{"id":"https://openalex.org/W2076484531","doi":"https://doi.org/10.1056/nejm197007022830106","title":"Biologic Concomitants of Alcoholism","display_name":"Biologic Concomitants of Alcoholism","publication_year":1970,"publication_date":"1970-07-02","ids":{"openalex":"https://openalex.org/W2076484531","doi":"https://doi.org/10.1056/nejm197007022830106","mag":"2076484531","pmid":"https://pubmed.ncbi.nlm.nih.gov/4911563"},"language":"en","primary_location":{"id":"doi:10.1056/nejm197007022830106","doi":"https://doi.org/10.1056/nejm197007022830106","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197007022830106","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2076484531"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108552073","display_name":"Jack H. Mendelson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jack H. Mendelson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108552073"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4286,"has_fulltext":false,"cited_by_count":177,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"283","issue":"1","first_page":"24","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.45339998602867126,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12494","display_name":"Alcoholism and Thiamine Deficiency","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":1.0},{"id":"https://openalex.org/keywords/alcohol-related-disorders","display_name":"alcohol-related disorders","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C169081014","wikidata":"https://www.wikidata.org/wiki/Q45996","display_name":"Mysticism","level":2,"score":0.7182571887969971},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6262074112892151},{"id":"https://openalex.org/C2777855551","wikidata":"https://www.wikidata.org/wiki/Q12310021","display_name":"Subject (documents)","level":2,"score":0.5484288334846497},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.40677568316459656},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.37354525923728943},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.33119136095046997},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2723684310913086},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.08285939693450928},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C27206212","wikidata":"https://www.wikidata.org/wiki/Q34178","display_name":"Theology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000079","descriptor_name":"Acetaldehyde","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000079","descriptor_name":"Acetaldehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000435","descriptor_name":"Alcoholic Intoxication","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003065","descriptor_name":"Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm197007022830106","doi":"https://doi.org/10.1056/nejm197007022830106","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197007022830106","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:4911563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4911563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":138,"referenced_works":["https://openalex.org/W77655761","https://openalex.org/W104801094","https://openalex.org/W212196354","https://openalex.org/W622609157","https://openalex.org/W651768918","https://openalex.org/W1524688136","https://openalex.org/W1527218533","https://openalex.org/W1545624024","https://openalex.org/W1558532288","https://openalex.org/W1820076867","https://openalex.org/W1844842999","https://openalex.org/W1886488942","https://openalex.org/W1892264246","https://openalex.org/W1904529132","https://openalex.org/W1917957806","https://openalex.org/W1935569230","https://openalex.org/W1940656453","https://openalex.org/W1954492637","https://openalex.org/W1969466328","https://openalex.org/W1969682035","https://openalex.org/W1973144136","https://openalex.org/W1973523390","https://openalex.org/W1973766659","https://openalex.org/W1974439447","https://openalex.org/W1978864215","https://openalex.org/W1979388850","https://openalex.org/W1979851190","https://openalex.org/W1980628368","https://openalex.org/W1981196498","https://openalex.org/W1983031892","https://openalex.org/W1985346619","https://openalex.org/W1989756401","https://openalex.org/W1990728049","https://openalex.org/W1995113130","https://openalex.org/W1995363240","https://openalex.org/W1996651364","https://openalex.org/W1997748517","https://openalex.org/W2000133993","https://openalex.org/W2002860396","https://openalex.org/W2003315903","https://openalex.org/W2003396104","https://openalex.org/W2004391347","https://openalex.org/W2006434628","https://openalex.org/W2007329835","https://openalex.org/W2008016770","https://openalex.org/W2008627044","https://openalex.org/W2009453265","https://openalex.org/W2011203792","https://openalex.org/W2012921876","https://openalex.org/W2018466510","https://openalex.org/W2020267550","https://openalex.org/W2021531290","https://openalex.org/W2024921948","https://openalex.org/W2026445426","https://openalex.org/W2027383504","https://openalex.org/W2030463249","https://openalex.org/W2033105076","https://openalex.org/W2036988635","https://openalex.org/W2038861520","https://openalex.org/W2045295454","https://openalex.org/W2046993119","https://openalex.org/W2049646574","https://openalex.org/W2051214047","https://openalex.org/W2053589048","https://openalex.org/W2058977565","https://openalex.org/W2062236047","https://openalex.org/W2062777325","https://openalex.org/W2064894869","https://openalex.org/W2067946758","https://openalex.org/W2067987953","https://openalex.org/W2068741751","https://openalex.org/W2069007287","https://openalex.org/W2069553395","https://openalex.org/W2070089899","https://openalex.org/W2071274265","https://openalex.org/W2072751464","https://openalex.org/W2074656525","https://openalex.org/W2077271472","https://openalex.org/W2077669642","https://openalex.org/W2078208528","https://openalex.org/W2082465554","https://openalex.org/W2085556285","https://openalex.org/W2086389322","https://openalex.org/W2087842705","https://openalex.org/W2097088407","https://openalex.org/W2109752014","https://openalex.org/W2118296699","https://openalex.org/W2121088692","https://openalex.org/W2134149452","https://openalex.org/W2143195771","https://openalex.org/W2143782306","https://openalex.org/W2144465325","https://openalex.org/W2148298238","https://openalex.org/W2154084570","https://openalex.org/W2172265933","https://openalex.org/W2177044365","https://openalex.org/W2234838718","https://openalex.org/W2235883004","https://openalex.org/W2241507950","https://openalex.org/W2242030295","https://openalex.org/W2245976523","https://openalex.org/W2249669855","https://openalex.org/W2253161376","https://openalex.org/W2265094805","https://openalex.org/W2269153198","https://openalex.org/W2269899168","https://openalex.org/W2271059470","https://openalex.org/W2295366206","https://openalex.org/W2313557472","https://openalex.org/W2315306185","https://openalex.org/W2318333038","https://openalex.org/W2320840617","https://openalex.org/W2327574812","https://openalex.org/W2328865616","https://openalex.org/W2331983223","https://openalex.org/W2335701682","https://openalex.org/W2339670185","https://openalex.org/W2397787235","https://openalex.org/W2408772619","https://openalex.org/W2410689561","https://openalex.org/W2411000230","https://openalex.org/W2411477948","https://openalex.org/W2415882252","https://openalex.org/W2417122939","https://openalex.org/W2418260399","https://openalex.org/W2419002997","https://openalex.org/W2419175685","https://openalex.org/W2435472205","https://openalex.org/W2474084520","https://openalex.org/W2488944319","https://openalex.org/W2598391796","https://openalex.org/W2766633284","https://openalex.org/W3017446616","https://openalex.org/W4252584771","https://openalex.org/W4321318588","https://openalex.org/W4365786839","https://openalex.org/W4366064369","https://openalex.org/W4406990190"],"related_works":["https://openalex.org/W1999685451","https://openalex.org/W1968151551","https://openalex.org/W2401890346","https://openalex.org/W2398549066","https://openalex.org/W2133387003","https://openalex.org/W4246389641","https://openalex.org/W2053979257","https://openalex.org/W2404612539","https://openalex.org/W2001038561","https://openalex.org/W1534704406"],"abstract_inverted_index":{"\"THE":[0],"sway":[1,26],"of":[2,21,31,50],"alcohol":[3],"over":[4],"mankind,\"":[5],"according":[6],"to":[7,13,16,37],"William":[8],"James,":[9],"\"is":[10],"unquestionably":[11],"due":[12],"its":[14],"power":[15],"stimulate":[17],"the":[18,95],"mystical":[19,25],"facilities":[20],"human":[22],"nature.\"2":[23],"But":[24],"represents":[27],"only":[28],"one":[29],"portion":[30],"a":[32,58,73,92],"continuum":[33],"that":[34],"may":[35],"extend":[36],"severe":[38],"biologic":[39],"and":[40,76],"social":[41],"impairment":[42],"for":[43,85],"certain":[44],"unfortunate":[45],"victims.":[46],"The":[47],"scientific":[48],"study":[49],"these":[51],"heterogeneous":[52],"persons,":[53],"designated":[54],"as":[55,72,81],"\"alcoholics,\"":[56],"is":[57],"relatively":[59],"new":[60],"undertaking":[61],"in":[62,91],"biomedical":[63],"science.":[64],"Until":[65],"recently,":[66],"most":[67],"alcohol-related":[68],"problems":[69],"were":[70],"perceived":[71],"moral":[74],"issue,":[75],"alcoholism":[77],"was":[78],"not":[79],"regarded":[80],"an":[82],"appropriate":[83],"subject":[84],"either":[86],"laboratory":[87],"or":[88],"clinical":[89],"investigation.Yet,":[90],"curious":[93],"way,":[94],"early":[96],"investigative":[97],"work":[98],".":[99,100,101]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}