{"id":"https://openalex.org/W2075580368","doi":"https://doi.org/10.1021/ja056702b","title":"Reflective Interferometric Fourier Transform Spectroscopy: A Self-Compensating Label-Free Immunosensor Using Double-Layers of Porous SiO2","display_name":"Reflective Interferometric Fourier Transform Spectroscopy: A Self-Compensating Label-Free Immunosensor Using Double-Layers of Porous SiO2","publication_year":2006,"publication_date":"2006-03-15","ids":{"openalex":"https://openalex.org/W2075580368","doi":"https://doi.org/10.1021/ja056702b","mag":"2075580368","pmid":"https://pubmed.ncbi.nlm.nih.gov/16568999"},"language":"en","primary_location":{"id":"doi:10.1021/ja056702b","doi":"https://doi.org/10.1021/ja056702b","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja056702b","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049477441","display_name":"Claudia Pacholski","orcid":"https://orcid.org/0000-0003-1620-5783","observed_orcids":["https://orcid.org/0000-0003-1620-5783"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["NZ","US"],"is_corresponding":false,"raw_author_name":"Claudia Pacholski","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, Dept. 0358, La Jolla, California 92093-0358, Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand, and Environment and Natural Resources, NSERC/CRSNG, 350 Albert, Ottawa, ON, K1A 1H5 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, Dept. 0358, La Jolla, California 92093-0358, Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand, and Environment and Natural Resources, NSERC/CRSNG, 350 Albert, Ottawa, ON, K1A 1H5 Canada","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083203208","display_name":"Christine J. Yu","orcid":"https://orcid.org/0000-0002-4720-0363","observed_orcids":["https://orcid.org/0000-0002-4720-0363"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["NZ","US"],"is_corresponding":false,"raw_author_name":"Christine Yu","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, Dept. 0358, La Jolla, California 92093-0358, Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand, and Environment and Natural Resources, NSERC/CRSNG, 350 Albert, Ottawa, ON, K1A 1H5 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, Dept. 0358, La Jolla, California 92093-0358, Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand, and Environment and Natural Resources, NSERC/CRSNG, 350 Albert, Ottawa, ON, K1A 1H5 Canada","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090541309","display_name":"Gordon M. Miskelly","orcid":"https://orcid.org/0000-0003-4748-0083","observed_orcids":["https://orcid.org/0000-0003-4748-0083"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["NZ","US"],"is_corresponding":false,"raw_author_name":"Gordon M. Miskelly","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, Dept. 0358, La Jolla, California 92093-0358, Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand, and Environment and Natural Resources, NSERC/CRSNG, 350 Albert, Ottawa, ON, K1A 1H5 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, Dept. 0358, La Jolla, California 92093-0358, Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand, and Environment and Natural Resources, NSERC/CRSNG, 350 Albert, Ottawa, ON, K1A 1H5 Canada","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001206508","display_name":"Denis Godin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["NZ","US"],"is_corresponding":false,"raw_author_name":"Denis Godin","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, Dept. 0358, La Jolla, California 92093-0358, Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand, and Environment and Natural Resources, NSERC/CRSNG, 350 Albert, Ottawa, ON, K1A 1H5 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, Dept. 0358, La Jolla, California 92093-0358, Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand, and Environment and Natural Resources, NSERC/CRSNG, 350 Albert, Ottawa, ON, K1A 1H5 Canada","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059375688","display_name":"Michael J. Sailor","orcid":"https://orcid.org/0000-0002-4809-9826","observed_orcids":["https://orcid.org/0000-0002-4809-9826"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["NZ","US"],"is_corresponding":false,"raw_author_name":"Michael J. Sailor","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, Dept. 0358, La Jolla, California 92093-0358, Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand, and Environment and Natural Resources, NSERC/CRSNG, 350 Albert, Ottawa, ON, K1A 1H5 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, Dept. 0358, La Jolla, California 92093-0358, Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand, and Environment and Natural Resources, NSERC/CRSNG, 350 Albert, Ottawa, ON, K1A 1H5 Canada","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.3967,"has_fulltext":false,"cited_by_count":135,"citation_normalized_percentile":{"value":0.88464471,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"128","issue":"13","first_page":"4250","last_page":"4252"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11169","display_name":"Silicon Nanostructures and Photoluminescence","score":0.5410000085830688,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11169","display_name":"Silicon Nanostructures and Photoluminescence","score":0.5410000085830688,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.3156999945640564,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.03009999915957451,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferometric-biosensor","display_name":"interferometric biosensor","score":0.8539999723434448},{"id":"https://openalex.org/keywords/porous-silicon","display_name":"porous silicon","score":0.6800000071525574},{"id":"https://openalex.org/keywords/label-free-immunoassay","display_name":"label-free immunoassay","score":0.7699999809265137},{"id":"https://openalex.org/keywords/optical-depth","display_name":"optical depth","score":0.5080000162124634},{"id":"https://openalex.org/keywords/immunoglobulin-g-binding","display_name":"immunoglobulin G binding","score":0.953000009059906},{"id":"https://openalex.org/keywords/matrix-effects","display_name":"matrix effects","score":0.5630000233650208},{"id":"https://openalex.org/keywords/nonspecific-binding","display_name":"non-specific binding","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8510605096817017},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.7198414206504822},{"id":"https://openalex.org/C166689943","wikidata":"https://www.wikidata.org/wiki/Q850283","display_name":"Interferometry","level":2,"score":0.6083254814147949},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.5779715776443481},{"id":"https://openalex.org/C41610221","wikidata":"https://www.wikidata.org/wiki/Q2047974","display_name":"Fourier transform spectroscopy","level":3,"score":0.5637126564979553},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.560920774936676},{"id":"https://openalex.org/C49102809","wikidata":"https://www.wikidata.org/wiki/Q300035","display_name":"Attenuated total reflection","level":3,"score":0.5023858547210693},{"id":"https://openalex.org/C160892712","wikidata":"https://www.wikidata.org/wiki/Q901559","display_name":"Fourier transform infrared spectroscopy","level":2,"score":0.481625497341156},{"id":"https://openalex.org/C102519508","wikidata":"https://www.wikidata.org/wiki/Q6520159","display_name":"Fourier transform","level":2,"score":0.4781949520111084},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.47029587626457214},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.46736523509025574},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.46212005615234375},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.44682610034942627},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.4171033799648285},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.33235716819763184},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2987654209136963},{"id":"https://openalex.org/C153642686","wikidata":"https://www.wikidata.org/wiki/Q70906","display_name":"Infrared spectroscopy","level":2,"score":0.22147119045257568},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005583","descriptor_name":"Fourier Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007368","descriptor_name":"Interferometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013205","descriptor_name":"Staphylococcal Protein A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/ja056702b","doi":"https://doi.org/10.1021/ja056702b","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja056702b","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:16568999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16568999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:researchspace.auckland.ac.nz:2292/10829","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2292/10829","pdf_url":null,"source":{"id":"https://openalex.org/S7407055463","display_name":"ResearchSpace (University of Auckland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154130895","host_organization_name":"University of Auckland","host_organization_lineage":["https://openalex.org/I154130895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3513714415","display_name":"Center of Nanotechnology for Treatment, Understanding, *","funder_award_id":"U54CA119335","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1968580328","https://openalex.org/W1970856301","https://openalex.org/W1988674219","https://openalex.org/W2026524260","https://openalex.org/W2047976728","https://openalex.org/W2050534908","https://openalex.org/W2074790130","https://openalex.org/W2084861802","https://openalex.org/W2086340242","https://openalex.org/W2145572269","https://openalex.org/W2885034522","https://openalex.org/W3127048131"],"related_works":["https://openalex.org/W2026524260","https://openalex.org/W2044760376","https://openalex.org/W2041589222","https://openalex.org/W2379596919","https://openalex.org/W2031955097","https://openalex.org/W2351484629","https://openalex.org/W4403129381","https://openalex.org/W2015601228","https://openalex.org/W1980767214","https://openalex.org/W2005484249"],"abstract_inverted_index":{"An":[0],"interferometric":[1],"biosensor":[2],"comprised":[3],"of":[4,7,14,24,37,49,62,80,106],"two":[5],"layers":[6,46],"porous":[8],"Si,":[9],"stacked":[10],"one":[11],"on":[12],"top":[13,39,64,72],"the":[15,25,34,38,41,60,63,71,92,104],"other,":[16],"is":[17,98],"described.":[18],"A":[19,55],"fast":[20],"Fourier":[21],"transform":[22],"(FFT)":[23],"reflectivity":[26,69],"spectrum":[27],"reveals":[28],"three":[29],"peaks":[30],"that":[31],"correspond":[32],"to":[33,52,59,88,100,103],"optical":[35],"thickness":[36],"layer,":[40,43],"bottom":[42],"and":[44],"both":[45],"together.":[47],"Binding":[48],"immunoglobulin":[50],"G":[51],"a":[53],"protein":[54],"capture":[56],"probe":[57],"adsorbed":[58],"surface":[61],"layer":[65],"induces":[66],"changes":[67,90],"in":[68,91],"at":[70],"layer/solution":[73],"interface.":[74],"The":[75,95],"FFT":[76],"method":[77],"allows":[78],"discrimination":[79],"target":[81],"analyte":[82,93],"binding":[83],"from":[84],"matrix":[85],"effects":[86],"due":[87],"nonspecific":[89],"solution.":[94],"sensor":[96],"response":[97],"shown":[99],"be":[101],"insensitive":[102],"addition":[105],"4000-fold":[107],"excess":[108,112],"sucrose":[109],"or":[110],"80-fold":[111],"bovine":[113],"serum":[114],"albumin":[115],"interferents.":[116]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}