.org/W6714740143","https://openalex.org/W6717523109"],"related_works":["https://openalex.org/W2090495249","https://openalex.org/W2010453176","https://openalex.org/W2028367966","https://openalex.org/W2124844645","https://openalex.org/W2120697371","https://openalex.org/W1986152239","https://openalex.org/W1968290615","https://openalex.org/W2064378547","https://openalex.org/W2344107469","https://openalex.org/W2005625705"],"abstract_inverted_index":{"The":[0],"relative":[1],"contributions":[2],"of":[3,49,139,152],"the":[4,56,137],"CD4+":[5,123,141],"and":[6,18,42,90],"CD8+":[7,143],"T":[8,144],"cell":[9],"subpopulations":[10],"in":[11,55,87],"xenotransplant":[12],"rejection":[13,151],"were":[14,33,85],"studied":[15],"using":[16],"CD4":[17,37,57,89,97],"CD8":[19,39,64,91],"knockout":[20],"(KO)":[21],"mice.":[22],"Wistar":[23],"Furth":[24],"(WF,":[25],"RT1a)":[26],"rat":[27],"pancreatic":[28],"islet":[29,51,69,117,129],"or":[30,38,142],"skin":[31,83,108,153],"xenografts":[32,52,70,84],"transplanted":[34],"into":[35],"either":[36,140],"KO":[40,58,65,92,98],"recipients":[41,93,99],"compared":[43],"to":[44,75,149],"wild-type":[45],"controls.":[46],"Long-term":[47],"survival":[48],"WF":[50,82,107],"was":[53],"observed":[54],"mice":[59,66],"(MST,":[60,77],">66+/-8":[61],"days)":[62],"whereas":[63],"rejected":[67,86,106],"their":[68,115],"within":[71,94,110],"8":[72,95],"days,":[73,112],"similar":[74],"controls":[76],"7+/-0.2":[78],"days).":[79],"In":[80],"contrast,":[81],"both":[88],"days.":[96],"which":[100],"maintained":[101],"xenoislets":[102],">90":[103],"days":[104],"posttransplant":[105],"grafts":[109],"9":[111],"without":[113],"rejecting":[114],"original":[116],"xenografts.":[118,154],"These":[119,132],"results":[120],"suggest":[121,135],"that":[122,136],"cells":[124,145],"are":[125],"essential":[126],"for":[127],"mediating":[128],"xenograft":[130],"rejection.":[131],"data":[133],"also":[134],"absence":[138],"is":[146],"not":[147],"sufficient":[148],"prevent":[150]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
