{"id":"https://openalex.org/W2076217008","doi":"https://doi.org/10.1128/aac.36.6.1230","title":"Practical computer-assisted dosing for aminoglycoside antibiotics","display_name":"Practical computer-assisted dosing for aminoglycoside antibiotics","publication_year":1992,"publication_date":"1992-06-01","ids":{"openalex":"https://openalex.org/W2076217008","doi":"https://doi.org/10.1128/aac.36.6.1230","mag":"2076217008","pmid":"https://pubmed.ncbi.nlm.nih.gov/1416822","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/190323"},"language":"en","primary_location":{"id":"doi:10.1128/aac.36.6.1230","doi":"https://doi.org/10.1128/aac.36.6.1230","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.36.6.1230","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/190323","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040777053","display_name":"Leslie Andrew Lenert","orcid":"https://orcid.org/0000-0002-9680-5094","observed_orcids":["https://orcid.org/0000-0002-9680-5094"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L A Lenert","raw_affiliation_strings":["Division Clinical Pharmacology, Stanford University Medical Center, Stanford University, California 94305-5113"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division Clinical Pharmacology, Stanford University Medical Center, Stanford University, California 94305-5113","institution_ids":["https://openalex.org/I4210137306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032130942","display_name":"Heidrun Klostermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Klostermann","raw_affiliation_strings":["Division Clinical Pharmacology, Stanford University Medical Center, Stanford University, California 94305-5113"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division Clinical Pharmacology, Stanford University Medical Center, Stanford University, California 94305-5113","institution_ids":["https://openalex.org/I4210137306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037567098","display_name":"Robert W. Coleman","orcid":"https://orcid.org/0000-0002-5872-2909","observed_orcids":["https://orcid.org/0000-0002-5872-2909"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R W Coleman","raw_affiliation_strings":["Division Clinical Pharmacology, Stanford University Medical Center, Stanford University, California 94305-5113"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division Clinical Pharmacology, Stanford University Medical Center, Stanford University, California 94305-5113","institution_ids":["https://openalex.org/I4210137306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015676344","display_name":"Jon D. Lurie","orcid":"https://orcid.org/0000-0001-5672-7725","observed_orcids":["https://orcid.org/0000-0001-5672-7725"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Lurie","raw_affiliation_strings":["Division Clinical Pharmacology, Stanford University Medical Center, Stanford University, California 94305-5113"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division Clinical Pharmacology, Stanford University Medical Center, Stanford University, California 94305-5113","institution_ids":["https://openalex.org/I4210137306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088392350","display_name":"Terrence F. Blaschke","orcid":"https://orcid.org/0000-0001-5307-2620","observed_orcids":["https://orcid.org/0000-0001-5307-2620"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T F Blaschke","raw_affiliation_strings":["Division Clinical Pharmacology, Stanford University Medical Center, Stanford University, California 94305-5113"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division Clinical Pharmacology, Stanford University Medical Center, Stanford University, California 94305-5113","institution_ids":["https://openalex.org/I4210137306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210137306"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.16113371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"36","issue":"6","first_page":"1230","last_page":"1235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aminoglycosides","display_name":"aminoglycosides","score":0.9350000023841858},{"id":"https://openalex.org/keywords/expert-systems","display_name":"expert systems","score":0.796999990940094},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.7630000114440918},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.5759999752044678},{"id":"https://openalex.org/keywords/drug-concentration-prediction","display_name":"drug concentration prediction","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.9498437643051147},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6047773957252502},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.5474052429199219},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.539499044418335},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40232905745506287},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4007505178451538},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.342481791973114},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27849799394607544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000617","descriptor_name":"Aminoglycosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004360","descriptor_name":"Drug Therapy, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/aac.36.6.1230","doi":"https://doi.org/10.1128/aac.36.6.1230","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.36.6.1230","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:190323","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/190323","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:1416822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1416822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:190323","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/190323","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6400147774","display_name":null,"funder_award_id":"H00028-01A1","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320310505","display_name":"Agency for Health Care Policy and Research","ror":"https://ror.org/03jmfdf59"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W19069773","https://openalex.org/W97420631","https://openalex.org/W1533954825","https://openalex.org/W1986503750","https://openalex.org/W1986598889","https://openalex.org/W1987417739","https://openalex.org/W1993512375","https://openalex.org/W1995504484","https://openalex.org/W2005751978","https://openalex.org/W2008449095","https://openalex.org/W2028520031","https://openalex.org/W2029376301","https://openalex.org/W2031339668","https://openalex.org/W2040282320","https://openalex.org/W2042161966","https://openalex.org/W2044106515","https://openalex.org/W2053234987","https://openalex.org/W2064602929","https://openalex.org/W2071850049","https://openalex.org/W2075883638","https://openalex.org/W2086631880","https://openalex.org/W2110293626","https://openalex.org/W2133108330","https://openalex.org/W2283022810","https://openalex.org/W2297760542","https://openalex.org/W2337930196","https://openalex.org/W2399351092","https://openalex.org/W2411133428","https://openalex.org/W2417538674","https://openalex.org/W3023766558","https://openalex.org/W4234044744","https://openalex.org/W4240693037"],"related_works":["https://openalex.org/W7100680839","https://openalex.org/W2321023608","https://openalex.org/W1885604522","https://openalex.org/W2016632367","https://openalex.org/W2151947780","https://openalex.org/W2292207290","https://openalex.org/W2784031172","https://openalex.org/W2436802377","https://openalex.org/W179564809","https://openalex.org/W2414649270"],"abstract_inverted_index":{"In":[0,18,168],"principle,":[1],"computer-assisted":[2],"individualization":[3,45],"of":[4,10,46,48,88,94,123,138,143,152,161,165,172,174,194,232],"antibiotic":[5],"dosing":[6,16,47,77,148,223],"offers":[7],"the":[8,21,136,146,153,175,182,187,195],"prospect":[9],"better":[11],"patient":[12],"outcomes":[13],"through":[14],"improved":[15],"precision.":[17],"practice,":[19],"however,":[20],"expertise":[22],"in":[23,53,58,98,120,131,135,203],"pharmacokinetics":[24,59],"required":[25],"to":[26,56,225],"operate":[27],"these":[28],"programs":[29,78,224],"has":[30],"precluded":[31],"their":[32],"use":[33],"by":[34,110],"most":[35],"physicians":[36],"and":[37,100,150],"pharmacists.":[38],"We":[39,106],"developed":[40],"a":[41,85,115,121,169],"computer":[42],"program":[43,63,81],"for":[44,71,102,201,230],"aminoglycoside":[49],"antibiotics":[50],"under":[51],"conditions":[52],"which":[54],"access":[55],"experts":[57,185],"is":[60,64,163],"impractical.":[61],"The":[62,80,141,212],"accurate,":[65],"yet":[66],"it":[67,113],"requires":[68],"less":[69,206,209],"effort":[70],"data":[72],"collection":[73],"than":[74,207,210],"previous":[75],"drug":[76,96,104,139],"did.":[79],"generates":[82],"advice":[83],"on":[84],"broad":[86],"spectrum":[87],"topics,":[89],"including":[90],"dose":[91],"adjustment,":[92],"interpretation":[93],"measured":[95],"concentrations":[97],"blood,":[99],"recommendations":[101,149,189,229],"monitoring":[103],"concentrations.":[105,140],"tested":[107],"its":[108],"performance":[109],"prospectively":[111],"comparing":[112],"with":[114,178,221],"clinical":[116,228],"pharmacokinetic":[117,222],"consultation":[118,154,196],"service":[119,155,197],"series":[122],"78":[124],"consecutive":[125],"patients.":[126],"There":[127],"were":[128],"no":[129],"differences":[130],"accuracy":[132],"or":[133],"bias":[134],"prediction":[137],"rate":[142,160],"agreement":[144,162],"between":[145],"program's":[147,188],"those":[151,193],"was":[156],"67":[157],"percent.":[158],"This":[159],"typical":[164],"interexpert":[166],"variation.":[167],"stratified":[170],"set":[171],"24":[173],"41":[176],"instances":[177],"significant":[179],"disagreement":[180],"regarding":[181],"recommended":[183],"dose,":[184],"ranked":[186],"as":[190,192],"highly":[191],"(95%":[198],"confidence":[199],"interval":[200],"difference":[202],"rank,":[204],"-0.30":[205],"chi":[208],"0.47).":[211],"results":[213],"suggest":[214],"that":[215],"expert":[216],"systems":[217],"can":[218],"be":[219],"coupled":[220],"deliver":[226],"high-quality":[227],"administration":[231],"antimicrobial":[233],"agents.":[234]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
