{"id":"https://openalex.org/W207547278","doi":null,"title":"Effect of prolonged exposure of HELA S3 cells to low concentrations of misonidazole.","display_name":"Effect of prolonged exposure of HELA S3 cells to low concentrations of misonidazole.","publication_year":1981,"publication_date":"1981-10-01","ids":{"openalex":"https://openalex.org/W207547278","mag":"207547278","pmid":"https://pubmed.ncbi.nlm.nih.gov/7327372"},"language":"en","primary_location":{"id":"pmid:7327372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7327372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075877411","display_name":"\u5e78\u96c4 \u5927\u6cc9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Y Ohizumi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Shibata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Shibata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H Maezawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Maezawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S Ushiro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Ushiro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"T Mori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Mori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075877411"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"5","first_page":"717","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.05559999868273735,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/misonidazole","display_name":"misonidazole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypoxic-cells","display_name":"hypoxic cells","score":0.7070000171661377},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9399999976158142},{"id":"https://openalex.org/keywords/hela-s3-cells","display_name":"HeLa S3 cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/low-dose-chemotherapy","display_name":"low-dose chemotherapy","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7279999852180481},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.8309999704360962},{"id":"https://openalex.org/keywords/continuous-drug-administration","display_name":"continuous drug administration","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2781305896","wikidata":"https://www.wikidata.org/wiki/Q6875874","display_name":"Misonidazole","level":3,"score":0.9283059239387512},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.5359929800033569},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4328075051307678},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43078893423080444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34570538997650146},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3378708064556122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.268400639295578},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22912296652793884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1145600974559784}],"mesh":[{"descriptor_ui":"D000693","descriptor_name":"Anaerobiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008920","descriptor_name":"Misonidazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009593","descriptor_name":"Nitroimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:7327372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7327372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan","raw_type":"Journal Article"},{"id":"mag:207547278","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/40000529675","pdf_url":null,"source":{"id":"https://openalex.org/S4306555421","display_name":"\u764c","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u764c","raw_type":null},{"id":"mag:2423400273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7327372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W607802591","https://openalex.org/W1602931679","https://openalex.org/W2328736834","https://openalex.org/W1557010102","https://openalex.org/W2104543126","https://openalex.org/W168256512","https://openalex.org/W1495170765","https://openalex.org/W2414255703","https://openalex.org/W4299971250","https://openalex.org/W3198420832"],"abstract_inverted_index":{"The":[0,54,97],"cytotoxic":[1],"and":[2,18,33,77],"radiosensitizing":[3,143],"effects":[4],"of":[5,8,14,20,44,56,64,86,99,158,161,173],"low":[6,159],"concentrations":[7],"misonidazole":[9,31,50,72,108,139,162],"were":[10,122],"examined":[11],"by":[12,69],"measurement":[13],"the":[15,30,34,41,61,88,93,113,171],"colony-forming":[16],"ability":[17,55],"growth":[19,62,95,98],"HeLa":[21],"S3":[22],"cells.":[23,147],"Under":[24],"hypoxic":[25,146,174],"conditions,":[26],"cytotoxicity":[27],"depended":[28],"on":[29,145,149],"concentration":[32],"exposure":[35],"time.":[36],"After":[37],"24":[38,74,134],"hr":[39,75,126,135],"exposure,":[40,136],"surviving":[42],"fraction":[43],"cells":[45,57,101,121,175],"treated":[46],"with":[47],"0.1":[48,70,106,137],"mM":[49,71,107,131,138],"decreased":[51],"to":[52,58,60,127],"0.2.":[53],"adhere":[59],"surface":[63],"plastic":[65],"dishes":[66],"was":[67,90,102,116],"reduced":[68],"upon":[73],"hypoxia":[76],"this":[78],"effect":[79,144],"persisted":[80],"even":[81],"during":[82],"subsequent":[83],"euoxia,":[84],"irrespective":[85],"whether":[87],"drug":[89],"removed":[91],"from":[92,112],"original":[94],"medium.":[96],"aerobic":[100],"not":[103],"affected":[104],"when":[105,119],"containing":[109],"medium,":[110],"obtained":[111],"hypoxia-treated":[114],"dishes,":[115],"applied,":[117],"nor":[118],"those":[120],"exposed":[123],"for":[124],"72":[125],"freshly":[128],"prepared":[129],"1.0":[130],"misonidazole.":[132],"Upon":[133],"exerted":[140],"no":[141],"obvious":[142],"Based":[148],"these":[150],"results,":[151],"it":[152],"is":[153],"suggested":[154],"that":[155],"continuous":[156],"administration":[157],"doses":[160],"may":[163],"be":[164],"efficacious":[165],"as":[166],"a":[167],"specific":[168],"chemotherapeutic":[169],"in":[170,176],"treatment":[172],"tumor":[177],"tissue.":[178]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
