{"id":"https://openalex.org/W2076469931","doi":"https://doi.org/10.1016/j.neurobiolaging.2007.01.013","title":"Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans","display_name":"Manipulation of serotonin signal suppresses early phase of behavioral aging in Caenorhabditis elegans","publication_year":2007,"publication_date":"2007-03-02","ids":{"openalex":"https://openalex.org/W2076469931","doi":"https://doi.org/10.1016/j.neurobiolaging.2007.01.013","mag":"2076469931","pmid":"https://pubmed.ncbi.nlm.nih.gov/17336425"},"language":"en","primary_location":{"id":"doi:10.1016/j.neurobiolaging.2007.01.013","doi":"https://doi.org/10.1016/j.neurobiolaging.2007.01.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neurobiolaging.2007.01.013","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086415350","display_name":"Hana Murakami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hana Murakami","raw_affiliation_strings":["Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 580 S Preston Street, BaxterII, RM102, Louisville, KY 40202, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 580 S Preston Street, BaxterII, RM102, Louisville, KY 40202, United States","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079194381","display_name":"Karalee Bessinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karalee Bessinger","raw_affiliation_strings":["Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 580 S Preston Street, BaxterII, RM102, Louisville, KY 40202, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 580 S Preston Street, BaxterII, RM102, Louisville, KY 40202, United States","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072415149","display_name":"Jason L. Hellmann","orcid":"https://orcid.org/0000-0001-9573-6843","observed_orcids":["https://orcid.org/0000-0001-9573-6843"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Hellmann","raw_affiliation_strings":["Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 580 S Preston Street, BaxterII, RM102, Louisville, KY 40202, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 580 S Preston Street, BaxterII, RM102, Louisville, KY 40202, United States","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070135323","display_name":"Shin Murakami","orcid":"https://orcid.org/0000-0001-8806-0611","observed_orcids":["https://orcid.org/0000-0001-8806-0611"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shin Murakami","raw_affiliation_strings":["Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 580 S Preston Street, BaxterII, RM102, Louisville, KY 40202, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 580 S Preston Street, BaxterII, RM102, Louisville, KY 40202, United States","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070135323"],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":null,"fwci":0.9226,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.72337278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"29","issue":"7","first_page":"1093","last_page":"1100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-signaling","display_name":"serotonin signaling","score":0.7329999804496765},{"id":"https://openalex.org/keywords/aging-behavior","display_name":"aging behavior","score":0.9860000014305115},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.531000018119812},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.8569999933242798},{"id":"https://openalex.org/keywords/serotonin-receptors","display_name":"serotonin receptors","score":0.6209999918937683},{"id":"https://openalex.org/keywords/tph-1","display_name":"tph-1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/serotonin-synthesis","display_name":"serotonin synthesis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/serotonin-receptor-antagonists","display_name":"serotonin antagonists","score":0.7570000290870667},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.7743632793426514},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.7103793621063232},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5747600793838501},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5635625720024109},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5195303559303284},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5065149068832397},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.4480677545070648},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.399586021900177},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3718046247959137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3543708920478821},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2777711749076843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12802910804748535},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12749826908111572},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11012479662895203},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neurobiolaging.2007.01.013","doi":"https://doi.org/10.1016/j.neurobiolaging.2007.01.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neurobiolaging.2007.01.013","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"},{"id":"pmid:17336425","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17336425","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of aging","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306354","display_name":"Gheens Foundation","ror":"https://ror.org/048h18548"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W187576616","https://openalex.org/W1948927501","https://openalex.org/W1975037912","https://openalex.org/W1977925481","https://openalex.org/W1989157146","https://openalex.org/W1997172163","https://openalex.org/W2015573703","https://openalex.org/W2027858580","https://openalex.org/W2030155143","https://openalex.org/W2034734284","https://openalex.org/W2049636331","https://openalex.org/W2053085388","https://openalex.org/W2056118767","https://openalex.org/W2058127437","https://openalex.org/W2058767256","https://openalex.org/W2063571630","https://openalex.org/W2067969645","https://openalex.org/W2078804850","https://openalex.org/W2080274663","https://openalex.org/W2102701326","https://openalex.org/W2108024591","https://openalex.org/W2113130542","https://openalex.org/W2119620429","https://openalex.org/W2122112571","https://openalex.org/W2127052819","https://openalex.org/W2137607459","https://openalex.org/W2151765253","https://openalex.org/W2157825253","https://openalex.org/W2159122349","https://openalex.org/W2164013248","https://openalex.org/W2171776652","https://openalex.org/W2188777107"],"related_works":["https://openalex.org/W1995759317","https://openalex.org/W2113130542","https://openalex.org/W4404473732","https://openalex.org/W2406004655","https://openalex.org/W2165536976","https://openalex.org/W2057119740","https://openalex.org/W2065599141","https://openalex.org/W4248362784","https://openalex.org/W2151199520","https://openalex.org/W2108024591"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
