{"id":"https://openalex.org/W2076092771","doi":"https://doi.org/10.1210/en.2013-2015","title":"Sweet Taste Receptors Regulate Basal Insulin Secretion and Contribute to Compensatory Insulin Hypersecretion During the Development of Diabetes in Male Mice","display_name":"Sweet Taste Receptors Regulate Basal Insulin Secretion and Contribute to Compensatory Insulin Hypersecretion During the Development of Diabetes in Male Mice","publication_year":2014,"publication_date":"2014-04-08","ids":{"openalex":"https://openalex.org/W2076092771","doi":"https://doi.org/10.1210/en.2013-2015","mag":"2076092771","pmid":"https://pubmed.ncbi.nlm.nih.gov/24712876","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4020927"},"language":"en","primary_location":{"id":"doi:10.1210/en.2013-2015","doi":"https://doi.org/10.1210/en.2013-2015","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2013-2015","pdf_url":"https://academic.oup.com/endo/article-pdf/155/6/2112/10826008/endo2112.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/endo/article-pdf/155/6/2112/10826008/endo2112.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035067005","display_name":"George A. Kyriazis","orcid":"https://orcid.org/0000-0001-9514-3482","observed_orcids":["https://orcid.org/0000-0001-9514-3482"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I4210135360","display_name":"Translational Research Institute for Metabolism and Diabetes","ror":"https://ror.org/03gj9g134","country_code":"US","type":"facility","lineage":["https://openalex.org/I188891513","https://openalex.org/I2799648416","https://openalex.org/I4210135360"]},{"id":"https://openalex.org/I4405270336","display_name":"AdventHealth","ror":"https://ror.org/00gqase94","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405270336"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George A. Kyriazis","raw_affiliation_strings":["Diabetes and Obesity Research Center (G.A.K., K.R.S., B.T., T.H., R.E.P.) Sanford-Burnham Medical Research Institute, Orlando, Florida 32827;","Translational Research Institute for Metabolism and Diabetes (G.A.K., R.E.P.), Florida Hospital, Orlando, Florida 32804;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes and Obesity Research Center (G.A.K., K.R.S., B.T., T.H., R.E.P.) Sanford-Burnham Medical Research Institute, Orlando, Florida 32827;","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Translational Research Institute for Metabolism and Diabetes (G.A.K., R.E.P.), Florida Hospital, Orlando, Florida 32804;","institution_ids":["https://openalex.org/I4210135360","https://openalex.org/I4405270336"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kathleen R. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen R. Smith","raw_affiliation_strings":["Diabetes and Obesity Research Center (G.A.K., K.R.S., B.T., T.H., R.E.P.) Sanford-Burnham Medical Research Institute, Orlando, Florida 32827;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes and Obesity Research Center (G.A.K., K.R.S., B.T., T.H., R.E.P.) Sanford-Burnham Medical Research Institute, Orlando, Florida 32827;","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014684613","display_name":"Bj\u00f6rn Tyrberg","orcid":"https://orcid.org/0000-0003-0976-1220","observed_orcids":["https://orcid.org/0000-0003-0976-1220"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn Tyrberg","raw_affiliation_strings":["Diabetes and Obesity Research Center (G.A.K., K.R.S., B.T., T.H., R.E.P.) Sanford-Burnham Medical Research Institute, Orlando, Florida 32827;","Translational Science (B.T.), Cardiovascular and Metabolic Disease, M\u00f6lndal, AstraZeneca, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes and Obesity Research Center (G.A.K., K.R.S., B.T., T.H., R.E.P.) Sanford-Burnham Medical Research Institute, Orlando, Florida 32827;","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Translational Science (B.T.), Cardiovascular and Metabolic Disease, M\u00f6lndal, AstraZeneca, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tania Hussain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tania Hussain","raw_affiliation_strings":["Diabetes and Obesity Research Center (G.A.K., K.R.S., B.T., T.H., R.E.P.) Sanford-Burnham Medical Research Institute, Orlando, Florida 32827;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes and Obesity Research Center (G.A.K., K.R.S., B.T., T.H., R.E.P.) Sanford-Burnham Medical Research Institute, Orlando, Florida 32827;","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059098934","display_name":"Richard E. Pratley","orcid":"https://orcid.org/0000-0002-2912-1389","observed_orcids":["https://orcid.org/0000-0002-2912-1389"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I4210135360","display_name":"Translational Research Institute for Metabolism and Diabetes","ror":"https://ror.org/03gj9g134","country_code":"US","type":"facility","lineage":["https://openalex.org/I188891513","https://openalex.org/I2799648416","https://openalex.org/I4210135360"]},{"id":"https://openalex.org/I4405270336","display_name":"AdventHealth","ror":"https://ror.org/00gqase94","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405270336"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard E. Pratley","raw_affiliation_strings":["Diabetes and Obesity Research Center (G.A.K., K.R.S., B.T., T.H., R.E.P.) Sanford-Burnham Medical Research Institute, Orlando, Florida 32827;","Translational Research Institute for Metabolism and Diabetes (G.A.K., R.E.P.), Florida Hospital, Orlando, Florida 32804;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes and Obesity Research Center (G.A.K., K.R.S., B.T., T.H., R.E.P.) Sanford-Burnham Medical Research Institute, Orlando, Florida 32827;","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Translational Research Institute for Metabolism and Diabetes (G.A.K., R.E.P.), Florida Hospital, Orlando, Florida 32804;","institution_ids":["https://openalex.org/I4210135360","https://openalex.org/I4405270336"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035067005"],"corresponding_institution_ids":["https://openalex.org/I188891513","https://openalex.org/I4210135360","https://openalex.org/I4405270336"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":6.5728,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.9720835,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"155","issue":"6","first_page":"2112","last_page":"2121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sweet-taste-receptor","display_name":"sweet taste receptor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/t1r2","display_name":"T1R2","score":0.8769999742507935},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.6959999799728394},{"id":"https://openalex.org/keywords/beta-cell-dysfunction","display_name":"beta-cell dysfunction","score":0.7149999737739563},{"id":"https://openalex.org/keywords/glucose-detection","display_name":"glucose detection","score":0.6100000143051147},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8560000061988831},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7179999947547913},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.8550000190734863},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.9610000252723694},{"id":"https://openalex.org/keywords/islets","display_name":"islets","score":0.5440000295639038},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.8309999704360962},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8951823711395264},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8908578753471375},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7483228445053101},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5999478101730347},{"id":"https://openalex.org/C144855686","wikidata":"https://www.wikidata.org/wiki/Q6042245","display_name":"Insulin oscillation","level":4,"score":0.5965430736541748},{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.5751537084579468},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.513997495174408},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.502926766872406},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.446257621049881},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4457017779350281},{"id":"https://openalex.org/C76923068","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Blood sugar regulation","level":3,"score":0.4302852749824524},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.42480435967445374},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.4235490560531616},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.2649628520011902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24727031588554382}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1210/en.2013-2015","doi":"https://doi.org/10.1210/en.2013-2015","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2013-2015","pdf_url":"https://academic.oup.com/endo/article-pdf/155/6/2112/10826008/endo2112.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3411472","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4020927","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4020927","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4020927","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Text"},{"id":"pmid:24712876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24712876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1210/en.2013-2015","doi":"https://doi.org/10.1210/en.2013-2015","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2013-2015","pdf_url":"https://academic.oup.com/endo/article-pdf/155/6/2112/10826008/endo2112.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2316242789","display_name":"Taste receptor signaling in beta cells and role in postprandial insulin secretion","funder_award_id":"F32DK089757","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2076092771.pdf","grobid_xml":"https://content.openalex.org/works/W2076092771.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1517377491","https://openalex.org/W1598254642","https://openalex.org/W1599250255","https://openalex.org/W1616790409","https://openalex.org/W1967135896","https://openalex.org/W1970250202","https://openalex.org/W1975775502","https://openalex.org/W1977563308","https://openalex.org/W1981583647","https://openalex.org/W1994944470","https://openalex.org/W1995573327","https://openalex.org/W2001040185","https://openalex.org/W2003416763","https://openalex.org/W2014410123","https://openalex.org/W2020053294","https://openalex.org/W2023939486","https://openalex.org/W2025603556","https://openalex.org/W2027329507","https://openalex.org/W2033050117","https://openalex.org/W2038573621","https://openalex.org/W2041129796","https://openalex.org/W2046325265","https://openalex.org/W2059117845","https://openalex.org/W2074369108","https://openalex.org/W2078729207","https://openalex.org/W2086339199","https://openalex.org/W2094177994","https://openalex.org/W2097271664","https://openalex.org/W2103430792","https://openalex.org/W2107797783","https://openalex.org/W2113356700","https://openalex.org/W2120476264","https://openalex.org/W2125388313","https://openalex.org/W2126918646","https://openalex.org/W2128326754","https://openalex.org/W2133222023","https://openalex.org/W2141063928","https://openalex.org/W2147945544","https://openalex.org/W2149860530","https://openalex.org/W2153302582","https://openalex.org/W2158822657","https://openalex.org/W2163903769","https://openalex.org/W2165816400","https://openalex.org/W2412974593","https://openalex.org/W2520432709","https://openalex.org/W4241883936","https://openalex.org/W4249590403"],"related_works":["https://openalex.org/W2940126562","https://openalex.org/W1982365101","https://openalex.org/W7098038273","https://openalex.org/W2541231122","https://openalex.org/W2130306710","https://openalex.org/W2099039337","https://openalex.org/W2743929579","https://openalex.org/W2163903769","https://openalex.org/W1987511086","https://openalex.org/W2921600526"],"abstract_inverted_index":{"\u03b2-Cells":[0],"rapidly":[1],"secrete":[2],"insulin":[3,19,43,56,78,103,130,144,191,201],"in":[4,9,74,98,118,176,185],"response":[5,177],"to":[6,17,153,178,190,224,238],"acute":[7],"increases":[8],"plasma":[10,143],"glucose":[11,81,134,155],"but,":[12],"upon":[13],"further":[14,228],"continuous":[15],"exposure":[16],"glucose,":[18],"secretion":[20,79,202],"progressively":[21],"decreases.":[22],"Although":[23],"the":[24,33,75,99,213],"mechanisms":[25],"are":[26,72],"unclear,":[27],"this":[28,93],"mode":[29],"of":[30,35,61,77,101,116,126,149,215],"regulation":[31,76,100],"suggests":[32],"presence":[34],"a":[36,59,83,196,234],"time-dependent":[37],"glucosensory":[38],"system":[39],"that":[40,230],"temporarily":[41],"attenuates":[42],"secretion.":[44,104],"Interestingly,":[45],"early-stage":[46],"\u03b2-cell":[47],"dysfunction":[48],"is":[49,82,203,219],"often":[50],"characterized":[51],"by":[52,199,206,221],"basal":[53,102],"(ie,":[54],"fasting)":[55],"hypersecretion,":[57],"suggesting":[58],"disruption":[60],"these":[62,186],"related":[63],"mechanisms.":[64],"Because":[65],"sweet":[66],"taste":[67],"receptors":[68],"(STRs)":[69],"on":[70],"\u03b2-cells":[71],"implicated":[73],"and":[80,96,113,122,145,208,240],"bona":[84],"fide":[85],"STR":[86,109,127,158,183,217],"ligand,":[87],"we":[88],"tested":[89],"whether":[90],"STRs":[91,117,207,231],"mediate":[92],"sensory":[94],"mechanism":[95,198],"participate":[97],"We":[105],"used":[106],"mice":[107,140],"lacking":[108],"signaling":[110,128],"(T1R2(-/-)":[111],"knockout)":[112],"pharmacologic":[114],"inhibition":[115],"human":[119,123],"islets.":[120],"Mouse":[121],"islets":[124,152,161],"deprived":[125],"hypersecrete":[129],"at":[131],"short-term":[132],"fasting":[133],"concentrations.":[135],"Accordingly,":[136],"5-hour":[137],"fasted":[138],"T1R2(-/-)":[139],"have":[141],"increased":[142],"lower":[146],"glucose.":[147],"Exposure":[148],"isolated":[150],"wild-type":[151],"elevated":[154],"levels":[156],"reduced":[157,182],"expression,":[159],"whereas":[160],"from":[162],"diabetic":[163],"(db/db)":[164],"or":[165],"diet-induced":[166],"obese":[167],"mouse":[168,187],"models":[169],"show":[170],"similar":[171],"down-regulation.":[172],"This":[173],"transcriptional":[174],"reprogramming":[175],"hyperglycemia":[179,222],"correlates":[180],"with":[181],"function":[184,218],"models,":[188],"leading":[189,223],"hypersecretion.":[192],"These":[193,226],"findings":[194],"reveal":[195],"novel":[197],"which":[200],"physiologically":[204],"regulated":[205],"also":[209],"suggest":[210,229],"that,":[211],"during":[212],"development":[214],"diabetes,":[216],"compromised":[220],"hyperinsulinemia.":[225],"observations":[227],"might":[232],"be":[233],"promising":[235],"therapeutic":[236],"target":[237],"prevent":[239],"treat":[241],"type":[242],"2":[243],"diabetes.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}