{"id":"https://openalex.org/W2075459286","doi":"https://doi.org/10.1378/chest.06-0965","title":"The Effects of 1-Year Treatment With a Herbst Mandibular Advancement Splint on Obstructive Sleep Apnea, Oxidative Stress, and Endothelial Function","display_name":"The Effects of 1-Year Treatment With a Herbst Mandibular Advancement Splint on Obstructive Sleep Apnea, Oxidative Stress, and Endothelial Function","publication_year":2007,"publication_date":"2007-03-01","ids":{"openalex":"https://openalex.org/W2075459286","doi":"https://doi.org/10.1378/chest.06-0965","mag":"2075459286","pmid":"https://pubmed.ncbi.nlm.nih.gov/17356088"},"language":"en","primary_location":{"id":"doi:10.1378/chest.06-0965","doi":"https://doi.org/10.1378/chest.06-0965","is_oa":false,"landing_page_url":"https://doi.org/10.1378/chest.06-0965","pdf_url":null,"source":{"id":"https://openalex.org/S76900504","display_name":"CHEST Journal","issn_l":"0012-3692","issn":["0012-3692","1931-3543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047175353","display_name":"Sarah Itzhaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Sarah Itzhaki","raw_affiliation_strings":["Sleep Laboratory, Technion-Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep Laboratory, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061527671","display_name":"Hezi Dorchin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Hezi Dorchin","raw_affiliation_strings":["Sleep Laboratory, Technion-Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep Laboratory, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108607289","display_name":"Glenn Thomas Clark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn Clark","raw_affiliation_strings":["Orofacial Pain and Oral Medicine Center, University of Southern California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orofacial Pain and Oral Medicine Center, University of Southern California, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074120211","display_name":"Lena Lavie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Lena Lavie","raw_affiliation_strings":["Sleep Laboratory, Technion-Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep Laboratory, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089044332","display_name":"Peretz Lavie","orcid":"https://orcid.org/0000-0003-4898-0776","observed_orcids":["https://orcid.org/0000-0003-4898-0776","https://orcid.org/0009-0006-6361-7210"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]},{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Peretz Lavie","raw_affiliation_strings":["Rambam Medical Center, and the Lloyd Rigler Sleep Apnea Research Laboratory, Technion-Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rambam Medical Center, and the Lloyd Rigler Sleep Apnea Research Laboratory, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211","https://openalex.org/I2801301638"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091280058","display_name":"Giora Pillar","orcid":"https://orcid.org/0000-0002-0553-4226","observed_orcids":["https://orcid.org/0000-0002-0553-4226"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Giora Pillar","raw_affiliation_strings":["Sleep Laboratory, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address: gpillar@tx.technion.ac.il","Sleep Laboratory, Technion-Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep Laboratory, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address: gpillar@tx.technion.ac.il","institution_ids":["https://openalex.org/I174306211"]},{"raw_affiliation_string":"Sleep Laboratory, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5091280058"],"corresponding_institution_ids":["https://openalex.org/I174306211"],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":null,"fwci":7.7995,"has_fulltext":false,"cited_by_count":172,"citation_normalized_percentile":{"value":0.97761912,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"131","issue":"3","first_page":"740","last_page":"749"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10356","display_name":"Orthodontics and Dentofacial Orthopedics","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10852","display_name":"Temporomandibular Joint Disorders","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3603","display_name":"Complementary and Manual Therapy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mandibular-advancement-device","display_name":"mandibular advancement device","score":0.9620000123977661},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8180000185966492},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.9599999785423279},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8690000176429749},{"id":"https://openalex.org/keywords/apnea-hypopnea-index","display_name":"apnea-hypopnea index","score":0.8429999947547913},{"id":"https://openalex.org/keywords/daytime-sleepiness","display_name":"daytime sleepiness","score":0.906000018119812},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.5360000133514404},{"id":"https://openalex.org/keywords/apnea-severity","display_name":"apnea severity","score":0.3610000014305115},{"id":"https://openalex.org/keywords/epworth-sleepiness-scale","display_name":"Epworth Sleepiness Scale","score":0.8700000047683716},{"id":"https://openalex.org/keywords/thiobarbituric-acid-reactive-substances","display_name":"TBARS","score":0.7549999952316284},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.42500001192092896},{"id":"https://openalex.org/keywords/sleep-disordered-breathing","display_name":"sleep-disordered breathing","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9411407709121704},{"id":"https://openalex.org/C2778664715","wikidata":"https://www.wikidata.org/wiki/Q1347756","display_name":"Epworth Sleepiness Scale","level":4,"score":0.6518924236297607},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.6398769021034241},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5498174428939819},{"id":"https://openalex.org/C2777935920","wikidata":"https://www.wikidata.org/wiki/Q213600","display_name":"Sleep apnea","level":2,"score":0.5197458267211914},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5112371444702148},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.5097851157188416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4945659339427948},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3629165291786194},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.2779175639152527}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001143","descriptor_name":"Arousal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014851","descriptor_name":"Wakefulness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017286","descriptor_name":"Polysomnography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017289","descriptor_name":"Orthodontic Appliances, Functional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017392","descriptor_name":"Thiobarbituric Acid Reactive Substances","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019186","descriptor_name":"Mandibular Advancement","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D045422","descriptor_name":"Continuous Positive Airway Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1378/chest.06-0965","doi":"https://doi.org/10.1378/chest.06-0965","is_oa":false,"landing_page_url":"https://doi.org/10.1378/chest.06-0965","pdf_url":null,"source":{"id":"https://openalex.org/S76900504","display_name":"CHEST Journal","issn_l":"0012-3692","issn":["0012-3692","1931-3543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"journal-article"},{"id":"pmid:17356088","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17356088","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"Controlled Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W39900388","https://openalex.org/W78083640","https://openalex.org/W133866210","https://openalex.org/W1590457525","https://openalex.org/W1788205751","https://openalex.org/W1841006369","https://openalex.org/W1968895937","https://openalex.org/W1981417640","https://openalex.org/W1984678806","https://openalex.org/W1988114644","https://openalex.org/W1995141700","https://openalex.org/W1997274278","https://openalex.org/W2007920108","https://openalex.org/W2009948616","https://openalex.org/W2018835478","https://openalex.org/W2033727169","https://openalex.org/W2034556696","https://openalex.org/W2035557978","https://openalex.org/W2036862523","https://openalex.org/W2045561532","https://openalex.org/W2046060950","https://openalex.org/W2051344677","https://openalex.org/W2067938560","https://openalex.org/W2073197000","https://openalex.org/W2082329013","https://openalex.org/W2089476892","https://openalex.org/W2100204228","https://openalex.org/W2101791017","https://openalex.org/W2104274405","https://openalex.org/W2105613623","https://openalex.org/W2108038374","https://openalex.org/W2112375249","https://openalex.org/W2113283606","https://openalex.org/W2114942155","https://openalex.org/W2116999983","https://openalex.org/W2128816052","https://openalex.org/W2139356364","https://openalex.org/W2139704316","https://openalex.org/W2141345969","https://openalex.org/W2142930560","https://openalex.org/W2154173751","https://openalex.org/W2154777157","https://openalex.org/W2157191239","https://openalex.org/W2158367419","https://openalex.org/W2170080991","https://openalex.org/W2254923557","https://openalex.org/W2264784497","https://openalex.org/W2335449614","https://openalex.org/W2396760804","https://openalex.org/W3022302886","https://openalex.org/W4233235818","https://openalex.org/W4243215475"],"related_works":["https://openalex.org/W2189362193","https://openalex.org/W2163820399","https://openalex.org/W2563632047","https://openalex.org/W2735433023","https://openalex.org/W2583380137","https://openalex.org/W2133689999","https://openalex.org/W1993723910","https://openalex.org/W1996115894","https://openalex.org/W2136654722","https://openalex.org/W2046149514"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":32},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":14}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
