{"id":"https://openalex.org/W2076201978","doi":"https://doi.org/10.1097/qai.0b013e3181f25574","title":"Evolution of CCR5 Antagonist Resistance in an HIV-1 Subtype C Clinical Isolate","display_name":"Evolution of CCR5 Antagonist Resistance in an HIV-1 Subtype C Clinical Isolate","publication_year":2010,"publication_date":"2010-09-19","ids":{"openalex":"https://openalex.org/W2076201978","doi":"https://doi.org/10.1097/qai.0b013e3181f25574","mag":"2076201978","pmid":"https://pubmed.ncbi.nlm.nih.gov/20856130","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3070184"},"language":"en","primary_location":{"id":"doi:10.1097/qai.0b013e3181f25574","doi":"https://doi.org/10.1097/qai.0b013e3181f25574","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qai.0b013e3181f25574","pdf_url":null,"source":{"id":"https://openalex.org/S157460402","display_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","issn_l":"1525-4135","issn":["1525-4135","1944-7884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3070184","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004908163","display_name":"Timothy J. Henrich","orcid":"https://orcid.org/0000-0002-6684-0622","observed_orcids":["https://orcid.org/0000-0002-6684-0622"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy J Henrich","raw_affiliation_strings":["Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA","Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053867160","display_name":"Athe M. N. Tsibris","orcid":"https://orcid.org/0000-0002-2681-3216","observed_orcids":["https://orcid.org/0000-0002-2681-3216"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Athe M N Tsibris","raw_affiliation_strings":["Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046276717","display_name":"Nicolas R. P. Lewine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas R P Lewine","raw_affiliation_strings":["Harvard University, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University, Cambridge, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ioannis Konstantinidis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ioannis Konstantinidis","raw_affiliation_strings":["Harvard University, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University, Cambridge, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013441943","display_name":"Kay E. Leopold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kay E Leopold","raw_affiliation_strings":["Harvard University, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University, Cambridge, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041459494","display_name":"Manish Sagar","orcid":"https://orcid.org/0000-0001-9803-6594","observed_orcids":["https://orcid.org/0000-0001-9803-6594"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Manish Sagar","raw_affiliation_strings":["Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058715015","display_name":"Daniel R. Kuritzkes","orcid":"https://orcid.org/0000-0001-6196-5883","observed_orcids":["https://orcid.org/0000-0001-6196-5883"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel R Kuritzkes","raw_affiliation_strings":["Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004908163","https://openalex.org/A5041459494","https://openalex.org/A5058715015"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":2.2725,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.8700795,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"55","issue":"4","first_page":"420","last_page":"427"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vicriviroc","display_name":"vicriviroc","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hiv-1-subtype-c","display_name":"HIV-1 subtype C","score":0.9639999866485596},{"id":"https://openalex.org/keywords/maraviroc","display_name":"maraviroc","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tak-779","display_name":"TAK-779","score":0.9729999899864197},{"id":"https://openalex.org/keywords/drug-resistance-evolution","display_name":"drug resistance evolution","score":0.6340000033378601},{"id":"https://openalex.org/keywords/site-directed-mutants","display_name":"site-directed mutants","score":0.7049999833106995},{"id":"https://openalex.org/keywords/ccr5-coreceptor","display_name":"CCR5 coreceptor","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C37044404","wikidata":"https://www.wikidata.org/wiki/Q5009692","display_name":"CCR5 receptor antagonist","level":5,"score":0.9353283643722534},{"id":"https://openalex.org/C2778899366","wikidata":"https://www.wikidata.org/wiki/Q421369","display_name":"Maraviroc","level":3,"score":0.7136098146438599},{"id":"https://openalex.org/C2779921545","wikidata":"https://www.wikidata.org/wiki/Q12085358","display_name":"V3 loop","level":4,"score":0.6842952966690063},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6211919784545898},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5890094041824341},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5722400546073914},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5579963326454163},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5230392217636108},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47847315669059753},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4619733393192291},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42814257740974426},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.34384119510650635},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2395457625389099},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1660500466823578},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.13095557689666748},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09739765524864197},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.05490005016326904},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077592","descriptor_name":"Maraviroc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000644","descriptor_name":"Quaternary Ammonium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003510","descriptor_name":"Cyclohexanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D065100","descriptor_name":"CCR5 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/qai.0b013e3181f25574","doi":"https://doi.org/10.1097/qai.0b013e3181f25574","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qai.0b013e3181f25574","pdf_url":null,"source":{"id":"https://openalex.org/S157460402","display_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","issn_l":"1525-4135","issn":["1525-4135","1944-7884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","raw_type":"journal-article"},{"id":"pmid:20856130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20856130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of acquired immune deficiency syndromes (1999)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3070184","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3070184","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Acquir Immune Defic Syndr","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3070184","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3070184","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Acquir Immune Defic Syndr","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1725631459","display_name":null,"funder_award_id":"AI07387-19","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1818537372","display_name":"HIV-1 Therapeutics and Drug Resistance","funder_award_id":"K24RR016482","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G263052797","display_name":"Dynamic HIV-1 Escape from CCR5 Antagonism in vito","funder_award_id":"K08AI081547","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4608637270","display_name":null,"funder_award_id":"R37 AI553537","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5984284208","display_name":"Genotypic and Phenotypic Characterization of Heterosexually Transmitted HIV-1","funder_award_id":"R01AI077473","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7047542158","display_name":"HIV-1 Resistance to Chemokine Receptor Antagonists","funder_award_id":"R37AI055357","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000903005","display_name":"Multidisciplinary HIV Training Program","funder_award_id":"T32AI007387","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000904381","display_name":"Harvard University Center for AIDS Research","funder_award_id":"P30AI060354","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1480555318","https://openalex.org/W1537640815","https://openalex.org/W1964317119","https://openalex.org/W1966515400","https://openalex.org/W1969779756","https://openalex.org/W1985440070","https://openalex.org/W1985722970","https://openalex.org/W1999048558","https://openalex.org/W2030050527","https://openalex.org/W2030565238","https://openalex.org/W2034053987","https://openalex.org/W2034673963","https://openalex.org/W2040186892","https://openalex.org/W2057550019","https://openalex.org/W2063176659","https://openalex.org/W2076349085","https://openalex.org/W2076991562","https://openalex.org/W2082651940","https://openalex.org/W2096965774","https://openalex.org/W2102277076","https://openalex.org/W2103831221","https://openalex.org/W2105965253","https://openalex.org/W2107773522","https://openalex.org/W2111283804","https://openalex.org/W2126887491","https://openalex.org/W2128618062","https://openalex.org/W2130165489","https://openalex.org/W2135581465","https://openalex.org/W2146478787","https://openalex.org/W2153898252","https://openalex.org/W2154467032","https://openalex.org/W2155312822","https://openalex.org/W2155445576","https://openalex.org/W2157024344","https://openalex.org/W2160767768","https://openalex.org/W2161416666","https://openalex.org/W2162748311","https://openalex.org/W2164108760","https://openalex.org/W2164585544","https://openalex.org/W2315305744"],"related_works":["https://openalex.org/W2068999738","https://openalex.org/W2033494104","https://openalex.org/W1978237106","https://openalex.org/W1976127266","https://openalex.org/W1985440070","https://openalex.org/W2129327998","https://openalex.org/W2916605906","https://openalex.org/W2168864508","https://openalex.org/W2162748311","https://openalex.org/W2323796316"],"abstract_inverted_index":{"OBJECTIVES:":[0],"We":[1],"previously":[2],"reported":[3],"vicriviroc":[4],"(VCV)":[5],"resistance":[6,42,69,122,163,173,178],"in":[7,153],"an":[8],"HIV-infected":[9],"subject":[10],"and":[11,15,43,77,114,128],"used":[12],"deep":[13],"sequencing":[14],"clonal":[16],"analyses":[17],"to":[18,39,73,98,142,204],"track":[19],"the":[20,34,52,154],"evolution":[21],"of":[22,29,36,84,119,185],"V3":[23,48,167,186,191],"sequence":[24],"forms":[25],"over":[26],"28":[27],"weeks":[28],"therapy.":[30],"Here,":[31],"we":[32],"test":[33],"contribution":[35],"gp120":[37,67],"mutations":[38,123,187,202],"CCR5":[40,143,176],"antagonist":[41,177],"investigate":[44],"why":[45],"certain":[46],"minority":[47],"variants":[49,193],"emerged":[50],"as":[51,88,137,147,196],"dominant":[53],"species":[54],"under":[55],"drug":[56],"pressure.":[57],"METHODS:":[58],"Nineteen":[59],"site-directed":[60],"HIV-1":[61],"mutants":[62,105,115],"were":[63,79,86,150,159,188],"generated":[64],"that":[65,116,169],"contained":[66,117],"VCV":[68,121,172,206],"mutations.":[70,174],"Viral":[71],"sensitivities":[72],"VCV,":[74],"maraviroc,":[75],"TAK-779,":[76],"HGS004":[78],"determined.":[80],"RESULTS:":[81],"Three":[82],"patterns":[83],"susceptibilities":[85],"observed":[87],"follows:":[89],"sigmoid":[90],"inhibition":[91,126],"curves":[92,127],"with":[93,106,112,124],"50%":[94,108],"inhibitory":[95,109],"concentration":[96],"similar":[97],"pretreatment":[99],"virus":[100,141,156],"[07J-week":[101],"0":[102],"(W0)],":[103],"single":[104,148],"decreased":[107,129],"concentrations":[110],"compared":[111],"07J-W0,":[113],"\u22655":[118],"7":[120],"flattened":[125],"or":[130],"negative":[131],"percent":[132],"maximal":[133,162],"inhibition.":[134],"Substitutions":[135],"such":[136],"S306P,":[138],"which":[139,200],"sensitized":[140],"antagonists":[144],"when":[145,164,182],"present":[146],"mutations,":[149],"not":[151],"detected":[152],"baseline":[155],"population":[157],"but":[158],"necessary":[160],"for":[161],"incorporated":[165],"into":[166],"backbones":[168],"included":[170],"preexisting":[171],"CONCLUSIONS:":[175],"was":[179],"reproduced":[180],"only":[181],"a":[183,197],"majority":[184],"present.":[189],"Minority":[190],"loop":[192],"may":[194],"serve":[195],"scaffold":[198],"upon":[199],"additional":[201],"lead":[203],"complete":[205],"resistance.":[207]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
