{"id":"https://openalex.org/W2076486765","doi":"https://doi.org/10.1016/j.jmb.2013.09.008","title":"Coordinated Transcriptional Regulation of Hspa1a Gene by Multiple Transcription Factors: Crucial Roles for HSF-1, NF-Y, NF-\u03baB, and CREB","display_name":"Coordinated Transcriptional Regulation of Hspa1a Gene by Multiple Transcription Factors: Crucial Roles for HSF-1, NF-Y, NF-\u03baB, and CREB","publication_year":2013,"publication_date":"2013-09-13","ids":{"openalex":"https://openalex.org/W2076486765","doi":"https://doi.org/10.1016/j.jmb.2013.09.008","mag":"2076486765","pmid":"https://pubmed.ncbi.nlm.nih.gov/24041570"},"language":"en","primary_location":{"id":"doi:10.1016/j.jmb.2013.09.008","doi":"https://doi.org/10.1016/j.jmb.2013.09.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jmb.2013.09.008","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052922455","display_name":"Binu Kandathilparambil Sasi","orcid":"https://orcid.org/0000-0002-3325-9874","observed_orcids":["https://orcid.org/0000-0002-3325-9874"]},"institutions":[{"id":"https://openalex.org/I24676775","display_name":"Indian Institute of Technology Madras","ror":"https://ror.org/03v0r5n49","country_code":"IN","type":"education","lineage":["https://openalex.org/I24676775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Binu K. Sasi","raw_affiliation_strings":["Cardiovascular Genetics Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Genetics Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India","institution_ids":["https://openalex.org/I24676775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079081169","display_name":"Parshuram J. Sonawane","orcid":"https://orcid.org/0000-0001-7764-219X","observed_orcids":["https://orcid.org/0000-0001-7764-219X"]},"institutions":[{"id":"https://openalex.org/I24676775","display_name":"Indian Institute of Technology Madras","ror":"https://ror.org/03v0r5n49","country_code":"IN","type":"education","lineage":["https://openalex.org/I24676775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Parshuram J. Sonawane","raw_affiliation_strings":["Cardiovascular Genetics Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Genetics Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India","institution_ids":["https://openalex.org/I24676775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057395731","display_name":"Vinayak Gupta","orcid":"https://orcid.org/0000-0003-1001-9269","observed_orcids":["https://orcid.org/0000-0003-1001-9269"]},"institutions":[{"id":"https://openalex.org/I24676775","display_name":"Indian Institute of Technology Madras","ror":"https://ror.org/03v0r5n49","country_code":"IN","type":"education","lineage":["https://openalex.org/I24676775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vinayak Gupta","raw_affiliation_strings":["Cardiovascular Genetics Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Genetics Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India","institution_ids":["https://openalex.org/I24676775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086607555","display_name":"Bhavani Shankar Sahu","orcid":"https://orcid.org/0000-0001-6019-8344","observed_orcids":["https://orcid.org/0000-0001-6019-8344"]},"institutions":[{"id":"https://openalex.org/I24676775","display_name":"Indian Institute of Technology Madras","ror":"https://ror.org/03v0r5n49","country_code":"IN","type":"education","lineage":["https://openalex.org/I24676775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bhavani S. Sahu","raw_affiliation_strings":["Cardiovascular Genetics Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Genetics Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India","institution_ids":["https://openalex.org/I24676775"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060455149","display_name":"Nitish R. Mahapatra","orcid":"https://orcid.org/0000-0002-0695-3510","observed_orcids":["https://orcid.org/0000-0002-0695-3510"]},"institutions":[{"id":"https://openalex.org/I24676775","display_name":"Indian Institute of Technology Madras","ror":"https://ror.org/03v0r5n49","country_code":"IN","type":"education","lineage":["https://openalex.org/I24676775"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Nitish R. Mahapatra","raw_affiliation_strings":["Cardiovascular Genetics Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India. Electronic address: nmahapatra@iitm.ac.in","[Indian Institute of Technology, Madras]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Genetics Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India. Electronic address: nmahapatra@iitm.ac.in","institution_ids":["https://openalex.org/I24676775"]},{"raw_affiliation_string":"[Indian Institute of Technology, Madras]","institution_ids":["https://openalex.org/I24676775"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060455149"],"corresponding_institution_ids":["https://openalex.org/I24676775"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":2.9848,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.91886588,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"426","issue":"1","first_page":"116","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hspa1a","display_name":"HSPA1A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.7710000276565552},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hsf1","display_name":"HSF1","score":0.8889999985694885},{"id":"https://openalex.org/keywords/nf-y","display_name":"NF-Y","score":0.9660000205039978},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":1.0},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":1.0},{"id":"https://openalex.org/keywords/promoter-cis-acting-elements","display_name":"promoter cis-acting elements","score":0.7419999837875366},{"id":"https://openalex.org/keywords/heat-shock-response","display_name":"heat shock response","score":0.8209999799728394},{"id":"https://openalex.org/keywords/ischemia","display_name":"ischemia","score":0.7699999809265137},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8659999966621399},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cardiomyoblasts","display_name":"cardiomyoblasts","score":0.9629999995231628},{"id":"https://openalex.org/keywords/transcription-factor-binding-sites","display_name":"transcription factor binding sites","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2776667301","wikidata":"https://www.wikidata.org/wiki/Q18027324","display_name":"HSF1","level":5,"score":0.7510625123977661},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.7484583854675293},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7478735446929932},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.7040663361549377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6611765623092651},{"id":"https://openalex.org/C52981337","wikidata":"https://www.wikidata.org/wiki/Q24782817","display_name":"Heat shock factor","level":5,"score":0.6063104271888733},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.593876838684082},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4752388000488281},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4412328004837036},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.43196558952331543},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.413385808467865},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41103535890579224},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38767653703689575},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.3569486737251282},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.3417922854423523},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20017051696777344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18464228510856628},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076249","descriptor_name":"Heat Shock Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019677","descriptor_name":"Artificial Gene Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023081","descriptor_name":"CCAAT-Binding Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jmb.2013.09.008","doi":"https://doi.org/10.1016/j.jmb.2013.09.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jmb.2013.09.008","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:24041570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24041570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4869868672","display_name":"Cellular Medicine at the Cambridge Institute for Medical Research.","funder_award_id":"100140","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320321024","display_name":"Defence Research and Development Organisation","ror":"https://ror.org/05k37v296"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W12159572","https://openalex.org/W1482432683","https://openalex.org/W1558596994","https://openalex.org/W1564388687","https://openalex.org/W1759362230","https://openalex.org/W1817295032","https://openalex.org/W1881449691","https://openalex.org/W1962269101","https://openalex.org/W1964873815","https://openalex.org/W1966340588","https://openalex.org/W1967557581","https://openalex.org/W1969772407","https://openalex.org/W1973135307","https://openalex.org/W1979520552","https://openalex.org/W1980014349","https://openalex.org/W1980760698","https://openalex.org/W1984861964","https://openalex.org/W1985542494","https://openalex.org/W1988823654","https://openalex.org/W1996470295","https://openalex.org/W2002495914","https://openalex.org/W2002878333","https://openalex.org/W2006115758","https://openalex.org/W2007480814","https://openalex.org/W2012166422","https://openalex.org/W2016224818","https://openalex.org/W2016904398","https://openalex.org/W2024113281","https://openalex.org/W2027099095","https://openalex.org/W2028968728","https://openalex.org/W2030360665","https://openalex.org/W2031089158","https://openalex.org/W2033682986","https://openalex.org/W2040560600","https://openalex.org/W2045725248","https://openalex.org/W2048978941","https://openalex.org/W2053211604","https://openalex.org/W2057107055","https://openalex.org/W2061047348","https://openalex.org/W2063062586","https://openalex.org/W2063664389","https://openalex.org/W2069312946","https://openalex.org/W2070616628","https://openalex.org/W2071761679","https://openalex.org/W2080919590","https://openalex.org/W2087110226","https://openalex.org/W2087401860","https://openalex.org/W2087475574","https://openalex.org/W2089792993","https://openalex.org/W2095435531","https://openalex.org/W2098659547","https://openalex.org/W2104199954","https://openalex.org/W2108201412","https://openalex.org/W2110440735","https://openalex.org/W2117841889","https://openalex.org/W2126943932","https://openalex.org/W2129327954","https://openalex.org/W2131778751","https://openalex.org/W2133751949","https://openalex.org/W2135093278","https://openalex.org/W2140471733","https://openalex.org/W2142541950","https://openalex.org/W2150785606","https://openalex.org/W2156667412","https://openalex.org/W2159024307","https://openalex.org/W2159979956","https://openalex.org/W2166811005","https://openalex.org/W2324992364","https://openalex.org/W6642056941","https://openalex.org/W6647405518","https://openalex.org/W6681016249"],"related_works":["https://openalex.org/W4247333443","https://openalex.org/W3177459385","https://openalex.org/W1564388687","https://openalex.org/W7095162642","https://openalex.org/W2387825924","https://openalex.org/W2148970133","https://openalex.org/W3086109635","https://openalex.org/W1987296896","https://openalex.org/W2027069379","https://openalex.org/W2104199954"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}