{"id":"https://openalex.org/W207569148","doi":null,"title":"Effect of high-fat diet on liver and placenta fatty infiltration in early onset preeclampsia-like mouse model.","display_name":"Effect of high-fat diet on liver and placenta fatty infiltration in early onset preeclampsia-like mouse model.","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W207569148","mag":"207569148","pmid":"https://pubmed.ncbi.nlm.nih.gov/23044319"},"language":"en","primary_location":{"id":"pmid:23044319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23044319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064447541","display_name":"Min-na Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min-Na Sun","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103843996","display_name":"Zi Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zi Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021506689","display_name":"Ruiqiong Ma","orcid":"https://orcid.org/0000-0002-1094-8992","observed_orcids":["https://orcid.org/0000-0002-1094-8992"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui-Qiong Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1991,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.85894547,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"125","issue":"19","first_page":"3532","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-onset-preeclampsia","display_name":"early-onset preeclampsia","score":0.9039999842643738},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9319999814033508},{"id":"https://openalex.org/keywords/fatty-liver-infiltration","display_name":"liver fatty infiltration","score":0.7950000166893005},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibition","display_name":"nitric oxide synthase inhibition","score":0.8889999985694885},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.7059999704360962},{"id":"https://openalex.org/keywords/maternal-hypertension","display_name":"maternal hypertension","score":0.44200000166893005},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.786230206489563},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.6774179339408875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6506924629211426},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6422168612480164},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.5121240615844727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5110417604446411},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.5012428760528564},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.45040446519851685},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4480760097503662},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.393424391746521},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2179620862007141},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.13724613189697266},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:23044319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23044319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:207569148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23044319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W22479020","https://openalex.org/W2462053861","https://openalex.org/W2461647756","https://openalex.org/W1724736104","https://openalex.org/W4410077220","https://openalex.org/W3169928324","https://openalex.org/W2428457281","https://openalex.org/W4402242908","https://openalex.org/W4389021830","https://openalex.org/W3173872421"],"abstract_inverted_index":{"BACKGROUND:":[0],"Preeclampsia,":[1],"especially":[2,216,384],"early":[3,336,379],"onset":[4],"of":[5,26,38,43,51,57,72,150,245,254,259,275,340,374,402],"preeclampsia":[6,398],"(PE),":[7],"is":[8,24,46],"a":[9,138],"common":[10],"and":[11,17,20,36,59,102,128,147,152,159,165,171,198,207,220,236,262,268,273,277,295,301,306,328,337,348,366,380,399],"serious":[12],"disorder":[13],"with":[14,81,112,332],"high":[15],"maternal":[16],"perinatal":[18],"morbidity":[19],"mortality.":[21],"Dietary":[22],"factor":[23],"one":[25],"the":[27,34,39,49,67,107,118,181,218,346,354,364,367,372,386,394,400],"most":[28],"important":[29],"factors":[30,53],"which":[31],"may":[32],"affect":[33],"occurrence":[35],"development":[37],"disease.":[40],"The":[41],"aim":[42],"this":[44],"study":[45],"to":[47,93,191,281,363],"investigate":[48],"effects":[50],"dietary":[52],"on":[54],"pathological":[55],"changes":[56,149],"liver":[58,153,195,235,375],"placenta":[60,151,202,237,347],"in":[61,154,179,201,205,210,217,223,234,240,266,271,320,335,345,385],"preeclampsia-like":[62,333],"mouse":[63,388],"model":[64,68,96],"by":[65,318,357],"establishing":[66],"at":[69,99,322,378],"multiple":[70],"stages":[71,339,383],"gestation.":[73],"METHODS:":[74],"Wild-type":[75],"(WT)":[76],"mice":[77,109,135,212,225,242,321,331],"were":[78,110,120,157,174,203,238],"injected":[79,111],"subcutaneously":[80],"nitric":[82],"oxide":[83],"synthase":[84],"(NOS)":[85],"inhibitor":[86],"L-arginine":[87],"methyl":[88],"ester":[89],"(L-NAME,":[90],"50":[91],"mg\u00d7kg(-1)\u00d7d(-1))":[92],"establish":[94],"PE-like":[95],"(L-NAME":[97],"group)":[98],"early-,":[100],"mid-,":[101],"late-pregnant":[103],"periods":[104],"respectively;":[105],"simultaneously,":[106],"control":[108,139],"normal":[113],"saline":[114],"(NS":[115],"group).":[116],"All":[117],"groups":[119,156,186,247,308],"divided":[121],"into":[122],"subgroups,":[123,168],"standard":[124],"chow":[125],"group":[126,131],"(SC),":[127],"high-fat":[129,359],"diet":[130,360,370],"(HF).":[132],"ApoE(-/-)":[133,241],"pregnant":[134],"served":[136],"as":[137],"group.":[140],"Systolic":[141],"blood":[142,169],"pressure":[143,170],"(SBP),":[144],"urine":[145,172],"protein,":[146],"histopathologic":[148,252],"all":[155,180],"observed":[158],"statistically":[160],"analyzed.":[161],"RESULTS:":[162],"In":[163],"WT":[164,246,278,307,327],"apoE(-/-)":[166,211,224,276,305,329,387],"L-NAME":[167,319],"protein":[173],"significantly":[175],"higher":[176],"than":[177,243],"those":[178],"gestational":[182,324,382],"age":[183],"matched":[184],"NS":[185,282],"(P":[187,213,226,248,284,298,309],"<":[188,214,227,249,285],"0.05).":[189,228,250,286,311],"Compared":[190],"other":[192],"groups,":[193],"remarkable":[194],"fatty":[196,350,376,403],"infiltration":[197,377],"lipid":[199,230,343],"storage":[200,231],"found":[204,239],"early-":[206,219,267],"mid-L-NAME":[208,269],"subgroups":[209,222,279,297],"0.05),":[215,300],"mid-HF+L-NAME":[221],"More":[229],"droplets":[232],"both":[233,270],"that":[244],"Morphology":[251],"examination":[253],"placentas":[255],"showed":[256],"varying":[257],"degrees":[258],"fibrinoid":[260],"necrosis":[261],"villous":[263],"interstitial":[264],"edema":[265],"HF":[272,294],"SC":[274,296],"compared":[280],"controls":[283],"But":[287],"there":[288],"was":[289,361],"no":[290,302],"significant":[291],"difference":[292,303],"between":[293,304,396],">":[299,310],"CONCLUSIONS:":[312],"Preeclampsia-like":[313],"conditions":[314],"could":[315],"be":[316],"induced":[317],"different":[323],"stages.":[325],"Both":[326],"genotype":[330],"symptoms":[334],"mid":[338,381],"pregnancy":[341],"presented":[342],"deposition":[344],"hepatic":[349],"infiltration.":[351],"To":[352],"alter":[353],"environmental":[355],"condition":[356],"feeding":[358],"harmful":[362],"mother":[365],"fetus.":[368],"High-fat":[369],"aggravated":[371],"impact":[373],"model.":[389],"These":[390],"results":[391],"further":[392],"revealed":[393],"association":[395],"early-onset":[397],"dysoxidation":[401],"acids.":[404]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
