{"id":"https://openalex.org/W2076010031","doi":"https://doi.org/10.1186/1471-213x-9-32","title":"Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NF\u03baB paradigm","display_name":"Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NF\u03baB paradigm","publication_year":2009,"publication_date":"2009-06-06","ids":{"openalex":"https://openalex.org/W2076010031","doi":"https://doi.org/10.1186/1471-213x-9-32","mag":"2076010031","pmid":"https://pubmed.ncbi.nlm.nih.gov/19500387","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2700095"},"language":"en","primary_location":{"id":"doi:10.1186/1471-213x-9-32","doi":"https://doi.org/10.1186/1471-213x-9-32","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-213x-9-32","pdf_url":"https://bmcdevbiol.biomedcentral.com/counter/pdf/10.1186/1471-213X-9-32","source":{"id":"https://openalex.org/S179646348","display_name":"BMC Developmental Biology","issn_l":"1471-213X","issn":["1471-213X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://bmcdevbiol.biomedcentral.com/counter/pdf/10.1186/1471-213X-9-32","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087921962","display_name":"Michael Melnick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Melnick","raw_affiliation_strings":["Laboratory for Developmental Genetics, USC, Los Angeles, CA, USA. mmelnick@usc.edu","Laboratory for Developmental Genetics, USC, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Developmental Genetics, USC, Los Angeles, CA, USA. mmelnick@usc.edu","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Laboratory for Developmental Genetics, USC, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016269795","display_name":"Robert D. Phair","orcid":"https://orcid.org/0000-0001-7979-2386","observed_orcids":["https://orcid.org/0000-0001-7979-2386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert D Phair","raw_affiliation_strings":["Integrative Bioinformatics Inc, Los Altos, CA, USA","Integrative Bioinformatics Inc, Los Altos, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Bioinformatics Inc, Los Altos, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Integrative Bioinformatics Inc, Los Altos, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082397822","display_name":"Smadar A. Lapidot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Smadar A Lapidot","raw_affiliation_strings":["Integrative Bioinformatics Inc, Los Altos, CA, USA","Integrative Bioinformatics Inc, Los Altos, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Bioinformatics Inc, Los Altos, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Integrative Bioinformatics Inc, Los Altos, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037656968","display_name":"Tina F. Jaskoll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina Jaskoll","raw_affiliation_strings":["Laboratory for Developmental Genetics, USC, Los Angeles, CA, USA","Laboratory for Developmental Genetics, USC, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Developmental Genetics, USC, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Laboratory for Developmental Genetics, USC, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087921962"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":2.2793,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.87903977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"32","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0771000012755394,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salivary-gland-development","display_name":"salivary gland development","score":0.8679999709129333},{"id":"https://openalex.org/keywords/branching-morphogenesis","display_name":"branching morphogenesis","score":0.972000002861023},{"id":"https://openalex.org/keywords/eda","display_name":"EDA","score":0.628000020980835},{"id":"https://openalex.org/keywords/edar","display_name":"EDAR","score":0.8560000061988831},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8930000066757202},{"id":"https://openalex.org/keywords/fgf8","display_name":"FGF8","score":0.972000002861023},{"id":"https://openalex.org/keywords/sonic-hedgehog","display_name":"Sonic hedgehog","score":0.8730000257492065},{"id":"https://openalex.org/keywords/c-ebpalpha","display_name":"C/EBP\u03b1","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8319211006164551},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5908209085464478},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.5702413320541382},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4297165870666504},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4266570210456848},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4056791067123413},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35345131158828735}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D012469","descriptor_name":"Salivary Glands","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053331","descriptor_name":"Ectodysplasins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053331","descriptor_name":"Ectodysplasins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053339","descriptor_name":"Edar Receptor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053339","descriptor_name":"Edar Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-213x-9-32","doi":"https://doi.org/10.1186/1471-213x-9-32","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-213x-9-32","pdf_url":"https://bmcdevbiol.biomedcentral.com/counter/pdf/10.1186/1471-213X-9-32","source":{"id":"https://openalex.org/S179646348","display_name":"BMC Developmental Biology","issn_l":"1471-213X","issn":["1471-213X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2700095","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2700095","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Dev Biol","raw_type":"Text"},{"id":"pmid:19500387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19500387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:39e9d323ebcb48bc82290cf667644ab8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/39e9d323ebcb48bc82290cf667644ab8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Developmental Biology, Vol 9, Iss 1, p 32 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-213x-9-32","doi":"https://doi.org/10.1186/1471-213x-9-32","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-213x-9-32","pdf_url":"https://bmcdevbiol.biomedcentral.com/counter/pdf/10.1186/1471-213X-9-32","source":{"id":"https://openalex.org/S179646348","display_name":"BMC Developmental Biology","issn_l":"1471-213X","issn":["1471-213X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4819397702","display_name":"Eda/Edar Regulation of Embryonic SMG Development","funder_award_id":"R01DE014535","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2076010031.pdf","grobid_xml":"https://content.openalex.org/works/W2076010031.grobid-xml"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W239577987","https://openalex.org/W1497256448","https://openalex.org/W1506708345","https://openalex.org/W1510241967","https://openalex.org/W1516855141","https://openalex.org/W1542772707","https://openalex.org/W1562763949","https://openalex.org/W1570009092","https://openalex.org/W1662498559","https://openalex.org/W1731872348","https://openalex.org/W1802527559","https://openalex.org/W1933156589","https://openalex.org/W1965583590","https://openalex.org/W1970270100","https://openalex.org/W1971786517","https://openalex.org/W1973223713","https://openalex.org/W1973636928","https://openalex.org/W1978122953","https://openalex.org/W1981041333","https://openalex.org/W1985200721","https://openalex.org/W1986401491","https://openalex.org/W1987298940","https://openalex.org/W1988699784","https://openalex.org/W1989053944","https://openalex.org/W1990689575","https://openalex.org/W2003199423","https://openalex.org/W2006510628","https://openalex.org/W2006824094","https://openalex.org/W2007570855","https://openalex.org/W2013739996","https://openalex.org/W2016804954","https://openalex.org/W2017353498","https://openalex.org/W2022809398","https://openalex.org/W2031313854","https://openalex.org/W2032074345","https://openalex.org/W2033439161","https://openalex.org/W2034455925","https://openalex.org/W2035616122","https://openalex.org/W2039267926","https://openalex.org/W2039425105","https://openalex.org/W2043837938","https://openalex.org/W2044890688","https://openalex.org/W2045924769","https://openalex.org/W2049871294","https://openalex.org/W2056383033","https://openalex.org/W2057562771","https://openalex.org/W2062347996","https://openalex.org/W2064137428","https://openalex.org/W2065339554","https://openalex.org/W2072813802","https://openalex.org/W2074886162","https://openalex.org/W2075744820","https://openalex.org/W2076372398","https://openalex.org/W2079404978","https://openalex.org/W2081146141","https://openalex.org/W2081466838","https://openalex.org/W2081499572","https://openalex.org/W2083137562","https://openalex.org/W2083223973","https://openalex.org/W2086253706","https://openalex.org/W2090598361","https://openalex.org/W2090970667","https://openalex.org/W2092240403","https://openalex.org/W2094036688","https://openalex.org/W2096797578","https://openalex.org/W2101730627","https://openalex.org/W2105291362","https://openalex.org/W2108723074","https://openalex.org/W2114582148","https://openalex.org/W2115293321","https://openalex.org/W2117530906","https://openalex.org/W2119751633","https://openalex.org/W2122723511","https://openalex.org/W2124782904","https://openalex.org/W2129488788","https://openalex.org/W2131653304","https://openalex.org/W2135852310","https://openalex.org/W2136631382","https://openalex.org/W2138516916","https://openalex.org/W2140854466","https://openalex.org/W2143784594","https://openalex.org/W2146200922","https://openalex.org/W2147470531","https://openalex.org/W2148390492","https://openalex.org/W2148741797","https://openalex.org/W2151527805","https://openalex.org/W2157523980","https://openalex.org/W2158601293","https://openalex.org/W2159944716","https://openalex.org/W2162902722","https://openalex.org/W2163347409","https://openalex.org/W2163429946","https://openalex.org/W2319490898","https://openalex.org/W2904250082","https://openalex.org/W2987025408","https://openalex.org/W3023540311","https://openalex.org/W3192901545","https://openalex.org/W4240835837","https://openalex.org/W4253136600"],"related_works":["https://openalex.org/W2215867425","https://openalex.org/W2020022277","https://openalex.org/W1580750039","https://openalex.org/W2119751633","https://openalex.org/W2023177646","https://openalex.org/W2149616898","https://openalex.org/W2166336686","https://openalex.org/W2020600328","https://openalex.org/W2028776559","https://openalex.org/W1994608435"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ectodysplasin-A":[1],"appears":[2,189],"to":[3,56,74,84,130,190,257],"be":[4,223],"a":[5,59,69,138,177,224,248],"critical":[6],"component":[7],"of":[8,40,90,97,119,140,158,185,201,211,247,261],"branching":[9,243,263],"morphogenesis.":[10],"Mutations":[11],"in":[12,62,94,125,146,170],"mouse":[13],"Eda":[14,64,98,220,267],"or":[15,22],"human":[16],"EDA":[17],"are":[18,254],"associated":[19],"with":[20,66,218],"absent":[21],"hypoplastic":[23],"sweat":[24],"glands,":[25,27,29],"sebaceous":[26],"lacrimal":[28],"salivary":[30],"glands":[31,34,39],"(SMGs),":[32],"mammary":[33],"and/or":[35],"nipples,":[36],"and":[37,44,73,169,203,230,234],"mucous":[38],"the":[41,76,87,95,108,115,156,186,192,199,209,212,259],"bronchial,":[42],"esophageal":[43],"colonic":[45],"mucosa.":[46],"In":[47,181],"this":[48,239],"study,":[49],"we":[50],"utilized":[51],"EdaTa":[52],"(Tabby)":[53],"mutant":[54],"mice":[55],"investigate":[57],"how":[58],"marked":[60],"reduction":[61],"functional":[63],"propagates":[65],"time":[67,117],"through":[68],"defined":[70],"genetic":[71],"subcircuit":[72],"test":[75],"proposition":[77],"that":[78,208,215,227],"canonical":[79,249],"NFkappaB":[80,135],"signaling":[81,221],"is":[82,122,134,142,216],"sufficient":[83],"account":[85],"for":[86,165],"differential":[88],"expression":[89,121],"developmentally":[91],"regulated":[92],"genes":[93,141],"context":[96],"polymorphism.":[99],"RESULTS:":[100],"The":[101],"quantitative":[102],"systems":[103],"analyses":[104],"do":[105],"not":[106],"support":[107,238],"stated":[109],"hypothesis.":[110],"For":[111],"most":[112],"NFkappaB-regulated":[113],"genes,":[114],"observed":[116],"course":[118],"gene":[120],"nearly":[123],"unchanged":[124],"Tabby":[126,147,182],"(EdaTa)":[127],"as":[128,133,176],"compared":[129],"wildtype":[131],"mice,":[132],"itself.":[136],"Importantly,":[137],"subset":[139],"dramatically":[143],"differentially":[144],"expressed":[145],"(Edar,":[148],"Fgf8,":[149],"Shh,":[150],"Egf,":[151],"Tgfa,":[152],"Egfr),":[153],"strongly":[154],"suggesting":[155],"existence":[157],"an":[159],"alternative":[160],"Eda-mediated":[161],"transcriptional":[162],"pathway":[163,188],"pivotal":[164],"SMG":[166],"ontogeny.":[167],"Experimental":[168],"silico":[171],"investigations":[172],"have":[173,206],"identified":[174],"C/EBPalpha":[175],"promising":[178],"candidate.":[179],"CONCLUSION:":[180],"SMGs,":[183],"upregulation":[184],"Egf/Tgfalpha/Egfr":[187],"mitigate":[191],"potentially":[193],"severe":[194],"abnormal":[195],"phenotype":[196],"predicted":[197],"by":[198,266],"downregulation":[200],"Fgf8":[202],"Shh.":[204],"Others":[205],"suggested":[207],"buffering":[210],"phenotypic":[213],"outcome":[214],"coincident":[217],"variant":[219],"could":[222],"common":[225],"mechanism":[226],"permits":[228],"viable":[229],"diverse":[231],"phenotypes,":[232],"normal":[233],"abnormal.":[235],"Our":[236],"results":[237,253],"proposition.":[240],"Further,":[241],"if":[242],"epithelia":[244],"use":[245],"variations":[246],"developmental":[250],"program,":[251],"our":[252],"likely":[255],"applicable":[256],"understanding":[258],"phenotypes":[260],"other":[262],"organs":[264],"affected":[265],"(EDA)":[268],"mutation.":[269]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
