{"id":"https://openalex.org/W2075636627","doi":"https://doi.org/10.1053/gast.2000.8522","title":"Changes in protein kinase C isoforms in association with vascular hyporeactivity in cirrhotic rat aortas","display_name":"Changes in protein kinase C isoforms in association with vascular hyporeactivity in cirrhotic rat aortas","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W2075636627","doi":"https://doi.org/10.1053/gast.2000.8522","mag":"2075636627","pmid":"https://pubmed.ncbi.nlm.nih.gov/10889170"},"language":"en","primary_location":{"id":"doi:10.1053/gast.2000.8522","doi":"https://doi.org/10.1053/gast.2000.8522","is_oa":true,"landing_page_url":"https://doi.org/10.1053/gast.2000.8522","pdf_url":"http://www.gastrojournal.org/article/S0016508500771101/pdf","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.gastrojournal.org/article/S0016508500771101/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111400469","display_name":"Khalid A. Tazi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2799502834","display_name":"H\u00f4pital Beaujon","ror":"https://ror.org/03jyzk483","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2799502834","https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Khalid A. Tazi","raw_affiliation_strings":["Laboratoire d'H\u00e9modynamique Splanchnique et de Biologie Vasculaire, INSERM Unit\u00e9 481, H\u00f4pital Beaujon, Clichy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'H\u00e9modynamique Splanchnique et de Biologie Vasculaire, INSERM Unit\u00e9 481, H\u00f4pital Beaujon, Clichy, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2799502834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001302118","display_name":"Richard Moreau","orcid":"https://orcid.org/0000-0003-0862-403X","observed_orcids":["https://orcid.org/0000-0003-0862-403X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2799502834","display_name":"H\u00f4pital Beaujon","ror":"https://ror.org/03jyzk483","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2799502834","https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Richard Moreau","raw_affiliation_strings":["Laboratoire d'H\u00e9modynamique Splanchnique et de Biologie Vasculaire, INSERM Unit\u00e9 481, H\u00f4pital Beaujon, Clichy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'H\u00e9modynamique Splanchnique et de Biologie Vasculaire, INSERM Unit\u00e9 481, H\u00f4pital Beaujon, Clichy, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2799502834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104349501","display_name":"J\u00f6rg Heller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2799502834","display_name":"H\u00f4pital Beaujon","ror":"https://ror.org/03jyzk483","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2799502834","https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Heller","raw_affiliation_strings":["Laboratoire d'H\u00e9modynamique Splanchnique et de Biologie Vasculaire, INSERM Unit\u00e9 481, H\u00f4pital Beaujon, Clichy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'H\u00e9modynamique Splanchnique et de Biologie Vasculaire, INSERM Unit\u00e9 481, H\u00f4pital Beaujon, Clichy, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2799502834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078908751","display_name":"Odile Poirel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2799502834","display_name":"H\u00f4pital Beaujon","ror":"https://ror.org/03jyzk483","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2799502834","https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Odile Poirel","raw_affiliation_strings":["Laboratoire d'H\u00e9modynamique Splanchnique et de Biologie Vasculaire, INSERM Unit\u00e9 481, H\u00f4pital Beaujon, Clichy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'H\u00e9modynamique Splanchnique et de Biologie Vasculaire, INSERM Unit\u00e9 481, H\u00f4pital Beaujon, Clichy, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2799502834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088338447","display_name":"Didier Lebrec","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2799502834","display_name":"H\u00f4pital Beaujon","ror":"https://ror.org/03jyzk483","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2799502834","https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Didier Lebrec","raw_affiliation_strings":["Laboratoire d'H\u00e9modynamique Splanchnique et de Biologie Vasculaire, INSERM Unit\u00e9 481, H\u00f4pital Beaujon, Clichy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'H\u00e9modynamique Splanchnique et de Biologie Vasculaire, INSERM Unit\u00e9 481, H\u00f4pital Beaujon, Clichy, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2799502834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":1.4224,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.81616907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"119","issue":"1","first_page":"201","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.7095000147819519,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.7095000147819519,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.11289999634027481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.040699999779462814,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pkc-isoforms","display_name":"PKC isoforms","score":0.9660000205039978},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/vascular-hyporeactivity","display_name":"vascular hyporeactivity","score":0.9610000252723694},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.7149999737739563},{"id":"https://openalex.org/keywords/protein-kinase-c-alpha","display_name":"protein kinase C alpha","score":0.972000002861023},{"id":"https://openalex.org/keywords/pkcdelta","display_name":"PKC\u03b4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pkc-zeta","display_name":"PKC zeta","score":0.8859999775886536},{"id":"https://openalex.org/keywords/pkc-beta","display_name":"PKC beta","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pkc-translocation","display_name":"PKC translocation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/endothelium-denuded-aorta","display_name":"endothelium-denuded aorta","score":0.8899999856948853},{"id":"https://openalex.org/keywords/vascular-smooth-muscle","display_name":"vascular smooth muscle","score":0.5529999732971191},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.8489999771118164},{"id":"https://openalex.org/keywords/phenylephrine","display_name":"phenylephrine","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pkc-down-regulation","display_name":"PKC down-regulation","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.9369379281997681},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.7414190173149109},{"id":"https://openalex.org/C2780043322","wikidata":"https://www.wikidata.org/wiki/Q2705359","display_name":"Phorbol","level":4,"score":0.607781171798706},{"id":"https://openalex.org/C2777952589","wikidata":"https://www.wikidata.org/wiki/Q421910","display_name":"Phenylephrine","level":3,"score":0.6051283478736877},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5774978995323181},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.562300443649292},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5463181734085083},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.5196039080619812},{"id":"https://openalex.org/C115302286","wikidata":"https://www.wikidata.org/wiki/Q14912643","display_name":"PKC alpha","level":4,"score":0.5066686272621155},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4517856538295746},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40091267228126526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.369213342666626},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26271694898605347},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24049299955368042},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12876716256141663},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.06874752044677734},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008106","descriptor_name":"Liver Cirrhosis, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014666","descriptor_name":"Vasomotor System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1053/gast.2000.8522","doi":"https://doi.org/10.1053/gast.2000.8522","is_oa":true,"landing_page_url":"https://doi.org/10.1053/gast.2000.8522","pdf_url":"http://www.gastrojournal.org/article/S0016508500771101/pdf","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},{"id":"pmid:10889170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10889170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1053/gast.2000.8522","doi":"https://doi.org/10.1053/gast.2000.8522","is_oa":true,"landing_page_url":"https://doi.org/10.1053/gast.2000.8522","pdf_url":"http://www.gastrojournal.org/article/S0016508500771101/pdf","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2075636627.pdf","grobid_xml":"https://content.openalex.org/works/W2075636627.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1514734464","https://openalex.org/W1603878868","https://openalex.org/W1976040875","https://openalex.org/W1979811142","https://openalex.org/W1981023296","https://openalex.org/W1981513678","https://openalex.org/W1982603534","https://openalex.org/W1994502825","https://openalex.org/W1995246796","https://openalex.org/W1996995529","https://openalex.org/W2015571904","https://openalex.org/W2031334877","https://openalex.org/W2039172540","https://openalex.org/W2044510333","https://openalex.org/W2049401019","https://openalex.org/W2055006638","https://openalex.org/W2055168506","https://openalex.org/W2056098856","https://openalex.org/W2060444215","https://openalex.org/W2061441464","https://openalex.org/W2065306750","https://openalex.org/W2068095073","https://openalex.org/W2076404162","https://openalex.org/W2081301776","https://openalex.org/W2083470439","https://openalex.org/W2089254280","https://openalex.org/W2103429867","https://openalex.org/W2128635872","https://openalex.org/W2131593855","https://openalex.org/W2132823212","https://openalex.org/W2136075579","https://openalex.org/W2140325096","https://openalex.org/W2162058371","https://openalex.org/W2172117026","https://openalex.org/W2186490363","https://openalex.org/W2187620959","https://openalex.org/W2254494228","https://openalex.org/W2279424556","https://openalex.org/W2333057087","https://openalex.org/W2399131254","https://openalex.org/W2409296454","https://openalex.org/W2413942490","https://openalex.org/W2415272838","https://openalex.org/W2419626516","https://openalex.org/W2472987639","https://openalex.org/W4248997983","https://openalex.org/W6695175784","https://openalex.org/W6713300293"],"related_works":["https://openalex.org/W2081301776","https://openalex.org/W2016053993","https://openalex.org/W2085591103","https://openalex.org/W2083470439","https://openalex.org/W2472987639","https://openalex.org/W2132823212","https://openalex.org/W2020296650","https://openalex.org/W2170508368","https://openalex.org/W2048540724","https://openalex.org/W1988054666"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
