{"id":"https://openalex.org/W2075696178","doi":"https://doi.org/10.1016/j.ymthe.2006.08.231","title":"206. Frequency and Analysis of Liver Tumors in AAV-Treated B6C3F1 Hybrid Mice","display_name":"206. Frequency and Analysis of Liver Tumors in AAV-Treated B6C3F1 Hybrid Mice","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2075696178","doi":"https://doi.org/10.1016/j.ymthe.2006.08.231","mag":"2075696178"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymthe.2006.08.231","doi":"https://doi.org/10.1016/j.ymthe.2006.08.231","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2006.08.231","pdf_url":"http://www.cell.com/article/S1525001606004886/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S1525001606004886/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083739731","display_name":"Peter L. Bell","orcid":"https://orcid.org/0000-0002-5420-4477","observed_orcids":["https://orcid.org/0000-0002-5420-4477"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter L. Bell","raw_affiliation_strings":["Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078049281","display_name":"Albert D. Moscioni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. David Moscioni","raw_affiliation_strings":["Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056786004","display_name":"Robert McCarter","orcid":"https://orcid.org/0000-0002-7911-6078","observed_orcids":["https://orcid.org/0000-0002-7911-6078"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. McCarter","raw_affiliation_strings":["Center for Genetic Medicine Research, Children's National Medical Center, Children's Research Institute, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genetic Medicine Research, Children's National Medical Center, Children's Research Institute, Washington, DC","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057482719","display_name":"Di Wu","orcid":"https://orcid.org/0000-0002-3440-1860","observed_orcids":["https://orcid.org/0000-0002-3440-1860"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Di Wu","raw_affiliation_strings":["Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009470292","display_name":"Guangping Gao","orcid":"https://orcid.org/0000-0003-0097-9012","observed_orcids":["https://orcid.org/0000-0003-0097-9012"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guang-Ping Gao","raw_affiliation_strings":["Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024562789","display_name":"Albert Hoang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert Hoang","raw_affiliation_strings":["Center for Genetic Medicine Research, Children's National Medical Center, Children's Research Institute, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genetic Medicine Research, Children's National Medical Center, Children's Research Institute, Washington, DC","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035340215","display_name":"Julio San Miguel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julio San Miguel","raw_affiliation_strings":["Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019798378","display_name":"Xun Sun","orcid":"https://orcid.org/0000-0002-4316-2988","observed_orcids":["https://orcid.org/0000-0002-4316-2988"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xun Sun","raw_affiliation_strings":["Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008689151","display_name":"Nelson A. Wivel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nelson Wivel","raw_affiliation_strings":["Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108437486","display_name":"Steven E. Raper","orcid":"https://orcid.org/0000-0001-9191-4681","observed_orcids":["https://orcid.org/0000-0001-9191-4681"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven E. Raper","raw_affiliation_strings":["Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042763431","display_name":"Emma Elizabeth Furth","orcid":"https://orcid.org/0000-0002-9309-985X","observed_orcids":["https://orcid.org/0000-0002-9309-985X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma E. Furth","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046895078","display_name":"Mark L. Batshaw","orcid":"https://orcid.org/0000-0001-7557-0700","observed_orcids":["https://orcid.org/0000-0001-7557-0700"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark L. Batshaw","raw_affiliation_strings":["Center for Genetic Medicine Research, Children's National Medical Center, Children's Research Institute, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genetic Medicine Research, Children's National Medical Center, Children's Research Institute, Washington, DC","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051344823","display_name":"James M. Wilson","orcid":"https://orcid.org/0000-0002-9630-3131","observed_orcids":["https://orcid.org/0000-0002-9630-3131","https://orcid.org/0000-0002-7988-0201"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Wilson","raw_affiliation_strings":["Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.1517,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45638032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"S80","last_page":"S80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adeno-associated-virus-vectors","display_name":"adeno-associated virus vectors","score":0.878000020980835},{"id":"https://openalex.org/keywords/liver-tumors","display_name":"liver tumors","score":0.7590000033378601},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/b6c3f1-mice","display_name":"B6C3F1 mice","score":0.8550000190734863},{"id":"https://openalex.org/keywords/otc-gene","display_name":"OTC gene","score":0.5849999785423279},{"id":"https://openalex.org/keywords/lacz-transgene","display_name":"lacZ transgene","score":0.6930000185966492},{"id":"https://openalex.org/keywords/tumorigenicity","display_name":"tumorigenicity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/gene-therapy-safety","display_name":"gene therapy safety","score":0.5690000057220459},{"id":"https://openalex.org/keywords/transgene-expression","display_name":"transgene expression","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7285593748092651},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6697924733161926},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.6552293300628662},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5701899528503418},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.5583778023719788},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5407417416572571},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4811343252658844},{"id":"https://openalex.org/C51456166","wikidata":"https://www.wikidata.org/wiki/Q182726","display_name":"Genetically modified organism","level":3,"score":0.46833133697509766},{"id":"https://openalex.org/C2776964913","wikidata":"https://www.wikidata.org/wiki/Q1671502","display_name":"Liver tumor","level":3,"score":0.445865273475647},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.41332173347473145},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3756615221500397},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3532242476940155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.303338885307312},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12509876489639282},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.09106260538101196}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ymthe.2006.08.231","doi":"https://doi.org/10.1016/j.ymthe.2006.08.231","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2006.08.231","pdf_url":"http://www.cell.com/article/S1525001606004886/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ymthe.2006.08.231","doi":"https://doi.org/10.1016/j.ymthe.2006.08.231","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2006.08.231","pdf_url":"http://www.cell.com/article/S1525001606004886/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2075696178.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2075638876","https://openalex.org/W2000627935","https://openalex.org/W1510240881","https://openalex.org/W4229508094","https://openalex.org/W3108417518","https://openalex.org/W3193664861","https://openalex.org/W7099075334","https://openalex.org/W2165926588","https://openalex.org/W2088797435","https://openalex.org/W4220663291"],"abstract_inverted_index":{"We":[0,294],"report":[1],"on":[2],"the":[3,21,38,85,98,116,119,130,142,159,162,171,206,210,217,224,232,280,305,318,324],"frequency":[4,32],"of":[5,20,33,41,61,118,164,173,182,219,227,262,273,307,320,326],"liver":[6,113,122,229,267],"tumors":[7,275],"observed":[8,131],"in":[9,17,37,68,97,158,216,241,310,330],"a":[10,30,214,314],"gene":[11,71],"therapy":[12],"study":[13],"with":[14,66,110,187,200,254,313,332],"AAV":[15,62,81,298],"vectors":[16,82,165,189,199,299],"male":[18],"mice":[19,65,178,242],"B6C3F1":[22],"hybrid":[23],"background,":[24],"which":[25],"are":[26],"known":[27],"to":[28,45,55,128,134,137,191,248,278,286,304,317],"have":[29],"high":[31],"spontaneous":[34],"tumor":[35,174,183],"formation":[36,184,218,306],"liver.":[39],"Because":[40],"their":[42,69,76,135],"increased":[43,180],"susceptibility":[44,316],"develop":[46],"tumors,":[47,308],"these":[48,177],"animals":[49,94,107,193,195,252],"should":[50],"serve":[51],"as":[52,202,235,282],"sensitive":[53],"models":[54],"reveal":[56],"any":[57],"potential":[58],"tumorigenic":[59],"properties":[60],"vectors.":[63],"Male":[64],"mutations":[67],"OTC":[70,87,288],"(spf":[72],"and":[73,75,105,154,231,269,290],"spf-ash)":[74],"wild-type":[77,104],"siblings":[78],"had":[79,197,244],"received":[80,198,245],"expressing":[83,166],"either":[84],"murine":[86],"(mOTC)":[88],"or":[89,194,251,329],"LacZ":[90,327],"gene.":[91],"Untreated":[92],"control":[93],"were":[95,124,150],"included":[96],"study.":[99],"All":[100],"experimental":[101],"groups":[102],"including":[103],"mOTC-deficient":[106],"not":[108,169,209,302],"treated":[109,186,253],"vector":[111,211,263,333],"developed":[112],"nodules.":[114],"In":[115,141,221],"majority":[117],"animals,":[120],"H&E-stained":[121],"samples":[123],"available":[125],"that":[126,196,205,243,297],"allowed":[127],"score":[129],"nodules":[132,230],"according":[133],"likelihood":[136],"represent":[138],"hepatocellular":[139,236],"carcinomas.":[140],"spf":[143],"group":[144,161],"no":[145],"statistically":[146],"significant":[147],"risk":[148,172,226],"differences":[149],"found":[151,277],"between":[152],"vector-treated":[153],"untreated":[155,192,249],"animals.":[156],"Likewise,":[157],"spf-ash":[160],"administration":[163],"mOTC":[167,201],"did":[168],"increase":[170],"development.":[175],"However,":[176,323],"showed":[179],"risks":[181],"when":[185],"LacZ-expressing":[188],"compared":[190,247],"transgene,":[203],"suggesting":[204],"transgene":[207,281],"but":[208],"might":[212],"play":[213],"role":[215],"tumors.":[220],"general,":[222],"both":[223],"overall":[225],"developing":[228],"histological":[233],"appearance":[234],"carcinoma":[237],"was":[238,276],"more":[239],"frequent":[240],"AAV-LacZ":[246],"controls":[250],"AAVmOTC.":[255],"Tumor":[256],"tissue":[257],"contained":[258],"consistently":[259],"lower":[260],"amounts":[261],"DNA":[264],"than":[265],"healthy":[266],"tissue,":[268],"only":[270],"one":[271],"out":[272],"16":[274],"express":[279],"determined":[283],"by":[284],"histochemistry":[285],"detect":[287],"activity":[289],"immunostaining":[291],"against":[292],"beta-galactosidase.":[293],"therefore":[295],"conclude":[296],"alone":[300,328],"do":[301],"contribute":[303],"even":[309],"mouse":[311],"strains":[312],"heightened":[315],"development":[319],"those":[321],"lesions.":[322],"expression":[325],"combination":[331],"may":[334],"be":[335],"problematic.":[336]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}