{"id":"https://openalex.org/W2076284890","doi":"https://doi.org/10.1097/01.chi.0000237704.05143.bd","title":"Steady-State Clinical Pharmacokinetics of Bupropion Extended-Release in Youths","display_name":"Steady-State Clinical Pharmacokinetics of Bupropion Extended-Release in Youths","publication_year":2006,"publication_date":"2006-11-28","ids":{"openalex":"https://openalex.org/W2076284890","doi":"https://doi.org/10.1097/01.chi.0000237704.05143.bd","mag":"2076284890","pmid":"https://pubmed.ncbi.nlm.nih.gov/17135996"},"language":"en","primary_location":{"id":"doi:10.1097/01.chi.0000237704.05143.bd","doi":"https://doi.org/10.1097/01.chi.0000237704.05143.bd","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.chi.0000237704.05143.bd","pdf_url":null,"source":{"id":"https://openalex.org/S60711021","display_name":"Journal of the American Academy of Child & Adolescent Psychiatry","issn_l":"0890-8567","issn":["0890-8567","1527-5418"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Academy of Child & Adolescent Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082157334","display_name":"W. Burleson Daviss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. BURLESON DAVISS","raw_affiliation_strings":["Western Psychiatric Institute & Clinic, University of Pittsburgh, USA. davissw@uthscsa.edu","All of the authors were affiliated with Western Psychiatric Institute & Clinic and the University of Pittsburgh at the time of this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western Psychiatric Institute & Clinic, University of Pittsburgh, USA. davissw@uthscsa.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"All of the authors were affiliated with Western Psychiatric Institute & Clinic and the University of Pittsburgh at the time of this study","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110105730","display_name":"James M. Perel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JAMES M. PEREL","raw_affiliation_strings":["All of the authors were affiliated with Western Psychiatric Institute & Clinic and the University of Pittsburgh at the time of this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All of the authors were affiliated with Western Psychiatric Institute & Clinic and the University of Pittsburgh at the time of this study","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014163066","display_name":"Boris B. Birmaher","orcid":"https://orcid.org/0000-0001-9299-6519","observed_orcids":["https://orcid.org/0000-0001-9299-6519"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BORIS BIRMAHER","raw_affiliation_strings":["All of the authors were affiliated with Western Psychiatric Institute & Clinic and the University of Pittsburgh at the time of this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All of the authors were affiliated with Western Psychiatric Institute & Clinic and the University of Pittsburgh at the time of this study","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002551601","display_name":"George R. Rudolph","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GEORGE R. RUDOLPH","raw_affiliation_strings":["All of the authors were affiliated with Western Psychiatric Institute & Clinic and the University of Pittsburgh at the time of this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All of the authors were affiliated with Western Psychiatric Institute & Clinic and the University of Pittsburgh at the time of this study","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056483403","display_name":"Imad Melhem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"IMAD MELHEM","raw_affiliation_strings":["All of the authors were affiliated with Western Psychiatric Institute & Clinic and the University of Pittsburgh at the time of this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All of the authors were affiliated with Western Psychiatric Institute & Clinic and the University of Pittsburgh at the time of this study","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040996077","display_name":"David Axelson","orcid":"https://orcid.org/0000-0002-1348-0707","observed_orcids":["https://orcid.org/0000-0002-1348-0707"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAVID A. AXELSON","raw_affiliation_strings":["All of the authors were affiliated with Western Psychiatric Institute & Clinic and the University of Pittsburgh at the time of this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All of the authors were affiliated with Western Psychiatric Institute & Clinic and the University of Pittsburgh at the time of this study","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082847636","display_name":"David A. Brent","orcid":"https://orcid.org/0000-0002-5756-2157","observed_orcids":["https://orcid.org/0000-0002-5756-2157"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAVID A. BRENT","raw_affiliation_strings":["All of the authors were affiliated with Western Psychiatric Institute & Clinic and the University of Pittsburgh at the time of this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All of the authors were affiliated with Western Psychiatric Institute & Clinic and the University of Pittsburgh at the time of this study","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082157334"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":3710,"currency":"USD","value_usd":3710},"apc_paid":null,"fwci":0.9738,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.78350208,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"45","issue":"12","first_page":"1503","last_page":"1509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.8715999722480774,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.8715999722480774,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.053700000047683716,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.048500001430511475,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/steady-state-pharmacokinetics","display_name":"steady-state pharmacokinetics","score":0.800000011920929},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.8190000057220459},{"id":"https://openalex.org/keywords/hydroxybupropion","display_name":"hydroxybupropion","score":0.8489999771118164},{"id":"https://openalex.org/keywords/once-daily-dosing","display_name":"once-daily dosing","score":0.9610000252723694},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C2779908668","wikidata":"https://www.wikidata.org/wiki/Q834280","display_name":"Bupropion","level":3,"score":0.9896780848503113},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8101222515106201},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.7069073915481567},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.7012988924980164},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6313976645469666},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5271896123886108},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4327765703201294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28454768657684326},{"id":"https://openalex.org/C2777843972","wikidata":"https://www.wikidata.org/wiki/Q2462253","display_name":"Smoking cessation","level":2,"score":0.054894596338272095},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001289","descriptor_name":"Attention Deficit Disorder with Hyperactivity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016642","descriptor_name":"Bupropion","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016642","descriptor_name":"Bupropion","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D016642","descriptor_name":"Bupropion","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018687","descriptor_name":"Antidepressive Agents, Second-Generation","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018687","descriptor_name":"Antidepressive Agents, Second-Generation","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D018687","descriptor_name":"Antidepressive Agents, Second-Generation","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D065702","descriptor_name":"Cytochrome P-450 CYP2B6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.chi.0000237704.05143.bd","doi":"https://doi.org/10.1097/01.chi.0000237704.05143.bd","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.chi.0000237704.05143.bd","pdf_url":null,"source":{"id":"https://openalex.org/S60711021","display_name":"Journal of the American Academy of Child & Adolescent Psychiatry","issn_l":"0890-8567","issn":["0890-8567","1527-5418"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Academy of Child & Adolescent Psychiatry","raw_type":"journal-article"},{"id":"pmid:17135996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17135996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Academy of Child and Adolescent Psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4212514910","display_name":"Bupropion in Adolescents with Comorbid ADHD & Depression","funder_award_id":"K23MH065375","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8352170253","display_name":"General Clinical Research Center","funder_award_id":"M01RR000084","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G848691723","display_name":"ACISR - Early-Onset Mood & Anxiety Disorder","funder_award_id":"P30MH066371","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W17444517","https://openalex.org/W1553253964","https://openalex.org/W1983302342","https://openalex.org/W1985047196","https://openalex.org/W2001448102","https://openalex.org/W2019412823","https://openalex.org/W2033428561","https://openalex.org/W2047007452","https://openalex.org/W2049710132","https://openalex.org/W2050912266","https://openalex.org/W2064911608","https://openalex.org/W2089213527","https://openalex.org/W2116058617","https://openalex.org/W2129954214","https://openalex.org/W2131966035","https://openalex.org/W2133582633","https://openalex.org/W2161209070","https://openalex.org/W2162060590","https://openalex.org/W2165995063","https://openalex.org/W2338977821","https://openalex.org/W2491374885","https://openalex.org/W2724146860","https://openalex.org/W6684161169"],"related_works":["https://openalex.org/W2089213527","https://openalex.org/W1978581647","https://openalex.org/W2061738516","https://openalex.org/W2903024464","https://openalex.org/W1977578038","https://openalex.org/W2064911608","https://openalex.org/W2051778796","https://openalex.org/W2045364643","https://openalex.org/W1997066747","https://openalex.org/W1978926017"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}