{"id":"https://openalex.org/W2076354865","doi":"https://doi.org/10.1126/science.715455","title":"\u03b2-Endorphin Is Associated with Overeating in Genetically Obese Mice ( ob / ob ) and Rats ( fa / fa )","display_name":"\u03b2-Endorphin Is Associated with Overeating in Genetically Obese Mice ( ob / ob ) and Rats ( fa / fa )","publication_year":1978,"publication_date":"1978-12-01","ids":{"openalex":"https://openalex.org/W2076354865","doi":"https://doi.org/10.1126/science.715455","mag":"2076354865","pmid":"https://pubmed.ncbi.nlm.nih.gov/715455"},"language":"en","primary_location":{"id":"doi:10.1126/science.715455","doi":"https://doi.org/10.1126/science.715455","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.715455","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112039705","display_name":"David L. Margules","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Margules","raw_affiliation_strings":["Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079570187","display_name":"Beatriz Moisset","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beatriz Moisset","raw_affiliation_strings":["Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057953393","display_name":"Michael J. Lewis","orcid":"https://orcid.org/0000-0003-3879-2026","observed_orcids":["https://orcid.org/0000-0003-3879-2026"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Lewis","raw_affiliation_strings":["Department of Psychology, Tufts University, Medford, Massachusetts 02155"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Tufts University, Medford, Massachusetts 02155","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111711976","display_name":"Haruo Shibuya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haruo Shibuya","raw_affiliation_strings":["Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021838201","display_name":"Candace B. Pert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Candace B. Pert","raw_affiliation_strings":["Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Biochemistry and Pharmacology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":24.9141,"has_fulltext":false,"cited_by_count":474,"citation_normalized_percentile":{"value":0.99944009,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"202","issue":"4371","first_page":"988","last_page":"991"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-endorphin","display_name":"beta-endorphin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/overeating","display_name":"overeating","score":0.984000027179718},{"id":"https://openalex.org/keywords/genetic-obesity","display_name":"genetic obesity","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.9750000238418579},{"id":"https://openalex.org/keywords/obese-zucker-rats","display_name":"Zucker fatty rats","score":0.9710000157356262},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.824999988079071},{"id":"https://openalex.org/keywords/opioid-antagonists","display_name":"opioid antagonists","score":0.765999972820282},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.8840000033378601},{"id":"https://openalex.org/keywords/plasma-beta-endorphin","display_name":"plasma beta-endorphin","score":0.7440000176429749},{"id":"https://openalex.org/keywords/leu-enkephalin","display_name":"leu-enkephalin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/appetite-regulation","display_name":"appetite regulation","score":0.5799999833106995},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2778792376","wikidata":"https://www.wikidata.org/wiki/Q331632","display_name":"Overeating","level":3,"score":0.9260973930358887},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8288204669952393},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8250402808189392},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.6734269857406616},{"id":"https://openalex.org/C2778140631","wikidata":"https://www.wikidata.org/wiki/Q2026938","display_name":"Opiate","level":3,"score":0.5428083539009094},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4850456118583679},{"id":"https://openalex.org/C2777557602","wikidata":"https://www.wikidata.org/wiki/Q2993328","display_name":"beta-Endorphin","level":2,"score":0.44176825881004333},{"id":"https://openalex.org/C2777803847","wikidata":"https://www.wikidata.org/wiki/Q325101","display_name":"Enkephalin","level":4,"score":0.41082438826560974},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3969627320766449},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.3694610595703125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30909767746925354},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.19350281357765198},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15678802132606506}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/science.715455","doi":"https://doi.org/10.1126/science.715455","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.715455","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:715455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/715455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1978-3141","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1978/2142","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1978","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1970132317","https://openalex.org/W1997973921","https://openalex.org/W1998835362","https://openalex.org/W2021678405","https://openalex.org/W2036455062","https://openalex.org/W2039382168","https://openalex.org/W2055753190","https://openalex.org/W2062144016","https://openalex.org/W2075811628","https://openalex.org/W2084881904","https://openalex.org/W2094355632","https://openalex.org/W2127784128","https://openalex.org/W2132759850","https://openalex.org/W2270012899","https://openalex.org/W2311743023","https://openalex.org/W2319488049"],"related_works":["https://openalex.org/W2243477611","https://openalex.org/W91105238","https://openalex.org/W7073858742","https://openalex.org/W7096376135","https://openalex.org/W2005283605","https://openalex.org/W1980878863","https://openalex.org/W2037487060","https://openalex.org/W1970886518","https://openalex.org/W2104956664","https://openalex.org/W1979732198"],"abstract_inverted_index":{"Small":[0],"doses":[1],"of":[2,20,31,40,46,66],"the":[3,21,29,37,41,64,67],"opiate":[4,24],"antagonist":[5],"naloxone":[6],"selectively":[7],"abolished":[8],"overeating":[9,68],"in":[10,28,36,63],"genetically":[11],"obese":[12,33,42],"mice":[13],"(ob/ob)":[14],"and":[15,35,48,69],"rats":[16],"(fa/fa).":[17],"Elevated":[18],"concentrations":[19],"naturally":[22],"occurring":[23],"beta-endorphin":[25,47,58],"were":[26,50],"found":[27],"pituitaries":[30],"both":[32],"species":[34],"blood":[38],"plasma":[39],"rats.":[43],"Brain":[44],"levels":[45],"Leu-enkephalin":[49],"unchanged.":[51],"These":[52],"data":[53],"suggest":[54],"that":[55],"excess":[56],"pituitary":[57],"may":[59],"play":[60],"a":[61],"role":[62],"development":[65],"obesity":[70],"syndrome.":[71]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}