{"id":"https://openalex.org/W2076009685","doi":"https://doi.org/10.1016/1043-6618(94)80101-0","title":"Effects on intestinal microflora, gastrointestinal tolerability and antiinflammatory efficacy of diclofenac and nitrofenac in adjuvant arthritic rats","display_name":"Effects on intestinal microflora, gastrointestinal tolerability and antiinflammatory efficacy of diclofenac and nitrofenac in adjuvant arthritic rats","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2076009685","doi":"https://doi.org/10.1016/1043-6618(94)80101-0","mag":"2076009685","pmid":"https://pubmed.ncbi.nlm.nih.gov/8202446"},"language":"en","primary_location":{"id":"doi:10.1016/1043-6618(94)80101-0","doi":"https://doi.org/10.1016/1043-6618(94)80101-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/1043-6618(94)80101-0","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025276299","display_name":"Laura Cuzzolin","orcid":"https://orcid.org/0000-0002-7848-2527","observed_orcids":["https://orcid.org/0000-0002-7848-2527"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Laura Cuzzolin","raw_affiliation_strings":["Institute of Pharmacology, University of Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, University of Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087380783","display_name":"Anita Conforti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anita Conforti","raw_affiliation_strings":["Institute of Pharmacology, University of Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, University of Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050926828","display_name":"Marta Donini","orcid":"https://orcid.org/0000-0003-3101-0183","observed_orcids":["https://orcid.org/0000-0003-3101-0183"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Donini","raw_affiliation_strings":["Institute of Pharmacology, University of Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, University of Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060313858","display_name":"Alessandra Adami","orcid":"https://orcid.org/0000-0002-1917-9296","observed_orcids":["https://orcid.org/0000-0002-1917-9296"]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Adami","raw_affiliation_strings":["Institute of Pharmacology, University of Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, University of Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065375189","display_name":"Piero Del Soldato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Piero Del Soldato","raw_affiliation_strings":["Metgrove Ltd, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metgrove Ltd, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001325455","display_name":"Giuseppina Benoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119439378","display_name":"University of Verona","ror":"https://ror.org/039bp8j42","country_code":"IT","type":"education","lineage":["https://openalex.org/I119439378"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppina Benoni","raw_affiliation_strings":["Institute of Pharmacology, University of Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, University of Verona, Italy","institution_ids":["https://openalex.org/I119439378"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025276299"],"corresponding_institution_ids":["https://openalex.org/I119439378"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":null,"fwci":3.2801,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.92979866,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"29","issue":"1","first_page":"89","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.10080000013113022,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diclofenac","display_name":"diclofenac","score":0.9760000109672546},{"id":"https://openalex.org/keywords/adjuvant-induced-arthritis","display_name":"adjuvant-induced arthritis","score":0.875},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8500000238418579},{"id":"https://openalex.org/keywords/gastrointestinal-tolerability","display_name":"gastrointestinal tolerance","score":0.9150000214576721},{"id":"https://openalex.org/keywords/anti-inflammatory-efficacy","display_name":"anti-inflammatory efficacy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9890000224113464},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9570000171661377},{"id":"https://openalex.org/keywords/anaerobic-bacteria","display_name":"anaerobic bacteria","score":0.9559999704360962},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.9470000267028809},{"id":"https://openalex.org/keywords/gastrointestinal-lesions","display_name":"gastrointestinal lesions","score":0.5879999995231628},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2779826273","wikidata":"https://www.wikidata.org/wiki/Q244408","display_name":"Diclofenac","level":2,"score":0.9140499234199524},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7801985740661621},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7390061616897583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6706228256225586},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5799053311347961},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5706409811973572},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.5649870038032532},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.5301816463470459},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4816397726535797},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.346160888671875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28552448749542236},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.12503069639205933}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004008","descriptor_name":"Diclofenac","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004008","descriptor_name":"Diclofenac","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004008","descriptor_name":"Diclofenac","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010438","descriptor_name":"Peptic Ulcer Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010438","descriptor_name":"Peptic Ulcer Hemorrhage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/1043-6618(94)80101-0","doi":"https://doi.org/10.1016/1043-6618(94)80101-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/1043-6618(94)80101-0","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},{"id":"pmid:8202446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8202446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W153921869","https://openalex.org/W1929009802","https://openalex.org/W1968299459","https://openalex.org/W1978140559","https://openalex.org/W1994389040","https://openalex.org/W2014753452","https://openalex.org/W2021138632","https://openalex.org/W2029521144","https://openalex.org/W2083781054","https://openalex.org/W2085518982","https://openalex.org/W2149688761","https://openalex.org/W2205113102","https://openalex.org/W2494252145"],"related_works":["https://openalex.org/W2079088383","https://openalex.org/W2066687954","https://openalex.org/W1997030973","https://openalex.org/W2023493405","https://openalex.org/W3083771735","https://openalex.org/W2019564380","https://openalex.org/W4252507727","https://openalex.org/W2418317646","https://openalex.org/W2038609986","https://openalex.org/W2335897289"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}