{"id":"https://openalex.org/W2075844835","doi":"https://doi.org/10.1101/gr.2156804","title":"Genomics, Prior Probability, and Statistical Tests of Multiple Hypotheses","display_name":"Genomics, Prior Probability, and Statistical Tests of Multiple Hypotheses","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2075844835","doi":"https://doi.org/10.1101/gr.2156804","mag":"2075844835","pmid":"https://pubmed.ncbi.nlm.nih.gov/15173107"},"language":"en","primary_location":{"id":"doi:10.1101/gr.2156804","doi":"https://doi.org/10.1101/gr.2156804","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.2156804","pdf_url":"https://genome.cshlp.org/content/14/6/997.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://genome.cshlp.org/content/14/6/997.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006448639","display_name":"Kenneth F. Manly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth F. Manly","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. kmanly@Tennessee.edu","Department of Molecular and Cellular Biology Roswell Park Cancer Institute Buffalo, New York 14263, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. kmanly@Tennessee.edu","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology Roswell Park Cancer Institute Buffalo, New York 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047522477","display_name":"Dan S. Nettleton","orcid":"https://orcid.org/0000-0002-6045-1036","observed_orcids":["https://orcid.org/0000-0002-6045-1036"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Nettleton","raw_affiliation_strings":["Department of Statistics, Iowa State University, Ames, Iowa 50011, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Iowa State University, Ames, Iowa 50011, USA;","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108523579","display_name":"J. T. Gene Hwang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.T. Gene Hwang","raw_affiliation_strings":["Departments of Mathematics and Statistical Science, Cornell University, Ithaca, New York 14853, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Mathematics and Statistical Science, Cornell University, Ithaca, New York 14853, USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"6","first_page":"997","last_page":"1001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.4025999903678894,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.4025999903678894,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.24779999256134033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.08089999854564667,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-testing","display_name":"multiple comparisons","score":0.9710000157356262},{"id":"https://openalex.org/keywords/prior-probability","display_name":"prior probability","score":0.7749999761581421},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"false discovery rate","score":1.0},{"id":"https://openalex.org/keywords/type-i-error","display_name":"type I error","score":0.6779999732971191},{"id":"https://openalex.org/keywords/statistical-power","display_name":"statistical power","score":0.6790000200271606},{"id":"https://openalex.org/keywords/microarray-data","display_name":"microarray data","score":0.5389999747276306},{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.9390000104904175}],"concepts":[{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.791655957698822},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7658737301826477},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.666753888130188},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.6598774790763855},{"id":"https://openalex.org/C191988596","wikidata":"https://www.wikidata.org/wiki/Q628374","display_name":"Null hypothesis","level":2,"score":0.6417737007141113},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.6222109794616699},{"id":"https://openalex.org/C40696583","wikidata":"https://www.wikidata.org/wiki/Q989120","display_name":"Type I and type II errors","level":2,"score":0.5858547687530518},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.5702343583106995},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5493981838226318},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.5385801196098328},{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.5174204111099243},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4509994387626648},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.37147679924964905},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3695659041404724},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2587164640426636},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19735288619995117},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15072566270828247},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1101/gr.2156804","doi":"https://doi.org/10.1101/gr.2156804","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.2156804","pdf_url":"https://genome.cshlp.org/content/14/6/997.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},{"id":"pmid:15173107","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15173107","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome research","raw_type":"Journal Article"},{"id":"pmh:oai:lib.dr.iastate.edu:stat_las_pubs-1238","doi":null,"is_oa":true,"landing_page_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=1238&context=stat_las_pubs","pdf_url":null,"source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Statistics Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1101/gr.2156804","doi":"https://doi.org/10.1101/gr.2156804","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.2156804","pdf_url":"https://genome.cshlp.org/content/14/6/997.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4742169899","display_name":"INFORMATICS CENTER FOR MOUSE NEUROGENETICS","funder_award_id":"P20MH062009","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7110897589","display_name":"Portable Software for Mapping Quantitative Traits","funder_award_id":"P41HG001656","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320332483","display_name":"Cooperative State Research, Education, and Extension Service","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2075844835.pdf","grobid_xml":"https://content.openalex.org/works/W2075844835.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W96717503","https://openalex.org/W1911245058","https://openalex.org/W1964895626","https://openalex.org/W2000522196","https://openalex.org/W2013672457","https://openalex.org/W2036714085","https://openalex.org/W2057758736","https://openalex.org/W2093463665","https://openalex.org/W2094248448","https://openalex.org/W2099107563","https://openalex.org/W2105381419","https://openalex.org/W2107115446","https://openalex.org/W2110065044","https://openalex.org/W2115012618","https://openalex.org/W2118308505","https://openalex.org/W2121044470","https://openalex.org/W2125905177","https://openalex.org/W2130494035","https://openalex.org/W2130530904","https://openalex.org/W2143079975","https://openalex.org/W2146273335","https://openalex.org/W2148860875","https://openalex.org/W2163285329","https://openalex.org/W4240455808","https://openalex.org/W4247420482"],"related_works":["https://openalex.org/W2099657218","https://openalex.org/W2093463665","https://openalex.org/W2024105897","https://openalex.org/W2046875666","https://openalex.org/W2132978825","https://openalex.org/W1497310156","https://openalex.org/W325754011","https://openalex.org/W2098762353","https://openalex.org/W2512172366","https://openalex.org/W84093231"],"abstract_inverted_index":{"Genomic":[0],"methods":[1,6,37,56,77,125],"have":[2],"made":[3],"statistical":[4,40],"multiple-test":[5,36],"important":[7,141],"to":[8,16,119],"geneticists":[9],"and":[10,22,126],"molecular":[11],"biologists.":[12],"These":[13,76],"tests":[14],"apply":[15],"identification":[17],"of":[18,24,44,61,69,104,131],"quantitative":[19],"trait":[20],"loci":[21],"measurement":[23],"changes":[25],"in":[26,63,80],"RNA":[27],"or":[28,67,89,102],"DNA":[29],"abundance":[30],"by":[31],"microarray":[32],"methods.":[33],"Recently":[34],"developed":[35],"provide":[38,58],"more":[39],"power":[41],"when":[42,65],"many":[43],"the":[45,52,70,93,110,121,129],"tested":[46,71,137],"null":[47,72,133],"hypotheses":[48,73,134,138],"are":[49,74],"false.":[50],"At":[51],"same":[53],"time,":[54],"these":[55,124],"can":[57],"stringent":[59],"control":[60,78],"errors":[62,79],"cases":[64],"most":[66],"all":[68,136],"true.":[75],"a":[81],"different":[82],"way":[83],"from":[84],"previous":[85],"hypothesis":[86],"tests,":[87],"controlling":[88],"estimating":[90],"quantities":[91],"called":[92],"posterior":[94],"error":[95],"rate":[96,100],"(PER),":[97],"false":[98,105],"discovery":[99],"(FDR),":[101],"proportion":[103,130],"positives":[106],"(PFP),":[107],"rather":[108],"than":[109],"type":[111],"I":[112],"error.":[113],"In":[114],"this":[115],"study,":[116],"we":[117],"attempt":[118],"clarify":[120],"relationships":[122],"among":[123,135],"demonstrate":[127],"how":[128],"true":[132],"plays":[139],"an":[140],"role.":[142]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
