{"id":"https://openalex.org/W2076145683","doi":"https://doi.org/10.1586/era.11.23","title":"Caspase 9b: a new target for therapy in non-small-cell lung cancer","display_name":"Caspase 9b: a new target for therapy in non-small-cell lung cancer","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2076145683","doi":"https://doi.org/10.1586/era.11.23","mag":"2076145683","pmid":"https://pubmed.ncbi.nlm.nih.gov/21504315"},"language":"en","primary_location":{"id":"doi:10.1586/era.11.23","doi":"https://doi.org/10.1586/era.11.23","is_oa":false,"landing_page_url":"https://doi.org/10.1586/era.11.23","pdf_url":null,"source":{"id":"https://openalex.org/S93370067","display_name":"Expert Review of Anticancer Therapy","issn_l":"1473-7140","issn":["1473-7140","1744-8328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anticancer Therapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085622932","display_name":"Jacqueline C. Shultz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline C Shultz","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009408265","display_name":"Charles Edward Chalfant","orcid":"https://orcid.org/0000-0002-5844-5235","observed_orcids":["https://orcid.org/0000-0002-5844-5235"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles E Chalfant","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Room 2-016, Sanger Hall, Virginia Commonwealth University \u2013 School of Medicine, 1101 East Marshall Street, PO Box 980614, Richmond, VA 23298-0614, USA and Research and Development, Hunter Holmes McGuire Veterans Administration Medical Center, Richmond, VA 23249, USA and The Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA. cechalfant@vcu.edu","Virginia Commonwealth University, Richmond, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Room 2-016, Sanger Hall, Virginia Commonwealth University \u2013 School of Medicine, 1101 East Marshall Street, PO Box 980614, Richmond, VA 23298-0614, USA and Research and Development, Hunter Holmes McGuire Veterans Administration Medical Center, Richmond, VA 23249, USA and The Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA. cechalfant@vcu.edu","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I2801770128","https://openalex.org/I4390039382"]},{"raw_affiliation_string":"Virginia Commonwealth University, Richmond, United States","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0585,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.04339797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"4","first_page":"499","last_page":"502"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9729999899864197},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6809999942779541},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.718999981880188},{"id":"https://openalex.org/keywords/lung-cancer-mortality","display_name":"lung cancer mortality","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9271253347396851},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.8113045692443848},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5556575059890747},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5388249158859253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46164506673812866},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.44622746109962463},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35795605182647705}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1586/era.11.23","doi":"https://doi.org/10.1586/era.11.23","is_oa":false,"landing_page_url":"https://doi.org/10.1586/era.11.23","pdf_url":null,"source":{"id":"https://openalex.org/S93370067","display_name":"Expert Review of Anticancer Therapy","issn_l":"1473-7140","issn":["1473-7140","1744-8328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anticancer Therapy","raw_type":"journal-article"},{"id":"pmid:21504315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21504315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of anticancer therapy","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1140289417","display_name":null,"funder_award_id":"HL072925","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1168596608","display_name":null,"funder_award_id":"CA 117950","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2066916702","display_name":"The Role of Ceramide Kinase in Eicosanoid Synthesis","funder_award_id":"R01HL072925","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6777326605","display_name":"Regulation of caspase 9 RNA splicing in NSCLC cancer","funder_award_id":"R01CA154314","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8752428544","display_name":"Sphingolipid Regulation of Caspase 9 Alternative Splicing","funder_award_id":"R01CA117950","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1531840277","https://openalex.org/W1970108031","https://openalex.org/W1984050410","https://openalex.org/W1987498240","https://openalex.org/W1999057673","https://openalex.org/W2002937040","https://openalex.org/W2022953341","https://openalex.org/W2023777764","https://openalex.org/W2031564845","https://openalex.org/W2037928868","https://openalex.org/W2049484790","https://openalex.org/W2050924783","https://openalex.org/W2073306419","https://openalex.org/W2076502151","https://openalex.org/W2080986274","https://openalex.org/W2094126824","https://openalex.org/W2096287391","https://openalex.org/W2096940705","https://openalex.org/W2097317917","https://openalex.org/W2098010370","https://openalex.org/W2103677278","https://openalex.org/W2115771186","https://openalex.org/W2126705594","https://openalex.org/W2128012941","https://openalex.org/W2130907457","https://openalex.org/W2137103099","https://openalex.org/W2143593381","https://openalex.org/W2154402764","https://openalex.org/W2162731265","https://openalex.org/W2165781226","https://openalex.org/W2263121100","https://openalex.org/W2332770285","https://openalex.org/W2614993331"],"related_works":["https://openalex.org/W2158794775","https://openalex.org/W7096988967","https://openalex.org/W2970539823","https://openalex.org/W2494902404","https://openalex.org/W2625924032","https://openalex.org/W4389870241","https://openalex.org/W4300816014","https://openalex.org/W2099333945","https://openalex.org/W2898359174","https://openalex.org/W7099348958"],"abstract_inverted_index":{"Lung":[0],"cancer":[1,6],"is":[2],"responsible":[3],"for":[4],"more":[5],"deaths":[7],"in":[8,21],"the":[9,25],"USA":[10],"than":[11],"any":[12],"other":[13],"type":[14],"of":[15],"cancer,":[16],"and":[17],"no":[18],"significant":[19],"decrease":[20],"mortality":[22],"rates":[23],"over":[24],"past":[26],"several":[27],"decades":[28],"has":[29],"been":[30],"observed.":[31],"Non-small...":[32]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
