{"id":"https://openalex.org/W2076038676","doi":"https://doi.org/10.1159/000010111","title":"Immunologic and Biochemical Factors in Hyperemesis gravidarumwith or wit hout Hyperthyroxinemia","display_name":"Immunologic and Biochemical Factors in Hyperemesis gravidarumwith or wit hout Hyperthyroxinemia","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2076038676","doi":"https://doi.org/10.1159/000010111","mag":"2076038676","pmid":"https://pubmed.ncbi.nlm.nih.gov/10352382"},"language":"en","primary_location":{"id":"doi:10.1159/000010111","doi":"https://doi.org/10.1159/000010111","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000010111","pdf_url":null,"source":{"id":"https://openalex.org/S207793224","display_name":"Gynecologic and Obstetric Investigation","issn_l":"0378-7346","issn":["0378-7346","1423-002X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic and Obstetric Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110089154","display_name":"\u00d6zkan Ayd\u0131n Leylek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ozkan Aydin Leylek","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey","Obstetrics and Gynecology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Cumhuriyet University School of Medicine, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"Obstetrics and Gynecology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087103076","display_name":"Mehmet Toyaksi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehmet Toyaksi","raw_affiliation_strings":["Obstetrics and Gynecology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynecology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014862618","display_name":"Taner Erselcan","orcid":"https://orcid.org/0000-0002-2352-3782","observed_orcids":["https://orcid.org/0000-0002-2352-3782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taner Erselcan","raw_affiliation_strings":["Nuclear Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037595072","display_name":"Hatice Sebila D\u00f6kmeta\u015f","orcid":"https://orcid.org/0000-0003-0300-4173","observed_orcids":["https://orcid.org/0000-0003-0300-4173"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sebila Dokmetas","raw_affiliation_strings":["Internal Medicine\u2013Division of Endocrinology, Cumhuriyet University School of Medicine, Sivas, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine\u2013Division of Endocrinology, Cumhuriyet University School of Medicine, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6102,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.67317671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"4","first_page":"229","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.04780000075697899,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperemesis-gravidarum","display_name":"hyperemesis gravidarum","score":1.0},{"id":"https://openalex.org/keywords/hyperthyroxinemia","display_name":"hyperthyroxinemia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/beta-human-chorionic-gonadotropin","display_name":"beta-human chorionic gonadotropin","score":0.9210000038146973},{"id":"https://openalex.org/keywords/immunological-factors","display_name":"immunological factors","score":0.4269999861717224},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.5889999866485596},{"id":"https://openalex.org/keywords/free-thyroxine","display_name":"free thyroxine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.8759999871253967},{"id":"https://openalex.org/keywords/immunoglobulins","display_name":"immunoglobulins","score":0.8960000276565552},{"id":"https://openalex.org/keywords/complement-c3-and-c4","display_name":"complement C3 and C4","score":0.8610000014305115},{"id":"https://openalex.org/keywords/lymphocyte-count","display_name":"lymphocyte count","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7757275700569153},{"id":"https://openalex.org/C2778409550","wikidata":"https://www.wikidata.org/wiki/Q391556","display_name":"Hyperemesis gravidarum","level":3,"score":0.7527017593383789},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7513095736503601},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6453320980072021},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5571914911270142},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5161765217781067},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5045162439346313},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4329444468021393},{"id":"https://openalex.org/C2775948956","wikidata":"https://www.wikidata.org/wiki/Q407172","display_name":"Human chorionic gonadotropin","level":3,"score":0.4303547143936157},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21039295196533203},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.20849904417991638},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10689491033554077},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003181","descriptor_name":"Complement C4","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006939","descriptor_name":"Hyperemesis Gravidarum","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006939","descriptor_name":"Hyperemesis Gravidarum","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006939","descriptor_name":"Hyperemesis Gravidarum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006981","descriptor_name":"Hyperthyroxinemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018997","descriptor_name":"Chorionic Gonadotropin, beta Subunit, Human","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000010111","doi":"https://doi.org/10.1159/000010111","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000010111","pdf_url":null,"source":{"id":"https://openalex.org/S207793224","display_name":"Gynecologic and Obstetric Investigation","issn_l":"0378-7346","issn":["0378-7346","1423-002X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic and Obstetric Investigation","raw_type":"journal-article"},{"id":"pmid:10352382","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10352382","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic and obstetric investigation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W17129754","https://openalex.org/W592191921","https://openalex.org/W1525710729","https://openalex.org/W1548133958","https://openalex.org/W1967375819","https://openalex.org/W1986900965","https://openalex.org/W1994972417","https://openalex.org/W2005144687","https://openalex.org/W2008196442","https://openalex.org/W2008869982","https://openalex.org/W2016535214","https://openalex.org/W2036409494","https://openalex.org/W2046770351","https://openalex.org/W2048374249","https://openalex.org/W2058630129","https://openalex.org/W2062585754","https://openalex.org/W2083761061","https://openalex.org/W2087523037","https://openalex.org/W2094363809","https://openalex.org/W2106290823","https://openalex.org/W2132436090","https://openalex.org/W2167503858","https://openalex.org/W2399912382","https://openalex.org/W2401194363","https://openalex.org/W2408877415","https://openalex.org/W2413502942","https://openalex.org/W2413627777","https://openalex.org/W2424358642"],"related_works":["https://openalex.org/W2048374249","https://openalex.org/W2027786544","https://openalex.org/W4386769711","https://openalex.org/W2555389794","https://openalex.org/W1975081674","https://openalex.org/W2328674211","https://openalex.org/W2008196442","https://openalex.org/W4382987985","https://openalex.org/W2912328957","https://openalex.org/W4362729287"],"abstract_inverted_index":{"OBJECTIVE:":[0],"This":[1],"study":[2],"was":[3,116,159],"set":[4],"up":[5],"to":[6,171,177,183],"investigate":[7],"the":[8,162,202],"relationship":[9],"between":[10,151],"immune":[11,30,67],"process":[12],"and":[13,32,41,49,74,100,138,153],"high":[14],"levels":[15,51],"of":[16,205],"human":[17],"chorionic":[18],"gonadotropin-beta":[19],"(betahCG)":[20],"in":[21,38,42,55,59,80,83,106,145,161,193,207],"hyperemesis":[22,39,56,92,107,146,163,208],"patients":[23,40,57,81,93,209],"with":[24,94,119,125,132,139,210],"or":[25,199,211],"without":[26,109,212],"hyperthyroxinemia.":[27,213],"METHODS:":[28],"betahCG,":[29,47,98],"parameters":[31,68],"thyroid":[33],"related":[34],"hormones":[35],"were":[36,52,77,102],"assayed":[37],"controls.":[43],"RESULTS:":[44],"Mean":[45],"serum":[46,97],"fT4":[48,120],"TSH":[50,154],"significantly":[53,78,103],"higher":[54,79,104],"than":[58,82,105],"controls":[60,84],"(p<0.":[61],"01,":[62],"p<0.01,":[63,86,87,89],"p<0.05,":[64,88,112,113],"respectively).":[65,90,114],"Further,":[66],"regarding":[69],"IgG,":[70],"IgM,":[71],"C3,":[72],"C4":[73],"lymphocyte":[75,126,184],"count":[76,127,185],"(p<0.05,":[85],"In":[91],"hyperthyroxinemia,":[95],"mean":[96],"IgG":[99,178],"IgM":[101,133,172],"women":[108],"hyperthyroxinemia":[110],"(p<0.001,":[111],"BetahCG":[115],"positively":[117],"correlated":[118],"(r":[121,128,134,141,155,173,179,186],"=":[122,129,135,142,156,174,180,187],"0.45,":[123,188],"p<0.05),":[124,182],"0.47,":[130],"p<0.01),":[131,176],"0.38,":[136],"p<0.05)":[137,144,158],"C3":[140],"0.40,":[143,181],"patients.":[147],"A":[148],"negative":[149],"correlation":[150],"betahCG":[152,206],"-0.43,":[157],"noted":[160],"group.":[164],"Free":[165],"T4":[166],"showed":[167],"a":[168],"positive":[169],"association":[170],"0.49,":[175],"p<0.05).":[189],"CONCLUSION:":[190],"Immunologic":[191],"activity":[192],"pregnancy":[194],"may":[195],"have":[196],"an":[197],"effect":[198],"role":[200],"on":[201],"stimulatory":[203],"mechanism":[204]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}