{"id":"https://openalex.org/W2075686355","doi":"https://doi.org/10.1016/s0306-3623(97)00358-3","title":"The Localization of Endogenous Zinc and the in vitro Effect of Exogenous Zinc on the GABA Immunoreactivity and Formation of Reactive Oxygen Species in the Retina*","display_name":"The Localization of Endogenous Zinc and the in vitro Effect of Exogenous Zinc on the GABA Immunoreactivity and Formation of Reactive Oxygen Species in the Retina*","publication_year":1998,"publication_date":"1998-03-01","ids":{"openalex":"https://openalex.org/W2075686355","doi":"https://doi.org/10.1016/s0306-3623(97)00358-3","mag":"2075686355","pmid":"https://pubmed.ncbi.nlm.nih.gov/9510077"},"language":"en","primary_location":{"id":"doi:10.1016/s0306-3623(97)00358-3","doi":"https://doi.org/10.1016/s0306-3623(97)00358-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0306-3623(97)00358-3","pdf_url":null,"source":{"id":"https://openalex.org/S3961818","display_name":"General Pharmacology The Vascular System","issn_l":"0306-3623","issn":["0306-3623","1879-0011"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General Pharmacology: The Vascular System","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114377382","display_name":"Marta Ugarte","orcid":"https://orcid.org/0000-0002-8132-5004","observed_orcids":["https://orcid.org/0000-0002-8132-5004"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marta Ugarte","raw_affiliation_strings":["Nuffield Laboratory of Ophthalmology, University of Oxford, United Kingdom","Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, Oxford OX2 6AW, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Laboratory of Ophthalmology, University of Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, Oxford OX2 6AW, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069352403","display_name":"Neville N. Osborne","orcid":"https://orcid.org/0000-0002-8091-734X","observed_orcids":["https://orcid.org/0000-0002-8091-734X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Neville N Osborne","raw_affiliation_strings":["Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, Oxford OX2 6AW, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, Oxford OX2 6AW, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069352403"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":null,"apc_paid":null,"fwci":3.6586,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.92885493,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"30","issue":"3","first_page":"297","last_page":"303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.836899995803833,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.836899995803833,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.11100000143051147,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zinc-localization","display_name":"zinc localization","score":0.6039999723434448},{"id":"https://openalex.org/keywords/retina","display_name":"retina","score":0.7160000205039978},{"id":"https://openalex.org/keywords/gaba-immunoreactivity","display_name":"GABA immunoreactivity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.921999990940094},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.6480000019073486},{"id":"https://openalex.org/keywords/mk-801","display_name":"MK-801","score":0.9700000286102295},{"id":"https://openalex.org/keywords/retinal-ischemia","display_name":"retinal ischemia","score":0.9010000228881836},{"id":"https://openalex.org/keywords/photoreceptors","display_name":"photoreceptors","score":0.824999988079071},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9660000205039978},{"id":"https://openalex.org/keywords/muller-cells","display_name":"M\u00fcller cells","score":0.8220000267028809},{"id":"https://openalex.org/keywords/gaba-metabolism","display_name":"GABA metabolism","score":0.7850000262260437},{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.9739999771118164},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8569999933242798},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.8822067975997925},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.8304385542869568},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6856002807617188},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6535202264785767},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.6062776446342468},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5134597420692444},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43856140971183777},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4258003830909729},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3857000172138214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3740323483943939},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3021453320980072},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0306-3623(97)00358-3","doi":"https://doi.org/10.1016/s0306-3623(97)00358-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0306-3623(97)00358-3","pdf_url":null,"source":{"id":"https://openalex.org/S3961818","display_name":"General Pharmacology The Vascular System","issn_l":"0306-3623","issn":["0306-3623","1879-0011"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General Pharmacology: The Vascular System","raw_type":"journal-article"},{"id":"pmid:9510077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9510077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General pharmacology","raw_type":"Comparative Study"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/4760f98d-c26c-4f6f-8c1b-a1e8fb484549","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/4760f98d-c26c-4f6f-8c1b-a1e8fb484549","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ugarte, M & Osborne, N N 1998, 'The localization of endogenous zinc and the in vitro effect of exogenous zinc on the GABA immunoreactivity and formation of reactive oxygen species in the retina', General Pharmacology, vol. 30, no. 3, pp. 297-303. https://doi.org/10.1016/S0306-3623(97)00358-3","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W45253651","https://openalex.org/W50296032","https://openalex.org/W68747868","https://openalex.org/W157666778","https://openalex.org/W1517534406","https://openalex.org/W1616090194","https://openalex.org/W1849874806","https://openalex.org/W1965261878","https://openalex.org/W1968267810","https://openalex.org/W1968740148","https://openalex.org/W1971192189","https://openalex.org/W1972173896","https://openalex.org/W1972614641","https://openalex.org/W1975951192","https://openalex.org/W1991647860","https://openalex.org/W1996011223","https://openalex.org/W2002536790","https://openalex.org/W2006746476","https://openalex.org/W2009997960","https://openalex.org/W2010095445","https://openalex.org/W2013986174","https://openalex.org/W2016489565","https://openalex.org/W2018883950","https://openalex.org/W2019958880","https://openalex.org/W2021116136","https://openalex.org/W2022382515","https://openalex.org/W2024105385","https://openalex.org/W2025008185","https://openalex.org/W2030198251","https://openalex.org/W2040066177","https://openalex.org/W2041399209","https://openalex.org/W2042717034","https://openalex.org/W2044981704","https://openalex.org/W2046423382","https://openalex.org/W2047735961","https://openalex.org/W2054406771","https://openalex.org/W2054566340","https://openalex.org/W2058050690","https://openalex.org/W2070738669","https://openalex.org/W2074736272","https://openalex.org/W2076083610","https://openalex.org/W2077150952","https://openalex.org/W2078951725","https://openalex.org/W2083068775","https://openalex.org/W2083987263","https://openalex.org/W2086010070","https://openalex.org/W2091124986","https://openalex.org/W2103199749","https://openalex.org/W2125407928","https://openalex.org/W2126180763","https://openalex.org/W2147737086","https://openalex.org/W2152587651","https://openalex.org/W2159554322","https://openalex.org/W2161829304","https://openalex.org/W2294786181","https://openalex.org/W2312204048","https://openalex.org/W2610821882","https://openalex.org/W4244676909","https://openalex.org/W6736810293"],"related_works":["https://openalex.org/W2427315150","https://openalex.org/W2003656293","https://openalex.org/W2091320610","https://openalex.org/W1967678662","https://openalex.org/W2025982574","https://openalex.org/W2054134808","https://openalex.org/W1975219311","https://openalex.org/W1517534406","https://openalex.org/W1976116995","https://openalex.org/W1979711007"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
