{"id":"https://openalex.org/W2075582004","doi":"https://doi.org/10.3892/ijo.21.1.49","title":"Effect of As2O3 on cell cycle progression and cyclins D1 and B1 expression in two glioblastoma cell lines differing in p53 status","display_name":"Effect of As2O3 on cell cycle progression and cyclins D1 and B1 expression in two glioblastoma cell lines differing in p53 status","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W2075582004","doi":"https://doi.org/10.3892/ijo.21.1.49","mag":"2075582004","pmid":"https://pubmed.ncbi.nlm.nih.gov/12063549"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.21.1.49","doi":"https://doi.org/10.3892/ijo.21.1.49","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijo.21.1.49","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111848167","display_name":"Shiguang Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shiguang Zhao","raw_affiliation_strings":["Department of Neurosurgery, Kansai Medical University, Moriguchi city, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Kansai Medical University, Moriguchi city, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takahiro Tsuchida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takahiro Tsuchida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102957825","display_name":"Katsuhiro Kawakami","orcid":"https://orcid.org/0000-0003-0000-3159","observed_orcids":["https://orcid.org/0000-0003-0000-3159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katsuhiro Kawakami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007880392","display_name":"Changbin Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Changbin Shi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111940567","display_name":"Keiji Kawamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keiji Kawamoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0298,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.85988283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"1","first_page":"49","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.05270000174641609,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":0.9909999966621399},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cyclin-b1","display_name":"cyclin B1","score":1.0},{"id":"https://openalex.org/keywords/tp53-status","display_name":"p53 status","score":0.9100000262260437},{"id":"https://openalex.org/keywords/p53-activation","display_name":"p53 activation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9010000228881836},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.8790000081062317},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.7919999957084656},{"id":"https://openalex.org/keywords/u87-cells","display_name":"U87 cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/t98g-cells","display_name":"T98G cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.893634557723999},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.77667236328125},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.7542519569396973},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.7407663464546204},{"id":"https://openalex.org/C2994037739","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle progression","level":4,"score":0.6785892844200134},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.6698715686798096},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.6411665678024292},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5520173907279968},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49670344591140747},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.4378279745578766},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.41556137800216675},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3514530062675476},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33160996437072754},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08595141768455505},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077237","descriptor_name":"Arsenic Trioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056744","descriptor_name":"Cyclin B1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3892/ijo.21.1.49","doi":"https://doi.org/10.3892/ijo.21.1.49","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijo.21.1.49","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmid:12063549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12063549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"},{"id":"mag:3143574013","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000405496","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2383458343","https://openalex.org/W2357880826","https://openalex.org/W2362905450","https://openalex.org/W2145641211","https://openalex.org/W2355621292","https://openalex.org/W3025850911","https://openalex.org/W2385464027","https://openalex.org/W2361406518","https://openalex.org/W2385636386","https://openalex.org/W1789901929"],"abstract_inverted_index":{"Recent":[0],"clinical":[1,298],"studies":[2],"have":[3,58],"demonstrated":[4],"that":[5,63,148,266,283],"As2O3":[6,46,79,95,120,149,197,242,267],"is":[7,47],"an":[8,199],"effective":[9],"drug":[10,285],"in":[11,30,33,87,104,106,113,201,207,218,224,232,237,280,290],"the":[12,24,41,70,92,124,127,130,151,154,164,171,174,238,252,284],"treatment":[13,42],"of":[14,26,43,53,78,94,129,153,173,177,189,209,246,254,275],"acute":[15],"promyelocytic":[16],"leukemia":[17,27],"(APL)":[18],"by":[19,142,187,251],"inducing":[20],"apoptosis":[21,245],"and":[22,32,73,98,132,137,166,193,204,277,296],"inhibiting":[23],"proliferation":[25,72,97,152,274],"cells":[28,134,248,255,279],"both":[29,162,219],"vitro":[31],"vivo.":[34],"As":[35],"a":[36,205,230],"novel":[37],"anticancer":[38],"agent":[39],"for":[40,289],"solid":[44,88],"cancer,":[45],"promising,":[48],"but":[49],"no":[50],"experimental":[51],"investigations":[52],"its":[54,181],"efficacy":[55],"on":[56,96,123,183,293,300],"glioblastoma":[57,109],"been":[59],"conducted":[60],"at":[61,163,216,268],"concentrations":[62],"may":[64,286],"be":[65,84,287],"achieved":[66],"clinically.":[67],"In":[68],"addition,":[69],"cell":[71,74,99,110,156,159,184,214,220,261],"cycle":[75,100,160],"regulating":[76],"mechanism":[77,172],"has":[80],"not":[81],"yet":[82],"to":[83,119],"clarified,":[85],"especially":[86],"cancers.":[89],"We":[90],"investigated":[91],"effect":[93,176,182],"regulation":[101],"with":[102,126,213,229,256],"change":[103],"cyclins":[105],"two":[107,155],"human":[108],"lines":[111,157],"differing":[112],"p53":[114,202],"status":[115],"(U87MG-wt;":[116],"T98G-mutated).":[117],"Sensitivity":[118],"varied":[121],"depending":[122],"dose":[125],"IC50":[128],"U87MG":[131,240,247,276],"T98G":[133,278],"being":[135],"1.78":[136],"3.55":[138],"microM,":[139],"respectively.":[140],"Analysis":[141],"laser":[143],"scanning":[144],"cytometry":[145],"(LSC)":[146],"indicated":[147],"inhibited":[150,273],"via":[158],"arrest":[161,215,223],"G1":[165],"G2":[167],"phases.":[168],"To":[169],"address":[170],"antiproliferative":[175],"As2O3,":[178],"we":[179],"examined":[180],"cycle-related":[185],"proteins":[186],"means":[188],"LSC,":[190],"confocal":[191],"microscopy":[192],"Western":[194],"blot":[195],"analysis.":[196],"induced":[198,244],"increase":[200],"level":[203,208],"decrease":[206],"cyclin":[210,233],"B1":[211],"combined":[212],"G2/M":[217],"lines.":[221],"Cell":[222],"G1,":[225],"however,":[226],"was":[227],"associated":[228],"decline":[231],"D1":[234],"expression":[235],"only":[236],"wt":[239],"cells.":[241],"also":[243],"as":[249],"evidenced":[250],"presence":[253],"fractional":[257],"DNA":[258],"content":[259],"(":[260],"populations).":[262],"The":[263],"present":[264],"evidence":[265],"relatively":[269],"low":[270],"concentration":[271],"effectively":[272],"vitro,":[281],"suggests":[282],"considered":[288],"vivo":[291],"testing":[292],"animal":[294],"models":[295],"possibly":[297],"trials":[299],"glioma":[301],"patients.":[302]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}