{"id":"https://openalex.org/W2076366012","doi":"https://doi.org/10.1016/0041-008x(88)90251-7","title":"Modulation of diethylnitrosamine-induced hepatocarcinogenesis and O6-ethylguanine formation in rainbow trout by indole-3-carbinol, \u03b2-naphthoflavone, and Aroclor 1254","display_name":"Modulation of diethylnitrosamine-induced hepatocarcinogenesis and O6-ethylguanine formation in rainbow trout by indole-3-carbinol, \u03b2-naphthoflavone, and Aroclor 1254","publication_year":1988,"publication_date":"1988-10-01","ids":{"openalex":"https://openalex.org/W2076366012","doi":"https://doi.org/10.1016/0041-008x(88)90251-7","mag":"2076366012","pmid":"https://pubmed.ncbi.nlm.nih.gov/3142102"},"language":"en","primary_location":{"id":"doi:10.1016/0041-008x(88)90251-7","doi":"https://doi.org/10.1016/0041-008x(88)90251-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0041-008x(88)90251-7","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113490535","display_name":"Arthur T. Fong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arthur T. Fong","raw_affiliation_strings":["Department of Food Science and Technology, Oregon State University, Corvallis 97331","Department of Food Science and Technology Oregon State University  Corvallis Oregon 97331 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Technology, Oregon State University, Corvallis 97331","institution_ids":["https://openalex.org/I131249849"]},{"raw_affiliation_string":"Department of Food Science and Technology Oregon State University  Corvallis Oregon 97331 USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108360452","display_name":"Jerry D. Hendricks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry D. Hendricks","raw_affiliation_strings":["Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331 USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082820494","display_name":"Roderick H. Dashwood","orcid":"https://orcid.org/0000-0003-0351-4034","observed_orcids":["https://orcid.org/0000-0003-0351-4034"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roderick H. Dashwood","raw_affiliation_strings":["Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331 USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048582082","display_name":"Samina Van Winkle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samina Van Winkle","raw_affiliation_strings":["Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331 USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065369023","display_name":"Brian C. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian C. Lee","raw_affiliation_strings":["Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331 USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112715943","display_name":"George Bailey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George S. Bailey","raw_affiliation_strings":["Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331 USA","institution_ids":["https://openalex.org/I131249849"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113490535"],"corresponding_institution_ids":["https://openalex.org/I131249849"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.9537,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.7332391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"96","issue":"1","first_page":"93","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diethylnitrosamine","display_name":"diethylnitrosamine","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/indole-3-carbinol","display_name":"indole-3-carbinol","score":0.8930000066757202},{"id":"https://openalex.org/keywords/beta-naphthoflavone","display_name":"beta-naphthoflavone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/aroclor-1254","display_name":"Aroclor 1254","score":0.9990000128746033},{"id":"https://openalex.org/keywords/o6-ethylguanine","display_name":"O6-ethylguanine","score":0.9399999976158142},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.6679999828338623},{"id":"https://openalex.org/keywords/liver-tumors","display_name":"liver tumors","score":0.7820000052452087},{"id":"https://openalex.org/keywords/rainbow-trout","display_name":"rainbow trout","score":0.925000011920929},{"id":"https://openalex.org/keywords/carcinogenesis-initiation","display_name":"carcinogenesis initiation","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7546470165252686},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6068814396858215},{"id":"https://openalex.org/C192527728","wikidata":"https://www.wikidata.org/wiki/Q1465700","display_name":"Indole test","level":2,"score":0.5123685598373413},{"id":"https://openalex.org/C2779107934","wikidata":"https://www.wikidata.org/wiki/Q4774590","display_name":"Anticarcinogen","level":4,"score":0.512131929397583},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.42276573181152344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4194459021091461},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21518239378929138},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07635346055030823},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001140","descriptor_name":"Aroclors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001571","descriptor_name":"Benzoflavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004052","descriptor_name":"Diethylnitrosamine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D011078","descriptor_name":"Polychlorinated Biphenyls","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012487","descriptor_name":"Salmonidae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014337","descriptor_name":"Trout","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019324","descriptor_name":"beta-Naphthoflavone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020111","descriptor_name":"Chlorodiphenyl (54% Chlorine)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0041-008x(88)90251-7","doi":"https://doi.org/10.1016/0041-008x(88)90251-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0041-008x(88)90251-7","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},{"id":"pmid:3142102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3142102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and applied pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1497661912","display_name":null,"funder_award_id":"ES-00-210","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G311403707","display_name":null,"funder_award_id":"CA-34732","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7890333585","display_name":null,"funder_award_id":"CA-39398","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1556673553","https://openalex.org/W1561841146","https://openalex.org/W1703620111","https://openalex.org/W1892296408","https://openalex.org/W1984330114","https://openalex.org/W1986538794","https://openalex.org/W1989040314","https://openalex.org/W1990044454","https://openalex.org/W1993378176","https://openalex.org/W1996201492","https://openalex.org/W1997718808","https://openalex.org/W2002695788","https://openalex.org/W2006108963","https://openalex.org/W2012143213","https://openalex.org/W2026757973","https://openalex.org/W2038124483","https://openalex.org/W2059999359","https://openalex.org/W2065840609","https://openalex.org/W2066199073","https://openalex.org/W2069890729","https://openalex.org/W2072703667","https://openalex.org/W2087897146","https://openalex.org/W2088533678","https://openalex.org/W2091281572","https://openalex.org/W2094662521","https://openalex.org/W2102374465","https://openalex.org/W2137065034","https://openalex.org/W2138366440","https://openalex.org/W2147485671","https://openalex.org/W2340676292","https://openalex.org/W2437412526","https://openalex.org/W4238001956","https://openalex.org/W6649374194","https://openalex.org/W6666744056","https://openalex.org/W6667720435","https://openalex.org/W6675193747","https://openalex.org/W7135369427"],"related_works":["https://openalex.org/W2012143213","https://openalex.org/W1989040314","https://openalex.org/W2081668720","https://openalex.org/W2158458688","https://openalex.org/W2017022701","https://openalex.org/W2041620233","https://openalex.org/W265961713","https://openalex.org/W26801062","https://openalex.org/W2095597132","https://openalex.org/W2341366200"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}